Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailEvaluation of [18F]UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain.
Warnock, Geoffrey; Aerts, Joël ULg; Bahri, Mohamed Ali ULg et al

in Journal of Nuclear Medicine (The) (2014), 55(8), 1336-1341

Synaptic vesicle 2 (SV2) proteins are critical to proper nervous system function and are involved in vesicle trafficking. The SV2A isoform has been identified as the binding site of the antiepileptic ... [more ▼]

Synaptic vesicle 2 (SV2) proteins are critical to proper nervous system function and are involved in vesicle trafficking. The SV2A isoform has been identified as the binding site of the antiepileptic levetiracetam (LEV), making it an interesting therapeutic target for epilepsy. [18F]UCB-H is a novel PET imaging agent with a nanomolar affinity for human SV2A. Methods: preclinical PET studies were carried out in isoflurane anesthetized rats. Arterial input function was measured using an arteriovenous shunt and beta microprobe system. [18F]UCB-H was injected IV (140 ± 20 MBq bolus). Results: brain uptake of [18F]UCB-H was high, matching the expected homogeneous distribution of SV2A. The distribution volume (Vt) for [18F]UCB-H was calculated using Logan’s graphical analysis and the effect of LEV pretreatment on Vt measured. In control animals the mean whole-brain Vt was 9.76 ± 0.52 ml/cm3 (mean ± SD, n=4, test-retest), and the mean reproducibility in test-retest studies was 10.4 ± 6.5 %. Uptake of [18F]UCB-H was dose-dependently blocked by pretreatment with LEV (0.1 - 100 mg/kg IV). Conclusion: our results indicate that [18F]UCB-H is a suitable radiotracer for the imaging of SV2A in vivo. This is the first PET tracer for in vivo quantification of SV2A. The necessary steps for implementation of [18F]UCB-H production under GMP conditions and first in human studies are planned. [less ▲]

Detailed reference viewed: 76 (26 ULg)
Full Text
Peer Reviewed
See detailcompte rendu de : Geiger, Joseph. Hellenism in the East: studies on Greek intellectuals in Palestine.
Rochette, Bruno ULg

in Bryn Mawr Classical Review [=BMCR] (2014)

Detailed reference viewed: 15 (1 ULg)
Full Text
See detailEn attendant Toussaint
Demoulin, Laurent ULg

E-print/Working paper (2014)

Présentation et analyse de deux courtes pièces, Rideau et Ni l'un ni l'autre, écrites par Jean-Philippe Toussaint en 1981, quand il était un jeune auteur inconnu influencé par Samuel Beckett.

Detailed reference viewed: 21 (4 ULg)
See detailX-rays from magnetic massive OB stars
Petit, V.; Cohen, D. H.; Nazé, Yaël ULg et al

in IAU Symposium (2014, August 01)

The magnetic activity of solar-type and low-mass stars is a well known source of coronal X-ray emission. At the other end of the main sequence, X-rays emission is instead associated with the powerful ... [more ▼]

The magnetic activity of solar-type and low-mass stars is a well known source of coronal X-ray emission. At the other end of the main sequence, X-rays emission is instead associated with the powerful, radiatively driven winds of massive stars. Indeed, the intrinsically unstable line-driving mechanism of OB star winds gives rise to shock-heated, soft emission (~0.5 keV) distributed throughout the wind. Recently, the latest generation of spectropolarimetric instrumentation has uncovered a population of massive OB-stars hosting strong, organized magnetic fields. The magnetic characteristics of these stars are similar to the apparently fossil magnetic fields of the chemically peculiar ApBp stars. Magnetic channeling of these OB stars' strong winds leads to the formation of large-scale shock-heated magnetospheres, which can modify UV resonance lines, create complex distributions of cooled Halpha emitting material, and radiate hard (~2-5 keV) X-rays. This presentation summarizes our coordinated observational and modelling efforts to characterize the manifestation of these magnetospheres in the X-ray domain, providing an important contrast between the emission originating in shocks associated with the large-scale fossil fields of massive stars, and the X-rays associated with the activity of complex, dynamo-generated fields in lower-mass stars. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailA Deep Chandra Observation of the Giant H II Region N11. I. X-Ray Sources in the Field
Nazé, Yaël ULg; Wang, Q. Daniel; Chu, You-Hua et al

in Astrophysical Journal Supplement Series (2014), 213

A very sensitive X-ray investigation of the giant H II region N11 in the Large Megallanic Cloud was performed using the Chandra X-ray Observatory. The 300 ks observation reveals X-ray sources with ... [more ▼]

