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See detailDroplet manipulation on fiber networks
Weyer, Floriane ULg; Pan, Zhao; Truscott, Tadd et al

Poster (2016, July)

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Peer Reviewed
See detailA Frasnian palynological assemblage from the NE Iberian Chain
Rial, Gonzalo; Cascales-Miñana, Borja ULg; Gerrienne, Philippe ULg et al

Poster (2016, July)

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See detailBridging the process/result gap in (EU) competition law and innovation debates
Van Cleynenbreugel, Pieter ULg

Scientific conference (2016, June 30)

In my conference paper, I outlined the general terms of the debates on EU competition law and innovation. Meant to introduce and frame, within the wider context of EU law, the conference theme, my ... [more ▼]

In my conference paper, I outlined the general terms of the debates on EU competition law and innovation. Meant to introduce and frame, within the wider context of EU law, the conference theme, my intervention above all sought to pave the way for a discussion on the conference theme. [less ▲]

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See detailCaractérisation phénotypique, morphologique et fonctionnelle des éosinophiles résidents du poumon
Raulier, Stéfanie ULg

Doctoral thesis (2016)

Eosinophils have long been considered as destructive effector cells implicated in parasitic infections and allergic reactions such as asthma. This traditional restrictive view of eosinophils has now been ... [more ▼]

Eosinophils have long been considered as destructive effector cells implicated in parasitic infections and allergic reactions such as asthma. This traditional restrictive view of eosinophils has now been considerably extended. Indeed, beside their pro-inflammatory functions, eosinophils are also able to finely shape local innate and adaptative immune responses. Moreover, recent studies indicate that steady-state resident eosinophils are now thought to contribute to immune homeostasis at mucosal sites such as the gut. In the normal lung, resident eosinophils (rEOS) have been little-studied so far. Here, we report that in mice, steady-state pulmonary rEOS are parenchymal Siglec-Fint CD125int cells characterized by a ring-shaped nucleus. [less ▲]

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See detailUnveiling new stellar companions from the EXOZODI survey : follow up
Marion, Lindsay ULg; Absil, Olivier ULg; Ertel, Steve et al

Poster (2016, June 30)

In 2012, we have conducted a survey of nearby main sequence stars with VLTI/PIONIER to search for the presence of circumstellar dust. We focused on the use of the closure phases and the square ... [more ▼]

In 2012, we have conducted a survey of nearby main sequence stars with VLTI/PIONIER to search for the presence of circumstellar dust. We focused on the use of the closure phases and the square visibilities in a combined way to search for faint companions around the whole sample. In this process, we found four new stellar companions, for which we conducted follow-up observations in 2014. This follow up allows us to confirm the four detections, and to detect another new companion. Only the case of HD202730 remains ambiguous. [less ▲]

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See detailSmart co-phasing system for segmented mirror telescopes
Simar, Juan Felipe ULg; Stockman, Yvan ULg; Surdej, Jean ULg

Poster (2016, June 30)

One of the main challenges in space observations is to observe always fainter and more compact objects. This can be achieved by increasing the telescope diameters. So, increasing the primary mirror ... [more ▼]

One of the main challenges in space observations is to observe always fainter and more compact objects. This can be achieved by increasing the telescope diameters. So, increasing the primary mirror diameters of the telescopes is the challenge solution but it is technically impossible to manufacture monolithic mirrors larger than 10m in diameter. The use of segmented mirrors thus becomes mandatory. This paper describes the results of a light co-phasing setup mounted in laboratory. This setup is able to correct a piston from 200μm to 15 nm based on coarse (200μm to 300nm) and fine (300nm to 15nm) measurement methods. Both measurements are then chained in a feedback system in order to completely co-phase and keep the segments aligned. [less ▲]

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Peer Reviewed
See detailSafety of Everolimus Plus Exemestane In Patients With Hormone-Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer Progressing on Prior Non-Steroidal Aromatase Inhibitors: Primary Results of a Phase 3b, Open-Label, Single-Arm, Expanded-Access Multicenter Trial (BALLET).
Jerusalem, Guy ULg; Mariani, G.; Ciruelos, E. M. et al

in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2016)

BACKGROUND: This European phase 3b, expanded-access multicenter trial evaluated the safety of EVE plus EXE in a patient population similar to BOLERO-2. PATIENTS AND METHODS: Postmenopausal women aged (3 ... [more ▼]

