Last 7 days     Results 861-880 of 53343.   39 40 41 42 43 44 45 46 47 48 49   The Liège Game Lab: presentation of a young research center on videogamesDozo, Björn-Olav ; Barnabé, Fanny ; Delbouille, Julie et alConference (2016, June 09)The main goals of the paper are, first, to present the Liège Game Lab, the different studies carried out in Liège on videogames and their specificities and, secondly, question our own position in the ... [more ▼]The main goals of the paper are, first, to present the Liège Game Lab, the different studies carried out in Liège on videogames and their specificities and, secondly, question our own position in the research field. To do so, we will situate ourselves in relation to the main paradigms of game studies dominated in France by social sciences and in the world by English-speakers, with a particular attention to the domination’s concerns of a peripheral position. This paper will focus on presentation and discussion of the videogames’ study in a midsized French speaking University. The aim is, first and foremost, to question the domination’s issues related to a triple peripheral position: geographic, methodological and linguistic. - The University of Liège is indeed peripheral in Belgium, in comparison to the centrality, geographically speaking, of the Universities of Brussels and Leuven. - The main group working on videogames, in French speaking Belgium, is the LabJMV (the “Games and Virtual Worlds” Laboratory), where the anthropological and sociological perspectives are dominant, while in Liège we developed more a communicative and literary outlook. - The OMNSH (the main association about game studies in France), which could be our “natural” link to the field because of the sharing language, is also dominated by social sciences and separated by a political frontier which could be seen as a boundary. - The DIGRA (the Digital Games Research Association), at the opposite, is geographically close to us (given that they are present as a chapter in Flanders), but disconnected owing to the difference of language (they publish mainly in English, we publish mainly in French). Despite of this peripheral position and making of it a strategic observatory of the tendencies of game studies, an original research hub emerged in Liège for two years. We chose to work on objects and/or with methodological perspectives which diverge of mainstream game studies: amateur game making, videogame press, Belgian players’ uses and poetical perspective on gaming practices. Various contingencies brought together at the University of Liège several researchers working more or less directly on videogames: students’ demands to write master’s thesis on videogames, the rise of grants from funding agencies like FNRS to study this medium and the development of Digital Humanities in the University of Liège. It is time, now, to question ourselves about the situation of the game studies in the University of Liège, but also the place of this University in the international field of this discipline. In first approximation, we can postulate that this gathering of researchers generated a shared research process, whose specificities stem particularly from the triple peripheral position (geographic, methodological and linguistic) of the University of Liège in the game studies field – as explained earlier. However, we would like to discuss this hypothesis not only on our own,but publicly, in the context of an international conference. Consequently, with this paper, we aim to present our group questioning our shared position and, at the same time, to expose a comparison of our five perspectives on videogames in order to understand in what ways they match each other and in what ways they create fruitful opposition. Björn-Olav Dozo and Boris Krywicky are interested in French speaking videogame press with book history’s methods. Pierre-Yves Hurel examines amateur game design with sociological tools (the dominant methodology in French speaking game studies), but these are serving communication and political investigations. Fanny Barnabé studies the same kind of objects (players’ creative practices of “misappropriation”), but through a formal and poetic approach (she analyzes the works so produced and not the players’ activities). Julie Delbouille, at the opposite, adopted a sociological and quantitative methodology, but investigated a restricted category of gaming practices: the French speaking Belgian players. [less ▲]Detailed reference viewed: 17 (3 ULg) Outils d’aide à la réussite dans le cadre du cours de Biologie en premier bachelier de la Faculté des Sciences à l’Université de Liège: présentation et analysePoffé, Corentin ; Rigo, Pierre ; Hindryckx, Marie-Noëlle et alConference (2016, June 