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Passive designs and strategies for low-cost housing using simulation-based optimization and different thermal comfort criteriaNguyen, Anh Tuan ; Reiter, Sigrid ![]() in Journal of Building Performance Simulation [=JBPS] (2013) An optimum design of low-cost housing offers low-income urban inhabitants great opportunities to obtain a shelter at an affordable price and acceptable indoor thermal conditions. In this paper, the design ... [more ▼] An optimum design of low-cost housing offers low-income urban inhabitants great opportunities to obtain a shelter at an affordable price and acceptable indoor thermal conditions. In this paper, the design and operation of a low-cost dwelling were numerically optimized using a simulation-based approach. Three multi-objective cost functions including construction cost, thermal comfort performance and 50-year operating cost were applied for naturally ventilated and air-conditioned buildings. Thermal environment inside the house was controlled and assessed by two thermal comfort models. Optimization problems which consist of 18 design parameters and 6 ventilation strategies were examined by two population-based probabilistic optimization algorithms (particle swarm optimization and hybrid algorithm). Optimum designs corresponding to each objective function, differences in optimal solutions, energy saving by the adaptive comfort approach and optimization effectiveness were outlined. The optimization method used in this paper shows a considerable potential of comfort improvement, energy saving and operating cost reduction. [less ▲] Detailed reference viewed: 18 (2 ULg) Associative memory in aging: The effect of unitization on source memoryBastin, Christine ; ; Simon, Jessica et alin Psychology & Aging (2013), 28(1), 275-283 In normal aging, memory for associations declines more than memory for individual items. Unitization is an encoding process defined by creation of a new single entity to represent a new arbitrary ... [more ▼] In normal aging, memory for associations declines more than memory for individual items. Unitization is an encoding process defined by creation of a new single entity to represent a new arbitrary association. The current study tested the hypothesis that age-related differences in associative memory can be reduced following encoding instructions that promote unitization. In two experiments, groups of 20 young and 20 older participants learned new associations between a word and a background color under two conditions. In the item detail condition, they had to imagine that the item is the same color as the background; an instruction promoting unitization of the associations. In the context detail condition, that did not promote unitization, they had to imagine that the item interacted with another colored object. At test, they had to retrieve the color that was associated to each word (source memory). In both experiments, the results showed an age-related decrement in source memory performance in the context detail but not in the item detail condition. Moreover, Experiment 2 examined receiver operating characteristics in older participants and indicated that familiarity contributed more to source memory performance in the item detail than in the context detail condition. These findings suggest that unitization of new associations can overcome the associative memory deficit observed in aging, at least for item-color associations. [less ▲] Detailed reference viewed: 41 (5 ULg) The impact of visual perceptual learning on sleep and local slow wave initiationMascetti, Laura ; Muto, Vincenzo ; et alin Journal of Neuroscience (2013) Detailed reference viewed: 35 (18 ULg) Impacts du changement climatique sur l’hydrologie et la gestion des ressources en eau du bassin de la Meuse : une synthèseBauwens, Alexandra ; Sohier, Catherine ; Degré, Aurore ![]() in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(1), 76-86 Detailed reference viewed: 42 (11 ULg) First retrievals of HCFC-142b from ground-based high resolution FTIR solar observations: application to high altitude Jungfraujoch spectraMahieu, Emmanuel ; ; et alin Geophysical Research Abstracts (2013), 15 Hydrofluorocarbons (HCFCs) are the first substitutes to the long-lived ozone depleting halocarbons, in particular the chlorofluorocarbons (CFCs). Given the complete ban of the CFCs by the Montreal ... [more ▼] Hydrofluorocarbons (HCFCs) are the first substitutes to the long-lived ozone depleting halocarbons, in particular the chlorofluorocarbons (CFCs). Given the complete ban of the CFCs by the Montreal Protocol, its Amendments and Adjustments, HCFCs are on the rise, with current rates of increase substantially larger than at the beginning of the 21st century. HCFC-142b (CH3CClF2) is presently the second most abundant HCFC, after HCFC-22 (CHClF2). It is used in a wide range of applications, including as a blowing foam agent, in refrigeration and air-conditioning. Its concentration will soon reach 25 ppt in the northern hemisphere, with mixing ratios increasing at about 1.1 ppt/yr [Montzka et al., 2011]. The HCFC-142b lifetime is estimated at 18 years. With a global warming potential of 2310 on a 100-yr horizon, this species is also a potent greenhouse gas [Forster et al., 2007]. First space-based retrievals of HCFC-142b have been reported by Dufour et al. [2005]. 