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See detailNatural patches in Posidonia oceanica meadows: the seasonal biogeochemical pore water characteristics of two edge types
Abadie, A; Borges, Alberto ULiege; Champenois, Willy ULiege et al

in Marine Biology (2017), 164:166

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural ... [more ▼]

Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural particularity which consist in a duality of their edge types. One edge is eroded by bottom currents, while the adjacent meadow colonizes the bare sediments. This study aims to study the dynamics of these two edges through the investigation of the biogeochemistry (pH, total alkalinity, dissolved inorganic carbon, CO2, CH4, N2O, H2S, dissolved inorganic nitrogen, PO4 3−) within vegetated and unvegetated sediments. These observations are compared with the adjacent meadow to have a better understanding of the colonization processes. Our results reveal that the P. oceanica matrix shows differences from the vegetated edges of sand patches, especially with regard to nutrient availability, which is generally more important at the colonized edge (dissolved inorganic nitrogen up to 65.39 μM in June). A clear disparity also occurs between the eroded and colonized edge with both a seasonal and bathymetrical variation of leaf biomass with higher disparities at 10 m in June (colonized edge 1415 gDW m−2; eroded edge 1133 gDW m−2). Themost important contrasts during this study were assessed in June, suggesting that the warm period of the year is more suitable for sampling to highlight disparate characteristics in temperate seagrass meadows. These findings put into light the potential importance of biogeochemical processes in the dynamics of natural patch edges. We hypothesize that they may influence the structural dynamics of P. oceanica seascapes. [less ▲]

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See detailEffects of User IT Capabilities and Organized Big Data Analytics on Competitive Advantage
Kamioka, Taro; Hosoya, Ryuichi; Tapanainen, Tommi ULiege

in Proceedings of the Pacific-Asian Conference on Information Systems (PACIS) (2017, July 20)

In the age of big data, it becomes important to develop capabilities for utilizing information technology (IT) in order to take advantage of the potential of data for business objectives. While users have ... [more ▼]

In the age of big data, it becomes important to develop capabilities for utilizing information technology (IT) in order to take advantage of the potential of data for business objectives. While users have received attention in many ways, we note that the capability literature has focused more on the IT supply side. We argue that user capabilities have moved to an integral position in firm competitive advantage, and call them “User IT Capabilities” (UIC). A survey was conducted to collect data from Japanese organizations, and a total valid sample of 1,170 respondents involved in big data use was extracted. The findings show the effect of UIC on the performance of big data analytics and firm competitiveness, mediated by the variable of organized big data analytics (OBDA). The direct effects are shown to be valid irrespective of company size, although the levels of UIC and OBDA are higher in larger firms. [less ▲]

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See detailQuality evaluation of peach chips and anticancer activity of pectin extracted from chips dehydrated by explosion puffing drying
Lyu, Jian ULiege

Doctoral thesis (2017)

The objectives of this research are to discriminate the overall quality level of peach and nectarine chips prepared by explosion puffing drying (EPD), determine the changes of texture and water soluble ... [more ▼]

The objectives of this research are to discriminate the overall quality level of peach and nectarine chips prepared by explosion puffing drying (EPD), determine the changes of texture and water soluble pectin (WSP) during EPD processing and study the anticancer activity of WSP on malignant mesothelioma (MM). Principle component analysis (PCA), Analytic hierarchy process (AHP), K-mean cluster and Discriminant analysis (DA) are used to distinguish the overall quality level of peach and nectarine chips and get the characteristic evaluation indicators, which of them (e. g. rehydration ratio and expansion ratio) are corresponding to texture properties of dehydrated products. Additionally, biochemical changes of the cell wall (e. g. pectin) are also related to texture changes. The investigate on the changes of texture and WSP at different stages of EPD processing in which osmotic dehydration (OD) was used as the pretreatment, show that OD with the appropriated concentration can improve the texture quality of dried products. The drying processing causes the degradation and structure modification of WSP, which can induce apoptosis in MM cells. EPD technology can be carried out as a potential pathway on modification of pectin, which may contribute to the development of a potential therapy against MM. [less ▲]

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See detailA palaeoecological model for the late Mesoproterozoic–early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULiege; Guilbaud, Romain; Poulton, Simon W. et al

in Precambrian Research (2017), 299

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions ... [more ▼]

Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions. Here, we combine the geological context and a reconstruction of palaeoenvironmental redox conditions (using iron speciation) with quantitative analysis of microfossil assemblages (eukaryotes andincertae sedis), to provide the first palaeoecological model for the Atar/El Mreïti Group of the Taoudeni Basin. Our model suggests that in the late Mesoproterozoic–early Neoproterozoic, the availability of both molecular oxygen and nutrients controlled eukaryotic diversity, higher in oxic shallow marginal marine environments, while coccoidal colonies and benthic microbial mats dominated respectively in anoxic iron-rich and euxinic waters during marine highstands or away from shore where eukaryotes are lower or absent. [less ▲]

