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See detailThe Sequence of Cyclophosphamide and Myeloablative Total Body Irradiation in Hematopoietic Cell Transplantation for Patients with Acute Leukemia
Holter-Chakrabarty, Jennifer; Pierson, Namali; Zhang, Mei-Jie et al

in Biology of Blood & Marrow Transplantation (in press)

Limited clinical data are available to assess whether the sequencing of cyclophosphamide (Cy) and total body irradiation (TBI) changes outcomes. We evaluated the sequence in 1769 (CyTBI, n ¼ 948; TBICy, n ... [more ▼]

Limited clinical data are available to assess whether the sequencing of cyclophosphamide (Cy) and total body irradiation (TBI) changes outcomes. We evaluated the sequence in 1769 (CyTBI, n ¼ 948; TBICy, n ¼ 821) recipients of related or unrelated hematopoietic cell transplantation who received TBI (1200 to 1500 cGY) for acute leukemia from 2003 to 2010. The 2 cohorts were comparable for median age, performance score, type of leukemia, first complete remission, Philadelphia chromosomeepositive acute lymphoblastic leukemia, HLAmatched siblings, stem cell source, antithymocyte globulin use, TBI dose, and type of graft-versus-host disease (GVHD) prophylaxis. The sequence of TBI did not significantly affect transplantation-related mortality (24% versus 23% at 3 years, P ¼.67; relative risk, 1.01; P ¼.91), leukemia relapse (27% versus 29% at 3 years, P ¼ .34; relative risk, .89, P ¼.18), leukemia-free survival (49% versus 48% at 3 years, P ¼.27; relative risk, .93; P ¼ .29), chronic GVHD (45% versus 47% at 1 year, P ¼.39; relative risk, .9; P ¼ .11), or overall survival (53% versus 52% at 3 years, P ¼.62; relative risk, .96; P ¼.57) for CyTBI and TBICy, respectively. Corresponding cumulative incidences of sinusoidal obstruction syndrome were 4% and 6% at 100 days (P ¼ .08), respectively. This study demonstrates that the sequence of Cy and TBI does not impact transplantation outcomes and complications in patients with acute leukemia undergoing hematopoietic cell transplantation with myeloablative conditioning. [less ▲]

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See detailPractical management of Chronic Myeloid Leukemia in Belgium
Benghiat, FS.; Beguin, Yves ULg; Dessars, B. et al

in Belgian Journal of Hematology (in press)

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation ... [more ▼]

Imatinib has drastically changed the outcome of patients with chronic myeloid leukemia (CML), with the majority of them showing a normal life span. Recently, the development of second and third generation tyrosine kinase inhibitors (TKIs) and the possibility of treatment discontinuation made the management of these patients more challenging. In this review, practical management guidelines of CML are presented, adapted to the Belgian situation in 2014. In first line chronic phase patients, imatinib, nilotinib and dasatinib can be prescribed. While second generation TKIs give faster and deeper responses, their impact on long-term survival remain to be determined. The choice of the TKI depends on CML risk score, priority for a deep response to allow a treatment-free remission protocol, age, presence of comorbid conditions, side effect profile, drug interactions, compliance concerns and price. Monitoring the response has to be made according the 2013 ELN criteria, and is based on the bone-marrow cytogenetic response during the first months and on the blood molecular response. Molecular follow-up is sufficient in patients with a complete cytogenetic response. For patients who fail frontline therapy, nilotinib, dasatinib, bosutinib and ponatinib are an option depending of the type of intolerance or resistance. T315I patients are only sensitive to ponatinib, which has to be carefully handled due to cardiovascular toxicity. Advanced phase diseases are more difficult to handle, with treatments including allogeneic stem cell transplantation, which is also an option for patients failing at least two TKIs. The possibility of treatment-free remission and pregnancy are also discussed. [less ▲]

