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See detailPharmacotherapy of 'treatment resistant' type 2 diabetes.
Scheen, André ULg

in Expert Opinion on Pharmacotherapy (2017), 1

INTRODUCTION: Despite type 2 diabetes (T2D) management offers a variety of pharmacological interventions targeting different defects, numerous patients remain with persistent hyperglycaemia responsible ... [more ▼]

INTRODUCTION: Despite type 2 diabetes (T2D) management offers a variety of pharmacological interventions targeting different defects, numerous patients remain with persistent hyperglycaemia responsible for severe complications. Unlike resistant hypertension, treatment resistant T2D is not a classical concept although it is a rather common observation in clinical practice. Areas covered: This article proposes a definition for 'treatment resistant diabetes', analyses the causes of poor glucose control despite standard therapy, briefly considers the alternative approaches to glucose-lowering pharmacotherapy and finally describes how to overcome poor glycaemic control, using innovative oral or injectable combination therapies. Expert opinion: Before considering intensifying the pharmacotherapy of a patient with poorly controlled T2D, it is important to verify treatment adherence, target obesity and consider various non pharmacological improvement quality interventions. If treatment resistant diabetes is defined as not achieving glycated haemoglobin target despite oral triple therapy with a third glucose-lowering agent added to metformin-sulfonylurea dual treatment, the combination of a dipeptidyl peptidase-4 (DPP-4) inhibitor and a sodium glucose cotransporter type 2 (SGLT2) inhibitor may offer new opportunities before considering injectable therapies. Insulin basal therapy (+/- metformin) may be optimized by the addition of a SGLT2 inhibitor or a glucagon-like peptide-1 (GLP-1) receptor agonist. [less ▲]

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See detailEffects of reducing blood pressure on renal outcomes in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME.
Scheen, André ULg; Delanaye, P.

in Diabètes & Métabolism (2017), (epub ahead of print),

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 ... [more ▼]

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 diabetes (T2D) and a history of cardiovascular disease in the EMPA-REG OUTCOME. These results have been attributed to haemodynamic rather than metabolic effects, in part due to the osmotic/diuretic action of empagliflozin and the reduction in arterial blood pressure (BP). The present narrative review includes the results of meta-analyses of trials evaluating the effects on renal outcomes of lowering BP in patients with T2D, with a special focus on the influence of baseline and achieved systolic BP, and compares the renal outcome results of the EMPA-REG OUTCOME with those of other major trials with inhibitors of the renin-angiotensin system in patients with T2D and the preliminary findings with other SGLT2 inhibitors, and also evaluates post hoc analyses from the EMPA-REG OUTCOME of special interest as regards the BP-lowering hypothesis and renal function. While systemic BP reduction associated to empagliflozin therapy may have contributed to the renal benefits reported in EMPA-REG OUTCOME, other local mechanisms related to kidney homoeostasis most probably also played a role in the overall protection observed in the trial. [less ▲]

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See detailPreliminary assessment of the possibilities of the Particle Finite Element Method in the numerical simulation of bird impact on aeronautical structures
Cerquaglia, Marco Lucio ULg; Deliège, Geoffrey ULg; Boman, Romain ULg et al

in Procedia Engineering (2017), 173

As well known, in the analysis of bird impact events the bird is often reduced, even experimentally, to a surrogate projectile modeled as a weakly compressible fluid (typically a mixture of water and air ... [more ▼]

As well known, in the analysis of bird impact events the bird is often reduced, even experimentally, to a surrogate projectile modeled as a weakly compressible fluid (typically a mixture of water and air). From a numerical standpoint, the presence of a free surface and the strong interaction with the aircraft structures represent a limit for traditional computational fluid dynamics methods based on an Eulerian grid. On the other hand, classical Lagrangian methods cannot cope with the extremely large deformations experienced by the projectile during the impact. The Particle Finite Element Method (PFEM) is a Lagrangian particle method that can account for very large deformations, preserving the robustness and generality of the finite element method, and thus owning a key advantage over other approaches, e.g. Smoothed Particle Hydrodynamics (SPH), usually cursed with consistency and stability issues. To assess the possibilities of the method in the context of bird impact, theoretical analyses are initially performed based on the impact of a water jet on a rigid surface. Then, the influence of the geometry of a more realistic projectile is analyzed and the capability of the method to take into account separation and fragmentation is highlighted. [less ▲]