17 occultations recorded in 2004 by the Canadian ACE-FTS instrument (Atmospheric Chemistry Experiment – Fourier Transform Spectrometer, onboard SCISAT-1) were analyzed, using two microwindows (1132.5–1135.5 and 1191.5–1195.5 cm-1). In 2009, Rinsland et al. determined the HCFC-142b trend near the tropopause, from the analysis of ACE-FTS observations recorded over the 2004–2008 time period. The spectral region used in this study extended from 903 to 905.5 cm-1. In this contribution, we will present the first HCFC-142b measurements from ground-based high-resolution Fourier Transform Infrared (FTIR) solar spectra. We use observations recorded at the high altitude station of the Jungfraujoch (46.5°N, 8°E, 3580 m asl), with a Bruker 120HR instrument, in the framework of the Network for the Detection of Atmospheric Composition Change (NDACC, visit http://www.ndacc.org). The retrieval of HCFC-142b is very challenging, with simulations indicating only weak absorptions, lower than 1% for low sun spectra and current concentrations. Among the four microwindows tested, the region extending from 900 to 906 cm-1 proved to be the most appropriate, with limited interferences, in particular from water vapor. A total column time series spanning the 2004-2012 time period will be presented, analyzed and critically discussed. After conversion of our total columns to concentrations, we will compare our results with in situ measurements performed in the northern hemisphere by the AGAGE network. [less ▲] Detailed reference viewed: 31 (8 ULg) L'équilibre des rations alimentaires des bovins: Quelques pistes pour améliorer l'efficience azotée ?Beckers, Yves ![]() in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(SPL1), 243-250 The main aim of this paper was to present some feeding recommendations, which, when applied on the farm, would increase nitrogen use by bovines and to give information as to how the effects of the ... [more ▼] The main aim of this paper was to present some feeding recommendations, which, when applied on the farm, would increase nitrogen use by bovines and to give information as to how the effects of the nitrogen produced can be reduced. Ruminants have the ability to digest structural carbohydrates and to produce meat and milk proteins for human consumption. At the animal cells level, amino acids are essential for biological functions, mainly involving their maintenance and production. These amino acids are supplied by the intestinal digestion of microbial protein and feed protein that escapes microbial degradation in the rumen. Today, the efficiency of nitrogen utilization is typically low and highly variable in ruminants. Nitrogen excretion by ruminants mainly depends on the level of nitrogen intake and of the animal's productivity. Optimal N utilization may be achieved through an understanding of the key mechanisms involved in the control of N digestion and metabolism. These include the efficiency of N capture in the rumen and the protein degradation according to the type of diet and forage, the control of the rumen microorganisms involved in protein degradation and the proper formulation of the diet, avoiding feeding excess protein in relation to requirements. The dependence on energy supply in transferring feed nitrogen into milk and meat protein is strong both at the rumen and the cell levels of ruminants. The rumen metabolism is identified as the single most important factor contributing to the low level of efficient use of nitrogen in ruminants and partially depends on practical farming operations. [less ▲] Detailed reference viewed: 16 (5 ULg) Analysis of mainstream tobacco smoke particulate phase using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometryBrokl, Michal ; ; et alin Journal of Separation Science (2013), 31 In tobacco research, the comparison of different tobacco blends as well as the puffdependent <br />behaviour of cigarettes is a matter of particular interest. For the investigation <br />of smoke ... [more ▼] In tobacco research, the comparison of different tobacco blends as well as the puffdependent <br />behaviour of cigarettes is a matter of particular interest. For the investigation <br />of smoke characteristics, GC6GC offers different ways for data analysis, <br />namely, compound target analysis, automated peak-based compound classification <br />and comprehensive pixel-based data analysis. This study will show the application <br />as well as the pros and cons of these types of data analysis for very complex matrices <br />like cigarette particulate matter. In addition, new aspects about the recently discovered <br />puff-dependent behaviour of compounds