Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailPrison 2.0 : Psychopathologie, pouvoir et postmodernité
Englebert, Jérôme ULg

in Englebert, Jérôme (Ed.) Psychopathologie de l'homme en situation - deuxième édition (2017)

Detailed reference viewed: 22 (2 ULg)
See detailSymogih Système modulaire de gestion de l'information historique
Henneau, Marie-Elisabeth ULg

Textual, factual or bibliographical database (2017)

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailFactors associated with self-perceived burden to the primary caregiver in older patients with hematologic malignancies: an exploratory study
Libert, Y; Borghgraef, C; BEGUIN, Yves ULg et al

in Psycho-oncology (2017), 10

Objective: Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of ... [more ▼]

Objective: Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of selfperceived burden to the primary caregiver (SPB-PC) and associated factors in an older patient population with hematologic malignancies at the time of chemotherapy initiation. Methods: In total, 166 consecutive patients with hematologic malignancies aged ≥65 years were recruited at the time of chemotherapy initiation. Patients’ SPB-PC was assessed using a 100-mm visual analogue scale (VAS). Characteristics potentially associated with SPB-PC, including sociodemographic and medical characteristics, physical functioning status (Karnofsky performance score, activities of daily living (ADL)/instrumental ADL), symptoms (fatigue, pain, nausea, quality of life), psychological distress (Hospital Anxiety and Depression Scale (HADS)), perceived cognitive function (Functional Assessment of Cancer Therapy Cognitive (FACT-Cog) Scale), and patients’/primary caregivers’ personal relationship characteristics (family tie, support), were assessed. Results: Thirty-five percent of patients reported moderate to severe SPB-PC (VAS ≥ 50 mm). Patients’ SPB-PC was associated with lower Karnofsky performance (β = 0.135, p = 0.058) and ADL (β = 0.148, p = 0.037) scores, and higher HADS (β = 0.283, p<0.001) and FACT-Cog perceived cognitive impairments subscale (β = 0.211, p = 0.004) scores. The proportion of explained variance was 23.5%. Conclusions: Health care professionals should be aware that about one third of older cancer patients experience moderate to severe SPB-PC at the time of chemotherapy initiation. They should adapt their support of patients who report such a feeling. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailGenomic Studies of Multiple Myeloma Reveal an Association between X Chromosome Alterations and Genomic Profile Complexity.
Sticca, Tiberio ULg; CABERG, Jean-Hubert ULg; Wenric, Stéphane ULg et al

in Genes, Chromosomes & Cancer (2017), 56

The genomic profile of multiple myeloma (MM) has prognostic value by dividing patients into a good prognosis hyperdiploid group and a bad prognosis non-hyperdiploid group with a higher incidence of IgH ... [more ▼]

The genomic profile of multiple myeloma (MM) has prognostic value by dividing patients into a good prognosis hyperdiploid group and a bad prognosis non-hyperdiploid group with a higher incidence of IgH translocations. This classification, however, is inadequate and many other parameters like mutations, epigenetic modifications and genomic heterogeneity may influence the prognosis. We performed a genomic study by array-based comparative genomic hybridization (aCGH) on a cohort of 162 patients to evaluate the frequency of genomic gains and losses. We identified a high frequency of X chromosome alterations leading to partial Xq duplication, often associated with Xi deletion in female patients. This partial X duplication could be a cytogenetic marker of aneuploidy as it is correlated with a high number of chromosomal breakages. Patient with high level of chromosomal breakage had reduced survival regardless the region implicated. A higher transcriptional level was shown for genes with potential implication in cancer and located in this altered region. Among these genes, IKBKG and IRAK1 are members of the NFKB pathway which plays an important role in MM and is a target for specific treatments. [less ▲]

Detailed reference viewed: 54 (13 ULg)
Full Text
Peer Reviewed
See detailThe role of mesenchymal stem cells in the treatment of ulcerative colitis and Crohn's disease
GREGOIRE, Céline ULg; Louis, Edouard ULg; BRIQUET, Alexandra ULg et al

in Atkinson, K; Ed (Eds.) The Biology and Therapeutic Applications of Mesenchymal Cells (2017)