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See detailIntraspecific variation of Zn hyperaccumulation in Arabidopsis halleri populations
Schvartzman Echenique, Maria Sol ULiege; Corso, Massimiliano; Fataftah, Nazeer ULiege et al

Conference (2017, July 19)

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See detailItem purification versus adjustments for multiple comparisons in DIF detection
Drabinova, Adela; Martinkova, Patricia; Magis, David ULiege

Poster (2017, July 18)

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See detailCompte-rendu de l'ouvrage de J. van der Steen: Memory Wars in the Low Countries, 1566-1700
Regibeau, Julien ULiege

in Émulations. Revue des jeunes chercheuses et chercheurs en sciences sociales (2017)

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See detailmstR: An R package to generate multistage testing designs
Magis, David ULiege; Yan, Duanli; von Davier, Alina

Conference (2017, July 18)

Multistage testing (MST; Yan, von Davier & Lewis, 2014) has become an important framework of tailored testing. Similarly to computerized adaptive testing (CAT) it proposes an optimal routing of the ... [more ▼]

Multistage testing (MST; Yan, von Davier & Lewis, 2014) has become an important framework of tailored testing. Similarly to computerized adaptive testing (CAT) it proposes an optimal routing of the administered items according to the previous test taker’s responses. However, items are not selected and administered as single units but as modules (subsets). The main goal of MST consists in selecting the optimal path of modules across the successive stages of the test. Unfortunately, if various operational testing programs are nowadays considering MST for practical administrations, there is still very limited access to accurate software that can either treat or generate MST scenarios for research purposes. In this talk we succinctly present a new package from the R software, called mstR (Magis, Yan & von Davier, 2017). Built in the same spirit of the package catR for CAT designs, it permits to generate repeated response patterns under a predefined MST scenario by providing the set of modules and related item parameters, the number of stages and the connections between modules from successive stages. Several rules for optimal module selection and ability estimation (under IRT framework or based on test scores) are also available. This talk will mostly focus on the (non-technical) description of package mstR and its main features. An example will also be described as an illustration of this framework. [less ▲]

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See detailFluencyBank: studying typical and disordered speech fluency across languages and contexts
MacWhinney, Brian; Leclercq, Anne-Lise ULiege; Zwitserlood, Rob et al

Conference (2017, July 18)

Mastering the skill to produce fluent speech is a complex task that is still poorly understood. Similarly, the threshold at which typical fluency breakdown begins to attract clinical concern is also a ... [more ▼]

Mastering the skill to produce fluent speech is a complex task that is still poorly understood. Similarly, the threshold at which typical fluency breakdown begins to attract clinical concern is also a matter of frequent disagreement. The goal of the recently funded FluencyBank project, an arm of TalkBank, is to facilitate collection and analysis of expressive speech samples across the lifespan, languages, and clinical diagnoses. Speakers will illustrate the challenges and opportunities available to the study of expressive language development skill. The first speaker (Leclercq) will examine the need for reference data across languages in order to distinguish typical developmental disfluency from stuttering, using data from French. The second speaker (Zwitserlood) will confirm and elaborate on the profile of elevated disfluency profiles in children with SLI, using Dutch data. The third speaker (Byrd) will describe the theoretical and practical challenges of discriminating typical fluency profiles from clinical stuttering in bilinguals, with emphasis on Spanish-English child speakers. The fourth speaker (Ratner) will update information linking language proficiency to stuttering onset and persistence/recovery, showing the complex interactions between speech and language formulation. Each speaker will emphasize the many intertwining skills that underlie the development of spoken language fluency and the benefits of specialized cooperative initiatives such as FluencyBank to collect data for exploration of otherwise impossible to answer hypotheses. Moderator Brian MacWhinney, Co-Investigator of FluencyBank will discuss its development, planned research projects and computational tool development, and illustrate potential applications for use by child language researchers. [less ▲]

Detailed reference viewed: 93 (2 ULiège)
See detailDesigning artificial (β/α)8-barrel proteins from scratch: the Octarellin model
Martina, Cristina Elisa ULiege

Speech/Talk (2017)

De novo protein design is a growing field in protein chemistry, where artificial proteins are first designed in silico and then validated experimentally. Our group has a long tradition in the design of ... [more ▼]

De novo protein design is a growing field in protein chemistry, where artificial proteins are first designed in silico and then validated experimentally. Our group has a long tradition in the design of artificial (β/α)8-barrel proteins, known as Octarellins [1]. This fold, also known as TIM-barrel, is widespread in nature, particularly in enzymes, and represent an interesting target for therapeutic or biological applications. Here we present a novel protocol for the de novo design of TIM-barrels. Both Rosetta and Modeller modeling softwares were used to create the backbone structure of a TIM-barrel fold and to generate more than 10.000 artificial amino acid sequences. Stability was tested for the more interesting models by running molecular dynamics (MD) simulations, using GROMACS. The best models were chosen for protein production and preliminary biophysical characterization. The design of artificial proteins and the improvement of bioinformatics tools for protein modeling, structure prediction and MD simulations seem to be essential for a comprehensive knowledge of protein structure in general, as well as for an optimal use of the massive amount of data resulting from the numerous genome sequencing projects. [less ▲]