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See detailP.PalauRib. inv. 391 : lettre réutilisée comme exercice d’écriture
Carlig, Nathan ULg

in Coptica Barcinonensia. Texts and Documents from the 5th International Seminar of Coptic Papyrology (Barceloe, 6-13 July 2014) (in press)

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See detail27 entrées du dictionnaire (Adorno, Bataille, Benjamin, Brecht, Burckhardt, etc.)
Hagelstein, Maud ULg

in Talon-Hugon, Carole (Ed.) Dictionnaire des théoriciens de l'art (in press)

Les notices du dictionnaire que je prends en charge : Adorno, Bataille, Benjamin, Burckhardt, Cassirer, Chastel, Deleuze, Dilthey, Faure, Focillon, Foucault, Francastel, Freud, Kracauer, Luckacs, Malraux ... [more ▼]

Les notices du dictionnaire que je prends en charge : Adorno, Bataille, Benjamin, Burckhardt, Cassirer, Chastel, Deleuze, Dilthey, Faure, Focillon, Foucault, Francastel, Freud, Kracauer, Luckacs, Malraux, Nietzsche, Panofsky, Riegl, Rousseau, Simmel, Valery, Vasari, Winkelman, Wölfflin, Worringer, Warburg. [less ▲]

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See detailThe Childhood Executive Function Inventory (CHEXI): Confirmatory Factor Analyses and Cross-Cultural Clinical Validity in a Sample of 8- to 11-Year-Old Children
Catale, Corinne ULg; Meulemans, Thierry ULg; Thorell, Lisa B.

in Journal of Attention Disorders (in press)

The Childhood Executive Functioning Inventory (CHEXI) is a new rating instrument for executive functioning developed by Thorell and Nyberg (2008). Through exploratory factor analyses, this inventory has ... [more ▼]

The Childhood Executive Functioning Inventory (CHEXI) is a new rating instrument for executive functioning developed by Thorell and Nyberg (2008). Through exploratory factor analyses, this inventory has been shown to tap into working memory and inhibition-related behaviors in young children. In this study, we present the psychometric characteristics of the French adaptation of the CHEXI in 8- to 11-year-old children. In addition, we explore the cross-cultural validity of the CHEXI in discriminating between children with ADHD and normally developing children in two culturally different samples (Belgian and Swedish). Confirmatory factor analyses replicated the two-factor solution, referred to as inhibition and working memory, that was identified in the original study with Swedish children. Supplementary analyses indicated that both subscales have good psychometric properties. From a clinical point of view, the CHEXI was found to discriminate, with high sensitivity and specificity, between children with ADHD and normally developing controls in both cultural samples. Cross-cultural clinical implications are discussed. [less ▲]

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See detailCircadian and homeostatic regulation of sleepiness and cognition and its neuronal underpinnings
Schmidt, Christina; Chellappa, Sarah Laxhmi ULg; Cajochen, Christian

in Garbarino, Sergio (Ed.) Sleepiness and Human Impact Assessment (in press)

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See detailCircadian Rhythm Sleep Disorder: Genetic and Environmental Factors
Chellappa, Sarah Laxhmi ULg; Viola, Antoine; Mongrain, Valerie

in Kushida, Clete (Ed.) Encyclopaedia of Sleep (in press)

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See detailMass-spectrometry-based method for screening of new peptide ligands for G-protein-coupled receptors
Cologna Takeno, Camila; Gilles, Nicolas; Echterbille, Julien ULg et al

in Analytical and Bioanalytical Chemistry (in press)

G-protein-coupled receptors (GPCRs) constitute the largest family of transmembrane proteins. Although implicated in almost all physiological processes in the human body, most of them remain unexploited ... [more ▼]