Detailed reference viewed: 135 (69 ULg)
Full Text
Peer Reviewed
See detailAllogeneic stem cell transplantation for patients with myelodysplastic syndrome 70 years of age or older: A retrospective study of the MDS subcommittee of the Chronic Malignancies Working Party (CMWP) of the EBMT
Heidenreich, S; Ziagkos, D; De Wreede, L et al

in Biology of Blood & Marrow Transplantation (2017), 23

In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n ... [more ▼]

In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors. Median age at HSCT was 72 years (range, 70 to 78). Conditioning regimen was nonmyeloablative (n = 54), reduced intensity (n = 207), or standard intensity (n = 52). Allogeneic HSCT for MDS patients ≥ 70 years was increasingly performed over time. Although during 2000 to 2004 only 16 patients received HSCT, during 2011 to 2013 the number of transplantations increased to 181. The cumulative incidence of nonrelapse mortality at 1 year and relapse at 3 years was 32% and 28%, respectively, with a 3-year overall survival rate of 34%. Good performance, determined by Karnofsky performance status, and recipients’ seronegativity for cytomegalovirus was associated with 3-year estimated overall survival rates of 43% (P = .01) and 46% (P = .002), respectively. Conditioning intensity did not impact survival. After careful patient selection, allogeneic HSCT can be offered to patients older than 70 years with MDS. [less ▲]

Detailed reference viewed: 28 (1 ULg)
Full Text
Peer Reviewed
See detailMesenchymal stromal cell therapy for inflmmatory bowel diseases
GREGOIRE, Céline ULg; LECHANTEUR, Chantal ULg; BRIQUET, Alexandra ULg et al

in Alimentary Pharmacology & Therapeutics (2017), 45

Background Inflammatory bowel diseases (IBD) are chronic relapsing diseases in which pro-inflammatory immune cells and cytokines induce intestinal tissue damage and disability. Mesenchymal stromal cells ... [more ▼]

Background Inflammatory bowel diseases (IBD) are chronic relapsing diseases in which pro-inflammatory immune cells and cytokines induce intestinal tissue damage and disability. Mesenchymal stromal cells (MSCs) exert powerful immunomodulatory effects and stimulate tissue repair. Aim To review the current data on mesenchymal stromal cell therapy in IBD. Method We searched PubMed and ‘ClinicalTrials.gov’ databases using the terms ‘mesenchymal stromal cells’, ‘mesenchymal stem cell transplantation’, ‘inflammatory bowel diseases’, ‘Crohn disease’ and ‘colitis, ulcerative’. Additional publications were identified from individual article reference lists. Results MSCs include inhibition of Th1/Th17 lymphocytes and recruitment of regulatory T lymphocytes, induction of antigen-presenting cells into a regulatorylike profile, and stimulation of epithelial cell differentiation and proliferation. More than 200 patients with refractory fistulas have been treated with local injections of MSCs, resulting in complete response in more than half, and in overall response in approximately two thirds of patients. In refractory luminal Crohn’s disease, 49 cases of systemic MSC infusions have been reported, while trials with autologous MSCs resulted in mitigated responses, studies using allogeneic MSCs were promising, with around 60% of patients experiencing a response and around 40% achieving clinical remission. Conclusions Mesenchymal stromal cells might represent a promising therapy for IBD, especially for Crohn’s disease. There remain many unsolved questions concerning the optimal origin and source of mesenchymal stromal cells, dosage and modalities of administration. Moreover, mesenchymal stromal cells still need to prove their effectiveness compared with conventional treatments in randomised controlled trials. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailIconic virtues of diagrams. Peirce on ampliative reasoning
Leclercq, Bruno ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

Detailed reference viewed: 30 (3 ULg)
See detailConverging views: the Belgian reception of Italy’s section at 1885 Antwerp’s World Exhibition. Artistic, economic, and political strategies on display
Prina, Daniela ULg

in Raizman, David; Robey, Ethan (Eds.) Expanding Nationalisms at World’s Fairs: Identity, Diversity and Exchange, 1855-1914 (2017)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailZonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Lesage, Julien; Suarez-Carmona, Meggy; Neyrinck-Leglantier, Deborah et al

in FASEB Journal (2017)