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See detailLong-term consistency of spatial patterns of primate seed dispersal
Heymann, E. W.; Culot, Laurence ULg; Knogge, Christoph et al

in Ecology and Evolution (2017)

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See detailPersistence of the effec of frugivore identity on post-dispersal seed fate: consequences for the assessment of functional redundancy
Lugon, Ana Paula; Boutefeu, Marion; Bovy, Emilie et al

in Biotropica (2017)

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See detailATLANTIC-FRUGIVORY: A PLANT-FRUGIVORE INTERACTION DATASET FOR THE ATLANTIC FOREST
Bello, C; Galetti, M; Montan, D et al

in Ecology (2017)

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See detailFeedback effect on children's global metacognitive judgments
Geurten, Marie ULg; Meulemans, Thierry ULg

Poster (2017)

In three experiments, we investigated whether the feedback effect on the accuracy of children’s metacognitive judgments results from an improvement in monitoring processes or the use of the Anchoring-and ... [more ▼]

In three experiments, we investigated whether the feedback effect on the accuracy of children’s metacognitive judgments results from an improvement in monitoring processes or the use of the Anchoring-and-Adjustment heuristic. The purpose of Experiment 1 was to investigate whether 4-, 6-, and 8-year-old children are able to use feedback to increase the accuracy of their memory judgments. To do so, children in three age groups were divided into two experimental conditions (feedback or no feedback). After studying a list of associated words, participants were instructed to predict their future memory performance, and then they were asked to recall as many items as possible. Next, half of the participants were given concrete feedback about the accuracy of their global prediction. Once the feedback was provided, all children were presented with another set of associated word pairs and the procedure was repeated. Our results revealed that children’s predictions were more accurate in the feedback than in the no feedback condition, indicating that getting feedback about the accuracy of their judgments had a positive influence on their subsequent memory predictions. In Experiment 2, we sought to determine whether young children are able to use the Anchoring-and-Adjustment heuristic to guide their global memory predictions. For this purpose, 4-, 6-, and 8-year-old children were divided into three experimental conditions depending on the anchor that was provided (high, low, or no anchor). Data indicated that children’s predictions were higher in the high than in the low anchor condition, suggesting that children in all age groups adjusted their prospective judgment depending on the random anchor they were given. Finally, the primary aim of Experiment 3 was to determine whether the feedback effect can serve as an external anchor for children’s global prospective judgments. To do so, children (aged 4, 6, and 8 years) were presented with two memory tasks that differed in terms of difficulty. Participants were randomly assigned to an anchoring (high, low, or no anchor) and a feedback (feedback or no feedback) condition to obtain a balanced experimental design. Results showed that children in the feedback condition adjusted their predictions toward the feedback, regardless of the task’s difficulty. These findings are consistent with the hypothesis that external information provided by feedback is used as an anchor for judgment. This interpretation is strengthened by the correlation found between the two scores computed to assess participants’ susceptibility to anchoring and feedback effects, which indicates that children who are more sensitive to the anchoring effect are also more sensitive to the feedback effect. [less ▲]

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See detailP-301 High Concentration Multistrain Probiotic Produced at Different Manufacturing Sites: Comparative Analysis.
Lombardi, Francesca; La Torre, Cristina; Giusti, Ilaria et al

in Inflammatory Bowel Diseases (2017), 23

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See detailRelevant Animal Models in Dermatophyte Research
Cambier, Ludivine ULg; Heinen, Marie-Pierre ULg; Mignon, Bernard ULg

in Mycopathologia (2017), 182(1), 229-240

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See detailNi utopie ni solidarisme. Une refonte matérialiste et critique de l'association est-elle possible ?
Frère, Bruno ULg

in Delaunay, Catarina (Ed.) Democracia, promessas, utopias e (des)ilusoes : dilemas e disputas nas arenas publicas (2017)