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See detailNegative velocity fluctuations and non-equilibrium fluctuation relation for a driven high critical current vortex state
Bag, Biplab; Shaw, Gorky ULiege; Banerjee, S. S. et al

in Scientific Reports (2017), 7(1), 5531

Under the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state ... [more ▼]

Under the influence of a constant drive the moving vortex state in 2H-NbS2 superconductor exhibits a negative differential resistance (NDR) transition from a steady flow to an immobile state. This state possesses a high depinning current threshold ( $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h ) with unconventional depinning characteristics. At currents well above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , the moving vortex state exhibits a multimodal velocity distribution which is characteristic of vortex flow instabilities in the NDR regime. However at lower currents which are just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , the velocity distribution is non-Gaussian with a tail extending to significant negative velocity values. These unusual negative velocity events correspond to vortices drifting opposite to the driving force direction. We show that this distribution obeys the Gallavotti-Cohen Non-Equilibrium Fluctuation Relation (GC-NEFR). Just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h , we also find a high vortex density fluctuating driven state not obeying the conventional GC-NEFR. The GC-NEFR analysis provides a measure of an effective energy scale (E eff ) associated with the driven vortex state. The E eff corresponds to the average energy dissipated by the fluctuating vortex state above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h . We propose the high E eff value corresponds to the onset of high energy dynamic instabilities in this driven vortex state just above $$\boldsymbolI_\boldsymbolc^\boldsymbolh$$ I c h . [less ▲]

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See detailProtein-polysaccharide complexes for improved protein delivery within CaCO3 microparticles
Ramalapa, Bathabile ULiege; Crasson, Oscar ULiege; Vandevenne, Marylène ULiege et al

Conference (2017, July 17)

Introduction: The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated due to accessibility, low cost, safety, pH-sensitive properties, high surface ... [more ▼]

Introduction: The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated due to accessibility, low cost, safety, pH-sensitive properties, high surface area and high porosity. The success of these carriers has been driven by the ionic interactions between proteins and particles making the encapsulation of proteins highly dependent on the pH of reaction solutions and the isoelectric point of the protein. This poses a great limitation on the successful loading of proteins into microparticles. In this study we explored the use of polysaccharide-protein complexes to enhance the encapsulation of otherwise poorly encapsulated proteins in CaCO3 microparticles. Methods: A chitin binding domain (ChBD) was inserted on the protein β-lactamase to form a chimeric protein. A protein-polysaccharide complex was formed between the protein and hyaluronic acid (HA) owing to the intrinsic affinity of the ChBD to HA. The chimeric protein was then loaded into CaCO3 microparticles using super critical CO2 technology aided by the templating effect of HA on CaCO3. The microparticles were characterised for size, surface charge, polymorphism and protein loading. Bioactivity and stability of the encapsulated β-lactamase was characterised by kinetic reaction with nitrocefin. A thrombin cleavage site was inserted onto the gene sequence of the protein to achieve release of the protein from the microparticles by proteases mediation using thrombin. Results: Vaterite CaCO3 microparticles of sizes ranging between 6 and 8 µm were produced. The presence of the ChBD on the β-lactamase increased the encapsulation of the protein by 6 fold when complexed with HA. Thrombin mediated release increased the release of the protein from the microparticles within 36 hours from <25% to 87%. The protein-polysaccharide complex demonstrated success in encapsulation of the protein while retaining up to 81% activity of the protein and allowing controlled release by proteases. Conclusion: Protein-polysaccharide complexation demonstrates an excellent approach for the delivery of sensitive biomacromolecules which can otherwise be complicated due to electrostatic hindrances. Future prospects include using the methods we have developed for encapsulation of therapeutic proteins and using calcium carbonate as a carrier and scaffold for example in bone regeneration. [less ▲]

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See detailPrevention Library and Resources in four languages (QP Library)
Comité de Bibliografía en Prevención Cuaternaria; WONCA SIG P4 & O; Pizanelli, Miguel et al

Textual, factual or bibliographical database (2017)

Since Quaternary Prevention is very extensive and complex, during the design process for database input, an indexing structure with the use of coding tools and categories was considered. This design will ... [more ▼]

Since Quaternary Prevention is very extensive and complex, during the design process for database input, an indexing structure with the use of coding tools and categories was considered. This design will allow the addition of materials and will provide easy access to them. To add documents, 13 data fields must be populated. To access the input data form, for the purpose of adding documents, use this link: http://j.tinyurl.com/P4-Library To avoid duplication of data entries, it is necessary to review and perform an audit. In the beginning, we will provide this tutorial to a few data entry collaborators. To become a data entry collaborator, please send an e-mail to the following address: quaternaryprevention@gmail.com Charts are available in eight languages to code with Q-Codes: http://3cgp.docpatient.net/tabular/ [less ▲]

Detailed reference viewed: 154 (1 ULiège)