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See detailPreparing physically educated citizens in physical education. Expectations and practices
Cloes, Marc ULg

in Retos (2017), 31

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being ... [more ▼]

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being increasingly linked to the promotion of physically active lifestyles. In this paper, we try to determine whether practitioners have the capacity to reach recent objectives for the subject or should reconsider their work on this issue. Moreover, we propose to extend the current focus on physical literacy to encompass the concept of societal transfer, underlining the need for an authentic pedagogy of PE. [less ▲]

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See detailCoude - Poignet - Main
Kaux, Jean-François ULg

Learning material (2017)

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

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See detailEstrogen receptors and estetroldependent neuroprotective actions: a pilot study
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Journal of Endocrinology (2017), 232(1), 85-95

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen ... [more ▼]

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERalpha (MPP dihydrochloride), ERbeta (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1 mg/kg/day, 5 mg/kg/day, 10 mg/kg/day, 50 mg/kg/day) was investigated using the hypoxic-ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic-ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4's effect was completely blocked by concomitant treatment either with ERalpha and ERbeta inhibitors (MPP and PHTPP, respectively), or ERalpha and ERbeta inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERbeta inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5 mg/kg/day and 50 mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4's antioxidative actions mostly depend on ERalpha and ERbeta, whereas neurogenesis and possibly promyelinating activities might be realized through ERbeta. [less ▲]

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See detailFluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state
Van Calster, Laurens ULg; D'Argembeau, Arnaud ULg; SALMON, Eric ULg et al

in Journal of Cognitive Neuroscience (2017)

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's ... [more ▼]

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top–down versus bottom–up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes. [less ▲]

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See detailIntersections on the "Map of Art": Metaphor in Ben Okri's Dangerous Love and Wilson Harris's The Mask of the Beggar
Tunca, Daria ULg

in Collier, Gordon; Davis, Geoffrey V.; Delrez, Marc (Eds.) et al The Cross-Cultural Legacy: Critical and Creative Writings in Memory of Hena Maes-Jelinek (2017)

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See detailUnderstanding and overcoming metformin gastrointestinal intolerance.
Bonnet, Fabrice; Scheen, André ULg

in Diabetes, Obesity & Metabolism (2017), 19(473-481),

Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacologic option as supported by multiple international guidelines, yet a rather large ... [more ▼]

Metformin is the most widely prescribed drug for patients with type 2 diabetes mellitus and the first-line pharmacologic option as supported by multiple international guidelines, yet a rather large proportion of patients cannot tolerate metformin in adequate amounts because of its associated gastrointestinal (GI) adverse events (AEs). GI AEs typically encountered with metformin therapy include diarrhoea, nausea, flatulence, indigestion, vomiting, and abdominal discomfort, with diarrhoea and nausea being the most common. Although starting at a low dose and titrating slowly may help prevent some of metformin's GI AEs, some patients are unable to tolerate metformin at all and it may also be difficult to convince patients to start metformin again after a bout of GI AEs. Despite this clinical importance the underlying mechanisms of metformin's GI intolerance are poorly known. This review discusses the epidemiology of metformin GI intolerance; its underlying mechanisms; genotype variability and associated factors affecting metformin GI intolerance, such as comorbidities, co-medications, and bariatric surgery; clinical consequences, and therapeutic strategies to overcome metformin GI intolerance. These strategies include appropriate titration of immediate-release metformin, use of extended-release metformin, the promise of delayed-release metformin and gut microbiome modulators, and alternative pharmacological therapies when metformin cannot be tolerated at all. Given the available data, all efforts should be made to maintain metformin before considering a shift to another drug therapy. [less ▲]

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See detailFactors associated with reaching or not reaching target HbA1c after initiation of basal or premixed insulin in patients with type 2 diabetes.
Scheen, André ULg; Schmitt, H.; Jiang, H. H. et al

in Diabètes & Métabolism (2017), 43(69-78),

AIMS: To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as ... [more ▼]

AIMS: To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insulin regimen in patients with type 2 diabetes. METHODS: This post-hoc analysis of insulin-naive patients in the DURABLE study randomised to receive either insulin glargine or insulin lispro mix 25 evaluated the percentages of patients achieving a target HbA1c of <7.0% (<53mmol/mol) per baseline HbA1c quartiles, and the effect of each insulin regimen on the relative contributions of PHG and FHG to overall hyperglycaemia. RESULTS: Patients had comparable demographic characteristics and similar HbA1c and FHG values at baseline in each HbA1c quartile regardless of whether they reached the target HbA1c. The higher the HbA1c quartile, the greater was the decrease in HbA1c, but also the smaller the percentage of patients achieving the target HbA1c. HbA1c and FHG decreased more in patients reaching the target, resulting in significantly lower values at endpoint in all baseline HbA1c quartiles with either insulin treatment. Patients not achieving the target HbA1c had slightly higher insulin doses, but lower total hypoglycaemia rates. CONCLUSION: Smaller decreases in FHG were associated with not reaching the target HbA1c, suggesting a need to increase basal or premixed insulin doses to achieve targeted fasting plasma glucose and improve patient response before introducing more intensive prandial insulin regimens. [less ▲]

