Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailZonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Lesage, Julien; Suarez-Carmona, Meggy; Neyrinck-Leglantier, Deborah et al

in FASEB Journal (2017)

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailSyllabus de droit social 2016-2017
Kéfer, Fabienne ULg

Learning material (2017)

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detailAlcohol-cue exposure decreases response inhibition towards alcohol-related stimuli in detoxified alcohol-dependent patients
Kreusch, Fanny; Billieux, Joël; Quertemont, Etienne ULg

in Psychiatry Research (2017), 249

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol ... [more ▼]

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol relapse. The aim of the present study is to investigate whether the induction of a craving state, using an alcohol cue exposure paradigm, influences response inhibition towards both neutral stimuli and alcohol-related stimuli in alcohol-dependent patients. Thirty-one detoxified alcohol-dependent patients were exposed to either their preferred alcoholic beverage or to a glass of water. They then performed a modified stop signal task, which used alcohol-related words, neutral words and non-words, and a lexical decision as the Go response. The alcohol-cue exposure group reported significantly higher alcohol craving and showed higher percentages of commission errors towards alcohol-related words than the control group. All participants, but especially those of the alcohol-cue exposure group, showed also shorter reaction times when alcohol words were used as targets in go trials. The induction of alcohol craving in detoxified alcohol-dependent patients increases the motivational salience value of alcohol stimuli, leading them to automatically approach alcohol-related cues and therefore impairing response inhibition towards those stimuli. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailComparison of Indium Tin Oxide and Indium Tungsten Oxide as Transparent Conductive Substrates for WO3-Based Electrochromic Devices
Maho, Anthony ULg; Nicolay, Sylvain; Manceriu, Laura ULg et al

in Journal of the Electrochemical Society (2017), 164(2), 25-31

Detailed reference viewed: 29 (11 ULg)
Full Text
See detailDatasets for Testing Probabilistic Models of Choice using Column Generation
Spieksma, Frits C.R.; Davis-Stober, Clint; Regenwetter, Mike et al

Textual, factual or bibliographical database (2017)

Detailed reference viewed: 31 (1 ULg)
Full Text
Peer Reviewed
See detailCan DEM time series produced by UAV be used to quantify diffuse erosion in an agricultural watershed?
Pineux, Nathalie ULg; Lisein, Jonathan ULg; Swerts, Gilles ULg et al

in Geomorphology (2017), 280

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion ... [more ▼]

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion monitoring approaches are labour intensive and costly. This calls for the development of new approaches for field erosion data acquisition. As a result of rapid technological developments and low cost, unmanned aerial vehicles (UAV) have recently become an attractive means of generating high resolution digital elevation models (DEMs). The use of UAV to observe and quantify gully erosion is now widely established. However, in some agro-pedological contexts, soil erosion results from multiple processes, including sheet and rill erosion, tillage erosion and erosion due to harvest of root crops. These diffuse erosion processes often represent a particular challenge because of the limited elevation changes they induce. In this study,we propose to assess the reliability and development perspectives of UAV to locate and quantify erosion and deposition in a context of an agricultural watershed with silt loam soils and a smooth relief. Erosion and deposition rates derived from high resolution DEM time series are compared to field measurements. The UAV technique demonstrates a high level of flexibility and can be used, for instance, after a major erosive event. It delivers a very high resolution DEM(pixel size: 6 cm) which allows us to compute high resolution runoff pathways. This could enable us to precisely locate runoff management practices such as fascines. Furthermore, the DEMs can be used diachronically to extract elevation differences before and after a strongly erosive rainfall and be validated by field measurements. While the analysis for this study was carried out over 2 years, we observed a tendency along the slope from erosion to deposition. Erosion and deposition patterns detected at the watershed scale are also promising. Nevertheless, further development in the processing workflow of UAV data is required in order to make this technique accurate and robust enough for detecting sediment movements in an agricultural watershed affected by diffuse erosion. This area of investigation holdsmuch potential as the images processing is relatively new and expanding. [less ▲]