in cigarette smoke will be presented. <br />Automated peak-based compound classification including mass spectrometric pattern <br />recognition is used for the classification of tobacco particulate matter samples <br />and the puff-dependent investigation of different compound classes. This compound <br />group specific analysis is further reinforced by applying an even more comprehensive <br />pixel-based analysis. This kind of analysis is used to generate fingerprints of <br />different types of cigarettes. The combination of fast feature reduction methods like <br />analysis of variance (ANOVA) and t-test with multivariate feature transformation <br />methods like partial least squares discriminate analysis (PLSDA) for feature selection <br />provides a powerful tool for a detailed inspection of different types of cigarettes. [less ▲] Detailed reference viewed: 34 (11 ULg) Assessment of the functional role of tree diversity: the multi-site FORBIO experiment; ; et al in Plant Ecology and Evolution (2013), 146(1), 26-35 Context – During the last two decades, functional biodiversity research has provided strong support for the hypothesis that more biodiverse ecosystems have the potential to deliver more and better ... [more ▼] Context – During the last two decades, functional biodiversity research has provided strong support for the hypothesis that more biodiverse ecosystems have the potential to deliver more and better services. However, most empirical support for this hypothesis comes from simple structured communities that are relatively easy to manipulate. The impact of forest biodiversity on forest ecosystem functioning has been far less studied. Experiment design – In this paper, we present the recently established, large-scale FORBIO experiment (FORest BIOdiversity and Ecosystem Functioning), specifically designed to test the effects of tree species diversity on forest ecosystem functioning. FORBIO’s design matches with that of the few other tree diversity experiments worldwide, but at the same time, the FORBIO experiment is unique as it consists of a similar experimental set-up at three sites in Belgium (Zedelgem, Hechtel-Eksel and Gedinne) with contrasting edaphic and climatological c haracteristics. This design will help to provide answers to one of the most interesting unresolved questions in functional biodiversity research, notably whether the effects of complementarity on ecosystem functioning decrease in less stressful and more productive environments. At each site, FORBIO consists of 41 to 44 plots (127 plots in total) planted with monocultures and mixtures up to four species, selected from a pool of five site-adapted, functionally different tree species. When allocating the treatments to the plots, we maximally avoided any possible covariation between environmental factors. Monitoring of ecosystem functioning already started at the Zedelgem and Gedinne sites and will start soon in Hechtel-Eksel. Multiple processes are being measured and as the trees grow older, we plan to add even more processes. Expected results – Not only basic science, but also forest management will benefit from the results coming from the FORBIO experiment, as FORBIO is, for instance, also a test case for uncommon, not well-known tree species mixtures. To conclude, FORBIO is an important ecosystem experiment that has the potential to deliver badly needed insights into the multiple relationships between biodiversity and ecosystem functioning, which will be valuable for both science and practice. [less ▲] Detailed reference viewed: 11 (2 ULg) Influence de facteurs environnementaux influençant la teneur en urée dans le lait de vache en Wallonie et estimation des rejets azotésDufrasne, Isabelle ; Knapp, Emilie ; Istasse, Louis et alin Vandenberghe, Christophe; Colinet, Gilles; Destain, Jean-Pierre (Eds.) et al 2ème Atelier Nitrate-Eau, évaluation du programme de gestion durable de l'azote (2013) En Wallonie, les teneurs en urée du lait de tank sont déterminées dans toutes les fermes lors de chaque livraison à la laiterie par le comité du lait. Un total de 8295337 données récoltées pendant l'année ... [more ▼] En Wallonie, les teneurs en urée du lait de tank sont déterminées dans toutes les fermes lors de chaque livraison à la laiterie par le comité du lait. Un total de 8295337 données récoltées pendant l'année 2000 et la période 2002-201 ont été analysées à l'aide d'un modèle linéaire. [less ▲] Detailed reference viewed: 1 (1 ULg) Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial.Reginster, Jean-Yves ; ; et alin Annals of the Rheumatic Diseases (2013), 72(2), 179-86 BACKGROUND: Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its ... [more ▼] BACKGROUND: Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis. METHODS: Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and knee pain. The trial is registered (ISRCTN41323372). RESULTS: The intention-to-treat population included 1371 patients. Treatment with strontium ranelate was associated with smaller