G-protein-coupled receptors (GPCRs) constitute the largest family of transmembrane proteins. Although implicated in almost all physiological processes in the human body, most of them remain unexploited, mostly because of the lack of specific ligands. The objective of this work is to develop a new mass-spectrometry-based technique capable of identifying new peptide ligands for GPCRs. The strategy is based on the incubation of cellular membranes overexpressing GPCRs with a mixture of peptides that contains potential ligands. Peptide ligands bind to the receptors, whereas other peptides remain in the binding buffer. Bound peptides are eluted from membranes and directly detected, identified, and characterized by MALDI TOF–TOF. The results reveal the efficacy of the procedure for selecting a specific ligand of GPCRs in both simple and complex mixtures of peptides. This new approach may offer direct purification, identification, and characterization of the new ligand in a single workflow. The proposed method is labeling-free and, unlike radio-binding and other techniques, it does not require a previously known labeled ligand of the studied GPCR. All these properties greatly reduce the experimental constraints. Moreover, because it is not based on the principle of a competitive specific binding, this technique constitutes a new tool to discover new ligands not only for known GPCRs, but also for orphan GPCRs [less ▲]

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See detailNegentiende-eeuwse anglofilie in Nederland
Steyaert, Kris ULg

in Spiegel der Letteren (in press), 57(3),

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See detailNeurophysiological basis of sleep and wakefulness
Chellappa, Sarah Laxhmi ULg; Schmidt, Christina; Cajochen, Christian

in Garbarino, Sergio (Ed.) Sleepiness and Human Impact Assessment (in press)

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See detailTwo time pieces for sleep regulation: the circadian clock and the homeostatic hourglass
Cajochen, Christian; Schmidt, Christina; Chellappa, Sarah Laxhmi ULg

in Garbarino, Sergio (Ed.) Sleepiness and Human Impact Assessment (in press)

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See detailThe mata'a and the "collapse hypothesis"
Flas, Damien ULg

in De Dapper, Morgan; Cauwe, Nicolas; Huyghe, Dirk (Eds.) Easter Island. Collapse or Transformation ? A State of the Art. Proceedings of the International Conference of Bruxelles (November 9th-10th 2012) (in press)

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See detailEvolution of Treatment and Investigative Approaches in Sleep Medicine
Ly, Julien; Chellappa, Sarah Laxhmi ULg; MAQUET, Pierre ULg

in Billiard, Michael (Ed.) Sleep Medicine: a comprehensive guide (in press)

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See detail« Observation relative au poème Un Coup de Dés jamais n’abolira le Hasard par Stéphane Mallarmé » : une préface d’un nouveau genre ?
Durand, Pascal ULg

in Björn-Olav, Dozo; Saint-Amand, Denis (Eds.) Jeux et enjeux de la préface (in press)

L’« Observation relative au poème UN COUP DE DÉS JAMAIS N’ABOLIRA LE HASARD », rédigée expressément à la demande de la rédaction de la revue Cosmopolis qui en avait procuré l’édition originale sous une ... [more ▼]

L’« Observation relative au poème UN COUP DE DÉS JAMAIS N’ABOLIRA LE HASARD », rédigée expressément à la demande de la rédaction de la revue Cosmopolis qui en avait procuré l’édition originale sous une première forme, est depuis lors, assez improprement, considérée et lue comme une « préface » au Coup de dés dans sa version définitive. Émanant d’un poète ayant marqué plus d’une fois la vive défiance que lui inspirait le geste de la préface, elle doit plutôt être lue, tout d’abord, comme un texte de circonstance imposé par des contingences éditoriales et comme un commentaire visant à assurer la lisibilité d’un texte monstre en le rabattant sur des codes reçus. Examinée sous l’angle de sa construction et de son dispositif d’énonciation, cette « Observation » tient sans doute moins, en outre, d’une préface apportée après coup à un « poème » que d’un manifeste esthétique faisant « observer » et se lever, à l’horizon du texte, l’émergence d’un genre poétique sans précédent. [less ▲]

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See detailThe Emergence of The Possessive Determiner in Ancient Egyptian
Sojic, Nathalie ULg

in Grossman, Eitan; Polis, Stéphane (Eds.) Possession in Ancient Egyptian (in press)

