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See detailL'évolution du droit dans le temps et dans l'espace
Gerkens, Jean-François ULg

Scientific conference (2014, October 06)

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See detailPotential Proteomic Biomarkers Associated To Mucosal Healing In Crohn’s Disease
MEUWIS, Marie-Alice ULg; Baiwir, Dominique ULg; Mazzucchelli, Gabriel ULg et al

Poster (2014, October 06)

Introduction and objectives: In Crohn's disease (CD), there is a discrepancy between clinical activity of the disease (symptoms) and intestinal healing. However absence of tissue healing is associated ... [more ▼]

Introduction and objectives: In Crohn's disease (CD), there is a discrepancy between clinical activity of the disease (symptoms) and intestinal healing. However absence of tissue healing is associated with the risk of relapse and tissue damage progression. Endoscopy is costly and invasive. Hence biomarkers correlating with intestinal healing could improve disease management. We aimed to identify potential biomarkers associated to CD mucosal healing by a shotgun proteomics label free study. Methods: We used the STORI clinical trial cohort (n=103) aiming at identifying markers associated to relapse prediction after Infliximab treatment withdrawals. We used serum samples of patients in clinical remission, grouped according to the degree of intestinal healing seen at endoscopy. We performed depletion of the 20 most abundant plasma proteins on each serum pools and ran a proteomics label free differential analysis using 2D-nanoUPLC-MSE HDMS Synapt G1 for data acquisition and Protein Lynks Global Server vs 2.4 for data analysis (Waters, Corp., Milford, USA). Results and Discussion: We obtained potential biomarkers and designed a multiplexed -selected reaction monitoring (SRM) method for validation of these candidates in each individual patient. The method may also be tested in an independent set of IBD patients with and without mucosal healing. Conclusions: This research strategy and results of SRM validation of potential biomarkers associated to mucosal healing in this cohort of CD patients as well as the tests done on other CD patients, may provide new opportunities for CD follow-up tests development. [less ▲]

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See detailHuman cortical excitability depends on time spent awake and circadian phase
Ly, Julien ULg; Gaggioni, Giulia ULg; Chellappa, Sarah Laxhmi ULg et al

Scientific conference (2014, October 04)

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking ... [more ▼]

At any point in time, human performance results from the interaction of two main factors: a circadian signal varying with the time of the day and the sleep need accrued throughout the preceding waking period. But what’s happen at the cortical cerebral level? We used a novel technique coupling transcranial magnetic stimulation with electroencephalography (TMS/EEG) to assess the influence of time spent awake and circadian phasis on human cortical excitability. Twenty-two healthy young men underwent 8 TMS/EEG sessions during a 28 hour sleep deprivation protocole. We found that cortical excitability depends on both time spent awake and circadian phasis. [less ▲]

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See detailNEAR-DEATH EXPERIENCES IN PATIENTS WITH LOCKED-IN SYNDROME
Charland-Verville, Vanessa ULg; Lugo Ramirez, Zulay del Rosario ULg; Jourdan, Jean-Pierre et al

Poster (2014, October 04)

Near-Death Experiences (NDEs) are classically associated with positive emotions like peacefulness, happiness and joy [1-3]. To date, few negative NDEs reports have been documented [4]. Although NDEs ... [more ▼]

Near-Death Experiences (NDEs) are classically associated with positive emotions like peacefulness, happiness and joy [1-3]. To date, few negative NDEs reports have been documented [4]. Although NDEs classically arise in the context of an acute severe brain damage, their associated memories are reported as being phenomenologically very rich and detailed [5]. To date, no satisfactory explanatory model exits to fully account for the rich phenomenology of NDEs following a severe acute brain injury [6]. Neurobiological hypotheses include cerebral hypoxia [7, 8] and temporal lobe dysfunctions [9] to account for some of the features occurring during NDEs. However, it has been recently shown that anoxic/hypoxic, traumatic and other supratentorial brain lesions do not seem to influence the content of a NDE when assessed with a standardized tool (i.e., Greyson NDE scale; [1]). Due to their particular brain lesion (i.e., pontine brainstem), locked-in syndrome (LIS) patients provide a unique opportunity to further investigate the neural correlates of NDEs. We here aimed at retrospectively characterizing the content of NDEs in patients with LIS having suffered from an acute brainstem lesion (cerebrovascular accident (CVA) or trauma; i.e., “LIS NDEs”) and to compare these experiences to those collected in a cohort of matched NDE experiencers after coma with supratentorial lesions (CVA or trauma; i.e., “classical NDEs”). [less ▲]

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See detailNeuropathies proximales du membre supérieur
WANG, François-Charles ULg

Conference (2014, October 04)

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See detailL'épaule un carrefour complexe
WANG, François-Charles ULg

Conference (2014, October 04)

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See detailEt si ce n'était pas un canal carpien
FERON, Frédéric ULg; WANG, François-Charles ULg

Conference (2014, October 04)

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See detailDiscussion de cas cliniques et atelier pratique
WANG, François-Charles ULg

Conference (2014, October 04)

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See detailOblitérations. Contacts et frictions dans "A Humument" de Tom Phillips
Delville, Michel ULg; Belloi, Livio ULg

Conference (2014, October 03)

Cette intervention examine "A Humument" de Tom Phillips en termes de contacts et de frictions entre le texte-source (un roman victorien) et sa réinterprétation par l'auteur.

