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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 29

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Patients & Methods: Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post-operative day 3±2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

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See detailMetabolomic, proteomic and preclinical imaging of patient-derived tumor xenografts for improving treatment of liver metastases patients
Perez Palacios, A; Blomme, A; Boutry, S et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 134

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See detailExpel: a novel non-destructive method for mining soluble tumor biomarkers
Costanza, B; Blomme, A; MUTIJIMA NZARAMBA, Eugène ULg et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 13

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See detailAnalysis of Martian nightglow and aurora
Stiepen, Arnaud ULg

Conference (2015, March)

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See detailAutoimmune thyroid diseases in early childhood three case reports
GUFFINS, A; HARVENGT, Julie ULg; LUYCKX, F et al

Poster (2015, March)

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See detailStakeholder incentives and aid effectiveness: A case study in the health district of Kayes in Mali
Devahive, Eva; Paul, Elisabeth ULg; Samaké, Salif et al

in Journal of Development Studies (2015)

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar ... [more ▼]

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar degree. Most projects have limited impact on health services, but many programmes supported by donors offer positive opportunities for health system strengthening. The representations of different categories of stakeholders diverge – notably, regarding the role of different actors in service provision. A number of consistent strategic logics influence actors’ behaviour. We show that while many donors have committed at global level to respect aid effectiveness principles, implementation lags behind. [less ▲]

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See detailImpact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in Journal de Traumatologie du Sport (2015), 32(1), 41-45

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a ... [more ▼]

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a bleeding arising during the daily brushing? Being not painful, it activates very often no concern and no request of consultation. It is nevertheless about one of the most obvious clinical signs of the periodontal diseases which affect, to varying degrees, practically 90 % of the population in France in all groups of ages and is responsible of the loss from 30 to 40 % of the teeth. For several decades, the scientific world admits a relation between the periodontal disease and certain systematic diseases, as the endocarditis, the atherosclerosis, the diabetes… And what about tendinopathies? Their appearance is often spontaneous without specific medical origin and their cure turns out long and painful. This review has for objective to highlight the relations between the oral hygiene and sportsmen. [less ▲]

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See detailDesign and implementation of a ‘physical activity day’ for overweight and obese youth
Cloes, Marc ULg; DEWANDRE, Anne-Cécile ULg; LEBRETHON, Marie-Christine ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March), 17(1),

This study aimed to analyze the development and implementation of an adapted physical activity day expected to underline to overweight/obese youth the role of PA and hw they could be more active in their ... [more ▼]

This study aimed to analyze the development and implementation of an adapted physical activity day expected to underline to overweight/obese youth the role of PA and hw they could be more active in their daily life. [less ▲]

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See detailChirurgie de l'atrésie anale du veau
Arengi, Ada; Sartelet, Arnaud ULg

in Point Vétérinaire (2015), 353

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See detailCompte rendu de Ulrich Herbert, Geschichte Deutschlands im 20. Jahrhundert
Brüll, Christoph ULg

in Wissenschaftlicher Literaturanzeiger [=WLA] (2015)

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See detailChina in Latin America: cooperation and hegemony?
Wintgens, Sophie ULg

in Wouters, Jan; Defraigne, Jean-Christophe; Burnay, Matthieu (Eds.) China, the European Union and the Developing World: A Triangular Relationship (2015)

Over the last decade, China has deeply affected the economic map of Latin America. All the Latin American countries quickly increased their exchanges with China and get engaged in new plans for exchanges ... [more ▼]

Over the last decade, China has deeply affected the economic map of Latin America. All the Latin American countries quickly increased their exchanges with China and get engaged in new plans for exchanges, cooperation and partnerships. These evolutions have highlighted the American lack of leadership and the European loss of competitiveness. Numbers of researches tend to analyse the Sino-Latin American relationship with the eyes of reciprocity. This contribution rather makes the choice of analysing China’s strategy for growth on the world stage, focusing on its ties with Latin America and Brazil especially: cooperation or hegemony? According to this approach, the increase of China’s influence doesn’t only depend on its resources, nor on its capacity to mobilize them opportunely. It also depends on its external recognition. Thus, the power of China can be measured through its capacity to “assert itself as a reference” for its emerging peers, or even for Western powers. By integrating all dimensions of the Chinese power through its foreign policy and its incantatory diplomacy (anti-hegemonism, world multipolarization, South-South cooperation, etc.) , this chapter will try to identify real Chinese influence by measuring the distance between perception and reality. Against the backdrop of the following hypothesis: does the Chinese penetration in Latin America have a notable impact on the relations of Europe and the United States with this part of the world? [less ▲]

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See detailScience policy narratives in Flanders and Wallonia: The interplay of characters and ideas
Charlier, Nathan ULg

Conference (2015, March)