BACKGROUND: This European phase 3b, expanded-access multicenter trial evaluated the safety of EVE plus EXE in a patient population similar to BOLERO-2. PATIENTS AND METHODS: Postmenopausal women aged (3)18 years with hormone receptor-positive, human epidermal growth factor-receptor-2-negative advanced breast cancer (ABC) recurring/progressing during/after prior non-steroidal aromatase inhibitors (NSAIs) were enrolled. Primary objective was safety of EVE plus EXE based on frequency of adverse events (AEs), and serious AEs (SAEs). Secondary objective was to evaluate AEs of grade 3/4 severity. RESULTS: Median treatment duration was 5.1 months (95% CI, 4.8-5.6) for EVE and 5.3 months (95% CI, 4.8-5.6) for EXE. Overall, 2131 patients were included in the analysis; 81.8% of patients experienced EVE- or EXE-related or EVE/EXE-related AEs (investigator assessed); 27.2% were of grade 3/4 severity. The most frequently reported non-hematologic AEs were (overall %, % EVE-related) stomatitis (52.8%; 50.8%) and asthenia (22.8%; 14.6%). The most frequently reported hematologic AE were (overall %, % EVE-related) anemia (14.4%; 8.1%) and thrombocytopenia (5.9%; 4.6%). AE-related treatment discontinuations were higher in elderly ((3)70 years) versus non-elderly patients (23.8% vs. 13.0%). The incidence of EVE-related AEs in both elderly and non-elderly patients appeared to be lower in first-line ABC versus later lines. The incidence of AEs (including stomatitis/pneumonitis) was independent of BMI status (post-hoc analysis). Overall, 8.5% of patients experienced at least one EVE-related SAE. Of the 121 on-treatment deaths (5.7%), 66 (3.1%) deaths were due to disease progression and 46 (2.2%) due to AEs; 4 deaths were suspected to be EVE-related. CONCLUSIONS: This is the largest ever reported safety dataset on a general patient population presenting ABC treated with EVE plus EXE and included a sizeable elderly subset. Although the patients were more heavily pretreated, the safety profile of EVE plus EXE in BALLET was consistent with BOLERO-2. CLINICAL TRIAL REGISTRATION: EudraCT Number: 2012-000073-23. [less ▲]

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See detailExploring potentialities of RanbP2-type Zinc Fingers in RNA-binding proteins design
De Franco, Simona ULg; Vandenameele, Julie ULg; Galleni, Moreno ULg et al

Poster (2016, June 29)

Transcriptomes consist of several classes of RNAs, whose roles are central to innumerable biological processes as well as diseases. These observations justify the increasing interest in the engineering of ... [more ▼]

Transcriptomes consist of several classes of RNAs, whose roles are central to innumerable biological processes as well as diseases. These observations justify the increasing interest in the engineering of functionalized RNA-binding proteins (RBPs) to specifically manipulate RNA function. In this context, the RanBP2-type Zinc Finger (ZF) domain emerged as a suitable scaffold for single-stranded RBPs design. The present study aimed to identify the sequence-specificity of several naturally occurring RanBP2-type ZFs by in vitro selection and use the natural variation in their substrate to create arrays of ZF domains displaying customized specificity. A parallel kinetic and thermodynamic characterization of ssRNA-ZFs interaction was performed by Isothermal Titration Calorimetry (ITC) and BioLayer Interferometry (BLI), respectively. Although our data showed that only little variations in the recognized sequence could be observed for the studied ZFs, they contribute to elucidate the molecular basis for the RanBP2-type ZF-ssRNA interaction. [less ▲]

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Peer Reviewed
See detailEulerian Formulation of Elastic Rods
Huynen, Alexandre ULg; Detournay, Emmanuel; Denoël, Vincent ULg

in Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences (2016), 472(2190),

In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations ... [more ▼]

In numerous biological, medical and engineering applications, elastic rods are constrained to deform inside or around tube-like surfaces. To solve efficiently this class of problems, the equations governing the deflection of elastic rods are reformulated within the Eulerian framework of this generic tubular constraint defined as a perfectly stiff canal surface. This reformulation hinges on describing the rod deformed configuration by means of its relative position with respect to a reference curve, defined as the axis or spine curve of the constraint, and on restating the rod local equilibrium in terms of the curvilinear coordinate parameterizing this curve. Associated with a segmentation strategy, which partitions the global problem into a sequence of rod segments either in continuous contact with the constraint or free of contact (except for their extremities), this approach not only trivializes the detection of new contacts but also suppresses the isoperimetric constraints resulting from the self-feeding feature of these elementary problems and the imposition of the rod position at the extremities of each rod segments. [less ▲]

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See detailIntegrating roots into a whole plant network of flowering time genes in Arabidopsis thaliana
Bouché, Frédéric ULg; D'Aloia, Maria; Tocquin, Pierre ULg et al

in Scientific Reports (2016), 6

Molecular data concerning the involvement of roots in the genetic pathways regulating floral transition are lacking. In this study, we performed global analyses of the root transcriptome in Arabidopsis in ... [more ▼]

