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See detailOption Replication and the Performance of a Market Timer
Hübner, Georges ULg

in Studies in Economics & Finance (in press)

The Treynor and Mazuy framework is a widely used return-based model of market timing. However, existing corrections to the regression intercept can be manipulated through derivatives trading. We propose ... [more ▼]

The Treynor and Mazuy framework is a widely used return-based model of market timing. However, existing corrections to the regression intercept can be manipulated through derivatives trading. We propose an adjustment based on Merton's option replication approach. The linear and quadratic coefficients of the regression are exploited to assess the cost of the replicating option that yields similar convexity for a passive portfolio. A similar reasoning applies for various timing patterns and in multi-factor models. The proposed framework induces a potential rebalancing risk and involves the delicate issue of choosing the cheapest option. We show that these issues can be overcome for reasonable tolerance levels. [less ▲]

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See detailAudiometric results after stapedotomy operations in patients with otosclerosis and preoperative small air-bone gaps
SALMON, Caroline ULg; BARRIAT, Sébastien ULg; DEMANEZ, Laurent CH P ULg et al

in Audiology & Neuro-otology (in press)

Objectives: The efficacy of stapedotomies performed on patients with small air-bone gaps (<25 dB, sABG) was compared to the efficacy of the operation in patients who had otosclerosis with high air-bone ... [more ▼]

Objectives: The efficacy of stapedotomies performed on patients with small air-bone gaps (<25 dB, sABG) was compared to the efficacy of the operation in patients who had otosclerosis with high air-bone gaps (≥25 dB, hABG). Methods: This retrospective study evaluates the short-term postoperative air and bone conduction thresholds and air-bone gaps after 181 CO2 laser stapedotomies. Results: A significantly smaller air-bone gap (ABG) and lower air conduction thresholds after surgery were observed in the group of patients who underwent surgery with preoperative ABGs of less than 25 dB. Bone conduction thresholds improve in sABG group after surgery. Conclusions: The results after stapedotomies are good even if the preoperative air-bone gap is small and that the overall risk of hearing deterioration due to stapes surgery remains low. [less ▲]

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See detailImmune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning
HANNON, Muriel ULg; BEGUIN, Yves ULg; Ehx, Grégory ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (in press)

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft ... [more ▼]

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n=28) or 8 Gy TLI plus anti-thymocyte globulin (TLI arm, n=25). Results: In comparison to TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P=0.02), a higher incidence of CMV reactivation (P<0.001), and a higher incidence of relapse (P=0.01). While recovery of total CD8+ T cells was similar in the two groups, with median CD8+ T cell counts reaching the normal values 40-60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4+ T cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Further, CD4+ T cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T cell (Treg) counts were comparable in TBI and TLI patients, Treg/naïve CD4+ T cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens possibly explaining the different clinical outcomes observed (NCT00603954). [less ▲]

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See detailGlobally, functional traits are weak predictors of juvenile tree growth, and we do not know why
Paine, C.E. Thimothy; Amissah, Lucy; Auge, Harald et al

in Journal of Ecology (in press)

1. Plant functional traits, in particular specific leaf area (SLA), wood density and seed mass, are often good predictors of individual tree growth rates within communities. Individuals and species with ... [more ▼]

1. Plant functional traits, in particular specific leaf area (SLA), wood density and seed mass, are often good predictors of individual tree growth rates within communities. Individuals and species with high SLA, low wood density and small seeds tend to have faster growth rates. 2. If community-level relationships between traits and growth have general predictive value, then similar relationships should also be observed in analyses that integrate across taxa, biogeographic regions and environments. Such global consistency would imply that traits could serve as valuable proxies for the complex suite of factors that determine growth rate, and, therefore, could underpin a new generation of robust dynamic vegetation models. Alternatively, growth rates may depend more strongly on the local environment or growth–trait relationships may vary along environmental gradients. 3. We tested these alternative hypotheses using data on 27 352 juvenile trees, representing 278 species from 27 sites on all forested continents, and extensive functional trait data, 38% of which were obtained at the same sites at which growth was assessed. Data on potential evapotranspiration (PET), which summarizes the joint ecological effects of temperature and precipitation, were obtained from a global data base. 4. We estimated size-standardized relative height growth rates (SGR) for all species, then related them to functional traits and PET using mixed-effect models for the fastest growing species and for all species together. 5. Both the mean and 95th percentile SGR were more strongly associated with functional traits than with PET. PET was unrelated to SGR at the global scale. SGR increased with increasing SLA and decreased with increasing wood density and seed mass, but these traits explained only 3.1% of the variation in SGR. SGR–trait relationships were consistently weak across families and biogeographic zones, and over a range of tree statures. Thus, the most widely studied functional traits in plant ecology were poor predictors of tree growth over large scales. 6. Synthesis. We conclude that these functional traits alone may be unsuitable for predicting growth of trees over broad scales. Determining the functional traits that predict vital rates under specific environmental conditions may generate more insight than a monolithic global relationship can offer. [less ▲]

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See detailMass-spectrometry-based method for screening of new peptide ligands for G-protein-coupled receptors
Cologna Takeno, Camila; Gilles, Nicolas; Echterbille, Julien ULg et al

in Analytical and Bioanalytical Chemistry (in press)

G-protein-coupled receptors (GPCRs) constitute the largest family of transmembrane proteins. Although implicated in almost all physiological processes in the human body, most of them remain unexploited ... [more ▼]

