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See detailRole of estradiol in the feminization of lordosis behavior in female mice
Trouillet, Anne-Charlotte ULg

Poster (2014, June)

The classic theory of mammalian brain and behavioral sexual differentiation holds that an organizational action of testosterone, secreted perinatally by the male’s testes, controls male-typical aspects of ... [more ▼]

The classic theory of mammalian brain and behavioral sexual differentiation holds that an organizational action of testosterone, secreted perinatally by the male’s testes, controls male-typical aspects of brain and behavioral development, whereas no active perinatal sex hormone signaling is required for female-typical differentiation. However, it has recently been shown using aromatase knock out (ArKO) mice, which are deprived of estradiol due to a targeted mutation in the aromatase gene, that estradiol may also actively contribute to the differentiation of female-typical aspects of behavior over a specific pre-pubertal period. Female ArKO mice showed significantly lower levels of lordosis behavior than wild type controls following adult ovariectomy and treatment with ovarian hormones. This deficit was restored by treating female ArKO mice with estradiol benzoate between postnatal days 15 and 25. However, the mechanism by which estradiol acts prepubertally in female mice to feminize lordosis behavior remains to be elucidated. Therefore, in a first attempt, we are determining which neuropeptides are in particularly sensitive to estradiol action over the prepubertal period. We will focus on neuropeptides which have been shown to be implicated in lordosis behavior. Studies by the group of Micevych have proposed an important role for NPY and beta-endorphin (B-END) neurons in the arcuate nucleus (ARC) in the estradiol-mediated activation of lordosis behavior in female rats. An in vitro study recently showed that kisspeptin directly activates ARC B-END neurons. This is particularly interesting since unpublished results from our laboratory showed that Kp neurons are directly involved in the expression of lordosis behavior. We are thus currently determining the expression of NPY, B-END, and kisspeptin in the ARC as well as μ-opioid receptors MORs in the MPN over the prepubertal period and their possible modulation by prepubertal estradiol treatment. [less ▲]

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See detailL’Afrique, nouveau terrain de jeu des puissances émergentes
Santander, Sébastian ULg

Book published by Karthala (2014)

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See detailL’Afrique à l’heure des émergents
Santander, Sébastian ULg

in Santander, Sébastian (Ed.) L’Afrique, nouveau terrain de jeu des puissances émergentes (2014)

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See detailLes émergents, l’Afrique et le décentrage progressif du pouvoir mondial
Santander, Sébastian ULg

in Santander, Sébastian (Ed.) L’Afrique, nouveau terrain de jeu des puissances émergentes (2014)

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See detailBook Review : Marc Hersant, Le discours de vérité dans les mémoires du duc de Saint-Simon
Donneau, Olivier ULg

in French History (2014), 28(2), 287

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See detailPortrait et imaginaire photographique. Cliché et anti-cliché du Nouveau Roman.
Lorent, Fanny ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2014), 14

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See detailMédecin de famille dans le premier monde
Jamoulle, Marc ULg

in Santé Conjuguée (2014), 68

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See detailPrediction of macroscopic mechanical properties of a polycrystalline microbeam subjected to material uncertainties
Lucas, Vincent ULg; Wu, Ling ULg; Arnst, Maarten ULg et al

in Cunha, Álvaro; Caetano, Elsa; Ribeiro, Pedro (Eds.) et al Proceedings of the 9th International Conference on Structural Dynamics, EURODYN 2014 (2014, June)

The first resonance frequency is a key performance characteristic of MEMS vibrometers. In batch fabrication, this first resonance frequency can exhibit scatter owing to various sources of manufacturing ... [more ▼]

The first resonance frequency is a key performance characteristic of MEMS vibrometers. In batch fabrication, this first resonance frequency can exhibit scatter owing to various sources of manufacturing variability involved in the fabrication process. The aim of this work is to develop a stochastic multiscale model for predicting the first resonance frequency of MEMS microbeams constituted of polycrystals while accounting for the uncertainties in the microstructure due to the grain orientations. At the finest scale, we model the microstructure of polycrystaline materials using a random Voronoï tessellation, each grain being assigned a random orientation. Then, we apply a computational homogenization procedure on statistical volume elements to obtain a stochastic characterization of the elasticity tensor at the second scale of interest, the meso-scale. In the future, using a stochastic finite element method, we will propagate these meso-scale uncertainties to the first resonance frequency at the coarser scale. [less ▲]