08)Detailed reference viewed: 16 (2 ULg) Impurity scattering effects on the superconducting properties and the tetragonal-to-orthorhombic phase transition in FeSeAbdel-Hafiez, Mahmoud; Pu, Y. J.; Brisbois, Jérémy et alin Physical Review B (2016), 93A comprehensive study of the doping dependence of the phase diagram of FeSe-based superconductors is still required due to the lack of a clean and systematic means of doping control. Here, we report on ... [more ▼]A comprehensive study of the doping dependence of the phase diagram of FeSe-based superconductors is still required due to the lack of a clean and systematic means of doping control. Here, we report on the magneto-optical imaging, thermodynamic and transport properties, as well as in situ angle-resolved photoemission spectroscopy (ARPES) studies, on the impurity scattering in stoichiometric FeSe single crystals. Co doping at the Fe site is found to decrease the superconducting transition temperature. The upper critical field and specific heat all indicate a possible multiband superconductivity with strong coupling in the Co-doped system. A remarkable feature in FeSe is that its temperature dependent resistivity exhibits a wide hump at high temperatures, a signature of a crossover from a semiconductinglike behavior to metallic behavior. A structural tetragonal-to-orthorhombic phase transition Ts (a consequence of the electronic nematicity) is suppressed by either physical or chemical pressures. Due to the reconstruction of the Fermi surface at Ts, specific heat anomalies at Ts present ΔCp/Ts≈γn, the Sommerfield coefficient at low temperature. This reflects additional electronic instability in the FeSe(1−x)Sx system. ARPES data between 180 and 282 K indicates the existence of a chemical potential shift with increasing thermal excitations, resulting in a change of the Fermi-surface topology and exhibiting a semimetal behavior. We found that the temperature-induced Lifshitz transition is much higher than the temperature for the nematic order. [less ▲]Detailed reference viewed: 35 (5 ULg) The MAR model performances over BelgiumWyard, Coraline ; Fettweis, Xavier Conference (2016, June 08)This presentation deals with the set-up of the regional climate model MAR over Belgium. It also presents the performances of MAR to simulate the present-day climate following three reanalysis used as ... [more ▼]This presentation deals with the set-up of the regional climate model MAR over Belgium. It also presents the performances of MAR to simulate the present-day climate following three reanalysis used as forcing of the model (ERA-Interim, ERA-20C and NCEP/NCAR-v1). [less ▲]Detailed reference viewed: 20 (1 ULg) Fire Resistance of Reinforced Concrete Columns Subjected to Standard Fire – Comparison of an Advanced and a Simplified MethodAchenbach, Marcus; Gernay, Thomas ; Morgenthal, Guidoin Garlock, Maria; Kodur, Venkatesh (Eds.) Structures in Fire (Proceedings of the Ninth International Conference) (2016, June 08)For designing concrete columns subjected to a standard fire exposure, the Eurocode permits the use of simplified or advanced calculation methods. For the designer, the question of the respective ... [more ▼]For designing concrete columns subjected to a standard fire exposure, the Eurocode permits the use of simplified or advanced calculation methods. For the designer, the question of the respective advantages of these two types of methods arises. Which situations demand the use of an advanced method? When does a simple method provide sufficient accuracy? In this paper, laboratory tests are recalculated using Finite Element Modeling (FEM) as an advanced and Extended Zone Model (EZM) as a simple method in order to investigate these questions. The recalculations indicate that the simple EZM is of sufficient accuracy for symmetric heated columns without restraints. In contrast, the mechanical behavior of columns heated on three sides demands an advanced method such as FEM to be properly described. [less ▲]Detailed reference viewed: 20 (4 ULg) Approche psychocriminologique et légale du processus de radicalisationGarcet, Serge Conference (2016, June 08)Detailed reference viewed: 19 (0 ULg) Prediction of intra- and inter-laminar failure of laminates using non-local damage-enhanced mean-field homogenization simulationsWu, Ling ; Sket, Federico; Adam, Laurent et alConference (2016, June 08)The failure of carbon fiber reinforced composites with a quasi-isotropic sequence ([90/45/-45/90/0]S) and open-hole geometry is studied using a multiscale method [1]. On the one hand, the intra-laminar ... [more ▼]The failure of carbon fiber reinforced composites with a quasi-isotropic sequence ([90/45/-45/90/0]S) and open-hole geometry is studied using a multiscale