This paper deals with adnominal possession in Ancient Egyptian, focusing on constructions involving a pronominal possessor. In early Egyptian, a single construction is attested: substantive (possessee ... [more ▼]

This paper deals with adnominal possession in Ancient Egyptian, focusing on constructions involving a pronominal possessor. In early Egyptian, a single construction is attested: substantive (possessee) + bound person marker (possessor). From the 6th Dynasty onwards, a new construction, which is built from a demonstrative determiner, appears: pAy + bound person marker (possessor) + substantive (possessee). In order to describe the gradual encroachment of the innovative possessive determiner pAy-f on the older construction with the possessive bound person marker, this study proposes a discourse-oriented analysis, using the notion of ‘subjective deixis.’ [less ▲]

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See detailTransgressions conservatrices. Les constituants du discours « néo-réactionnaire »
Durand, Pascal ULg; Sindaco, Sarah ULg

Book published by CNRS éditions (in press)

Extrait de l'introduction générale au volume : « La fortune journalistique de l’appellation “nouveaux réactionnaires” doit très certainement beaucoup au paradigme dont elle relève, qui met le collectif ... [more ▼]

Extrait de l'introduction générale au volume : « La fortune journalistique de l’appellation “nouveaux réactionnaires” doit très certainement beaucoup au paradigme dont elle relève, qui met le collectif ainsi désigné en balance avec d’autres courants littéraires, intellectuels et politiques agrégés de même, depuis près d’un demi-siècle, sous l’invocation de la nouveauté : “nouveaux romanciers” des années 1950-1960, “nouvelle critique” des années 1960-1970, “nouveaux philosophes” et “nouvelle droite” des années 1970-1980. Il va sans dire que cette appellation, produit d’une construction éditoriale à haute intensité polémique, et productrice elle-même de puissants effets de construction, oppose à toute analyse du phénomène social et idéologique qu’elle entend recouvrir les obstacles qu’installent en règle très générale les objets qui semblent s’offrir spontanément à l’appréhension. C’est pourquoi – et en raison même des effets produits par cette pré-construction, et aussi du caractère de plus en plus saillant et donc banal de thèmes qui, depuis 2002, sont devenus des lieux communs du débat public –, les contributions rassemblées dans le présent volume ont été organisées de façon à répondre à un triple effort de construction raisonnée de l’objet : construction généalogique et morphologique d’abord ; construction thématique et discursive ensuite ; construction métalittéraire enfin, dans la mesure où, comme on le verra, le débat autour des « néo-réactionnaires » et les débats qu’alimentent volontiers ceux qui sont ainsi visés, à tort ou à raison, s’inscrivent dans une tradition très française de la littérature ou des prétentions à l’éthos littéraire. » [less ▲]

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See detailSynthesis of polyphosphodiesters by ring-opening polymerization of cyclic phosphates bearing allyl phosphoester protecting groups
Clément, Benoit; Molin, Daniel G.; Jérôme, Christine ULg et al

in Journal of Polymer Science. Part A-1, Polymer Chemistry (in press)

The allyl phosphoester group is shown to be a protecting group for the synthesis of anionic polyphosphodiesters. Our strategy relies on the synthesis of a cyclic phosphate monomer bearing a pendant allyl ... [more ▼]

The allyl phosphoester group is shown to be a protecting group for the synthesis of anionic polyphosphodiesters. Our strategy relies on the synthesis of a cyclic phosphate monomer bearing a pendant allyl phosphoester group, its easy purification by fractional distillation, its organocatalyzed ring-opening polymerization by 1,8-diazobicyclo[5.4.0]undec-7-ene (DBU) and 1-[3,5-bis(trifluoromethyl)phenyl]-3-cyclohexyl-thiourea (TU). Finally, the deprotection of the allyl phosphoester group is carried out by reaction with sodium benzenethiolate in the absence of any detectable degradation. [less ▲]

Detailed reference viewed: 36 (1 ULg)