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See detailCould Piano key weirs be subject to nappe oscillations?
Lodomez, Maurine ULg; Pirotton, Michel ULg; Dewals, Benjamin ULg et al

in 3rd International Workshop on Labyrinth and Piano Key Weirs - PKW 2017 (2017)

Nappe oscillation may affect a variety of free overflow hydraulic structures operating at low heads such as crest gates and various types of weirs. This phenomenon produces oscillations in the thin nappe ... [more ▼]

Nappe oscillation may affect a variety of free overflow hydraulic structures operating at low heads such as crest gates and various types of weirs. This phenomenon produces oscillations in the thin nappe cascading downstream of the control structure. These oscillations can result in a high noise levels that may affect people and structures located nearby. With long linear and thin overtopping walls, piano key weirs might be subject to strong nappe oscillation risks, as a few documented cases with labyrinth weirs. However, the specific geometric features of piano key weirs, such as the outlet ramps or the limited width of the inlet apex, could perhaps prevent the development of nappe oscillation. In this paper, a prototype-scale linear weir is operated to assess the risk of nappe oscillations on a piano key weir like configuration (sidewall). In particular, the effect of the weir width and inclined apron is analyzed. The experimental results show that nappe oscillation development should not occur on piano key weir, contrary to what might be observed on a labyrinth weir with the same crest. [less ▲]

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See detailFluvial archives, a valuable record of vertical crustal deformation
Demoulin, Alain ULg; Mather, Anne; Whittaker, Alexander

in Quaternary Science Reviews (2017)

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature ... [more ▼]

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature of crustal deformation and its history. In recent decades, geomorphic analysis of rivers has proved powerful in elucidating the tectonic evolution of actively uplifting and eroding orogens. Here, we review the main recent developments that have improved and expanded qualitative and quantitative information about vertical tectonic motions (the effects of horizontal deformation are not addressed). Channel long profiles have received considerable attention in the literature, and we briefly introduce basic aspects of the behaviour of bedrock rivers from field and numerical modelling perspectives, before describing the various metrics that have been proposed to identify the information on crustal deformation contained within their steady-state characteristics. Then, we review the literature dealing with the transient response of rivers to tectonic perturbation, through the production of knickpoints propagating through the drainage network. Inverse modelling of river profiles for uplift in time and space is also shown to be very effective in reconstructing regional tectonic histories. Finally, we present a synthetic morphometric approach for deducing the tectonic record of fluvial landscapes. As well as the erosional imprint of tectonic forcing, sedimentary deposits, such as fluvial terrace staircases, are also considered as a classical component of tectonic geomorphology. We show that these studies have recently benefited from rapid advances in dating techniques, allowing more reliable reconstruction of incision histories and estimation of incision rates. The combination of progress in the understanding of transient river profiles and larger, more rigorous data sets of terrace ages has led to improved understanding of river erosion and the implications for terrace profile correlation, i.e., extrapolation of local data to entire profiles. Finally, planform changes in fluvial systems are considered at the channel scale in alluvial rivers and regional level in terms of drainage reorganisation. Examples are given of how numerical modelling can efficiently combine with topographic data to shed new light on the (dis)equilibrium state of drainage systems across regional drainage divides. [less ▲]

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See detailFrançois Ier et les arts du Nord (1515-1547)
Fagnart, Laure ULg; Lecocq, Isabelle

Book published by Picard (2017)

Whereas the exchanges between Francis I and Italy have attracted much attention, the King’s relations with the old Southern Netherlands, as rich and complex, have not been carefully studied. The book ... [more ▼]

Whereas the exchanges between Francis I and Italy have attracted much attention, the King’s relations with the old Southern Netherlands, as rich and complex, have not been carefully studied. The book "Francis I and Artists of the North (1515-1547)" aims to fill this gap by considering the interest of the King of France - in artists and musicians from the old Southern Netherlands and their works. [less ▲]

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See detailFrançois Ier, 'second César' et l'appartement des bains du château de Fontainebleau
Fagnart, Laure ULg

in Petey-Girard, Bruno; Polizzi, Gilles; Tran, Trung (Eds.) François Ier imaginé (2017)

En 1527, alors que François Ier entame la rénovation architecturale et décorative du château de Fontainebleau, l’assimilation du prince avec Jules César est devenu un topos du discours royal ... [more ▼]

En 1527, alors que François Ier entame la rénovation architecturale et décorative du château de Fontainebleau, l’assimilation du prince avec Jules César est devenu un topos du discours royal. Inévitablement, un tel imaginaire imprègne l’aménagement du château de Fontainebleau. On le retrouve dans la galerie François Ier mais aussi dans l'appartement des bains, un ensemble que le roi et le cercle de lettrés et d’érudits qui l’entoure imaginèrent sur le modèle des thermes de la Rome impériale. Cette contribution propose une confrontation entre la suite bellifontaine et les infrastructures antiques, mais aussi quelques installations contemporaines, et ce dans le but de préciser l’originalité des bains de François Ier. [less ▲]