method [1]. On the one hand, the intra-laminar failure is captured using a damage-enhanced mean-field homogenization scheme. To this end, each ply is modeled as a homogenized material whose anisotropic damage behavior is captured from the homogenization method [2]. In order to avoid the problem of loss of solution uniqueness the mean-field homogenization process is formulated in the context of the non-local continuum damage theory [3]. On the other hand, an hybrid discontinuous Galerkin/extrinsic cohesive law method is used to model the delamination process at the ply interfaces. This hybrid method avoids the need to propagate topological changes in the mesh with the propagation of the delamination while it preserves the consistency and stability in the un-cracked interfaces. As a result, the multiscale framework allows predicting damage propagation directions in each ply along the fiber directions accordingly to the experimental results as it is demonstrated by considering an openhole [90/45/-45/90/0]S-laminate studied both numerically and experimentally. [1] L. Wu, et al., Composite Struct., 126, 246–264, 2015. [2] L. Wu, L. Noels, L. Adam, I. Doghri, Int. J. of Solids and Struct., 50, 3843-3860, 2013. [3] R. Peerlings, et al., Int. J. for Numer. Meth. in Eng., 39, 3391-3403, 1996 [less ▲]Detailed reference viewed: 18 (5 ULg) Integrated and systemic management of storm damage by the forest-based sector and public authoritiesRiguelle, Simon ; Hebert, Jacques ; Jourez, Benoît in Annals of Forest Science : a Multidisciplinary and International Journal (2016)The paper’s goals are to identify key challenges in the currentwindthrow management framework and present a blueprint for howto progress in the settlement of regional strategies.SWOT analyses are used to ... [more ▼]The paper’s goals are to identify key challenges in the currentwindthrow management framework and present a blueprint for howto progress in the settlement of regional strategies.SWOT analyses are used to highlight relevant issues and opportunities in classical approaches from both the forest-based sector and public authorities’ perspectives. Despite the large body of knowledge that allows decision-makers to react promptly after huge storms, strategic responses still suffer from too individual and fragmented decisions and a lack of holistic economic assessments. To tackle these issues, the paper suggests using systemic and integrated risk management approaches. It also presents the ways to enhance the forest-based sector’s resistance and resilience towards economic shock and supports decision-making with the help of systemic analysis. This shift of paradigm is one of the key requirements in optimizing the way of dealing with storm damage, but public authorities should concur with it more actively by improving decisional and administrative frameworks. Contribution of the co-authors Co-authors are PhD thesis’ supervisors and have thoroughly reviewed the paper. [less ▲]Detailed reference viewed: 16 (2 ULg) Multifractal analysis of the divergence of wavelet seriesEsser, Céline Conference (2016, June 07)In this talk, we study pointwise divergence properties of wavelet expansions of functions in a given Besov space. We obtain deterministic upper bounds for the Hausdorff dimensions of the sets of points ... [more ▼]In this talk, we study pointwise divergence properties of wavelet expansions of functions in a given Besov space. We obtain deterministic upper bounds for the Hausdorff dimensions of the sets of points where a given rate of divergence is observed, and we show that these bounds are generically (in the sense of Baire's categories) optimal. This gives a complement to the works done by F. Bayart and Y. Heurteaux in the case of Fourier series and by J.M. Aubry. [less ▲]Detailed reference viewed: 13 (4 ULg) Boltzmann Transport Calculations in Systems with Electron-phonon CouplingPike, Nicholas Scientific conference (2016, June 07)Recent experimental and theoretical calculations point to a complex interplay between the electron and phonon baths in a wide variety of materials [1,2]. We propose a method of coupling the Boltzmann ... [more ▼]Recent experimental and theoretical calculations point to a complex interplay between the electron and phonon baths in a wide variety of materials [1,2]. We propose a method of coupling the Boltzmann equations for the electron and phonon baths within the relaxation time approximation to describe the changes in the electron and phonon distributions and thus calculate the thermoelectric transport coefficients. Our model for the coupled system will include tight-binding and ${\bf k \cdot p}$ Hamiltonians for both the electron and phonon energies and analytic calculations for the electron