A very sensitive X-ray investigation of the giant H II region N11 in the Large Megallanic Cloud was performed using the Chandra X-ray Observatory. The 300 ks observation reveals X-ray sources with luminosities down to 10[SUP]32[/SUP] erg s[SUP]–1[/SUP], increasing the number of known point sources in the field by more than a factor of five. Among these detections are 13 massive stars (3 compact groups of massive stars, 9 O stars, and one early B star) with log (L [SUB]X[/SUB]/L [SUB]BOL[/SUB]) ~–6.5 to –7, which may suggest that they are highly magnetic or colliding-wind systems. On the other hand, the stacked signal for regions corresponding to undetected O stars yields log (L [SUB]X[/SUB]/L [SUB]BOL[/SUB]) ~–7.3, i.e., an emission level comparable to similar Galactic stars despite the lower metallicity. Other point sources coincide with 11 foreground stars, 6 late-B/A stars in N11, and many background objects. This observation also uncovers the extent and detailed spatial properties of the soft, diffuse emission regions, but the presence of some hotter plasma in their spectra suggests contamination by the unresolved stellar population. [less ▲]

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailStandardization of DiaSorin and Roche automated third generation PTH assays with an international standard: impact on clinical populations
CAVALIER, Etienne ULg; DELANAYE, Pierre ULg; LUKAS, Pierre ULg et al

in Clinical Chemistry & Laboratory Medicine (2014), 52(8), 1137-41

Background: Standardization of parathyroid hormone (PTH) assays is a major issue, especially in hemodialyzed (HD) patients. Two automated third generation PTH assays (Roche Elecsys and DiaSorin Liaison ... [more ▼]

Background: Standardization of parathyroid hormone (PTH) assays is a major issue, especially in hemodialyzed (HD) patients. Two automated third generation PTH assays (Roche Elecsys and DiaSorin Liaison) are now available. These assays are specific for the (1-84) PTH and do not cross-react with the (7-84) fragment, contrary to second generation (intact) assays. We aimed to calibrate the two methods against the WHO International PTH Standard (IS) 95/646 to see if the two assays could provide comparable results in a population of healthy subjects, HD patients and patients suffering from primary hyperparathyroidism (PHP). Methods: We selected 79 healthy subjects and two populations of patients presenting PTH disorders: 56 HD and 27 PHP patients. We reconstituted the IS in a pool of human serum containing undetectable levels of 1-84 PTH and prepared 13 serum standards ranging from 0 to 2000 pg/mL. The standards were run on the two instruments to calibrate the assays on the IS. The different populations were run before and after restandardization. Results: As these kits were differently calibrated, the results obtained after restandarization were significantly different. Restandardization process improved concordance between assays and, taking the analytical variability of the two kits into account, the results could be considered to be similar. Conclusions: Restandardization of automated third generation PTH assays with the WHO 1-84 PTH Standard significantly reduces inter-method variability. Reference ranges and raw values are totally transposable from one method to the other in healthy subjects, but also in diseased patients, e.g., with HD or those suffering from PHP. [less ▲]

Detailed reference viewed: 36 (15 ULg)
Full Text
Peer Reviewed
See detailAbundance analysis, spectral variability, and search for the presence of a magnetic field in the typical PGa star HD 19400
Hubrig, S.; Castelli, F.; González, J. F. et al

in Monthly Notices of the Royal Astronomical Society (2014), 442

The aim of this study is to carry out an abundance determination, to search for spectral variability and for the presence of a weak magnetic field in the typical PGa star HD 19400. High-resolution, high ... [more ▼]