degradations in JSW than placebo (1 g/day: -0.23 (SD 0.56) mm; 2 g/day: -0.27 (SD 0.63) mm; placebo: -0.37 (SD 0.59) mm); treatment-placebo differences were 0.14 (SE 0.04), 95% CI 0.05 to 0.23, p<0.001 for 1 g/day and 0.10 (SE 0.04), 95% CI 0.02 to 0.19, p=0.018 for 2 g/day. Fewer radiological progressors were observed with strontium ranelate (p<0.001 and p=0.012 for 1 and 2 g/day). There were greater reductions in total WOMAC score (p=0.045), pain subscore (p=0.028), physical function subscore (p=0.099) and knee pain (p=0.065) with strontium ranelate 2 g/day. Strontium ranelate was well tolerated. CONCLUSIONS: Treatment with strontium ranelate 1 and 2 g/day is associated with a significant effect on structure in patients with knee osteoarthritis, and a beneficial effect on symptoms for strontium ranelate 2 g/day. [less ▲] Detailed reference viewed: 1 (1 ULg) Elévation faible d’hCG en dehors d’un contexte gravidique : à propos de deux cas et revue de la littératureDE BACKER, Benjamin ; GOFFIN, Frédéric ; NISOLLE, Michelle et alin Annales de Biologie Clinique (2013), Sous presse Unexpected finding or persistence of low human chorionic gonadotropin (hCG) levels is not a rare situation. It requires a clinico-biological approach in order to avoid misunderstandings that could lead to ... [more ▼] Unexpected finding or persistence of low human chorionic gonadotropin (hCG) levels is not a rare situation. It requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Outside the context of a pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophile antibodies. We report the cases of two non-pregnant patients with low serum hCG. In the first case, hCG levels raised during several years following a spontaneous abortion. The likelihood of heterophilic antibodies interference was ruled out and extensive clinical investigation excluded the presence of a tumour. The diagnosis was QTD. In the second case, elevated hCG came to light as an incidental finding in a women with chronic renal failure and led the clinicians to question the laboratory. The cause was probably an increase in pituitary hCG consecutive to terminal renal failure. These cases illustrate the importance of understanding the biology of the hCG and the causes of its persistent low elevation, which are reviewed in this article. It is essential to demonstrate clinically the presence of a tumour in order to avoid unnecessary and ineffective chemotherapy and/or hysterectomy. [less ▲] Detailed reference viewed: 16 (1 ULg) Approche du surpoids et de l’obésité en milieu scolaire (2ème partie – Exemple pratique); Cloes, Marc ![]() in Revue de l'Education Physique (2013), 53(1), 11-23 L'ancrage théorique de ce projet didactique a été présenté dans une première partie (http://hdl.handle.net/2268/127970). Dans la partie théorique, nous avons rappelé les notions principales de la ... [more ▼] L'ancrage théorique de ce projet didactique a été présenté dans une première partie (http://hdl.handle.net/2268/127970). Dans la partie théorique, nous avons rappelé les notions principales de la problématique du surpoids et de l'obésité. Nous avons aussi souligné que, en éducation physique, il convenait de proposer des leçons dans lesquelles les élèves peuvent s'engager dans un travail de réflexion susceptible de les amener à devenir des citoyens responsables de leur corps sans porter préjudice à leur taux d'activité physique réel. Dans cette seconde partie, nous proposons une séance type dont l'objectif consiste donc à améliorer les connaissances des élèves sur la problématique du surpoids tout en leur permettant d'être actifs. Nous avons choisi une leçon de renforcement musculaire, notamment parce que cela nécessite peu de matériel. [less ▲] Detailed reference viewed: 30 (2 ULg) Compte rendu critique de H.S. Versnel, Copying with the gods, 2011Pirenne-Delforge, Vinciane ![]() in Mnemosyne (2013), 66 Detailed reference viewed: 11 (2 ULg) Epidémiologie de la brucellose et de la tuberculose animales dans les milieux urbain, périurbain et rural au NigerBoukary, Abdou Razac ![]() Doctoral thesis (2013) Detailed reference viewed: 56 (6 ULg) Projet Appui à la mise en oeuvre du FLEGT dans les Forêts Communautaires – AFFC-Rapport final; ; et al Report (2013) Le projet « Appui à la mise en oeuvre du FLEGT dans les Forêts Communautaires » (AFFC) vise à promouvoir la mise en oeuvre du FLEGT au Cameroun et s’est fixé comme objectif spécifique de renforcer les ... [more ▼] Le projet « Appui à la mise en oeuvre du FLEGT dans les Forêts Communautaires » (AFFC) vise à promouvoir la mise en oeuvre du FLEGT au Cameroun et s’est fixé comme objectif spécifique de renforcer les capacités des acteurs locaux pour améliorer leur responsabilisation effective dans ce processus. Parmi les bénéficiaires de l’action figurent 13 Forêts Communautaires (FC) de Mindourou, Lomié et Messamena ainsi que le regroupement de forêts communautaires REFOCOD, tous situés dans la Région de l’Est, Département du Haut-Nyong. La figure 1 reprend la carte de localisation des