and phonon relaxation mechanisms. From these calculations we hope to better understand the role and interplay of electron-phonon and phonon-phonon interactions on the thermoelectric transport coefficients. [1] - Phys. Rev. Lett. ${\bf 114}$, 115901 (2015). [2] - PNAS ${\bf 112}$, 14777-14782 (2015). [less ▲]Detailed reference viewed: 35 (2 ULg) Universal amorphous-amorphous transition in GexSe100−x glasses under pressureYildirim, Can ; Micoulaut, Matthieu; Boolchand, Punit et alin Scientific Reports (2016), 6Pressure induced structural modifications in vitreous GexSe100−x (where 10 ≤ x ≤ 25) are investigated using X-ray absorption spectroscopy (XAS) along with supplementary X-ray diffraction (XRD) experiments ... [more ▼]Pressure induced structural modifications in vitreous GexSe100−x (where 10 ≤ x ≤ 25) are investigated using X-ray absorption spectroscopy (XAS) along with supplementary X-ray diffraction (XRD) experiments and ab initio molecular dynamics (AIMD) simulations. Universal changes in distances and angle distributions are observed when scaled to reduced densities. All compositions are observed to remain amorphous under pressure values up to 42 GPa. The Ge-Se interatomic distances extracted from XAS data show a two-step response to the applied pressure; a gradual decrease followed by an increase at around 15–20 GPa, depending on the composition. This increase is attributed to the metallization event that can be traced with the red shift in Ge K edge energy which is also identified by the principal peak position of the structure factor. The densification mechanisms are studied in details by means of AIMD simulations and compared to the experimental results. The evolution of bond angle distributions, interatomic distances and coordination numbers are examined and lead to similar pressure-induced structural changes for any composition. [less ▲]Detailed reference viewed: 10 (1 ULg) Aménorhhée primaire : le point de vue endocrinienVALDES SOCIN, Hernan Gonzalo Scientific conference (2016, June 07)Aménorhhée primaire : le point de vue endocrinien Dr Hernan Valdés-Socin Chef de Clinique. Service d’Endocrinologie. CHU de Liège Résumé L’alternance de la phase folliculaire et lutéale ovarienne ... [more ▼]Aménorhhée primaire : le point de vue endocrinien Dr Hernan Valdés-Socin Chef de Clinique. Service d’Endocrinologie. CHU de Liège Résumé L’alternance de la phase folliculaire et lutéale ovarienne, s’accompagne d’une variation de la sécrétion oestroprogestative déterminant le cycle menstruel de l’utérus. Les différentes perturbations pouvant toucher les circuits hypothalamiques (neurones à kisspeptines, neurones a GnRH), le fonctionnement hypophysaire et son contrôle des différentes glandes endocrines, les anomalies acquises et génétiques des ovaires (syndrome de Turner, insuffisance ovarienne primaire,etc) et de l’utérus (syndrome d’Asherman, Syndrome de Rokytanski, etc) peuvent déterminer selon les cas une aménorrhée primaire ou secondaire. L’aménorrhée primaire est définie par l’absence de ménarche chez une fille arrivée à l’âge de 16 ans alors que l’aménorrhée secondaire est l’absence de menstruation depuis plus de 3 mois, chez une patiente antérieurement bien réglée. Nous discutons et résumons ici les différentes étiologies d’aménorrhée primaire et secondaire, ainsi que leur prise en charge. La disponibilité récente au CHU de Liège d’un panel de 16 gènes responsables d’hypogonadisme hypogonadotrope nous a permis d’approfondir la recherche sur les causes du syndrome de Kallmann et de l’hypogonadisme hypogonadotrope normosmique. Références H. Valdes-Socin , F.G. Debray, A.S. Parent, M.C. Lebrethon, J.P. Bourguignon, V. Bours A. Beckers. Comment je diagnostique un hypogonadisme hypogonadotrope congénital isolé? Rev Med Liège 2010 Nov;65(11):634-41 Valdes-Socin H, Rubio Almanza M, Tomé Fernández-Ladreda M, Debray FG, Bours V, Beckers A. Reproduction, Smell and Neurodevelopmental disorders: Genetic defects in different hypogonadotropic hypogonadal syndromes. Frontiers in Endocrinology 2014 (5) 109 1-8. Valdes-Socin H, Beckers A. El síndrome de Pasqualini. Medicina (B Aires). 