Both in Europe and in the United States, scientific research and science, technology and innovation (STI) policies have undergone profound changes in the last thirty years. In the literature, these ... [more ▼]

Both in Europe and in the United States, scientific research and science, technology and innovation (STI) policies have undergone profound changes in the last thirty years. In the literature, these transitions are often framed along dichotomous lines : an 'old regime' characterized by strong public funding, independent academia and a linear conception of innovation has supposedly been replaced by a 'new regime' in which research and innovation are conceived in systemic terms, regarding their economic and societal relevance (Rip 2000). These conceptions have been criticized regarding their historical accuracy, or regarding their (un)political-reading of those evolutions (Pestre, 2003). More broadly, Nowotny has recently emphasized the fact that the political understanding of science has been black boxed in STS (Nowotny, 2014). My proposal aims at investigating the multiple political conceptions of science in a regional context: what value is attributed to science? What are its aims? How should it be organized and funded? More specifically, this paper relies on an analytical framework based on the notion of "policy narratives" for science to examine how coexisting, and sometimes competing narratives are embedded in situated discourses, policies and practices. Policy narratives include the following elements (Jones & McBeth, 2010): A context, a plot (a sequence with a beginning, a middle and an expected end: Roe, 1992), characters that have a role and intervene in the plot, and some kind of 'moral' of the story advanced as a policy solution. As narratives help actors to make sense of things and orient their actions, they are both descriptive and performative. Hence, they relate to the notion of imaginary in a very concrete sense: narrative are related to actual institutions, and emerging policy narrative can serve as rationale for change. In this paper, narratives like, e.g., the "Knowledge-based Economy", the "Grand societal Challenges", "Science, the endless Frontier", are studied. Each attribute a different public value to science: improving economic growth, tackling specific issues such as cancer or ageing population, or increasing knowledge as a good in itself. Each also propose a specific organization for the STI system, and assign a specific role to the various stakeholders (the scientists, the university authorities, policy makers, industrialists and entrepreneurs, etc.). In order to understand how these global policy narrative are locally articulated, and thereby grounded in regional STI policymaking, my research is based on interviews with a range of stakeholders in Wallonia: biotech lab leaders, members of university boards, and representatives of labor and employers' organizations in regional advisory boards. In the analysis, a particular attention is paid to the various narratives used by the stakeholders when answering broad questions, with regards to their position. More specifically, the way stakeholders depict and scenarize their own role(s) and their relations with other actors is highly political and hence should be assessed. A main thesis of the paper is that one narrative does not constitute the only resource of a (group of) actor(s). Actors refer to different narratives regarding the context and regarding the evolution they promote. [less ▲]

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See detailActors valuing science in neoliberal science regimes
Charlier, Nathan ULg; Delvenne, Pierre ULg

Conference (2015, March)

With the underlying hypothesis of a shift toward neoliberal science regimes, much work has been done to analyze the multiple transformations of science institutions and policies over the last decades (e.g ... [more ▼]

With the underlying hypothesis of a shift toward neoliberal science regimes, much work has been done to analyze the multiple transformations of science institutions and policies over the last decades (e.g. Mirowski and Sent 2008; Slaughter & Rhoades, 2004; Bruno, 2008). The trends towards privatization and commodification of science are undisputable but we argue that little attention has been paid so far to the various political conceptions of research and innovation (R&I) coexisting within neoliberal science regimes. Cognitive approaches to public policy already stressed the circular relationship between meaning and power (e.g. Muller and Surel, 1998; Roe, 1994), but neoliberal science has remained out of the scope of such analyses. Regarding R&I policies, this leads to different ways to conceive of the “value” of science, some related to preexisting institutions and narratives, and some branching out toward new cognitive resources to achieve politico-economic aims. In our proposal, we hypothesize the coexistence of at least four policy narratives which help structuring the representations and actions of scientists and policymakers when they address science as a political object: ‘science for the sake of science’, ‘science, the endless frontier (continued)’, ‘knowledge-based economy’ and ‘grand societal challenges’. Each one attributes a different value to science, proposes a specific organization for the R&I system, and addresses the relation between economy and society differently. In order to understand how these policy narratives are locally articulated, and thereby grounded in R&I policymaking, we analyze the political discourses on science at three different institutional levels (biotechnology labs, university management, science policy advisory boards) in Belgium. Our data were gathered through semi-structured interviews with key members of the institutions studied. By analyzing the interplay of policy narratives for R&I in a context of neoliberal science, we aim to contribute to a better understanding of the ways science is valued at different levels. [less ▲]

