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See detailHuman cortical excitability depends on time spent awake and circadian phase
Ly, Julien ULg; Gaggioni, Giulia ULg; Chellappa, Sarah Laxhmi ULg et al

Scientific conference (2014, October 04)

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking ... [more ▼]

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking period. But what’s happen at the cortical cerebral level? We used a novel technique coupling transcranial magnetic stimulation with electroencephalography (TMS/EEG) to assess the influence of time spent awake and circadian phasis on human cortical excitability. Twenty-two healthy young men underwent 8 TMS/EEG sessions during a 28 hour sleep deprivation protocole. We found that cortical excitability depends on both time spent awake and circadian phasis. [less ▲]

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See detailNEAR-DEATH EXPERIENCES IN PATIENTS WITH LOCKED-IN SYNDROME
Charland-Verville, Vanessa ULg; Lugo Ramirez, Zulay del Rosario ULg; Jourdan, Jean-Pierre et al

Poster (2014, October 04)

Near-Death Experiences (NDEs) are classically associated with positive emotions like peacefulness, happiness and joy [1-3]. To date, few negative NDEs reports have been documented [4]. Although NDEs ... [more ▼]

Near-Death Experiences (NDEs) are classically associated with positive emotions like peacefulness, happiness and joy [1-3]. To date, few negative NDEs reports have been documented [4]. Although NDEs classically arise in the context of an acute severe brain damage, their associated memories are reported as being phenomenologically very rich and detailed [5]. To date, no satisfactory explanatory model exits to fully account for the rich phenomenology of NDEs following a severe acute brain injury [6]. Neurobiological hypotheses include cerebral hypoxia [7, 8] and temporal lobe dysfunctions [9] to account for some of the features occurring during NDEs. However, it has been recently shown that anoxic/hypoxic, traumatic and other supratentorial brain lesions do not seem to influence the content of a NDE when assessed with a standardized tool (i.e., Greyson NDE scale; [1]). Due to their particular brain lesion (i.e., pontine brainstem), locked-in syndrome (LIS) patients provide a unique opportunity to further investigate the neural correlates of NDEs. We here aimed at retrospectively characterizing the content of NDEs in patients with LIS having suffered from an acute brainstem lesion (cerebrovascular accident (CVA) or trauma; i.e., “LIS NDEs”) and to compare these experiences to those collected in a cohort of matched NDE experiencers after coma with supratentorial lesions (CVA or trauma; i.e., “classical NDEs”). [less ▲]

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See detailNeuropathies proximales du membre supérieur
WANG, François-Charles ULg

Conference (2014, October 04)

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See detailL'épaule un carrefour complexe
WANG, François-Charles ULg

Conference (2014, October 04)

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See detailEt si ce n'était pas un canal carpien
FERON, Frédéric ULg; WANG, François-Charles ULg

Conference (2014, October 04)

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See detailDiscussion de cas cliniques et atelier pratique
WANG, François-Charles ULg

Conference (2014, October 04)

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See detailOblitérations. Contacts et frictions dans "A Humument" de Tom Phillips
Delville, Michel ULg; Belloi, Livio ULg

Conference (2014, October 03)

Cette intervention examine "A Humument" de Tom Phillips en termes de contacts et de frictions entre le texte-source (un roman victorien) et sa réinterprétation par l'auteur.

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See detailWhat's happening in Adenoma Valley
Beckers, Albert ULg

Scientific conference (2014, October 03)

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See detailMultibody Modelling of Mechanical Transmission Systems in Vehicle Dynamics
Virlez, Geoffrey ULg

Doctoral thesis (2014)

This thesis addresses the dynamic modelling of automotive driveline components by means of the nonlinear finite element method for flexible multibody systems. Starting from a detailed study of an ... [more ▼]

This thesis addresses the dynamic modelling of automotive driveline components by means of the nonlinear finite element method for flexible multibody systems. Starting from a detailed study of an industrial application, the TORSEN differential, several contributions are proposed in the field of contact modelling. The contact between rigid bodies in several geometric configurations is investigated and the influence of the squeeze film of lubricating oil is studied. A contact formulation between flexible bodies modelled as superelements is also developed and applied to the modelling of 3D flexible gear pairs. [less ▲]

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See detailKnowledge transfer from Belgian government to medical doctors
MORTELMANS, Katrien; REMMEN, Roy; BERKEIN, Philip et al

Conference (2014, October 02)

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See detailManuel d'analyse qualitative. Analyser sans compter ni classer
Lejeune, Christophe ULg

Book published by De Boeck (2014)

La méthode qualitative s'est dotée d'outils et de techniques : journal de bord, propriété, dimension, catégorie, échantillonnage, saturation, scénario, mémo et compte rendu, codage (ouvert, axial et ... [more ▼]