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See detailHow to account for new forms of resistance to domination: An argument for a materialist renewal in European social theory
Frère, Bruno ULg; Tulle, Emmanuelle

E-print/Working paper (2017)

Many significant intellectual developments have taken place in 20th century European social theories. Notably the first Frankfurt School and Bourdieu’s work have successfully shown how workers, social ... [more ▼]

Many significant intellectual developments have taken place in 20th century European social theories. Notably the first Frankfurt School and Bourdieu’s work have successfully shown how workers, social actors, etc. are alienated or dominated by capitalist social structures. But according to Habermas, neither perspective successfully allows for the possibility that people could contribute to their own emancipation. The emergence of new forms of social resistance to domination such as those embodied by the Indignados, Anonymous, Femen, the practitioners of alternative economy, movements of unemployed people or illegals compels us to envisage the possibility for emancipation, but how? In this paper we explore opportunities for accounting for this by considering the work of a range of other European social theorists, more specifically Boltanski whose critical intent is embodied in his pragmatic sociology, and evident in his coining and use of the concept of the world. In addition we will consider Latour’s own pragmatic stance as we believe that despite his disinterest in new social movements, his work, informed by pure immanence, might offer potential solutions. But we would argue that even in these innovations there is either a persistent tendency to imagine emancipation primarily as a return to some ideal state or a lack of critical engagement with alienation. In response, we propose a materialist renewal, which will lead us to ponder on the political role of sociologists. [less ▲]

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See detailBack to materialism Reflections on Marx’s labour, praxis, cooperative and libertarian socialism in the 19th century
Frère, Bruno ULg

E-print/Working paper (2017)

From Marx to Althusser, the materialist approach has tended to assume that individuals (that is, workers, proletarians and other social actors), unconsciously reproduce the social structures of capitalism ... [more ▼]

From Marx to Althusser, the materialist approach has tended to assume that individuals (that is, workers, proletarians and other social actors), unconsciously reproduce the social structures of capitalism which alienate them. It is assumed that individuals accept the conditions forced upon them and no longer seek to rebel against a world which substantially impoverishes their labour, their spirit and their creativity. In this paper, I will try to show that by dint of favouring almost exclusively Marx's concept of alienation, there is a considerable risk that materialist thought will adopt only a negative path. Whilst I acknowledge Marx’s significance to materialism, I wish to argue that his stance should be combined with that of the anarchist and libertarian French thinker Proudhon. Proudhon has succeeded in presenting a conception of the worker as more than just alienated. Workers can also cooperate and experience a reciprocity seemingly at odds with the character of capitalism. Under Proudhon’s influence materialism takes a positive turn, enabling us to avoid falling into the utopianism that the theory of social economy employs to critique capitalism – a utopianism that renders its critique even less effective than that of Marx. [less ▲]

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See detailBaldassare Galuppi, « il Buranello » : l’œuvre opératique, instrumental et religieux
Corswarem, Emilie ULg; Pirenne, Christophe

Book published by Garnier (2017)

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See detailStudy Protocol: Effect of prenatal wheel-running exercise (before and during gestation) on cocaine psychomotor sensitization expressed in the offspring in periadolescent females and males C57BL/6J mice
Lespine, Louis-Ferdinand ULg; Plenevaux, Alain ULg; Tirelli, Ezio ULg

E-print/Working paper (2017)

The present study principally aims at determining to which extent prenatal exercise (before and during gestation) could affect the initiation (establishment) and the expression of psychomotor ... [more ▼]

The present study principally aims at determining to which extent prenatal exercise (before and during gestation) could affect the initiation (establishment) and the expression of psychomotor sensitization induced by a representative dose of cocaine in young female and male mice. More specifically, we will assess cocaine-induced acute psychomotor-activating effects, psychomotor sensitization developing over 9 daily sessions (daily peritoneal injections of cocaine or saline) and the long-term expression of the sensitized response (30 days after the last sensitizing injection) in C57BL/6J mice born from mothers housed with or without a running wheel before and during gestation. Based on literature and on our prior results, the mice born from exercised mothers are expected to show significantly reduced levels of cocaine responsiveness in comparison with the control mice (born from unexercised mothers). [less ▲]