The aim of this study is to carry out an abundance determination, to search for spectral variability and for the presence of a weak magnetic field in the typical PGa star HD 19400. High-resolution, high signal-to-noise High Accuracy Radial-velocity Planet Searcher (HARPS) spectropolarimetric observations of HD 19400 were obtained at three different epochs in 2011 and 2013. For the first time, we present abundances of various elements determined using an ATLAS12 model, including the abundances of a number of elements not analysed by previous studies, such as Ne I, Ga II, and Xe II. Several lines of As II are also present in the spectra of HD 19400. To study the variability, we compared the behaviour of the line profiles of various elements. We report on the first detection of anomalous shapes of line profiles belonging to Mn and Hg, and the variability of the line profiles belonging to the elements Hg, P, Mn, Fe, and Ga. We suggest that the variability of the line profiles of these elements is caused by their non-uniform surface distribution, similar to the presence of chemical spots detected in HgMn stars. The search for the presence of a magnetic field was carried out using the moment technique and the Singular Value Decomposition (SVD) method. Our measurements of the magnetic field with the moment technique using 22 Mn II lines indicate the potential existence of a weak variable longitudinal magnetic field on the first epoch. The SVD method applied to the Mn II lines indicates <B[SUB]z[/SUB]> = -76 ± 25 G on the first epoch, and at the same epoch the SVD analysis of the observations using the Fe II lines shows <B[SUB]z[/SUB]> = -91 ± 35 G. The calculated false alarm probability values, 0.008 and 0.003, respectively, are above the value 10[SUP]-3[/SUP], indicating no detection. [less ▲]

See detailDeveloping a common Key Performance Indicators framework for biodiversity management in gypsum quarries throughout Europe for Eurogypsum
Pitz, Carline ULg; Mahy, Grégory ULg; Marlet, Christine

Conference (2014, August)

This study aimed to establish a common Key Performance Indicators (KPIs) framework to report biodiversity for the Gypsum Industry at the European level. An original approach of participatory process has ... [more ▼]

This study aimed to establish a common Key Performance Indicators (KPIs) framework to report biodiversity for the Gypsum Industry at the European level. An original approach of participatory process has been developed in order to integrate the different opinions and to reach a consensus framework between different stakeholders’ groups: Eurogypsum stakeholders, European and local authorities, universities and consulting offices, European and local associations for the conservation of nature and stakeholders from the mining sector. The strategy is based on five main steps: (i) To build a stakeholders’ network; (ii) ) To build a framework proposal to be submitted to stakeholders by selecting a maximum set of indicators based on the literature and reaching an agreement on indicators with Eurogypsum (Focus Group); (iii) Reaching a consensus framework with all the stakeholders and evaluating feasibility by a Delphi Policy survey, by the analysis of the Environmental Impact Assessments of the Gypsum Industry and by visiting three quarries; (iv) Final validation with Eurogypsum; (v) Creating indicators’ Factsheets and a Eurogyspum report to the destination of the public. The resulting framework contains eleven indicators which are the most acceptable set of indicators for all the stakeholders. It answers to European legislation and strategies for biodiversity. It is intended to improve sustainability in the quarries and to help managing biodiversity, to allow setting up of appropriate reporting systems. It is a flexible framework adaptable given the local context of each gypsum quarry in order to prove if a No Net Loss has been reached at a quarry’s scale. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailWASP-117b: a 10-day-period Saturn in an eccentric and misaligned orbit
Lendl, Monika ULg; Triaud, A. H. M. J.; Anderson, D. R. et al

in Astronomy and Astrophysics (2014), 568

We report the discovery of WASP-117b, the first planet with a period beyond 10 days found by the WASP survey. The planet has a mass of M_p = 0.2755 (+/-0.0090) M_jup, a radius of R_p = 1.021 (-0.065 +0 ... [more ▼]

We report the discovery of WASP-117b, the first planet with a period beyond 10 days found by the WASP survey. The planet has a mass of M_p = 0.2755 (+/-0.0090) M_jup, a radius of R_p = 1.021 (-0.065 +0.076) R_jup and is in an eccentric (e = 0.302 +/-0.023), 10.02165 +/- 0.00055 d orbit around a main-sequence F9 star. The host star's brightness (V=10.15 mag) makes WASP-117 a good target for follow-up observations, and with a planetary equilibrium temperature of T_eq = 1024 (-26 +30) K and a low planetary density (rho_p = 0.259 (-0.048 +0.054) rho_jup) it is one of the best targets for transmission spectroscopy among planets with periods around 10 days. From a measurement of the Rossiter-McLaughlin effect, we infer a projected angle between the planetary orbit and stellar spin axes of beta = -44 (+/-11) deg, and we further derive an orbital obliquity of psi = 69.5 (+3.6 -3.1) deg. Owing to the large orbital separation, tidal forces causing orbital circularization and realignment of the planetary orbit with the stellar plane are weak, having had little impact on the planetary orbit over the system lifetime. WASP-117b joins a small sample of transiting giant planets with well characterized orbits at periods above ~8 days. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailModel-Based Computation of Total Stressed Blood Volume from a Preload Reduction Experiment
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geoffrey et al