Detailed reference viewed: 22 (6 ULg)
Full Text
Peer Reviewed
See detailNonlinear system identification in structural dynamics: 10 more years of progress
Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Mechanical Systems & Signal Processing (2017), 83

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved ... [more ▼]

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved until then, it was concluded that the identification of simple continuous structures with localised nonlinearities was within reach. The past decade witnessed a shift in emphasis, accommodating the growing industrial need for a first generation of tools capable of addressing complex nonlinearities in larger-scale structures. The objective of the present paper is to survey the key developments which arose in the field since 2006, and to illustrate state-of-the-art techniques using a real-world satellite structure. Finally, a broader perspective to nonlinear system identification is provided by discussing the central role played by experimental models in the design cycle of engineering structures. [less ▲]

Detailed reference viewed: 18 (8 ULg)
Full Text
Peer Reviewed
See detailStudy of the photocatalytic activity of Fe3+, Cr3+, La3+ and Eu3+ single-doped and co-doped TiO2 catalysts produced by aqueous sol-gel processing
Malengreaux, Charline; Pirard, Sophie ULg; Léonard, Géraldine ULg et al

in Journal of Alloys and Compounds (2017), 691

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination ... [more ▼]

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination step, has been adapted to produce Fe3+, Cr3+, La3+ or Eu3+ single-doped TiO2 photocatalysts as well as La3+-Fe3+ and Eu3+-Fe3+ co-doped TiO2 catalysts. The physicochemical properties of the obtained catalysts have been characterized using a suite of complementary techniques, including ICP-AES, XRD, UV-Vis spectroscopy, nitrogen adsorption-desorption and Fe-57 Mössbauer. The active crystalline phase is obtained without requiring any calcination step and all the different catalysts are composed of nanocrystallites of anatase with a size of 6-7 nm and a high specific surface area varying from 181 to 298 m² g-1. In this study, the effect of the NO3:Ti(IV) mole ratio used to induce the peptisation reaction during the synthesis has been studied and the results revealed that this ratio can influence significantly the textural properties of the resulting catalyst. A screening of the photocatalytic activity of the undoped and Fe3+, Cr3+, La3+ or Eu3+ single-doped and co-doped photocatalysts has been performed by evaluating the degradation of 4-nitrophenol under UV-Visible light (330 nm < λ < 800 nm). This study suggests that the photocatalytic activity is significantly influenced by the dopant nature and content with an optimal dopant content being observed in the case of Fe3+ or La3+ single-doped as well as in the case of La3+-Fe3+ and Eu3+-Fe3+ co-doped catalysts. In the case of Cr3+ single-doped catalysts, a detrimental effect of the dopant on the photocatalytic degradation of 4-nitrophenol has been observed while no significant influence of the dopant has been detected in the case of Eu3+ single-doped catalysts. The role of the different dopants in modulating the photocatalytic activity is discussed. [less ▲]

Detailed reference viewed: 40 (8 ULg)
Full Text
Peer Reviewed
See detailImplementation of the biogenic emission model MEGAN(v2.1) into the ECHAM6-HAMMOZ chemistry climate model
Henrot, Alexandra-Jane ULg; Stanelle, T.; Schröder, S. et al

in Geoscientific Model Development [=GMD] (2017)

Detailed reference viewed: 9 (0 ULg)
See detailThe lure of pedogenesis. An anthropological foray into making urban soils in contemporary France
Meulemans, Germain ULg

Doctoral thesis (2017)

This thesis is an anthropological inquiry into the emergence of urban soils as matters of concern in the worlds of soil scientists and other fields more traditionally involved with cities. City soils have ... [more ▼]