La méthode qualitative s'est dotée d'outils et de techniques : journal de bord, propriété, dimension, catégorie, échantillonnage, saturation, scénario, mémo et compte rendu, codage (ouvert, axial et sélectif). Cet ouvrage présente le rôle respectif de chacun de ces éléments et permet à tous de s'approprier la logique qui les sous-tend. S'appuyant sur des exemples issus de recherches réelles, il expose avec clarté comment conduire sa propre recherche. Il fournit des astuces développées par les praticiens les plus aguerris et permet ainsi au lecteur d'évaluer sa propre avancée dans le monde passionnant de la recherche qualitative. [less ▲]

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See detailIl ne suffit pas de lire les étiquettes, mais bien de discuter avec le producteur
Ozer, Pierre ULg

Article for general public (2014)

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See detailRational Design of a Safe and Efficacious Attenuated Recombinant Vaccine Against Cyprinid Herpesvirus 3 Using Prokaryotic Mutagenesis and In Vivo Imaging System
Boutier, Maxime ULg

Conference (2014, October 02)

Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease in common and koi carp. Since its emergence, in the late 1990s, CyHV 3 has caused severe economic losses worldwide creating a ... [more ▼]

Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease in common and koi carp. Since its emergence, in the late 1990s, CyHV 3 has caused severe economic losses worldwide creating a need for a safe and efficacious vaccine. With this goal in mind, recombinant strains deleted for single gene were produced using prokaryotic recombination technologies. While producing such a recombinant for ORF134, we unexpectedly obtained a clone deleted for ORF56 and ORF57 in addition to the expected deletion of ORF134. Interestingly, this triple deleted recombinant replicated efficiently in vitro, exhibited an attenuated profile and induced an immune protection against a lethal challenge in vivo. To determine the role of each deleted locus in the phenotype of the triple deleted recombinant, a series of recombinant were produced and tested in vivo. Firstly, to investigate the role of ORF134 deletion, a double ORF56-57 deleted recombinant and an independent triple ORF56-57-ORF134 deleted recombinant were produced. These experiments revealed that ORF134 deletion did contribute significantly neither to the attenuation nor to the immune protection observed for the triple deleted recombinant. Secondly, to determine the relative importance of ORF56 and ORF57 deletion in the attenuation observed, two single deleted recombinants were produced for ORF56 and ORF57. These experiments demonstrated that ORF57 deletion, in contrast to ORF56 deletion, correlates with an attenuated phenotype. Based on its safety-efficacy profile, the ORF56-57 double deleted recombinant was selected as a candidate vaccine. Complementary experiments were performed to further investigate the potential of this strain as a safe and efficacious attenuated recombinant vaccine. The results obtained can be summarized as follows: (i) In vivo imaging (IVIS) of vaccinated fish challenged with a wild type strain expressing luciferase as a reporter gene, suggested that vaccination induces a sterile immunity at the portal of entry. (ii) Study of viral tropism by qPCR, IVIS, and histopathological analyses, demonstrated that in comparison to the wild type parental strain, the vaccine strain replicates at lower level, at later time post-infection and for a shorter period of time. (iii) Transmission studies demonstrated that there is no detectable spread of the vaccine from freshly vaccinated fish to naive fish located immediately down stream of vaccinated fish (water sharing). All together, the results of the present study demonstrate the potential of ORF56-ORF57 double deleted CyHV-3 recombinant strain for safe and efficacious mass vaccination of carp. [less ▲]

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See detailQTL analysis and candidate gene mapping for the polyphenol content in cider apple
Verdu, Cindy ULg; Guyot, Sylvain; Childebrand, Nicolas et al

in PLoS ONE (2014), 9(10), 107103

Polyphenols have favorable antioxidant potential on human health suggesting that their high content is responsible for the beneficial effects of apple consumption. They control the quality of ciders as ... [more ▼]

Polyphenols have favorable antioxidant potential on human health suggesting that their high content is responsible for the beneficial effects of apple consumption. They control the quality of ciders as they predominantly account for astringency, bitterness, color and aroma. In this study, we identified QTLs controlling phenolic compound concentrations and the average polymerization degree of flavanols in a cider apple progeny. Thirty two compounds belonging to five groups of phenolic compounds were identified and quantified by reversed phase liquid chromatography on both fruit extract and juice, over three years. The average polymerization degree of flavanols was estimated in fruit by phloroglucinolysis coupled to HPLC. Parental maps were built using SSR and SNP markers and used for the QTL analysis. Sixty-nine and 72 QTLs were detected on 14 and 11 linkage groups of the female and male maps, respectively. A majority of the QTLs identified in this study are specific to this population, while others are consistent with previous studies. This study presents for the first time in apple, QTLs for the mean polymerization degree of procyanidins, for which the mechanisms involved remains unknown to this day. Identification of candidate genes underlying major QTLs was then performed in silico and permitted the identification of 18 enzymes of the polyphenol pathway and six transcription factors involved in the apple anthocyanin regulation. New markers were designed from sequences of the most interesting candidate genes in order to confirm their co-localization with underlying QTLs by genetic mapping. Finally, the potential use of these QTLs in breeding programs is discussed. [less ▲]