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See detailVolitional electromyographic responses in disorders of consciousness
Habbal, Dina; Gosseries, Olivia ULg; Noirhomme, Quentin ULg et al

in Brain Injury (2014)

The aim of the study was to validate the use of electromyography (EMG) for detecting responses to command in patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS) or in minimally ... [more ▼]

The aim of the study was to validate the use of electromyography (EMG) for detecting responses to command in patients in vegetative state/unresponsive wakefulness syndrome (VS/UWS) or in minimally conscious state (MCS). Methods: Thirty-eight patients were included in the study (23 traumatic, 25 patients >1 year post-onset), 10 diagnosed as being in VS/UWS, eight in MCS- (no response to command) and 20 in MCS+ (response to command). Eighteen age-matched controls participated in the experiment. The paradigm consisted of three commands (i.e. 'Move your hands', 'Move your legs' and 'Clench your teeth') and one control sentence (i.e. 'It is a sunny day') presented in random order. Each auditory stimulus was repeated 4-times within one block with a stimulus-onset asynchrony of 30 seconds. Results: Post-hoc analyses with Bonferroni correction revealed that EMG activity was higher solely for the target command in one patient in permanent VS/UWS and in three patients in MCS+. Conclusion: The use of EMG could help clinicians to detect conscious patients who do not show any volitional response during standard behavioural assessments. However, further investigations should determine the sensitivity of EMG as compared to neuroimaging and electrophysiological assessments. [less ▲]

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See detailNetworks for improving care in patients with acute coronary syndrome: A framework.
Radke, Peter W.; Halvorsen, Sigrun; Jukema, J. Wouter et al

in Acute cardiac care (2014), 16(2), 41-8

In recent years, it has become evident that the level of guideline adherence in patients presenting with acute coronary syndrome (ACS) is highly correlated with patient outcomes. Unfortunately, guideline ... [more ▼]

In recent years, it has become evident that the level of guideline adherence in patients presenting with acute coronary syndrome (ACS) is highly correlated with patient outcomes. Unfortunately, guideline adherence is low in some geographic areas and especially in those patients at high-risk. Regional networks including ambulance systems and hospitals with catheterization laboratories are able to increase guideline adherence and patient outcomes by streamlining the critical pre- and intra-hospital processes as well as improving timely access to invasive procedures and recommended medication. Successful organization of an ACS network requires engagement of multiple stakeholders to create effective solutions for the specific local setting. There is no 'one-size-fits all' strategy to set-up and successfully run an ACS network. We present a framework for how to set up and organize an effective ACS network, delivering guideline-based care to improve patient outcomes. [less ▲]

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See detailWelcoming the New Gods. Some Reflections on the Interactions between Rulers and Traditional Gods within Ritual Practice
Paul, Stéphanie ULg

Conference (2014, June)

One of the major changes identified as characteristic of Hellenistic religion is the introduction of new cults, and notably cultic honours for mortal rulers. Hellenistic poleis displayed various ... [more ▼]

One of the major changes identified as characteristic of Hellenistic religion is the introduction of new cults, and notably cultic honours for mortal rulers. Hellenistic poleis displayed various expedients to integrate these newcomers within their civic and religious landscape, operating a balanced dialectic between innovation and tradition. This integration happened at several levels, whether from a topographic point of view - e.g. consecration of a temenos, installation of altars, statues in sanctuaries of other gods (Schmidt-Dounas 1995) - or through ritual practice - e.g. the foundation of sacrifices and festivals, that were sometimes “appended” to a pre-existing festival (Buraselis 2012). The decree from Teos founding the cult of Antiochos III and Laodike exemplifies with great detail how a ruler cult could be integrated within a civic pantheon and how it echoed other cults (Chaniotis 2007). Based on a few selected inscriptions, this paper will explore some interactions between rulers and local gods as noted in ritual practice. A newly-published inscription from Aigai in Aiolis (EA 42 [2009], 32-60), regulating the foundation of honours for Seleukos I and Antiochos I after their victory over Lysimachos in 281 BC, exemplifies some of these interactions. The decree refers explicitly to Apollo, one of the main god of Aigai, regarding both the localization of the temenos of the kings next to the sanctuary of the god, and also sacrificial regulations, which were modelled after the sacrifices to Apollo. Other cultic associations with a goddess named Sôteira and Zeus Sôter echoed the epithet given to the kings and emphasised the circumstances that led to the introduction of their cult. Further lines of enquiry include the associations with traditional gods of the civic pantheon in prayers and sacrifices that are performed in honour of the king, thus placing the latter in an intermediary position between the polis and the gods. This is the case of an inscription from Ilion (I.Ilion 32), associating a king Antiochos with Athena Ilias on the one hand, Apollo, Zeus and Nike on the other hand, in a dialectic similar to the one observed at Aigai. Although the nature of ritual performance is not very informative as regards the specificity of ruler cult – in so far as it little differed from traditional rituals (Wikander 2005) – the interactions with the gods of the civic pantheon within ritual practice is nonetheless interesting to explore from the point of view of the integration of these new cults. Indeed, although the “practicalities of ruler cult” are not per se very specific, the mechanisms put in place by the poleis may differ in so far as they correspond to a local, specific, context. [less ▲]