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See detailWhat's happening in Adenoma Valley
Beckers, Albert ULg

Scientific conference (2014, October 03)

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See detailMultibody Modelling of Mechanical Transmission Systems in Vehicle Dynamics
Virlez, Geoffrey ULg

Doctoral thesis (2014)

This thesis addresses the dynamic modelling of automotive driveline components by means of the nonlinear finite element method for flexible multibody systems. Starting from a detailed study of an ... [more ▼]

This thesis addresses the dynamic modelling of automotive driveline components by means of the nonlinear finite element method for flexible multibody systems. Starting from a detailed study of an industrial application, the TORSEN differential, several contributions are proposed in the field of contact modelling. The contact between rigid bodies in several geometric configurations is investigated and the influence of the squeeze film of lubricating oil is studied. A contact formulation between flexible bodies modelled as superelements is also developed and applied to the modelling of 3D flexible gear pairs. [less ▲]

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See detailKnowledge transfer from Belgian government to medical doctors
MORTELMANS, Katrien; REMMEN, Roy; BERKEIN, Philip et al

Conference (2014, October 02)

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See detailManuel d'analyse qualitative. Analyser sans compter ni classer
Lejeune, Christophe ULg

Book published by De Boeck (2014)

La méthode qualitative s'est dotée d'outils et de techniques : journal de bord, propriété, dimension, catégorie, échantillonnage, saturation, scénario, mémo et compte rendu, codage (ouvert, axial et ... [more ▼]

La méthode qualitative s'est dotée d'outils et de techniques : journal de bord, propriété, dimension, catégorie, échantillonnage, saturation, scénario, mémo et compte rendu, codage (ouvert, axial et sélectif). Cet ouvrage présente le rôle respectif de chacun de ces éléments et permet à tous de s'approprier la logique qui les sous-tend. S'appuyant sur des exemples issus de recherches réelles, il expose avec clarté comment conduire sa propre recherche. Il fournit des astuces développées par les praticiens les plus aguerris et permet ainsi au lecteur d'évaluer sa propre avancée dans le monde passionnant de la recherche qualitative. [less ▲]

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See detailIl ne suffit pas de lire les étiquettes, mais bien de discuter avec le producteur
Ozer, Pierre ULg

Article for general public (2014)

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See detailRational Design of a Safe and Efficacious Attenuated Recombinant Vaccine Against Cyprinid Herpesvirus 3 Using Prokaryotic Mutagenesis and In Vivo Imaging System
Boutier, Maxime ULg

Conference (2014, October 02)

Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease in common and koi carp. Since its emergence, in the late 1990s, CyHV 3 has caused severe economic losses worldwide creating a ... [more ▼]

Cyprinid herpesvirus 3 (CyHV-3) is the causative agent of a lethal disease in common and koi carp. Since its emergence, in the late 1990s, CyHV 3 has caused severe economic losses worldwide creating a need for a safe and efficacious vaccine. With this goal in mind, recombinant strains deleted for single gene were produced using prokaryotic recombination technologies. While producing such a recombinant for ORF134, we unexpectedly obtained a clone deleted for ORF56 and ORF57 in addition to the expected deletion of ORF134. Interestingly, this triple deleted recombinant replicated efficiently in vitro, exhibited an attenuated profile and induced an immune protection against a lethal challenge in vivo. To determine the role of each deleted locus in the phenotype of the triple deleted recombinant, a series of recombinant were produced and tested in vivo. Firstly, to investigate the role of ORF134 deletion, a double ORF56-57 deleted recombinant and an independent triple ORF56-57-ORF134 deleted recombinant were produced. These experiments revealed that ORF134 deletion did contribute significantly neither to the attenuation nor to the immune protection observed for the triple deleted recombinant. Secondly, to determine the relative importance of ORF56 and ORF57 deletion in the attenuation observed, two single deleted recombinants were produced for ORF56 and ORF57. These experiments demonstrated that ORF57 deletion, in contrast to ORF56 deletion, correlates with an attenuated phenotype. Based on its safety-efficacy profile, the ORF56-57 double deleted recombinant was selected as a candidate vaccine. Complementary experiments were performed to further investigate the potential of this strain as a safe and efficacious attenuated recombinant vaccine. The results obtained can be summarized as follows: (i) In vivo imaging (IVIS) of vaccinated fish challenged with a wild type strain expressing luciferase as a reporter gene, suggested that vaccination induces a sterile immunity at the portal of entry. (ii) Study of viral tropism by qPCR, IVIS, and histopathological analyses, demonstrated that in comparison to the wild type parental strain, the vaccine strain replicates at lower level, at later time post-infection and for a shorter period of time. (iii) Transmission studies demonstrated that there is no detectable spread of the vaccine from freshly vaccinated fish to naive fish located immediately down stream of vaccinated fish (water sharing). All together, the results of the present study demonstrate the potential of ORF56-ORF57 double deleted CyHV-3 recombinant strain for safe and efficacious mass vaccination of carp. [less ▲]

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