2015;75(1):53-8. B. González Aguilera, P. Syrios, R. Gadisseur, F. Luyckx, E. Cavalier, A. Beckers, H. Valdes-Socin. Persistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease. Gynecology Endocrinology 2015 Jun;32(6):439-41. H. Valdes-Socin, Fg. Debray, C. Libioulle, A. Pintiaux, As. Parent, V. Corman, K. Gellner, V. Geenen, L. Vroonen, V. Dideberg, V. Bours, A. Beckers. Caractérisation clinique, neuroendocrinienne, génétique et résultats thérapeutiques dans le syndrome de Kallmann et de l’hypogonadisme normosmique idiopathique: expérience liégeoise. Annales d'Endocrinologie - 32ème congrès de la société Française d'Endocrinologie 2016. Bordeaux. France. H. Valdes-Socin (Dr), A. Verloesb , Fg. Debrayc , C. Libioullec , A. Pintiauxd , P. Maquet, A. Beckers) Le Syndrome de De Morsier : une cause congénitale méconnue d’hypopituitarisme. Annales d'Endocrinologie - 32ème congrès de la société Française d'Endocrinologie 2016. Bordeaux. France [less ▲]Detailed reference viewed: 19 (2 ULg) Cohesive band model: a triaxiality-dependent cohesive model for damage to crack transition in a non-local implicit discontinuous Galerkin frameworkLeclerc, Julien ; Wu, Ling ; Noels, Ludovic et alConference (2016, June 07)Numerical modelling of the complete ductile failure process is still a challenge. On the one hand, continuous approaches, described by damage models, succeed in the initial diffuse damage stage but are ... [more ▼]Numerical modelling of the complete ductile failure process is still a challenge. On the one hand, continuous approaches, described by damage models, succeed in the initial diffuse damage stage but are still unable to represent physical discontinuities. On the other hand, discontinuous approaches, such as the cohesive zone models, are able to represent the crack propagation behaviour. They are suited for local damaging processes as crack initiation and propagation, and so, fail in diffuse damage prediction of ductile materials. Moreover, they do not usually capture triaxiality effects, mandatory for accurate ductile failure simulations. To describe the ductile failure process, the numerical scheme proposed here combines both approaches [1] in order to beneficiate from their respective advantages: a non-local damage model combined with an extrinsic cohesive law in a discontinuous Galerkin finite element framework. An application example of this scheme is shown on the attached figure. The initial diffuse damage stage is modelled by an implicit nonlocal damage model as suggested by [2]. Upon damage to crack transition, a cohesive band [3] is used to introduce in-plane stretch effects inside the cohesive law or in other words, a triaxiality-dependent behaviour. Indeed, these in-plane strains play an important role during the ductile failure process and have to be considered. Concretely, when crack appears in the last failure stage, all the damaging process is assumed to occur inside a thin band ahead of the crack surface. Thanks to the small but finite numerical band thickness, the strains inside this band can be obtained from the in-plane strains and from the cohesive jump. Then, the stress-state inside the band and the cohesive traction forces on the crack lips are deduced from the underlying continuum damage model. The band thickness is not a new material parameter but is computed to ensure the energetic consistency during the transition. [1] Wu L, Becker G, Noels L. Elastic damage to crack transition in a coupled non-local implicit discontinuous Galerkin/extrinsic cohesive law framework. Comput. Methods Appl. Mech. Eng. 279 (2014): 379–409 [2] Peerlings R., de Borst R., Brekelmans W., Ayyapureddi S. Gradient-enhanced damage for quasi-brittle materials, Int. J. for Num. Methods in Eng. 39 (1996): 3391-3403 [3] Remmers J. J. C., de Borst R., Verhoosel C. V., Needleman A. The cohesive band model: a cohesive surface formulation with stress triaxiality. Int. J. Fract. 181 (2013): 177–188 [less ▲]Detailed reference viewed: 21 (6 ULg) De l'avatar au personnage : regards croisés entre game studies et études littérairesDozo, Björn-Olav ; Delbouille, Julie Conference (2016, June 07)Si les game studies se sont développées en prenant appui, dans un premier temps, sur les études littéraires et en particulier sur la narratologie (Ryan 2004, Atkins et Krzywinska 2007) pour interroger la ... [more ▼]Si les game studies se sont développées en prenant appui, dans un premier temps, sur les études littéraires et en particulier sur la narratologie (Ryan 2004, Atkins et Krzywinska 2007) pour interroger la notion de récit appliquée au jeu vidéo, elles ont ensuite fait appel à d’autres disciplines (psychologie et sociologie en particulier) pour construire leur approche de certaines notions, dont celle d’avatar qui nous paraît utile dans le cadre de recherches sur le personnage en littérature. Confrontées à des objets irréductibles à leur textualité (l’étude de la composante « play » du jeu a pris le pas sur celle du « game », surtout en francophonie – voir à ce sujet Triclot, 2011), les game studies se sont dotées d’outils et de théories propres, réélaborant pragmatiquement certaines notions à partir de théories antérieures (les « univers fictionnels », voir Barnabé, 2014) ou forgeant des concepts spécifiques (l’« impératif d’action », voir Genvo, 2005). Dans cette communication, nous souhaitons