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See detailSimulation and optimization of a CHP biomass plant and district heating network
Sartor, Kevin ULg; Quoilin, Sylvain ULg; Dewallef, Pierre ULg

in Applied Energy (2014), 130

Biomass Combined Heat and Power (CHP) plants connected to district heating (DH) networks are recognized nowadays as a very good opportunity to increase the share of renewable sources into energy systems ... [more ▼]

Biomass Combined Heat and Power (CHP) plants connected to district heating (DH) networks are recognized nowadays as a very good opportunity to increase the share of renewable sources into energy systems. However, as CHP plants are not optimized for electricity production, their operation is profitable only if a sufficient heat demand is available throughout the year. Most of the time, pre-feasibility studies are based on peak power demand and business plans only assume monthly or yearly consumption data. This approach usually turns out to overestimate the number of operating hours or oversize the plant capacity. This contribution presents a methodology intended to be simple and effective that provides accurate estimations of economical, environmental and energetic performances of CHP plants connected to district heating networks. A quasi-steady state simulation model of a CHP plant combined with a simulation model of the district heating network installed on the Campus of the University in Liège (Belgium) is used as an application framework to demonstrate the effectiveness of the selected approach. Based on the developed model and actual consumption data, several scenarios for energy savings are considered and ranked. The potential energy savings and resulting energy costs are estimated enabling more general conclusions to be drawn on the opportunity of using district heating networks in urban districts for Western Europe countries. [less ▲]

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See detailÉTUDE DU COMPLEXE ENZYMATIQUE DES SYMBIONTES DU TERMITE RETICULITERMES FLAVIPES (EX. SANTONENSIS)
Tarayre, Cédric ULg

Doctoral thesis (2014)

In the light of the economic, environmental and social context in which we live today, it has become obvious that the use of fossil fuels is not conceivable over the long term. Some alternatives have ... [more ▼]

In the light of the economic, environmental and social context in which we live today, it has become obvious that the use of fossil fuels is not conceivable over the long term. Some alternatives have therefore emerged in recent years. Second-generation biofuels are one of those alternatives and are based on the exploitation of vegetal biomass, also called lignocellulosic biomass. These materials require a hydrolysis step which can notably be achieved by enzymes. Some insects, such as termites, harbor complex microbial communities inside their digestive tracts. Those communities are able to produce enzymes which can be used in the field of the hydrolysis of vegetal biomass. This is what this thesis deals with. The main part of the work done focused on the research of enzyme-producing microorganisms (bacteria, mycetes and protists) responsible for the degradation of hemicelluloses and cellulose, the hydrolysis of which releases fermentable sugars. The insect which was used in this work was Reticulitermes flavipes (ex. santonensis), a lower termite, harboring a highly diversified internal microflora. This thesis describes the characterization of the microbial strains which were isolated and the enzymes they secrete. A complementary part of this research focussed on termites grown on artificial diets. The objective of this part was multiple : isolating enzyme-producing strains, not extractable according to the standard technique, and characterizing the microflora resulting from the applied artificial diets. This multidisciplinary approach was based on microscopy, proteomics, metagenomics and the assessment of metabolism applied to the different microbial consortia. [less ▲]

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See detailTIGRE: A new robotic spectroscopy telescope at Guanajuato, Mexico
Schmitt, J. H. M. M.; Schröder, K.-P.; Rauw, Grégor ULg et al

in Astronomische Nachrichten (2014), 335

TIGRE is a new robotic spectroscopy telescope located in central Mexico at the La Luz Observatory of the University of Guanajuato. The 1.2 m telescope is fiber-coupled to an échelle spectrograph with a ... [more ▼]

TIGRE is a new robotic spectroscopy telescope located in central Mexico at the La Luz Observatory of the University of Guanajuato. The 1.2 m telescope is fiber-coupled to an échelle spectrograph with a spectral resolving power exceeding 20 000 over most of the covered spectral range between 3800 Å and 8800 Å, with a small gap of 130 Å around 5800 Å. TIGRE operates robotically, i.e. it (normally) carries out all observations without any human intervention, including, in particular, the target selection in any given observing night. In this paper we describe the properties of the TIGRE instrumentation and its technical realization, as well as our first operational experience with the performance and efficiency of the overall system. Finally, we present some examples of recent TIGRE observations. [less ▲]

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