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See detailValidation of the Food Frequency Questionnaire Used to Assess the Association between Dietary Habits and Cardiovascular Risk Factors in the NESCAV Study
Sauvageot, Nicolas ULg; Guillaume, Michèle ULg; Albert, Adelin ULg et al

in Journal of Food Science (2013), 3(3),

Abstract Background: In epidemiological studies, the validation of dietary assessment instruments is important to avoid biased associations with outcome measures. Objective: Our objective was to assess ... [more ▼]

Abstract Background: In epidemiological studies, the validation of dietary assessment instruments is important to avoid biased associations with outcome measures. Objective: Our objective was to assess the validity of the 134-item food frequency questionnaire (FFQ) used in the Nutrition Environment and Cardiovascular Health (NESCAV) study. Methods: The FFQ was validated against a 3-day dietary record (DR) on a sample of 29 women. The intra- class correlation coefficient (ICC) and Bland and Altman plots were used to assess absolute agreement, whereas relative agreement was appraised by Spearman’s correlation coefficient and Cohen kappa coefficient based on cross classification of 3-category nutrient intake. Results: The two methods differed significantly for the majority of micronutrients with FFQ yielding higher intakes than the DR. The bias between the two methods was nonetheless acceptable with an average overestimation by the FFQ of 11% for macronutrients and 29% for micronutrients. Regarding precision, results differed by 48% for micronutrients and 50% for macronutrients. Correlations on energy-adjusted data by the two methods were satisfactory with an average correlation of 0.47 and 16/25 coefficients above 0.40. Only vitamin A and cholesterol showed poor correlations of 0.02 and 0.05, respectively. On average, the correct classification rate in 3 categories was 50.3% and 19/25 kappa coefficients were above 0.20. Poor agreement was found for protein, cholesterol, starch, vitamins A, B12 and E with weighted kappa coefficient less than 0.20. Conclusion: Although absolute values of dietary intakes were not always accurate, the relationship and agreement between FFQ and DR may be considered as satisfactory. In particular, the FFQ was able to categorize subjects into 3 broad categories of intakes for most nutrients. Results for proteins, cholesterol, starch, vitamins A, E and B12 however ought to be interpreted with caution [less ▲]

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See detailChirurgie et cancer en 2013
DETRY, Olivier ULg

Scientific conference (2013, April 29)

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See detailZinc Beta-lactamase superfamily
Bebrone, Carine ULg

in Kretsinger, Robert; Uversky, Vladimir; Permyakov, Eugene (Eds.) Encyclopedia of Metalloproteins (2013)

The metallo-beta-lactamase superfamily was first defined in 1997 on the basis of a sequence alignment. The members of this superfamily are characterized by the presence of a common alpha-beta-beta-alpha ... [more ▼]

The metallo-beta-lactamase superfamily was first defined in 1997 on the basis of a sequence alignment. The members of this superfamily are characterized by the presence of a common alpha-beta-beta-alpha fold and share five conserved motifs: Asp84, His116-Xaa-His118-Xaa-Asp120-His121, His196, Asp221 and His263, which are (with the exception of Asp84) involved in the binding of two metal ions. This superfamily contains now more than 23,900 members divided into 17 biological groups. Besides metallo-beta-lactamases which cleave the amide bond of the β-lactam ring of penicillins, cephalosporins or carbapenems (thus inactivating the antibiotic), the metallo-beta-lactamase superfamily includes enzymes which hydrolyze thiol-ester, phosphodiester and sulfuric ester bonds as well as oxydoreductases. [less ▲]

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See detailThe transcription factor Egr1 in zebrafish cartilage development
Dalcq, Julia ULg

Doctoral thesis (2013)

The cartilaginous elements forming the pharyngeal arches of the zebrafish derive from cranial neural crest cells. Their proper differentiation and patterning are regulated by reciprocal interactions ... [more ▼]