Conference (2014, August)

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which is a treatment for cardiac failure. From an engineering point of view, this parameter dictates the cardiovascular system's dynamic behavior. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a method is developed to compute stressed blood volume from preload reduction experiments. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the most sensitive parameters; and (3) adjust only these sensitive parameters. Stressed blood volume was determined sensitive for all datasets, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal mean squared error of 11.77 %. Stressed blood volume has been computed to range between 450 and 963 ml, or 15 to 28 ml/kg, which matches previous independent experiments on pigs, dogs and humans. Consequently, the method proposed in this work provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Peer Reviewed
See detailModel-Based Computation of Total Stressed Blood Volume from a Preload Reduction Experiment
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geofrrey et al

in Preprints of the 19th World Congress (2014, August)

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid resuscitation therapy, which is a treatment for cardiac failure. From an engineering point of view, this parameter dictates the cardiovascular system’s dynamic behavior. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a method is developed to compute stressed blood volume from preload reduction experiments. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the most sensitive parameters; and (3) adjust only these sensitive parameters. Stressed blood volume was determined sensitive for all datasets, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal mean squared error of 11.77 %. Stressed blood volume has been computed to range between 450 and 963 ml, or 15 to 28 ml/kg, which matches previous independent experiments on pigs, dogs and humans. Consequently, the method proposed in this work provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

Detailed reference viewed: 14 (9 ULg)
Full Text
Peer Reviewed
See detailRegional, Interregional and Global Arrangements and Multilateral Organizations
Santander, Sébastian ULg

in Telò, Mario (Ed.) European Union and New Regionalism. Regional actors and global governance in a post-hegemonic era (2014)

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailThe instability strip of ZZ Ceti white dwarfs
Van Grootel, Valérie ULg; Fontaine, G.; Brassard, P. et al

Conference (2014, August)

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection ... [more ▼]

The determination of the location of the theoretical ZZ Ceti instability strip in the log g − Teff diagram has remained a challenge over the years, due to the lack of a suitable treatment for convection in these stars. We report here a detailed stability survey over the whole ZZ Ceti regime, including the low and extremely low masses. We computed to this aim 29 evolutionary sequences of DA models with various masses, chemical layering, and core compositions. These models are characterized by the so- called ML2/α=1.0 convective efficiency and take into account the important feedback effect of convection on the atmospheric structure. We computed pulsation spectra for these models with the Liège nonadiabatic pulsation code MAD, which is the only one to conveniently incorporate a full time-dependent convection treatment and, thus, provides the best available description of the blue edge of the instability strip. On the other hand, given the failure of all nonadiabatic codes to account properly for the red edge of the strip, including MAD, we tested the idea that the red edge is due to energy leakage through the atmosphere. Using this approach, we found that our theoretical ZZ Ceti instability strip accounts remarkably well for the boundaries of the empirical strip. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailImprovement of defect detection in shearography by using Principal Component Analysis
Vandenrijt, Jean-François ULg; Lièvre, Nicolas; Georges, Marc ULg

in Proceedings of Conference on Interferometry XVII: Techniques and Analysis (2014, August)

Detailed reference viewed: 23 (10 ULg)
Full Text
Peer Reviewed
See detailA First Look at the Nonadiabatic Properties of Pulsating Accreting White Dwarfs of the GW Lib Type
Van Grootel, Valérie ULg; Fontaine, G.; Brassard, P. et al

Poster (2014, August)

We present results of a detailed stability survey of the pulsation properties of accreting white dwarfs of the GW Lib type. This is based on several state-of-the- art white dwarf evolutionary sequences ... [more ▼]

We present results of a detailed stability survey of the pulsation properties of accreting white dwarfs of the GW Lib type. This is based on several state-of-the- art white dwarf evolutionary sequences with varying envelope compositions, from pure hydrogen to pure helium. Using the same tools as in Van Grootel et al. (2013), where we have presented the first consistent view of the ZZ Ceti instability strip, we have mapped the GW Lib instability strip over the effective temperature-surface gravity plane, and as a function of envelope composition. We find that the location of the GW Lib instability domain is a strong and continuous function of the assumed envelope composition. We can accomodate all of the known GW Lib pulsators in various strips according to their atmospheric compositions. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailWhich agritourism for which suburban countryside? A heuristic and comparative analysis in Wallonia and Grand-Duchy of Luxembourg (part 2)
Dubois, Charline ULg; Schmitz, Serge ULg

in Ianos, Ioan (Ed.) Rural life and rural systems between tradition and integrated urban-rural development (2014, August)