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See detailAlexandre VI Borgia, le pape de la débauche
Marchandisse, Alain ULg

in Historia (2015), (Spécial 22),

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See detailA connection between the instability strips of ZZ Ceti and V777 Her white dwarfs
Van Grootel, Valérie ULg; Fontaine, Gilles; Brassard, Pierre et al

in Astronomy and Astrophysics (2015), 575

Aims. We aim to determine the theoretical instability strips of white dwarfs with diverse H and He content in their atmospheres, from a solar composition to a H-depleted atmosphere. Pulsators with mixed H ... [more ▼]

Aims. We aim to determine the theoretical instability strips of white dwarfs with diverse H and He content in their atmospheres, from a solar composition to a H-depleted atmosphere. Pulsators with mixed H-He atmospheres are indeed known to exist, and these are the white dwarfs in cataclysmic accreting systems of the GW Lib type. We thus also aim to determine the range of periods of excited pulsation modes, and to qualitatively compare these to the observed periods in GW Lib white dwarf pulsators. Methods. In the first full nonadiabatic stability analysis of pulsators of this kind, we applied a time-dependent convection treatment and an energy leakage argument to compute, for cooling models of white dwarfs with various masses and envelope compositions, the location of the blue and the red edges, as well as the properties of pulsation modes. Results. We find that our derived instability strips form a true continuum in the log g-Teff plane and that their individual location depends uniquely on the assumed atmospheric composition, from the solar composition models at low effective temperatures to the H-depleted models at much higher temperatures. Taking into account our previous results from the ZZ Ceti (pure H atmosphere) and V777 Her (pure He atmosphere) white dwarf pulsators, this implies that all of these instability domains are connected via the same fundamental driving mechanism. Applying our results to the case of white dwarf pulsators of the GW Lib type, we find that our theoretical instability strips can qualitatively account for all of the known cases. The computed range of periods of excited modes also compares qualitatively very well to the observed ones. Conclusions. The GW Lib pulsators are very similar in nature to ZZ Ceti and V777 Her white dwarfs. It is the diverse chemical compositions in their atmosphere and envelope that defines their specific pulsation properties. Beyond GW Lib pulsators, white dwarfs can sometimes exhibit mixed H-He atmospheres, such as in the recently found proto-He white dwarf pulsators. Our results open the way towards quantitative asteroseismology of these various kinds of white dwarfs. [less ▲]

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See detailComplexity markers in morphosyntactic productions in French-speaking children with specific language impairment (SLI)
Prigent, Gaïd ULg; Parisse, Christophe; Leclercq, Anne-Lise ULg et al

in Clinical Linguistics & Phonetics (2015)

The usage-based theory considers that the morphosyntactic productions of children with SLI are particularly dependent on input frequency. When producing complex syntax, the language of these children is ... [more ▼]

The usage-based theory considers that the morphosyntactic productions of children with SLI are particularly dependent on input frequency. When producing complex syntax, the language of these children is, therefore, predicted to have a lower variability and to contain fewer infrequent morphosyntactic markers than that of younger children matched on morphosyntactic abilities. Using a spontaneous language task, the current study compared the complexity of the morphological and structural productions of 20 children with SLI and 20 language-matched peers (matched on both morphosyntactic comprehension and mean length of utterance). As expected, results showed that although basic structures were produced in the same way in both groups, several complex forms (i.e. tenses such as Imperfect, Future or Conditional and Conjunctions) were less frequent in the productions of children with SLI. Finally, we attempted to highlight complex linguistic forms that could be good clinical markers for these children. [less ▲]

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See detailFamily farming in a changing landscape : how activities change when forest disappears
Feintrenie, Laurène; Gillet, Pauline ULg; Garcia, Claude et al

Conference (2015, March)

In the Congo Basin forests, local communities used to live from hunting, fishing and gathering, and from slash and burn agriculture. Nowadays, few places remain isolated from the external world, and local ... [more ▼]

In the Congo Basin forests, local communities used to live from hunting, fishing and gathering, and from slash and burn agriculture. Nowadays, few places remain isolated from the external world, and local practices often have to integrate new parameters. How do family farming and forest activities evolve in a changing landscape, when forest disappears? To answer this question we selected three social and ecological systems positioned in specific places on the forest transition curve (Mather 1992), to constitute a synchronic sample of forested social and ecological system representative of the evolution of Congo Basin Forests. We conducted in 2013 and 2014 a deep analysis of family farming in 8 villages distributed in these 3 studied sites. The method crosses a systemic approach with a systematic approach: agrarian diagnoses were conducted in the three sites (Boulaud 2014; Ferlay 2014) to evaluate technical and economic performances of family farming and forest extractive activities, in parallel, census of households were conducted (Codina Llavinia 2014; Gillet et al. 2014; Lehnebach 2014) to range family activities according to their share in the family income and as subsistence means. Results were harmonized and allowed a deep understanding of the strategy of adaptation to changes of households. [less ▲]

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