Detailed reference viewed: 16 (0 ULg)
Full Text
See detailSyllabus de droit social 2016-2017
Kéfer, Fabienne ULg

Learning material (2017)

Detailed reference viewed: 35 (7 ULg)
Full Text
Peer Reviewed
See detailAlcohol-cue exposure decreases response inhibition towards alcohol-related stimuli in detoxified alcohol-dependent patients
Kreusch, Fanny; Billieux, Joël; Quertemont, Etienne ULg

in Psychiatry Research (2017), 249

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol ... [more ▼]

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol relapse. The aim of the present study is to investigate whether the induction of a craving state, using an alcohol cue exposure paradigm, influences response inhibition towards both neutral stimuli and alcohol-related stimuli in alcohol-dependent patients. Thirty-one detoxified alcohol-dependent patients were exposed to either their preferred alcoholic beverage or to a glass of water. They then performed a modified stop signal task, which used alcohol-related words, neutral words and non-words, and a lexical decision as the Go response. The alcohol-cue exposure group reported significantly higher alcohol craving and showed higher percentages of commission errors towards alcohol-related words than the control group. All participants, but especially those of the alcohol-cue exposure group, showed also shorter reaction times when alcohol words were used as targets in go trials. The induction of alcohol craving in detoxified alcohol-dependent patients increases the motivational salience value of alcohol stimuli, leading them to automatically approach alcohol-related cues and therefore impairing response inhibition towards those stimuli. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailComparison of Indium Tin Oxide and Indium Tungsten Oxide as Transparent Conductive Substrates for WO3-Based Electrochromic Devices
Maho, Anthony ULg; Nicolay, Sylvain; Manceriu, Laura ULg et al

in Journal of the Electrochemical Society (2017), 164(2), 25-31

Detailed reference viewed: 32 (13 ULg)
Full Text
See detailDatasets for Testing Probabilistic Models of Choice using Column Generation
Spieksma, Frits C.R.; Davis-Stober, Clint; Regenwetter, Mike et al

Textual, factual or bibliographical database (2017)

Detailed reference viewed: 35 (1 ULg)
Full Text
Peer Reviewed
See detailCan DEM time series produced by UAV be used to quantify diffuse erosion in an agricultural watershed?
Pineux, Nathalie ULg; Lisein, Jonathan ULg; Swerts, Gilles ULg et al

in Geomorphology (2017), 280

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion ... [more ▼]

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion monitoring approaches are labour intensive and costly. This calls for the development of new approaches for field erosion data acquisition. As a result of rapid technological developments and low cost, unmanned aerial vehicles (UAV) have recently become an attractive means of generating high resolution digital elevation models (DEMs). The use of UAV to observe and quantify gully erosion is now widely established. However, in some agro-pedological contexts, soil erosion results from multiple processes, including sheet and rill erosion, tillage erosion and erosion due to harvest of root crops. These diffuse erosion processes often represent a particular challenge because of the limited elevation changes they induce. In this study,we propose to assess the reliability and development perspectives of UAV to locate and quantify erosion and deposition in a context of an agricultural watershed with silt loam soils and a smooth relief. Erosion and deposition rates derived from high resolution DEM time series are compared to field measurements. The UAV technique demonstrates a high level of flexibility and can be used, for instance, after a major erosive event. It delivers a very high resolution DEM(pixel size: 6 cm) which allows us to compute high resolution runoff pathways. This could enable us to precisely locate runoff management practices such as fascines. Furthermore, the DEMs can be used diachronically to extract elevation differences before and after a strongly erosive rainfall and be validated by field measurements. While the analysis for this study was carried out over 2 years, we observed a tendency along the slope from erosion to deposition. Erosion and deposition patterns detected at the watershed scale are also promising. Nevertheless, further development in the processing workflow of UAV data is required in order to make this technique accurate and robust enough for detecting sediment movements in an agricultural watershed affected by diffuse erosion. This area of investigation holdsmuch potential as the images processing is relatively new and expanding. [less ▲]