G-protein-coupled receptors (GPCRs) constitute the largest family of transmembrane proteins. Although implicated in almost all physiological processes in the human body, most of them remain unexploited, mostly because of the lack of specific ligands. The objective of this work is to develop a new mass-spectrometry-based technique capable of identifying new peptide ligands for GPCRs. The strategy is based on the incubation of cellular membranes overexpressing GPCRs with a mixture of peptides that contains potential ligands. Peptide ligands bind to the receptors, whereas other peptides remain in the binding buffer. Bound peptides are eluted from membranes and directly detected, identified, and characterized by MALDI TOF–TOF. The results reveal the efficacy of the procedure for selecting a specific ligand of GPCRs in both simple and complex mixtures of peptides. This new approach may offer direct purification, identification, and characterization of the new ligand in a single workflow. The proposed method is labeling-free and, unlike radio-binding and other techniques, it does not require a previously known labeled ligand of the studied GPCR. All these properties greatly reduce the experimental constraints. Moreover, because it is not based on the principle of a competitive specific binding, this technique constitutes a new tool to discover new ligands not only for known GPCRs, but also for orphan GPCRs [less ▲]

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See detailArticle "Hippocrate"
Ricciardetto, Antonio ULg

in Zawieja, Philippe (Ed.) Dictionnaire de la fatigue (in press)

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See detailArticle "Galien"
Ricciardetto, Antonio ULg

in Zawieja, Philippe (Ed.) Dictionnaire de la fatigue (in press)

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See detailRisques d'inégalités liés à certaines caractéristiques des manuels contemporains de langues modernes
Simons, Germain ULg; Delbrassine, Daniel ULg; Van Hoof, Florence ULg

in Recherche en Education (2016), 25

Cet article épingle huit caractéristiques de trois manuels de langues contemporains (anglais, allemand, espagnol), qui présentent des risques d'inégalités pour les apprenants. Chacune des caractéristiques ... [more ▼]

Cet article épingle huit caractéristiques de trois manuels de langues contemporains (anglais, allemand, espagnol), qui présentent des risques d'inégalités pour les apprenants. Chacune des caractéristiques est illustrée par des exemples issus des trois manuels. [less ▲]

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See detailHistoire, géographie et esthétique : peut-on récapituler la psychologie clinique ?
Englebert, Jérôme ULg

Scientific conference (2016, January 16)

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See detailBrentano, la théorie des catégories et la définition de la substance
Boccaccini, Federico ULg

in Etudes Philosophiques (2016)

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See detailIntroduction
Englebert, Jérôme ULg; Follet, Valérie

in Englebert, Jérôme; Follet, Valérie (Eds.) Adaptation : Essai collectif à partir des paradigmes éthologiques et évolutionnistes (2016)

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See detailConclusion : Anormalité ou anomalie ?
Englebert, Jérôme ULg; Follet, Valérie

in Englebert, Jérôme; Follet, Valérie (Eds.) Adaptation : Essai collectif à partir des paradigmes éthologiques et évolutionnistes (2016)

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See detailPressure-impulse diagram of a beam under developing non-linear membrane action under
Hamra, Lotfi ULg; Demonceau, Jean-François ULg; Denoël, Vincent ULg

in International Journal of Impact Engineering (2016)

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See detailAdaptation : Essai collectif à partir des paradigmes éthologiques et évolutionnistes
Englebert, Jérôme ULg; follet, Valérie

Book published by Hermann (2016)

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See detailDépasser le paradoxe évolutionniste de la schizophrénie : psychopathologie éthologique et adaptation perpétuelle
Englebert, Jérôme ULg

in Englebert, Jérôme; Follet, Valérie (Eds.) Adaptation : Essai collectif à partir des paradigmes éthologiques et évolutionnistes (2016)

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See detailProvenance of Ichthyosaura alpestris (Caudata: Salamandridae) introductions to France and New Zealand assessed by mitochondrial DNA analysis
Arntzen, Jan W.; King, Tania M.; Denoël, Mathieu ULg et al

in The Herpetological Journal (2016), 26

The last century has seen an unparalleled movement of species around the planet as a direct result of human activity, which has been a major contributor to the biodiversity crisis. Amphibians represent a ... [more ▼]

The last century has seen an unparalleled movement of species around the planet as a direct result of human activity, which has been a major contributor to the biodiversity crisis. Amphibians represent a particularly vulnerable group, exacerbated by the devastating effects of chytrid fungi. We report the malicious translocation and establishment of the alpine newt (Ichthyosaura alpestris) to its virtual antipode in North Island of New Zealand. We use network analysis of mitochondrial DNA haplotypes to identify the original source population as I. a. apuana from Tuscany, Italy. Additionally, a population in southern France, presumed to be introduced, is identified as I. a. alpestris from western Europe. However, the presence of two differentiated haplotypes suggests a mixed origin. This type of analysis is made possible by the recent availability of a phylogenetic analysis of the species throughout its natural range. We discuss the particulars of both introductions. [less ▲]

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See detailReview of Véronique Maisier’s Violence in Caribbean Literature: Stories of Stones and Blood
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2016), 90(3&4),

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See detailReconnaissance et parentification: des mots qui vont si bien ensemble?
Haxhe, Stéphanie ULg

Conference given outside the academic context (2015)

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See detailA probabilistic model for predicting the uncertainties of the humid stiction phenomenon on hard materials
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Journal of Computational & Applied Mathematics (2015), 289

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the ... [more ▼]

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the surfaces roughness and the adhesive force range, the real contact areas are usually smaller than the apparent one, resulting in a scatter in the adhesive forces. Consequently, the stiction is an uncertain phenomenon. In this work, we develop a probabilistic model to predict the uncertainties of stiction due to the capillary forces acting on stiff materials. This model contains two levels: at the deterministic level, the model can predict the pull-out adhesive contact forces for a given surface topology; at the probabilistic level, the model generates independent identically distributed surfaces on which the deterministic solution can be applied to evaluate the uncertainties related to the stiction phenomenon. [less ▲]

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