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See detailPostoperative care in endoscopic sinus surgery: a critical review.
Eloy, Philippe; Andrews, Peter; POIRRIER, Anne-Lise ULg

in Current Opinion in Otolaryngology & Head & Neck Surgery (2017), 25(1), 35-42

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard ... [more ▼]

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard treatment for medically refractive disease. Postoperative care is recommended by international leaders as an important part of the patient's management. This article is a critical review and discussion focusing on postoperative care, which is based on expert opinion, clinical studies, randomized controlled trials and meta-analysis studies. RECENT FINDINGS: Postoperative care including nasal rinsing, topical corticosteroids, antibiotics and avoidance of nasal packing are unanimously considered to be the cornerstone of best practice following FESS. However, the effectiveness of in-office nasal debridement is still under debate. SUMMARY: There is a lack of consensus regarding the necessity of performing in-office nasal debridement and the majority of clinicians carry out their postoperative care according to experience and their own preference. This is often determined by the extent of surgery performed, the severity of the postoperative inflammation, as well as being dependent on the patient's discomfort, the time constraints associated with postoperative care and the costs associated with additional appointments. Ideally, nasal debridement should be performed by the operating surgeon under endoscopic control both gently and atraumatically. [less ▲]

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See detailPsychopathologie de l'homme en situation - deuxième édition avec préface de l'auteur
Englebert, Jérôme ULg

Book published by Hermann - 2ème éd. (2017)

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See detailEdgar Allan Poe, Eureka
Delville, Michel ULg; Bertrand, Jean-Pierre ULg

Book published by Gallimard (2017)

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See detailInstitutional pedagogy for an autonomous society: Castoriadis & Lapassade
Wustefeld, Sophie ULg

in Educational Philosophy & Theory (2017)

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See detailFish habitat selection in a large hydropeaking river: Strong individual and temporal variations revealed by telemetry
Capra, Hervé; Plichard, Laura; Bergé, Julien et al

in Science of the Total Environment (2017), 578

Modeling individual fish habitat selection in highly variable environments such as hydropeaking rivers is required for guiding efficient management decisions. We analyzed fish microhabitat selection in ... [more ▼]

Modeling individual fish habitat selection in highly variable environments such as hydropeaking rivers is required for guiding efficient management decisions. We analyzed fish microhabitat selection in the heterogeneous hydraulic and thermal conditions (modeled in two-dimensions) of a reach of the large hydropeaking Rhône River locally warmed by the cooling system of a nuclear power plant. We used modern fixed acoustic telemetry techniques to survey 18 fish individuals (five barbels, six catfishes, seven chubs) signaling their position every 3 s over a three-month period. Fish habitat selection depended on combinations of current microhabitat hydraulics (e.g. velocity, depth), past microhabitat hydraulics (e.g. dewatering risk or maximum velocities during the past 15 days) and to a lesser extent substrate and temperature. Mixed-effects habitat selection models indicated that individual effects were often stronger than specific effects. In the Rhône, fish individuals appear to memorize spatial and temporal environmental changes and to adopt a “least constraining” habitat selection. Avoiding fast-flowing midstream habitats, fish generally live along the banks in areas where the dewatering risk is high. When discharge decreases, however, they select higher velocities but avoid both dewatering areas and very fast-flowing midstream habitats. Although consistent with the available knowledge on static fish habitat selection, our quantitative results demonstrate temporal variations in habitat selection, depending on individual behavior and environmental history. Their generality could be further tested using comparative experiments in different environmental configurations. [less ▲]

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See detailNuclear Medicine techniques in transplantation
LOVINFOSSE, Pierre ULg; HUSTINX, Roland ULg

in Clinical and Translational Imaging (2017)

Organ transplantation has grown over the past decades thanks to major improvements in surgical techniques and immunosuppressive treatment. Nuclear medicine is used for non-invasively improving the ... [more ▼]

Organ transplantation has grown over the past decades thanks to major improvements in surgical techniques and immunosuppressive treatment. Nuclear medicine is used for non-invasively improving the selection of candidates to give or receive a transplant, for monitoring graft recipients and for diagnosing and managing early and late complications. This review describes the clinical role of nuclear medicine in transplantation and discusses some of the possible perspectives. [less ▲]

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See detailGrowth velocity of preterm infants - analysis and recommendations
Fenton, Tanis; Hoyos, Angela; Groh-Wargo, Sharon et al

Conference (2017)

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See detailGrowth velocity of preterm infants - analysis and recommendations
Fenton, Tanis; Hoyaos, Angela; Groh-Wargo, Sharon et al

Conference (2017)

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