Detailed reference viewed: 26 (7 ULg)
Full Text
Peer Reviewed
See detailOn the numerical simulation of sheet metal blanking process
Canales Cardenas, Cristian ULg; Bussetta, Philippe; Ponthot, Jean-Philippe ULg

in International Journal of Material Forming (2017), 10

The use of the blanking process has been widely spread in mass production industries. In this technique, the quality of the final product is directly related to the setting parameters of the process and ... [more ▼]

The use of the blanking process has been widely spread in mass production industries. In this technique, the quality of the final product is directly related to the setting parameters of the process and the material response of the sheet. In the present work, a general framework based on the finite element method for the simulation of the sheet metal blanking process is presented. The proposed approach properly addresses all the numerical challenges related to blanking. First, an extension of elasto-viscoplastic constitutive equations for the large strain regime is used to take into account the material strain-rate sensitivity. Then, the inertial effects coming from high velocity operations are considered by means of an implicit time integration scheme. Moreover, the frictional contact interactions are simulated with the classical Coulomb law and an energetically consistent formulation of area regularization. Finally, ductile fracture is modeled thanks to the element deletion method coupled with a fracture criterion. The blanking process is then simulated for different setting parameters. The accuracy of this approach is evaluated by comparing the numerical predictions to experimental results for both quasi-static and dynamic conditions. Good agreement is found between experimental and numerical results for all cases. [less ▲]

Detailed reference viewed: 29 (16 ULg)
Full Text
Peer Reviewed
See detailNonlinear system identification in structural dynamics: 10 more years of progress
Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Mechanical Systems & Signal Processing (2017), 83

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved ... [more ▼]

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved until then, it was concluded that the identification of simple continuous structures with localised nonlinearities was within reach. The past decade witnessed a shift in emphasis, accommodating the growing industrial need for a first generation of tools capable of addressing complex nonlinearities in larger-scale structures. The objective of the present paper is to survey the key developments which arose in the field since 2006, and to illustrate state-of-the-art techniques using a real-world satellite structure. Finally, a broader perspective to nonlinear system identification is provided by discussing the central role played by experimental models in the design cycle of engineering structures. [less ▲]

Detailed reference viewed: 18 (8 ULg)
Full Text
Peer Reviewed
See detailStudy of the photocatalytic activity of Fe3+, Cr3+, La3+ and Eu3+ single-doped and co-doped TiO2 catalysts produced by aqueous sol-gel processing
Malengreaux, Charline; Pirard, Sophie ULg; Léonard, Géraldine ULg et al

in Journal of Alloys and Compounds (2017), 691

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination ... [more ▼]

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination step, has been adapted to produce Fe3+, Cr3+, La3+ or Eu3+ single-doped TiO2 photocatalysts as well as La3+-Fe3+ and Eu3+-Fe3+ co-doped TiO2 catalysts. The physicochemical properties of the obtained catalysts have been characterized using a suite of complementary techniques, including ICP-AES, XRD, UV-Vis spectroscopy, nitrogen adsorption-desorption and Fe-57 Mössbauer. The active crystalline phase is obtained without requiring any calcination step and all the different catalysts are composed of nanocrystallites of anatase with a size of 6-7 nm and a high specific surface area varying from 181 to 298 m² g-1. In this study, the effect of the NO3:Ti(IV) mole ratio used to induce the peptisation reaction during the synthesis has been studied and the results revealed that this ratio can influence significantly the textural properties of the resulting catalyst. A screening of the photocatalytic activity of the undoped and Fe3+, Cr3+, La3+ or Eu3+ single-doped and co-doped photocatalysts has been performed by evaluating the degradation of 4-nitrophenol under UV-Visible light (330 nm < λ < 800 nm). This study suggests that the photocatalytic activity is significantly influenced by the dopant nature and content with an optimal dopant content being observed in the case of Fe3+ or La3+ single-doped as well as in the case of La3+-Fe3+ and Eu3+-Fe3+ co-doped catalysts. In the case of Cr3+ single-doped catalysts, a detrimental effect of the dopant on the photocatalytic degradation of 4-nitrophenol has been observed while no significant influence of the dopant has been detected in the case of Eu3+ single-doped catalysts. The role of the different dopants in modulating the photocatalytic activity is discussed. [less ▲]

Detailed reference viewed: 42 (10 ULg)