This thesis is an anthropological inquiry into the emergence of urban soils as matters of concern in the worlds of soil scientists and other fields more traditionally involved with cities. City soils have typically been neglected in modern thinking about nature and urbanism. They have long been framed solely as a technical question which seemed to require no further pondering until – in the last two decades – they entered the scope of the soil sciences. This thesis draws on over 13 months of multi-locale fieldwork conducted in Paris and Lorraine with soil scientists, gardeners and foundation builders. Through the lens of soil-making practices, it seeks to elucidate the specificity of new forms of urban pedogenesis, including the growth of soils and the lives of the humans associated with them. Building on scholarship in anthropology, the soil sciences, science studies, and speculative philosophy, it follows how these actors learn to be affected in the material performance of different relations between people and soils. Occasionally turning to narrative to complement analysis and more traditional ethnography, each chapter pulls a different diffractive string from the mesh of urban soil matters, and follows where it leads in what Deleuze and Guattari call an ‘itinerant’ mode of research. As ways of knowing that emerge from soil construction are described, the question of what making soils does to knowing them becomes a central thread of the thesis. In this, it looks at how soils participate in apparatuses where they become ‘lures for feelings’ – affective interweavings in which worlds are experienced. The introduction sets the stage for the thesis, and explains how the fieldwork was conducted. It sets pointers for the rest of the work by explaining the attentive, yet critical posture it adopts towards scientific theories of soils. The thesis is then divided into two parts: the first part (chapters 1-4) presents a detailed consideration of the world being newly explored by urban soil scientists, and showcases key points of encounter between pedology, the environmental sciences and themes such as urban sprawl, ‘peak soil’, and ‘the Anthropocene’. It starts by problematizing the movement by which, in the 19th century, urban soils became ‘blackboxed’ when their hard sealing initiated a long standing separation between earth and sky. This is followed by an examination of the renewed interest towards urban soils in realms as diverse as city planning, waste management and hydraulics. The thesis then turns to exploring more specifically the impact of urban soils on soil science research in France. It describes how the new urban soil sciences invoke non-linear ecological dynamics, and how they question distinctions such as those between the living and the non-living, and between the human and the natural. In the face of this questioning, scientists started to experiment with urban soils by engaging directly in their construction through their ‘ecological engineering’. Rejecting separations between making and theory, these practices are understood by attending to soil scientist’s digging practices, described as ways of learning to be affected by soils and their liveliness. This part concludes with a study of the multispecies interactions entailed in soil ecologists’ attempts to ‘collaborate’ with earthworms and other soil organisms. An analysis of the modes of joint becoming of soils and humans at play in soil construction is developed by way of a reinterpretation of the soil sciences’ concept of pedogenesis. These ideas are developed in the second part of the thesis (chapters 5-7), which addresses practices of urban soil construction in the fields of urban gardening and foundation building, and introduces an art and anthropology experiment. It first presents the work of urban gardeners who develop their own understanding of city soils and botany, and attempt to grow knowledge, soils and community by adapting ancient rural practices of earth working to the reclamation of city interstices. It then introduces the work of foundation builders, and shows that far from entailing soils as inert matter that would be malleable at will, their work can be characterised as a play on equilibrium across interfaces of exchange. The thesis concludes with the presentation of an art, anthropology and soil science experiment in which the author participated. In this experiment fieldwork was re-interrogated by means of narrative speculation and installation making. This finally provides the grounds from which to draw methodological conclusions for an experimental anthropology, premised on the interweaving of imagination and practice. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailEmployee perspectives on safety citizenship behaviors and safety violations
Chmiel, Nik; Laurent, Julie ULg; Hansez, Isabelle ULg

in Safety Science (2017), 93

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two ... [more ▼]

