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See detailAntiplasmodial activity of Heinsia crinita (Rubiaceae) and identification of new iridoids.
Tshisekedi Tshibangu, P.; Mutwale Kapepula, P.; Kabongo Kapinga, M. J. et al

in Journal of Ethnopharmacology (2017), 196

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in the Democratic Republic of the Congo (DRC) as a remedy against malaria. Investigations were conducted on crude extracts of leaves, fruits and stem barks in view to validate their use and to determine which plant part possesses the best antiplasmodial properties. MATERIALS AND METHODS: Different plant parts were extracted with methanol, ethanol and dichloromethane. Based on the preliminary assays, the dichloromethane extract of the stem bark was subjected to fractionation using preparative HPLC system and column chromatography. This step led to the isolation of two new iridoids which had their structures elucidated by NMR, UV, MS and FT-IR spectroscopic techniques. Extracts and pure compounds were tested in vitro against the 3D7 strain of Plasmodium falciparum. The inhibition of the parasite growth was evaluated in vitro by colorimetric method (p-LDH assay) and their cytotoxicity evaluated in vitro against the human non-cancer fibroblast cell line (WI38) through WST1 assay. The in vivo antiplasmodial activity was assessed by the inhibition of Plasmodium berghei growth in infected mice treated with the ethanol extract of H. crinita stem bark at the concentrations of 200 and 300mg/Kg/day per os, using a protocol based on the 4-d suppressive test of Peters and compared to a non-treated negative control group of mice (growth =100%). Finally the antioxidant activity of the same extract was evaluated using ABTS, DPPH and cell-based assays. RESULTS: A moderate in vitro antiplasmodial activity was observed for the dichloromethane extract of the stem bark of H. crinita (IC50 =29.2+/-1.39microg/mL) and for the two new iridoids, lamalbide 6, 7, 8- triacetate (IC50 =16.39+/-0.43microg/mL) as well as for its aglycone lamiridosin 6, 7, 8-triacetate (IC50 =0.44.56+/-1.12microg/mL). The ethanolic stem bark extract (200 and 300mg/kg/day, oral route) showed a moderate in vivo antimalarial activity in Plasmodium berghei-infected mice with 27.84+/-2.75% and 48.54+/-3.76% of inhibition of the parasite growth, respectively (p<0.01).). This extract displayed high cellular antioxidant activity using dichlorofluorescein-diacetate (DCFDA) on HL-60 monocytes. These crude extracts and pure compounds tested at the higher concentration of 100microg/mL did not show any cytotoxicity against WI38 cells. CONCLUSIONS: The results showed that H. crinita extracts possess antimalarial activity and contain some unusual iridoids with moderate antiplasmodial activity, therefore justifying to some extent its traditional use by the local population in DRC for this purpose. This is the first report of the isolation and antiplasmodial activity of these two new iridoids. [less ▲]

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See detailInvestigation of the added mass method for seismic design of lock gates
Buldgen, Loïc ULg; Le Sourne, Hervé; Caprace, Jean-David ULg et al

in Engineering Structures (2017)

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See detailDancing without listening to the music: learning from some failures of the ‘national innovation systems’ in Latin America
Delvenne, Pierre ULg; Thoreau, François ULg

in Kuhlmann, Stefan; Ordóñez-Matamoros, Gonzalo (Eds.) Research Handbook on Innovation Governance for Emerging Economies (2017)

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See detailFast In-Plane Dynamics of a Beam with Unilateral Constraints
Liakou, Anna; Denoël, Vincent ULg; Detournay, Emmanuel

in Journal of Engineering Mechanics (2017), 0(0), 04016116

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See detailIterated local search for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in Network (2017)

In this article an Iterated Local Search algorithm for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints is presented. Axle weight limits impose a ... [more ▼]

In this article an Iterated Local Search algorithm for the capacitated vehicle routing problem with sequence-based pallet loading and axle weight constraints is presented. Axle weight limits impose a great challenge for transportation companies. Yet, the literature on the incorporation of axle weight constraints in vehicle routing models is very scarce. The effect of introducing axle weight constraints in a CVRP on total routing cost is analyzed. Results show that integrating axle weight constraints does not lead to a large cost increase. However, not including axle weight constraints in the planning process may induce major axle weight violations. [less ▲]

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See detailZeit-Räume im langen 19. Jahrhundert. Erfahrungen von Verdichtung, Beschleunigung und Beharrung
Brüll, Christoph ULg; Fickers, Andreas

in Lejeune, Carlo (Ed.) Grenzerfahrungen. Eine Geschichte der Deutschsprachigen Gemeinschaft Belgiens. Vol. 3: Code Civil, beschleunigte Moderne und Dynamiken des Beharrens (1794-1919) (2017)