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See detailDiet effects on bumblebee health
Roger, N.; Michez, D.; Wattiez, R. et al

in Journal of Insect Physiology (2017), 96

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as ... [more ▼]

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as the ability of an organism to mount an immune response, either in cellular, humoral or behavioural forms. In insects, immune capacity can be affected by a variety of factors including pesticides, genetic diversity or diet. Here we focus on an important species of domesticated pollinator, Bombus terrestris, and the potential impact of a poor pollen diet (low nutritional content and toxic) on its health. We investigate three responses at both colony and individual levels: behavioural, humoral and cellular. Our results show that poor pollen diets decrease larval and pupal masses and increase larval ejection as well as adult constitutive immunity (i.e., prophenoloxidase assays). The susceptibility of bumblebees to disease and infection might therefore be greater after a nutritive stress. These findings raise the importance of available plant hosts, especially floral plant species providing pollen with suitable nutritive quality (i.e., nutrient pollen content) for bumblebees. © 2016 Elsevier Ltd [less ▲]

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See detailPeur de l'intimité dans la relation amoureuse adolescente : L'implication de l'attachement parental et de l'attachement romantique
Courtain, Audrey ULg; Glowacz, Fabienne ULg

in Annales Médico-Psychologiques (2017)

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment ... [more ▼]

Teen dating is a developmental stage questioning dramatically the relationships to be expected with others, especially when feelings of tenderness and love are involved. It mobilizes parental attachment and the internal working models related to it, while being colored by the emerging romantic attachment and its brand new internal working models. Attachments are deeply shaped by a dynamic interaction whereby the self tries to figure out how to reach security and autonomy still taking the other into account. This considered, intimacy also implies a dynamic feature: on the one hand, closeness and sharing of feelings and/or experiences, and on the other hand, individuality and maintaining of one’s ego. However, just like attachments may be insecure, a fear of intimacy cannot be underestimated during dating. Eventually, bearing in mind the societal and cultural components of attachment and intimacy, gendered explanations cannot be ignored, especially during adolescence. Objectives: Three hypotheses are being tested. First, the continuity from parental to romantic attachment is postulated, meaning that a secure, preoccupied or dismissing attachment to parents might lead to a subsequent secure, preoccupied or dismissing attachment to romantic partners. Second, the influence of parental attachment on the fear of intimacy during teen dating is questioned. The difficult dynamic of closeness/individuality might be explained by the parental attachment’s patterns. Third, the impact of romantic attachment on the fear of intimacy during teen dating is assessed. Also, dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship are studied and put in perspective with the romantic attachment. Materials and methods: The initial sample is made of 283 Belgian students (61% girls) from different teaching systems, aged of 16-22 years old (mean age : 17.43), and 232 of them had already had a dating experience by this time. They were questioned about dating characteristics such as number of love relationships, age of the first dating experience and the longest lasting relationship. Two questionnaires were also self-administered: the Behavioral Systems Questionnaire (assessing attachment) and the Fear of Intimacy Scale. Statistical analyses such as Pearson Chi², Anova and Post-Hoc LSD were carried out. Results: First, we cannot see any continuity between parental and romantic attachment. Second, dismissing attachment to parents fosters the fear on intimacy, compared to secure profiles; this is especially true for dismissing girls. Third, dismissing and preoccupied attachments to romantic partners foster the fear of intimacy, compared to secure profiles; this is especially true for dismissing and even more for preoccupied boys. Also, preoccupied attachment to romantic partners fosters the multiplication of datings, compared to secure; this is especially true for preoccupied and even more for dismissing girls. Finally, there is no effect of romantic attachment on the age of the first dating experience or on the longest lasting relationship. Conclusion: Parental and romantic attachments are involved in the fear of intimacy experienced by adolescents during dating. Still, attachment styles’ influence seems different for girls and boys, and highlights the need to distinguish girls’ from boys’ teen dating experiences. [less ▲]

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