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two types of safety violation: routine violations conceptualized as related to an individual’s available cognitive energy or ‘effort’; and situational violations, which are those provoked by the organization (Reason, 1990). Study 1 showed SCRDs predicted situational violations only, and partially mediated the relationships between Perceived Management Commitment to Safety (PMCS) and work engagement with situational violations. These findings add to those by Hansez and Chmiel (2010), showing that routine and situational violations have predictors that differ. Study 1 findings also extend research reported by Turner et al. (2005), by showing that the effect of Job Control on SCRDs was mediated by both PMCS and work engagement. In study 2, participation in discretionary safety activities (safety participation) mediated the relationship between SCRDs and situational violations. Similar to study 1 The link between SCRDs and routine violations was non-significant and, strikingly, so was the link between safety participation and routine violations. These results support the view that processes involving SCRDs and safety participation are not cognitive-energetical in nature. In addition, study 2 findings extend previous work by Neal and Griffin (2006) by showing that SCRDs and safety knowledge partially mediated relationships between safety motivation and safety participation, whereas the direct effect of safety motivation on safety participation was non-significant. The results from both studies support the view that SCRDs are important in predicting situational violations. In study 2 SCRDs were shown to partially mediate the relationship between safety motivation and selfreported participation in discretionary safety activities (Safety Participation) which, in turn, related to situational violations. Interestingly there was no significant direct link between SCRDs and situational violations. These findings support the view that the effect of SCRDs on situational violations is fully mediated by participation in discretionary safety activities. [less ▲]

Detailed reference viewed: 22 (8 ULg)
Full Text
Peer Reviewed
See detailCabergoline for Cushing's disease: a large retrospective multicenter study.
Ferriere, A.; Cortet, C.; Chanson, P. et al

in European Journal of Endocrinology (2017), 176(3), 305-314

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of ... [more ▼]

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded. RESULTS: Twenty-one (40%) of 53 patients who received cabergoline monotherapy had normal urinary free cortisol (UFC) values within 12 months (complete responders), and five of these patients developed corticotropic insufficiency. The fall in UFC was associated with significant reductions in midnight cortisol and plasma ACTH, and with clinical improvement. Compared to other patients, complete responders had similar median baseline UFC (2.0 vs 2.5xULN) and plasma prolactin concentrations but received lower doses of cabergoline (1.5 vs 3.5 mg/week, P < 0.05). During long-term treatment (>12 months), cabergoline was withdrawn in 28% of complete responders because of treatment escape or intolerance. Overall, sustained control of hypercortisolism was obtained in 23% of patients for 32.5 months (19-105). Nine patients on steroidogenesis inhibitors received cabergoline add-on therapy for 19 months (1-240). Hypercortisolism was controlled in 56% of these patients during the first year of treatment with cabergoline at 1.0 mg/week (0.5-3.5). CONCLUSIONS: About 20-25% of CD patients are good responders to cabergoline therapy allowing long-term control of hypercortisolism at relatively low dosages and with acceptable tolerability. No single parameter, including the baseline UFC and prolactin levels, predicted the response to cabergoline. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailQue peut la doctrine en droit et sociétés (et ailleurs)?
Thirion, Nicolas ULg

in Revue Pratique des Sociétés - Tijdschrift voor Rechtspersoon en Vennootschap (2017), 1

A quelle condition la doctrine peut-elle relever d'une démarche proprement scientifique? Telle est la question qu'abord cet éditorial.

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailRezeption Thibauts in Belgien und in Frankreich
Gerkens, Jean-François ULg

in Baldus, Christian; Hattenhauer, Christian; Schroeder, Klaus-Peter (Eds.) Anton Friedrich Justus Thibaut (1772-1840) Bürger und Gelehrter (2017)

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailSwimmer's Itch in Belgium: First Recorded Outbreaks, Molecular Identification of the Parasite Species and Intermediate Hosts.
Caron, Yannick ULg; Cabaraux, Ariane; Marechal, Francoise et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017)

BACKGROUND: Cercarial dermatitis or swimmer's itch is a skin condition in humans due to the larval forms of bird schistosomes of some species of the genus Trichobilharzia. The life cycle of these ... [more ▼]