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See detailL'épidémie au cinéma : de l'infiniment grand à l'infiniment petit
De Re, Margaux ULg

Master's dissertation (2014)

« You know where this comes from, shaking hands? It was a way of showing a stranger you weren't carrying a weapon in the old days. » Contagion, Steven Soderbergh, 2011 For decades film directors, inspired ... [more ▼]

« You know where this comes from, shaking hands? It was a way of showing a stranger you weren't carrying a weapon in the old days. » Contagion, Steven Soderbergh, 2011 For decades film directors, inspired by numerous novelists, have exploited the epidemic in various ways: as a general historical context to tell another story (Isle of the Dead, Robson, 1945), as a medical topic at the heart of an investigation (Medical Investigation, Horwitch, 2004), or as a process allowing the proliferation of zombies (Resident Evil, Anderson, 2000) or even vampires (Daybreakers, Spierig, 2010). This work aims at theorising a fascinating and surprising topic – which goes as far as haunting public restrooms with the “Stop Germs: Wash Your Hands” signs – and to offer an overview of films that are very present on our screens and yet absent from scholarly works about cinema. By combining the analysis of photography with that of narrative, this research tries to address issues which may seem, at first sight, plain and transparent (showing the epidemic is showing contaminated individuals) but prove to be, in practice, much more complex (how can contamination be represented since this microscopic phenomenon is invisible to the eye?). The developed method leans on science and the ties between epidemic, contagion and contamination in order to establish an approach going from the more general (epidemic, which belongs to the global and is illustrated as far as the film’s synopsis) to the more particular (contamination, which falls under the interpersonal and is represented only in precise sequence of the film). Beyond questions about cinema or narrative in the strict sense, this final dissertation aims at exploring the other side of epidemic: the collective imaginary it creates. Indeed, the way cinema represents these phenomena indicates a certain conception of epidemic, which spreads from a film to the other, from a viewer to the other. [less ▲]

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See detailRevascularisation versus medical treatment in patients with stable coronary artery disease: network meta-analysis.
Windecker, Stephan; Stortecky, Stefan; Stefanini, Giulio G. et al

in BMJ (Clinical research ed.) (2014), 348

OBJECTIVE: To investigate whether revascularisation improves prognosis compared with medical treatment among patients with stable coronary artery disease. DESIGN: Bayesian network meta-analyses to combine ... [more ▼]