Der Begriff des Zeitraums ist eine Besonderheit der deutschen Sprache. Zeit und Raum müssen in der historischen Betrachtung gemeinsam gedacht werden. Doch über welche Zeit reden wir in diesem Band? Wie ... [more ▼]

Der Begriff des Zeitraums ist eine Besonderheit der deutschen Sprache. Zeit und Raum müssen in der historischen Betrachtung gemeinsam gedacht werden. Doch über welche Zeit reden wir in diesem Band? Wie können historische Brüche und Kontinuitäten erfasst und als Teil einer globalen Geschichte gedeutet werden? Über welchen Raum reden wir? Waren die Grenzregionen zwischen Rhein und Maas nur Randregionen, deren Bedeutung allein aus dem Blickwinkel der Zentren deutlich wird? Oder waren sie eher Zwischenräume, deren Potenzial aus dem Miteinander über alle Grenzen hinweg gelesen werden kann? Grundsätzliche Fragen, zahlreiche Anregungen und Beispiele über Zeit und Raum im langen 19. Jahrhundert und das Konzept dieses Bandes. [less ▲]

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See detailDie beständige Suche nach Heimaten. Über Lebensperspektiven von Auswanderern, Einwanderern und Minderheiten
Giesdorf, Jens; Lindig, Anja; Brüll, Christoph ULg

in Lejeune, Carlo (Ed.) Grenzerfahrungen. Eine Geschichte der Deutschsprachigen Gemeinschaft Belgiens. Vol. 3: Code Civil, beschleunigte Moderne und Dynamiken des Beharrens (1794-1919) (2017)

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See detailEin Schattendasein in der Geschichtsschreibung. Wenige Blicke auf die Zwischenräume im langen 19. Jahrhundert
Brüll, Christoph ULg; Lejeune, Carlo

in Lejeune, Carlo (Ed.) Grenzerfahrungen. Eine Geschichte der Deutschsprachigen Gemeinschaft Belgiens. Vol. 3: Code Civil, beschleunigte Moderne und Dynamiken des Beharrens (1794-1919) (2017)

Die Sekundärliteratur zum langen 19. Jahrhundert zwischen Göhl und Our ist übersichtlich. Dieser Grenz- und Übergangsraum wird meist mit Blick auf die Zentren analysiert. Dabei wird die Modernisierung mit ... [more ▼]

Die Sekundärliteratur zum langen 19. Jahrhundert zwischen Göhl und Our ist übersichtlich. Dieser Grenz- und Übergangsraum wird meist mit Blick auf die Zentren analysiert. Dabei wird die Modernisierung mit der Nationalisierung gleichgesetzt. Die Grenzerfahrungen bleiben weitgehend ausgeblendet. Die Grenzregion als „Zwischenraum“ zwischen Nationalstaaten zu betrachten, bleibt eine aktuelle Herausforderung für die Geschichtsschreibung in dieser Region. Einblicke in die Vielfalt unterschiedlicher Sichtweisen und Geschichtsbilder über eine spannende Zeit. [less ▲]

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See detailEvidence of a fine-scale genetic structure for the endangered Pyrenean desman (Galemys pyrenaicus) in the French Pyrenees
Gillet, F; Cabria, M.; Blanc, F. et al

in Journal of Mammalogy (2017)

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing mountain streams. This species is currently classified as vulnerable on the IUCN Red List and has been undergoing habitat loss and fragmentation for decades, inevitably impacting its distribution. A recent genetic study, based on mitochondrial and intronic sequences, showed that the genetic variability of the Pyrenean desman is very low in the Pyrenees. In this study, we investigated the potential existence of genetic structure and gene flow at a smaller scale using 24 polymorphic microsatellite loci. As the Pyrenean desman is a very elusive species, we supplemented our tissue sample collection with samples of feces collected in the French range of this species. We successfully identified 70 individuals based on 355 fecal samples. Bayesian analyses revealed 3 genetic and geographic clusters (1 eastern, 1 central, and 1 western, including 3 genetic sub-clusters), with origins tracing back only 200 years. These clusters were characterized by low levels of genetic diversity and high inbreeding coefficients. Although gene flow among clusters appeared to be limited, populations seem to have exchanged alleles recently. Therefore, connectivity between watersheds should be enhanced to maintain genetic diversity and potentially improve the long-term survival of the Pyrenean desman in France [less ▲]

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See detailContrasted terrace systems of the lower Moulouya river as indicator of crustal deformation in NE Morocco
Rixhon, Gilles; Bartz, Melanie; El Ouahabi, Meriam ULg et al

in Journal of African Earth Sciences (2017)