BACKGROUND: Cercarial dermatitis or swimmer's itch is a skin condition in humans due to the larval forms of bird schistosomes of some species of the genus Trichobilharzia. The life cycle of these schistosomes requires freshwater snails (intermediate host) and waterfowl (definitive host). Repeated exposures to cercariae can lead to skin sensitization with the induction of pruritic skin lesions. METHODS: We describe, in this study, two outbreaks of human cercarial dermatitis at the Eau d'Heure Lakes, Belgium. In July and August 2012, a total of, respectively, 78 and 10 people reported a sudden skin rash accompanied by pruritus following recreational activities in the Plate Taille Lake. However, no ocellate furcocercariae were detected following light exposure of the snails collected between September 2012 and September 2013 (n = 402). No outbreaks were recorded in 2013 and 2014. In August 2015, about 30 new cases were recorded. Snails were collected (n = 270) in different locations around the lake. PCR was used to identify accurately the intermediate hosts and the parasite species involved. RESULTS: After light exposure, seven Radix spp. (2.6%) shed ocellate furcocercariae. Molecular identification based on the rDNA internal transcribed spacer 2 sequence ascribed the infected snails to R. balthica ( = R. peregra = R. ovata) (6/7) and R. auricularia (1/7). Based on the amplification of the D2 domain of the 28S rDNA, the cercariae were shown to belong to two different haplotypes of Trichobilharzia franki. CONCLUSIONS: This is the first record in Belgium of T. franki and associated skin condition. [less ▲]

Detailed reference viewed: 23 (1 ULg)
See detailAnalyse de Risque SIAMU
Kasprzyk, Jean-Paul ULg

Software (2017)

The tool allows users from SIAMU to generate different risk maps based on past interventions (recurring risk), punctual risk (schools, hospitals, etc.) and the accessibility of SIAMU resources ... [more ▼]

The tool allows users from SIAMU to generate different risk maps based on past interventions (recurring risk), punctual risk (schools, hospitals, etc.) and the accessibility of SIAMU resources (firestations and ambulance departures). This decision support tool helps SIAMU to fairly distribute their resources In Brussels agglomeration. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailA multivariable prediction model for pegvisomant dosing: monotherapy and in combination with long-acting somatostatin analogues
Franck, Sanne Elisabeth; Korevaar, Tim; PETROSSIANS, Patrick ULg et al

in European Journal of Endocrinology (2017)

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and ... [more ▼]

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. Objective: To identify predictors of the PEGV dose required to normalize insulin-like growth factor I (IGF-I) levels during PEGV monotherapy and in combination with long-acting somatostatin analogues (LA-SSAs). 188) were meta-analysed as a form of external replication to study the predictors of PEGV dosing in addition to LA-SSA, the LAS (n=83) was used to study the predictors of PEGV monotherapy dosing. Multivariable regression models were used to identify predictors of the PEGV dose required to normalize IGF-I levels. <0.001, p=<0.001, p=0.028 and p=0.047, respectively). Taken together, these characteristics predicted the PEGV normalization dose correctly in 63.3% of all patients within a range of +/- 60 mg/week (21.3% within a range of +/- 20 mg/week). For monotherapy, only weight was associated with the PEGV normalization dose (p=<0.001) and predicted this dosage correctly in 77.1% of all patients within a range of +/- 60 mg/week (31.3% within a range of +/- 20 mg/week). Conclusion: In this study, we show that IGF-I levels, weight, height and age can contribute to define the optimal PEGV dose in order to normalize IGF-I levels in addition to LA-SSA. For PEGV monotherapy, only the patient's weight was associated with the IGF-I normalization PEGV dosage. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailRationalising vitamin B6 biofortification in crop plants.
Fudge, Jared; Mangel, Nathalie; Gruissem, Wilhelm et al

in Current Opinion in Biotechnology (2017), 44

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are ... [more ▼]