Molecular data concerning the involvement of roots in the genetic pathways regulating floral transition are lacking. In this study, we performed global analyses of the root transcriptome in Arabidopsis in order to identify flowering time genes that are expressed in the roots and genes that are differentially expressed in the roots during the induction of flowering. Data mining of public microarray experiments uncovered that about 200 genes whose mutations are reported to alter flowering time are expressed in the roots (i.e. were detected in more than 50% of the microarrays). However, only a few flowering integrator genes passed the analysis cutoff. Comparison of root transcriptome in short days and during synchronized induction of flowering by a single 22-h long day revealed that 595 genes were differentially expressed. Enrichment analyses of differentially expressed genes in root tissues, gene ontology categories, and cis-regulatory elements converged towards sugar signaling. We concluded that roots are integrated in systemic signaling, whereby carbon supply coordinates growth at the whole plant level during the induction of flowering. This coordination could involve the root circadian clock and cytokinin biosynthesis as a feed forward loop towards the shoot. [less ▲]

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See detail"Les Diables rouges sont-ils instrumentalisés en politique ?"
Verjans, Pierre ULg

Article for general public (2016)

"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de ... [more ▼]

"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de s’abstenir. Ils ne vont pas s’enthousiasmer un drapeau tricolore à la main. Il y a une évidente contradiction entre leur vision flamande avant tout et la diversité et le bilinguisme qu’affichent les Diables." [less ▲]

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See detailFast and not furious: an inquiry into the current low-risk/high-gain configuration of public participation
Rosskamp, Benedikt ULg; Delvenne, Pierre ULg; Charlier, Nathan ULg et al

Conference (2016, June 29)

For several years scholars pointed at the development of a “participatory turn” in science, technology and innovation (STI). Decisively informed by STS, “public involvement” and then “public engagement” ... [more ▼]

For several years scholars pointed at the development of a “participatory turn” in science, technology and innovation (STI). Decisively informed by STS, “public involvement” and then “public engagement” with STI have been enacted in a broad array of participatory experiments across Europe. These experiments were usually informed by rhetoric of citizen empowerment and distributed governance, against the limitations of technocratic approaches and traditional innovation processes, in order to “enrich”, “deepen”, “broaden” the knowledge base of our democracies. As “embarked researchers”, STS scholars played a crucial role in facilitating and legitimizing the organization of participatory events engaging a variety of publics. This paper will rely on the knowledge and expertise we gathered when organizing multiple participatory events over the last decade, while still trying maintain a critical distance with regard to our own engagement and the types of participation we contributed to enact. More specifically, we propose to draw on the lessons learnt from two recent projects, the organization of a citizens’ summit (Europe Wide Views on Sustainable Consumption) and a prospective study to gauge the potential of involving users in a Living Lab in the health sector in Wallonia. These two projects produced different publics (“citizens-consumers” or “users”), were informed by different political rationales (“sustainability” or “inclusive innovation”), took place in diverse settings (a European FP7 project or a project funded by the Walloon Region) and connected to several narratives of public empowerment through participation (“being heard in policymaking” or “accelerating and improving health”). Our contribution maps and compares the different instrumental and strategic framings of the engagement of publics in those two projects, emphasizing the roles attributed to fabricated publics but also the construction of categories such as the “state” and the “economy”. It unpacks some critical issues related to the methods and techniques used in the concrete implementation of participatory exercises such as, for example, the relation between the assigned tasks, the allowed forms of dialogue between the participants, the room for engagement with the issue(s) at stake and the broader understanding of processes these inputs were supposed to contribute to. Our analysis highlights a tension between the justificatory rationales for public engagement and its specific enactments. In these fast and optimized exercises, participants and their inputs become resources that need to be methodologically maximized and from which “value” may be extracted for instrumental use, i.e. innovation or policy-making. In this configuration in which, we argue, most participation experiments are stuck, the increasing involvement of publics in either policy-making or innovation will only be likely to produce low risk and high gain for powerful actors, who manage to take the best advantage of unpaid and uncritical labour from participants. Due attention (including self-reflexive critique) will be paid to alternative framings and critical insights, which were methodologically eliminated or ‘tamed’ to avoid threatening the design of the overall participatory exercise. By externalizing critique to favour unconditional compliance with imposed notions of the “greater good”, we scrutinize the risk for participation to become a mere space of experimentation for the sake of innovation and economic growth. Furthermore, we argue that critical scholarly work should help to move beyond this particular division of labour and responsibilities between the spheres of science, society and the state in order to avoid re-enacting traditional conceptions of the policy-making process and innovation pathways. [less ▲]

Detailed reference viewed: 26 (9 ULg)