OBJECTIVE: To investigate whether revascularisation improves prognosis compared with medical treatment among patients with stable coronary artery disease. DESIGN: Bayesian network meta-analyses to combine direct within trial comparisons between treatments with indirect evidence from other trials while maintaining randomisation. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: A strategy of initial medical treatment compared with revascularisation by coronary artery bypass grafting or Food and Drug Administration approved techniques for percutaneous revascularization: balloon angioplasty, bare metal stent, early generation paclitaxel eluting stent, sirolimus eluting stent, and zotarolimus eluting (Endeavor) stent, and new generation everolimus eluting stent, and zotarolimus eluting (Resolute) stent among patients with stable coronary artery disease. DATA SOURCES: Medline and Embase from 1980 to 2013 for randomised trials comparing medical treatment with revascularisation. MAIN OUTCOME MEASURE: All cause mortality. RESULTS: 100 trials in 93,553 patients with 262,090 patient years of follow-up were included. Coronary artery bypass grafting was associated with a survival benefit (rate ratio 0.80, 95% credibility interval 0.70 to 0.91) compared with medical treatment. New generation drug eluting stents (everolimus: 0.75, 0.59 to 0.96; zotarolimus (Resolute): 0.65, 0.42 to 1.00) but not balloon angioplasty (0.85, 0.68 to 1.04), bare metal stents (0.92, 0.79 to 1.05), or early generation drug eluting stents (paclitaxel: 0.92, 0.75 to 1.12; sirolimus: 0.91, 0.75 to 1.10; zotarolimus (Endeavor): 0.88, 0.69 to 1.10) were associated with improved survival compared with medical treatment. Coronary artery bypass grafting reduced the risk of myocardial infarction compared with medical treatment (0.79, 0.63 to 0.99), and everolimus eluting stents showed a trend towards a reduced risk of myocardial infarction (0.75, 0.55 to 1.01). The risk of subsequent revascularisation was noticeably reduced by coronary artery bypass grafting (0.16, 0.13 to 0.20) followed by new generation drug eluting stents (zotarolimus (Resolute): 0.26, 0.17 to 0.40; everolimus: 0.27, 0.21 to 0.35), early generation drug eluting stents (zotarolimus (Endeavor): 0.37, 0.28 to 0.50; sirolimus: 0.29, 0.24 to 0.36; paclitaxel: 0.44, 0.35 to 0.54), and bare metal stents (0.69, 0.59 to 0.81) compared with medical treatment. CONCLUSION: Among patients with stable coronary artery disease, coronary artery bypass grafting reduces the risk of death, myocardial infarction, and subsequent revascularisation compared with medical treatment. All stent based coronary revascularisation technologies reduce the need for revascularisation to a variable degree. Our results provide evidence for improved survival with new generation drug eluting stents but no other percutaneous revascularisation technology compared with medical treatment. [less ▲]

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See detailL'impact de la gestion de la mobilité par les entreprises wallonnes sur les déplacements domicile-travail
Halleux, Jean-Marie ULg; Vandermeer, Marie-Caroline ULg

in Recherche - Transports - Securité (2014), 2014(2-3), 83-100

Although mobility management by employers is an increasingly common practice, literature is scarce on the real impact of the applied measures. In this perspective, the objective of this paper is to assess ... [more ▼]

Although mobility management by employers is an increasingly common practice, literature is scarce on the real impact of the applied measures. In this perspective, the objective of this paper is to assess the impact on car use of the measures adopted by employers located in Wallonia. In order to achieve this objective, the article develops simulations that put forward the impact of the measures based on their interrelations with other modal choice factors. Our assessment leads to the conclusion that measures promoting public transport and car-pooling can reduce solo car driving between 7,2 % and 8,4 %. In contrast to our assumption, measures promoting public transport are less effective in central areas than in urban outskirts. Regarding measures promoting the use of bicycle, the findings suggest that the modal shift occurs from other modes rather than from car use. [less ▲]

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See detailL’effet des dispositifs d’intermédiation sur les trajectoires professionnelles des travailleurs. Le cas d’un bureau de recrutement, recherche et sélection de personnel.
Gérard, Julie ULg

Conference (2014, June)

Au cours de ces dernières années, le souci d’allier flexibilité et sécurité au travail a conduit à l’essor considérable des métiers de l’intermédiation (Orianne et Maroy, 2008). En particulier dans le ... [more ▼]