The cartilaginous elements forming the pharyngeal arches of the zebrafish derive from cranial neural crest cells. Their proper differentiation and patterning are regulated by reciprocal interactions between neural crest cells and surrounding endodermal, ectodermal and mesodermal tissues. In this study, we show that the endodermal factors Runx3 and Sox9b form a regulatory cascade with Egr1 resulting in transcriptional repression of the fsta gene, encoding a BMP antagonist, in pharyngeal endoderm. Using a transgenic line expressing a dominant negative BMP receptor or a specific BMP inhibitor (dorsomorphin), we show that BMP signaling is indeed required around 30 hpf in the neural crest cells to allow cell differentiation and proper pharyngeal cartilage formation. Runx3, Egr1, Sox9b and BMP signaling are required for expression of runx2b, one of the key regulators of cranial cartilage maturation and bone formation. Finally, we show that egr1 depletion leads to increased expression of fsta and inhibition of BMP signaling in the pharyngeal region. In conclusion, we show that the successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish. [less ▲]

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See detailLa restauration des papyrus de l'Université de Liège
Marganne, Marie-Hélène ULg

Scientific conference (2013, April 28)

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See detailComparison of Real-Time Aspergillus PCR with Platelia™AspergillusEIA in broncho-alveolar lavage fluids for the diagnosis of invasive aspergillosis in neutropenic and non-neutropenic patients
RUZICKA, NADIA; BOREUX, Raphaël ULg; LEVAUX, Laetitia ULg et al

Poster (2013, April 27)

Objectives. Because of low sensitivity of fungal cultures and lack of standardization of Aspergillus PCR, laboratory diagnosis of invasive aspergillosis still relies on galactomannan (GM) detection in ... [more ▼]

Objectives. Because of low sensitivity of fungal cultures and lack of standardization of Aspergillus PCR, laboratory diagnosis of invasive aspergillosis still relies on galactomannan (GM) detection in broncho-alveolar lavage (BAL) fluids and serum. The aim of this study was double: first, to assess the place of a 18S rRNA Aspergillus real-time PCR test performed in BAL fluid for the diagnosis of invasive aspergillosis (IA) in neutro- and non-neutropenic patients in comparison with GM detection; secondly, to evaluate the use of three different GM cut-off values. Materials and methods. A total of 111 neutropenic and non-neutropenic patients hospitalized at the University hospital of Liège from March to October 2012 with suspicion of IA were included in the study. A total of 138 broncho-alveolar lavage fluids were evaluated by three laboratory diagnostic methods: 1/ culture on Sabouraud agar slants with antibiotics (bioMérieux, France) incubated at 28°C for 28 days; 2/ GM detection (Platelia ™Aspergillus EIA, Biorad) using GM index cut-off values at 0.5, 0.8 and 1, performed three times a week; 3/ a real-time Aspergillus PCR assay performed daily and targeting the 18S rRNA genes by using an in-house method. Clinical, radiological and microbiological data were reviewed for classification of patients. Results. Nine patients developed probable or possible IA. The sensitivity/specificity/positive (VPP) and negative (NPV) predictive values (%) for culture, PCR, and GM using 0,5 as cut-off value were respectively 41/100/100/94, 58/97/70/96, and 91/83/34/99. The use of 0,8 and 1 as GM index cut-off values increased the specificity to 89 and 92% respectively, and the VPP to 44 and 54%. PCR had a better turn-around time and allowed the detection of Aspergillus colonisation. Conclusion: GM detection in BAL fluids using a cut-off value of 1 was the most efficient laboratory test for the diagnosis of IA in neutropenic and non-neutropenic patients. Despite a lower sensitivity, PCR had a better VPP, and allowed the detection of culture-negative Aspergillus colonisations. A shorter turnaround time (TAT) due to daily practice of PCR tests may reduce the time-to-treatment up to 24 hours. [less ▲]

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See detailGestion du stress et de la fatigue, que nous apprend la simulation
Nyssen, Anne-Sophie ULg

Conference (2013, April 26)

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See detailUse of supercritical carbon dioxide to elaborate drug-loaded polymeric implants
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Jérôme, Christine ULg et al