Vitamin B6 encompasses a group of related compounds (vitamers) that can only be biosynthesised de novo by plants and microorganisms. Enzymatic cofactor and antioxidant functions for vitamin B6 are established in all kingdoms. Human vitamin B6 dietary insufficiency or genetic defects in B6 vitamer interconversion result in various neurological and inflammatory pathologies with several populations at-risk or marginal for vitamin B6 status. Three (rice, wheat and cassava) of the world's top five staple crops do not meet the recommended dietary allowance for vitamin B6, when consumed as a major proportion of the diet. In addition, controlled enhancement of the appropriate B6 vitamer in crops has the potential to confer stress resistance. Thus, crop biofortification strategies represent an opportunity to reduce the risk of deficiency in populations with limited diet diversity and quality, as well as improving stress tolerance. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailExome copy number variation detection: Use of a pool of unrelated healthy tissue as reference sample
Wenric, Stéphane ULg; Sticca, Tiberio ULg; CABERG, Jean-Hubert ULg et al

in Genetic Epidemiology (2017)

An increasing number of bioinformatic tools designed to detect CNVs (copy number variants) in tumor samples based on paired exome data where a matched healthy tissue constitutes the reference have been ... [more ▼]

An increasing number of bioinformatic tools designed to detect CNVs (copy number variants) in tumor samples based on paired exome data where a matched healthy tissue constitutes the reference have been published in the recent years. The idea of using a pool of unrelated healthy DNA as reference has previously been formulated but not thoroughly validated. As of today, the gold standard for CNV calling is still aCGH but there is an increasing interest in detecting CNVs by exome sequencing. We propose to design a metric allowing the comparison of two CNV profiles, independently of the technique used and assessed the validity of using a pool of unrelated healthy DNA instead of a matched healthy tissue as reference in exome-based CNV detection. We compared the CNV profiles obtained with three different approaches (aCGH, exome sequencing with a matched healthy tissue as reference, exome sequencing with a pool of eight unrelated healthy tissue as reference) on three multiple myeloma samples. We show that the usual analyses performed to compare CNV profiles (deletion/amplification ratios and CNV size distribution) lack in precision when confronted with low LRR values, as they only consider the binary status of each CNV. We show that the metric-based distance constitutes a more accurate comparison of two CNV profiles. Based on these analyses, we conclude that a reliable picture of CNV alterations in multiple myeloma samples can be obtained from whole-exome sequencing in the absence of a matched healthy sample. [less ▲]

Detailed reference viewed: 28 (8 ULg)
Full Text
Peer Reviewed
See detailThe role of fatty acid beta-oxidation in lymphangiogenesis.
Wong, Brian W.; Wang, Xingwu; Zecchin, Annalisa et al

in Nature (2017), 542(49),

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in ... [more ▼]

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health. However, the role of metabolism in lymphatic development has not yet been elucidated. Here we report that in transgenic mouse models, LEC-specific loss of CPT1A, a rate-controlling enzyme in fatty acid beta-oxidation, impairs lymphatic development. LECs use fatty acid beta-oxidation to proliferate and for epigenetic regulation of lymphatic marker expression during LEC differentiation. Mechanistically, the transcription factor PROX1 upregulates CPT1A expression, which increases acetyl coenzyme A production dependent on fatty acid beta-oxidation. Acetyl coenzyme A is used by the histone acetyltransferase p300 to acetylate histones at lymphangiogenic genes. PROX1-p300 interaction facilitates preferential histone acetylation at PROX1-target genes. Through this metabolism-dependent mechanism, PROX1 mediates epigenetic changes that promote lymphangiogenesis. Notably, blockade of CPT1 enzymes inhibits injury-induced lymphangiogenesis, and replenishing acetyl coenzyme A by supplementing acetate rescues this process in vivo. [less ▲]

Detailed reference viewed: 18 (1 ULg)