Au cours de ces dernières années, le souci d’allier flexibilité et sécurité au travail a conduit à l’essor considérable des métiers de l’intermédiation (Orianne et Maroy, 2008). En particulier dans le domaine de l’accompagnement et du développement de carrière, divers dispositifs privés d’aide et de suivi ont vu le jour afin de contribuer à l’amélioration des conditions de travail et d’assister les travailleurs dans leurs transitions professionnelles. Par leur action, ces nouveaux dispositifs n’hésitent pas à complexifier les temporalités sociales en créant de nouvelles opportunités d’emploi et en redéfinissant les rythmes de carrière. À l’aide d’une étude de cas dans le secteur du recrutement belge, nous analyserons la capacité d’un processus de mise en emploi à remplir de tels objectifs dans un contexte de gestion mixte du marché du travail. Approchée d’une manière qualitative (entretiens semi-directifs et observations), nous étudierons l’apport de cette agence de placement au travers d’un cadre théorique qui intègre les concepts de dispositif (Foucault, 1977 ; Peeters et Charlier, 1999 ; Raffnsoe, 2008) et de réseaux sociaux (Grossetti 2005, 2008 et 2011). Nous montrerons qu’un plus de régir l’offre et la demande de travail, ce dispositif d’intermédiation, par son système de cooptation et son accompagnement de carrière, assure la fluidification du marché et sécurise la dynamique des transitions professionnelles. [less ▲]

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See detailSlope instabilities in the north-eastern Algeria: Triggering factors and evolution's mecahnisms
Draidia, Salah ULg; Havenith, Hans-Balder ULg; Ahcene, Bourefis et al

Scientific conference (2014, June)

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See detailAnalyse du métier de facilitateur et de son rôle dans la diffusion de normes d’emploi : le cas d’un bureau de chômage belge
Orianne, Jean-François ULg; Beuker, Laura ULg

Conference (2014, June)

En 2004, suite aux injonctions européennes en matière d’activation impulsées par les lignes directrices de 2003-2005, la Belgique met en place le PAC (ou Plan d’Accompagnement des chômeurs). Cette ... [more ▼]

En 2004, suite aux injonctions européennes en matière d’activation impulsées par les lignes directrices de 2003-2005, la Belgique met en place le PAC (ou Plan d’Accompagnement des chômeurs). Cette importante réforme prévoit – notamment – la mise en place de la procédure d’activation du comportement de recherche d’emploi par l’Office National de l’Emploi (Ou l’ONEm). Désormais, des agents sont spécifiquement dédiés à l’évaluation des efforts menés par les demandeurs d’emploi (ou DE) pour s’insérer sur le marché du travail : ce sont les facilitateurs. Si la procédure d’évaluation est officiellement définie, la décision, quant à elle, est bel et bien fonction de l’agent, qui doit interpréter le cadre réglementaire général à l’aune de la situation singulière du demandeur d’emploi. À l’aide d’une étude de cas réalisée au sein d’un bureau de chômage situé en Belgique francophone, nous allons tenter d’ouvrir la « boîte noire » du jugement des facilitateurs. À partir d’une approche qualitative cumulant des entretiens semi-directifs et de l’observation d’interactions entre facilitateurs et demandeurs d’emploi, nous montrerons que la décision des facilitateurs n’est ni arbitraire, ni déterminée. Elle est, au contraire, le fruit de la mobilisation d’une multitude d’appuis conventionnels dans l’action (Dodier, 1993). En outre, dans la lignée des travaux de Benarrosh (2000 ; 2006 ; 2012) nous démontrerons que ces agents sont des « pourvoyeurs » de normes institutionnelles précises à destination des demandeurs d’emploi. [less ▲]

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See detailL’effet d’un dispositif public d’accompagnement et de formation belge sur les trajectoires professionnelles des demandeurs d’emploi
Gérard, Julie ULg

Conference (2014, June)

: Suite aux récents bouleversements économiques et sociaux touchant les pays de l’Union Européenne, de nombreux partenariats entre services publics d’emploi et agences d’emploi privées se sont développés ... [more ▼]

: Suite aux récents bouleversements économiques et sociaux touchant les pays de l’Union Européenne, de nombreux partenariats entre services publics d’emploi et agences d’emploi privées se sont développés et complexifiés, suivant une logique de gestion mixte du marché de l’emploi. Cette communication porte sur l’étude d’un partenariat public-privé entre un service public régional belge et un organisme de formation. À partir des apports conceptuels et théoriques de la sociologie de l’action publique et de la littérature propre aux agences d’emploi privées et aux partenariats public-privé, nous analyserons la capacité d’un dispositif public à assurer la remise à l’emploi de son public-cible. Pour ce faire, nous étudierons son rôle et ses effets sur les trajectoires professionnelles des demandeurs d’emploi y recourant. [less ▲]

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See detailPolitique d'immigration: identité et approche de chaque parti
Martiniello, Marco ULg

Article for general public (2014)

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