FC partenaires. Le projet AFFC se décline en 3 volets principaux. Le premier concerne la sensibilisation des acteurs locaux au programme FLEGT et aux accords de partenariat volontaires. Un deuxième volet se focalise sur le renforcement des capacités de contrôle de la société civile et de l'administration grâce, notamment, à des formations sur des thématiques en rapport avec l'APV-FLEGT et identifiées par la grille d'analyse de l'autonomie, un des outils d'évaluation interne du projet. Enfin, le troisième axe consiste en un diagnostic confrontant les réalités du terrain aux exigences de l'APV. Le premier trimestre a été, en majeure partie, consacré au lancement du projet du point de vue organisationnel, à l'étude d'état des lieux [KERKHOFS, 2012a] et à l'initiation de certaines activités principales telles que le road-show. Dans le courant des deuxième et troisième trimestres, nous nous sommes focalisés sur le renforcement des capacités des acteurs locaux ainsi que sur les activités de diagnostic telles que le test de la grille de légalité et le suivi de la légalité lors de l'exploitation dans les Forêts Communautaires. Pendant cette période, une étude à mi parcours [KERKHOFS, 2012b] a été réalisée. Enfin, les derniers mois du projet ont été consacrés à la finalisation des différentes activités, à l'étude d'état des lieux de sortie du projet [KERKHOFS et al, 2013a] et à la clôture de l'action par des séances de synthèses tenues dans les communautés et des ateliers de restitution. En matière de sensibilisation, en collaboration avec le partenaire local ASTEVI, nous avons organisé des séances de sensibilisation sur « L'illégalité », « Le programme FLEGT et les Accords de Partenariats Volontaires en réponse à l'illégalité » ainsi que sur le « Comité de vigilance1 et la Stratégie Nationale de Contrôle Forestier et Faunique (SNCFF) ». Des séances de réflexion sur le FLEGT et l'APV ont été menées avec les entités de gestion des forêts communautaires et une pièce de théâtre participatif a été mise en scène dans les différentes communautés. Par ailleurs, trois émissions radio portant sur ces thématiques ont été élaborées et diffusées. De plus, divers supports de sensibilisation à destination des acteurs locaux ont été conçus (dépliants, posters, bande dessinée,...), dont certains en collaboration de l'ONG Fédération Camerounaise Terre Vivante (FCTV). Enfin, deux articles scientifiques ont été soumis. Quant au renforcement des capacités de contrôle de la société civile et de l'administration, 2eme axe stratégique du projet AFFC, des formations ont été dispensées portant sur l’ « Initiation à l'informatique et l'encodage des données d'exploitation », le « Remplissage des documents sécurisés », la « Traçabilité », l' « Utilisation du GPS et de la boussole » ainsi que sur le « Suivi, contrôle et observation indépendante des forêts ». Afin de contribuer à la mise en place d'un système de contrôle, le projet a pris soin de sensibiliser les communautés à la création d'un comité de vigilance, à informer les acteurs locaux quant à la stratégie nationale de contrôle et à appuyer la mise en place d'un système de traçabilité interne aux FC. Enfin, toutes les études de diagnostic prévues ont été réalisées, à savoir les « Tests de la grille de légalité dans 30 FC du Haut Nyong », le « Suivi de l'exploitation dans 6 forêts communautaires » et le « Test du système de traçabilité dans 3 forêts communautaires ». [less ▲] Detailed reference viewed: 7 (0 ULg) Nominal group technique to select attributes for discrete choice experiments: an example for drug treatment choice in osteoporosis.Hiligsmann, Mickaël ; ; et alin Patient preference and adherence (2013), 7 BACKGROUND: Attribute selection represents an important step in the development of discrete-choice experiments (DCEs), but is often poorly reported. In some situations, the number of attributes identified ... [more ▼] BACKGROUND: Attribute selection represents an important step in the development of discrete-choice experiments (DCEs), but is often poorly reported. In some situations, the number of attributes identified may exceed what one may find possible to pilot in a DCE. Hence, there is a need to gain insight into methods to select attributes in order to construct the final list of attributes. This study aims to test the feasibility of using the nominal group technique (NGT) to select attributes for DCEs. METHODS: Patient group discussions (4-8 participants) were convened to prioritize a list of 12 potentially important attributes for osteoporosis drug therapy. The NGT consisted of three steps: an individual ranking of the 12 attributes by importance from 1 to 12, a group discussion on each of the attributes, including a group review of the aggregate score of the initial rankings, and a second ranking task of the same attributes. RESULTS: Twenty-six osteoporotic patients participated in five NGT sessions. Most (80%) of the patients changed their ranking after the discussion. However, the average initial and final ranking