mobiliser une série de réflexions récentes sur la notion d’avatar vidéoludique pour les étendre à l’étude des personnages au sein de la littérature contemporaine. [less ▲]Detailed reference viewed: 18 (1 ULg) Méthodes historiques de recherche en architectureFrankignoulle, Pierre Diverse speeche and writing (2016)Detailed reference viewed: 17 (2 ULg) MOISTURE CONTENT DETERMINATION OF FREEZE-DRIED PRODUCTS BY NEAR-INFRARED SPECTROSCOPY: A CASE STUDY FOR UNIVERSAL REGRESSION MODELClavaud, Matthieu ; Roggo, Yves; Degardin, Klara et alPoster (2016, June 06)Karl Fischer titration is the reference method for moisture content determination in the pharmaceutical industry. Near-infrared spectroscopy is considered the most suitable alternative technique. Indeed ... [more ▼]Karl Fischer titration is the reference method for moisture content determination in the pharmaceutical industry. Near-infrared spectroscopy is considered the most suitable alternative technique. Indeed, NIRS is a safe and fast method which does not require sample preparation. Nevertheless, the development and validation phases are time-consuming. In addition, the NIRS methods presented so far were mostly product specific. The main objective of this study is to highlight that an universal calibration model can be validated for several freeze-dried products in order to speed up the validation time. This objective was led in two steps. A universal model was first evaluated. A calibration set and a validation set were built up with three freeze-dried products. An antibody drug conjugate, a large molecule and a small molecule all packed in sealed vials were used to introduce more variability. Regression methods were then compared in order to optimize the prediction values. [less ▲]Detailed reference viewed: 51 (6 ULg) Imprinting superconducting vortex footsteps in a magnetic layerBrisbois, Jérémy ; Motta, Maycon; Avila Osses, Jonathan et alin Scientific Reports (2016), 6Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit ... [more ▼]Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit cards and computer hard drives. Here we experimentally show that a similar principle can be applied for imprinting the trajectory of quantum units of flux (vortices), travelling in a superconducting film (Nb), into a soft magnetic layer of permalloy (Py). In full analogy with the magnetic drawing board, vortices act as tiny magnetic scribers leaving a wake of polarized magnetic media in the Py board. The mutual interaction between superconducting vortices and ferromagnetic domains has been investigated by the magneto-optical imaging technique. For thick Py layers, the stripe magnetic domain pattern guides both the smooth magnetic flux penetration as well as the abrupt vortex avalanches in the Nb film. It is however in thin Py layers without stripe domains where superconducting vortices leave the clearest imprints of locally polarized magnetic moment along their paths. In all cases, we observe that the flux is delayed at the border of the magnetic layer. Our findings open the quest for optimizing magnetic recording of superconducting vortex trajectories. [less ▲]Detailed reference viewed: 47 (23 ULg) L’hypothèse d’une Pax Persiana. L’Iran et ses rapports avec l’Occident des années 1850 à 2016Genin, Vincent Conference given outside the academic context (2016)Detailed reference viewed: 15 (2 ULg) Screening study of SFC critical method parameters for the determination of pharmaceutical compoundsDispas, Amandine ; Lebrun, Pierre ; Sacre, Pierre-Yves et alin Journal of Pharmaceutical & Biomedical Analysis (2016), 125Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and ... [more ▼]Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and sample preparation of pharmaceutical compounds remain a challenge and peak distortion was previously highlighted. The main objective of the present work was to evaluate the impact of different critical method parameters (CMPs), i.e. stationary phase, mobile phase composition and injection solvent nature. The experiments were performed considering two groups of antimalarial molecules: one group with neutral/apolar compounds and the other one with salt form of polar compounds. In this context, another objective was to propose a suitable sample solvent for quantitative analysis. The interest of new generation stationary phase to obtain good peak shape and the interest to tune the mobile phase composition were demonstrated. During this study, design of experiments and desirability function approach enabled to highlight optimal chromatographic conditions in order to maximise peak capacity and to get acceptable value of symmetry factor. Regarding sample injection solvent composition, some counterintuitive results were