Mutations, transformations, transitions are keywords which open the door to many questions regarding the global European agriculture. The resources of the rural countryside in Europe are subject to many ... [more ▼]

Mutations, transformations, transitions are keywords which open the door to many questions regarding the global European agriculture. The resources of the rural countryside in Europe are subject to many pressures. Agricultural activities are decreasing and farmers are losing importance. In some northwestern European countryside, the declining agriculture compels to diversify activities in farms. Some farmers need to rethink their business goals in order to successfully sustain their operations in the economic space. In many areas, one of the solutions suggested is the development of agritourism. Agritourism in Wallonia and in the Grand-Duchy of Luxembourg is a tourist activity proposed by the farmer in his farm. While addressing the challenges and countering threats of their agriculture, both suburban areas present many advantages and opportunities for tourism development. Different tourist and leisure developments are conceived and proposed. The activity is reinforced by popular images of sustainability and ecology. Is agritourism a universal solution or is it a reflected contextualized solution? In the Tel-Aviv CSRS meeting, in 2010, we presented a communication on this issue. While the theoretical review and the aim of the first paper were well presented, the empirical results were not well documented because we were at the beginning of the PhD research. Today, we propose, in this paper, to improve information and to answer to the different comments from the members of the commission. Agritourism should be defined, localized, differentiated. Between 2010 and 2014, we conducted interviews of Walloon and Luxembourg tenants (n = 33), surveys among potential tourists (n = 1148) in seven tourist places, interviews of privileged witnesses (n = 31), and field observations. Working on two regions of Western Europe which had not been analyzed previously, the Walloon and Luxembourg suburban countryside, we want to understand the agritourism dynamics, the factors that influence the location and development, and the images of farm tourism. The purpose of this research is to understand the geographical relationship between agritourism, countryside, local resources, agriculture, and tourism specialization. This issue is underdeveloped in the literature and our PhD thesis contributes to fill this gap. We scrutinize the spatial distribution of agritourism in both regions, the logic of emergence of tourism in a farm, the links between these tourist functions and these agricultural functions. We analysed the tenants and visitors’ reasons and motivations in regards of the regional and local context. Finally, we build a typology of the countryside according to agritourism. We conclude that the farm diversification should pay attention to several local and regional factors to succeed in a win-win combination of tourism and agriculture. These factors are listed in a heuristic model, which is a user-friendly tool to think future development of agritourism in the European countryside. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailReliabilität und Validität des "Voice Handicap Index (VHI) adaptiert an die Gesangsstimme"
Barsties, B.; Kropp, J.; Dicks, P. et al

in Laryngo Rhino Otologie (2014)

Reliability and Validity of the "Voice Handicap Index (VHI) Adapted to the Singing Voice" in German. Background : The Voice Handicap Index (i.e., VHI) is one of the most reliable standardized self ... [more ▼]

Reliability and Validity of the "Voice Handicap Index (VHI) Adapted to the Singing Voice" in German. Background : The Voice Handicap Index (i.e., VHI) is one of the most reliable standardized self-evaluation assessments in diagnosis of voice disorders. That tool is the most used in daily clinic,. In 2007, the VHI was adapted to the singing population, called"VHI adapté aux chanteurs". The aim of our study was to investigate the reliability and validity of the German version of the VHI adapted to the singing voice. Materials and Methods: 113 German singers (41 males and 72 females) with diverse singing styles and profession were included in the study. They were divided into 2 groups : a test-group (n=20) with self-perceived vocal complaints and a control-group (n=93) without vocal complaints. Statistical analysis to measure the reliability and validity was conducted with the Cronbach's alpha (i.e., cron.a), independant t-test and receiver operating characteristics as well likelihood ratio, respectively. Results : Reliability was confirmed by acceptable Cron. a (0,713-0,850) for each of the sub-scales and total score. The validity between the 2 groups showed high signifiant differences for each of the sub-scales and total score by which the test-group indicated higher scores than the control-group. Only the construct validity revealed no clear results. Conclusion : The VHI adapted to the singing voice is suited as reliable and valid standardizing evaluation tool, but the diagnostic accuracy has to be investigated again because of too high inaccuracy in the interpretation of the outcome of the present data. [less ▲]

Detailed reference viewed: 12 (3 ULg)