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See detailEconomie sociale et transition polycentrique
Bauwens, Thomas ULg; Mertens de Wilmars, Sybille ULg

in Cassiers, Isabelle; Maréchal, Kevin; Méda, Dominique (Eds.) Vers une société post-croissance. intégrer les défis écologiques et sociaux. (2017)

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See detailObservations of asymmetric turbulent stirring in inner and marginal seas using satellite imagery
Karimova, Svetlana ULg

in International Journal of Remote Sensing (2017), 38(6), 1642-1664

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale ... [more ▼]

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale cyclonic and anticyclonic eddies in a number of inner and marginal marine basins, namely in the Baltic, Black, North, and Western Mediterranean Seas. As research material, over 9700 eddy manifestations in the thermal infrared, visible-range, and radar satellite imagery were used. The analysis performed showed that in all the seas the typical and average values of the diameter of anticyclonic eddies were greater than those of cyclonic eddies. The main factor that defines the ratio between anticyclonic and cyclonic eddies in the basins under consideration was discovered to be the intensity of their surface currents. Thus, in the presence of a strong jet flow at the scales of about 2–4 baroclinic Rossby radii the cyclonic eddy dominance typical for smaller eddies was replaced by the anticyclonic one. If strong jet streams were missing, as that typical of the Baltic Sea, cyclonic eddies were prevailing over the entire spectrum of eddy diameters. [less ▲]

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See detailComputerized adaptive testing with R: Recent updates of the package catR
Magis, David ULg; Barrada, Juan Ramon

in Journal of Statistical Software (2017), 76(1), 1-19

The purpose of this paper is to list the recent updates of the R package catR. This package allows for generating response patterns under a computerized adaptive testing (CAT) framework with underlying ... [more ▼]

The purpose of this paper is to list the recent updates of the R package catR. This package allows for generating response patterns under a computerized adaptive testing (CAT) framework with underlying item response theory (IRT) models. Among the most important updates, well-known polytomous IRT models are now supported by catR; several item selection rules have been added; and it is now possible to perform post-hoc simulations. Some functions were also rewritten or withdrawn to improve the usefulness and performances of the package. [less ▲]

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See detailEntre impulsions nationales et influences transnationales : l’état belge et la promotion des « arts industriels » au xixe siècle.
Prina, Daniela Nicolosa ULg

in Jimeno-Martinez, Javier; Serulus, Katharina (Eds.) Panorama (2017)

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See detailCHAPTER 7 NHC-Iron, Ruthenium and Osmium Complexes in Catalysis
Delaude, Lionel ULg; Demonceau, Albert ULg

in Diez-Gonzalez, Silvia (Ed.) N-Heterocyclic Carbenes: From Laboratory Curiosities to Efficient Synthetic Tools, 2nd Edition (2017)

In this chapter, the catalytic applications of organometallic species - either pre-formed or generated in situ - based on Group 8 transition metals and N-heterocyclic carbene (NHC) ligands are surveyed ... [more ▼]

In this chapter, the catalytic applications of organometallic species - either pre-formed or generated in situ - based on Group 8 transition metals and N-heterocyclic carbene (NHC) ligands are surveyed. Although the coordination chemistry of iron with NHCs was first explored in the 1970s, the use of NHC-Fe complexes in catalysis did not start until the new millennium and is still in its infancy. Significant developments reported thus far concern mainly polymerisation, cyclisation, coupling, or reduction reactions. Other important transformations mediated by NHC-Fe species have been reported in organometallic synthesis and biocatalysis. Contrastingly, the chemistry of NHC-Ru complexes has reached an unprecedented level of maturity, thanks to the relentless research efforts thrown into the development of olefin metathesis catalysts. Other carbon skeletal transformations based on NHC-Ru promoters include cyclopropanation, allylation, or cycloisomerisation reactions. Some of them were carried out in tandem with olefin metathesis. Lastly, with only a handful of reports to date concerning olefin metathesis and hydrogen transfer reactions, NHC-Os-based catalysis can hardly be considered anything else than a curiosity. [less ▲]

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See detailTroubles du comportement alimentaire et régulation émotionnelle
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2017), 7

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See detailPreparing physically educated citizens in physical education. Expectations and practices
Cloes, Marc ULg

in Retos (2017), 31

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being ... [more ▼]

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being increasingly linked to the promotion of physically active lifestyles. In this paper, we try to determine whether practitioners have the capacity to reach recent objectives for the subject or should reconsider their work on this issue. Moreover, we propose to extend the current focus on physical literacy to encompass the concept of societal transfer, underlining the need for an authentic pedagogy of PE. [less ▲]

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See detailCoude - Poignet - Main
Kaux, Jean-François ULg

Learning material (2017)

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

Detailed reference viewed: 44 (2 ULg)