Poster (2013, April 25)

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See detailNourishing the body, crafting the self, facing the other. Subjectivities and encounters through Moroccan food in Italy
Mescoli, Elsa ULg

Scientific conference (2013, April 25)

Each individual is composed of material objects and practices that witness one’s personal life history and everyday life and which shape one’s same subjectivity (Julien and Rosselin 2009). Subjectivity ... [more ▼]

Each individual is composed of material objects and practices that witness one’s personal life history and everyday life and which shape one’s same subjectivity (Julien and Rosselin 2009). Subjectivity that is fulfilled through material culture, the performing of which turns out to be a technology of the self (Martin, Gutman, Hutton 1988). Considering the subject as the result of praxeological activities and of the incorporation of objects belonging to one’s meaningful universe of reference and action, my paper aims at exploring the construction of the self of Moroccan female migrants through their body techniques exerted while cooking. Specific gestures are performed to adhere to a cultural heritage which needs to be preserved while living abroad. An essentialized bodily tradition, relying on a set of specific objects, becomes the place where, on the one hand, the members of a community share knowledge. On the other hand, such tradition lets an encounter with otherness take place. As a matter of fact, in the context considered, food is a frequent object of intercultural policies and practices, giving migrants a controlled opportunity to express themselves while producing material culture. A locally held Arabic cooking class, for example, provides the occasion to perform cultural differences (or similarities) by means of corporeal languages. My presentation will consider the body both in its private and public dimensions, since constantly intertwined. Through images and videos I will show what such embodied material knowledge consists of and in which ways it is the object of social dynamics and interactions. [less ▲]

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See detailReturn-To-Play criteria after hamstring injury: actual medicine practice in professional soccer
Delvaux, François ULg; Rochcongar, Pierre; Bruyère, Olivier ULg et al

Poster (2013, April 25)

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See detailLe montage comme réponse moderne à la crise du sens
Hagelstein, Maud ULg; Hamers, Jérémy ULg

Scientific conference (2013, April 24)

Notre idée est ici de repartir de la conjoncture moderne pour étudier sous un angle renouvelé le problème du montage (à partir des textes de Kracauer, notamment) – problème qui nous semble déboucher sur ... [more ▼]

Notre idée est ici de repartir de la conjoncture moderne pour étudier sous un angle renouvelé le problème du montage (à partir des textes de Kracauer, notamment) – problème qui nous semble déboucher sur des enjeux politiques et esthétiques toujours actuels (que l’on tentera d’éclairer au fur et à mesure de l’exposé à travers quelques cas précis). Le débat autour du montage semble atteindre son maximum de vivacité dans les années 1920 (aussi bien dans les milieux intellectuels que dans les milieux artistiques). À cette époque, suite aux transformations amenées par l’essor de la société industrielle (sur le plan axiologique, sociologique ou technologique), suite à la première Guerre mondiale surtout et au déchaînement de la violence sur les individus, l’homme moderne se dépeint fréquemment sur le mode de celui qui, ayant perdu l’essentiel de ses repères, et déstabilisé dans ses croyances, se voit contraint à errer dans un monde désenchanté qu’il ne reconnaît plus. Or, ces mêmes années sont aussi celles qui voient se développer toutes sortes d’avant-gardes artistiques pour lesquelles l’opération du montage constitue un outil primordial. [less ▲]

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See detailL'automate spirituel : pensée et cinéma chez Walter Benjamin
Barbion, Sébastien ULg

Conference (2013, April 24)

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See detailCOMPARISON OF PIEZOELECTRIC AND CRUSHER MEASUREMENTS OF CHAMBER PRESSURE WITH FINITE ELEMENT MODELING RESULTS
Coghe, Frédéric; Elkarous, Lamine ULg

in International Symposium on Ballistics (2013, April 23)

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See detailLes problèmes cutanés liés aux médicaments
GADISSEUR, Romy ULg

Conference (2013, April 23)

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