observed: solvents closer to the mobile phase polarity (i.e heptane or 2-propanol/heptane mixture) did not provide best results in terms of peak symmetry. In addition, acetonitrile and short aliphatic alcohols offered an interesting alternative as injection solvent: toxicity of solvents used is clearly reduced and better quantitative performances could be expected while keeping high peak capacity and symmetric sharp peaks. Finally, the quantitative performances were evaluated by the method validation for the quantitative determination of quinine sulfate in a pharmaceutical formulation. These better understandings on critical method parameters led SFC to be an even more promising technique in the field of the analysis of pharmaceutical compounds. [less ▲]Detailed reference viewed: 34 (11 ULg) Rewriting History in the Time of Late Capitalism: Uses and Abuses of Built Heritage : introduction to the sessionHoubart, Claudine ; Dawans, Stéphane Conference (2016, June 05)With his expression ceci tuera cela, Hugo established almost two centuries ago a strong link between words and stones as transmission vehicles of human memory. We heritage experts would be inclined to ... [more ▼]With his expression ceci tuera cela, Hugo established almost two centuries ago a strong link between words and stones as transmission vehicles of human memory. We heritage experts would be inclined to consider stones as more reliable than words, what semiology seems to confirm : stones are clues, and clues are, according to Roland Barthes, tangible proves of “what has been”. But the inspector Columbo has often shown how we can play with these clues, and Umberto Eco would easily forgive us this incursion into mass culture to agree on the idea that we can rewrite history using false justified clues, that is also, tangible heritage. Since the emergence of the restoration discipline, experts have been aware of the danger of falsification : Ruskin’s texts, Boito’s philological restoration, Brandi’s historical instance or the Venice charter are so many illustrations of this concern. But since the 1990’s in Europe, a growing number of restoration and reconstruction projects very clearly depart from this fundamental idea. Of course, the collapse of the Soviet bloc has created a particular political context in which (re-)emerging nations attempted to (re-)build their identity through architectural symbols (leading to the writing of the Riga charter). But more generally, this phenomenon is closely linked to the cultural context : on the one hand, the postmodern movement has deeply questioned the idea of “sincerity”, with a tendency to blur the limits between true and false and, as a consequence, between original and copy. And on the other hand, in the heritage sphere, the globalisation of the debate progressively rattled european certitudes about concepts as essential as authenticity, leading to the replacement of the self-confidence expressed by the Venice charter by a careful relativism, illustrated by the Nara document thirty years later. These contemporary phenomenons have important side effects. In the context of late capitalism, heritage has become a major economic issue, especially as many cities have well understood its potentialities in terms of city branding. This could of course be seen as a positive opportunity for heritage conservation ; nevertheless, a rich scientific literature has shown that tourism can deeply transform our representation of the past. The tourist is a client rather than an amateur, and his quest of authenticity is often satisfied by what the French philosopher Yves Michaud has called “adulterated authenticity”, the one from over-restored monuments, reconstructed city centres, eco-museums, and, why not, theme parks. More than authentic built remains, the “tourist gaze” shapes more and more our representation of “what has been”, and the arguments developed by heritage experts in response to globalisation and identity issues are seized upon by city marketing specialists willing to meet a mostly commercial demand, sometimes tinged with dubious political motivations. What we intend to question in this session is the limit between uses and abuses of heritage and heritage discourse and more particularly whether, as suggested by Theodore Scaltsas’ inspiring paper “Identity, origin and spatiotemporal continuity” (1981), the intentions underpinning restoration and reconstruction projects affect the very essence of restored or reconstructed objects. Besides architectural history and conservation theory, we welcome contributions in the fields of sociology, anthropology, philosophy, history, political sciences, geography, tourism economy and even psychology. [less ▲]Detailed reference viewed: 11 (1 ULg)