did not differ markedly. In the final ranking, the most important medication attributes were effectiveness, side effects, and frequency and mode of administration. Some (15%) of the patients did not correctly rank from 1 to 12, and the order of attributes did play a role in the ranking. CONCLUSION: The NGT is feasible for selecting attributes for DCEs. Although in the context of this study, the NGT session had little impact on prioritizing attributes, this approach is rigorous, transparent, and improves the face validity of DCEs. Additional research in other contexts (different decisional problems or different diseases) is needed to determine the added value of the NGT session, to assess the optimal ranking/rating method with control of ordering effects, and to compare the attributes selected with the different approaches. [less ▲] Detailed reference viewed: 1 (1 ULg) Treatment of osteoporosis in men.; Reginster, Jean-Yves ; et alin BONE (2013), 53(1), 134-44 SUMMARY: Aspects of osteoporosis in men, such as screening and identification strategies, definitions of diagnosis and intervention thresholds, and treatment options (both approved and in the pipeline ... [more ▼] SUMMARY: Aspects of osteoporosis in men, such as screening and identification strategies, definitions of diagnosis and intervention thresholds, and treatment options (both approved and in the pipeline) are discussed. INTRODUCTION: Awareness of osteoporosis in men is improving, although it remains under-diagnosed and under-treated. A European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) workshop was convened to discuss osteoporosis in men and to provide a report by a panel of experts (the authors). METHODS: A debate with an expert panel on preselected topics was conducted. RESULTS AND CONCLUSIONS: Although additional fracture data are needed to endorse the clinical care of osteoporosis in men, consensus views were reached on diagnostic criteria and intervention thresholds. Empirical data in men display similarities with data acquired in women, despite pathophysiological differences, which may not be clinically relevant. Men should receive treatment at a similar 10-year fracture probability as in women. The design of mixed studies may reduce the lag between comparable treatments for osteoporosis in women becoming available in men. [less ▲] Detailed reference viewed: 3 (2 ULg) Compte-rendu de l'ouvrage de Daniel Carlo PANGERL : Die metropolitanverfassung des karolingischen FrankenreichesClose, Florence ![]() in Francia-Recensio (2013), (1), Detailed reference viewed: 15 (0 ULg) Hypovitaminosis D and osteoporosis in burn patients: are the current practices enough ?ROUSSEAU, Anne-Françoise ; LEDOUX, Didier ; DAMAS, Pierre et alin Osteoporosis International (2013), 24(Suppl 1), 377 Detailed reference viewed: 17 (2 ULg) Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).; ; et al in Current Medical Research & Opinion (2013), 29(4), 1-9 Abstract Background: Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis. Scope: There is currently no clear ... [more ▼] Abstract Background: Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis. Scope: There is currently no clear consensus on definitions of vitamin D insufficiency or minimal targets for vitamin D concentrations and proposed targets vary with the population. In view of the potential confusion for practitioners on when to treat and what to achieve, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) convened a meeting to provide recommendations for clinical practice, to ensure the optimal management of elderly and postmenopausal women with regard to vitamin D supplementation. Findings: Vitamin D has both skeletal and extra-skeletal benefits. Patients with serum 25-hydroxyvitamin D (25-(OH)D) levels <50 nmol/L have increased bone turnover, bone loss, and possibly mineralization defects compared with patients with levels >50 nmol/L. Similar relationships have been reported for frailty, nonvertebral and hip fracture, and all-cause mortality, with poorer outcomes at <50 nmol/L. Conclusion: The ESCEO recommends that 50 nmol/L (i.e. 20 ng/mL) should be the minimal serum 25-(OH)D concentration at the population level and in patients with osteoporosis to ensure optimal bone health. Below this threshold, supplementation is recommended at 800 to 1000 IU/day. Vitamin D supplementation is safe up to 10,000 IU/day (upper limit of safety) resulting in an upper limit of adequacy of 125 nmol/L 25-(OH)D. Daily consumption of calcium- and vitamin-D-fortified food products (e.g. yoghurt or milk) can help improve vitamin D intake. Above the threshold of 50 nmol/L, there is no clear evidence for additional benefits of supplementation. On the other hand, in fragile elderly subjects who are at elevated risk for falls and fracture, the ESCEO recommends a minimal serum 25-(OH)D level of 75 nmol/L (i.e. 30 ng/mL), for the greatest impact on fracture. [less ▲] Detailed reference viewed: 8 (5 ULg) |
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