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Peer Reviewed
See detailThe « boring billion » : an exciting time for early eukaryotes !
Javaux, Emmanuelle ULg; Beghin, Jérémie ULg; Houzay, JP et al

Conference (2013, August)

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See detailRecipes of the self. Moroccan women and culinary practices in migration context.
Mescoli, Elsa ULg

Scientific conference (2013, August)

This paper aims at exploring the culinary practices exerted by Moroccan women living in Milan's (Italy) hinterland, highlighting their role in the definition of one’s own identity in the context of ... [more ▼]

This paper aims at exploring the culinary practices exerted by Moroccan women living in Milan's (Italy) hinterland, highlighting their role in the definition of one’s own identity in the context of migration. The analysis will focus on the praxeological and material basis of female agency and on the role of the concept of “style” in the dynamics and processes studied. In the context of the everyday life of some Moroccan women living in a city of the province of Milan (Italy), cooking practices play a fundamental role, because of their importance in the construction of personal and collective identities. The ethnographic work reveals that the choice of the used objects and the performing of precise gestures reflect a dynamical positioning between two poles. On the one hand a commitment to the home country’s culinary traditions is needed to overcome a state of disorientation due to being perceived as a foreigner in Italy as in Morocco; on the other hand taking a distance of these same practices is functional to adhere to the "modernity" rules or the dietary ones. Within these processes, the active dialogue with the concept of Moroccan “style”, defined locally as transnationally, results as a crucial factor. The life stories collected and the material culture analyzed reveal in fact singular strategies of self-definition, which allow women to exercise their own agency both in the family context and in public spaces. [less ▲]

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See detailDam break flow modelling with uncertainty analysis
Dewals, Benjamin ULg; Erpicum, Sébastien ULg; Pirotton, Michel ULg et al

in Gourbesville, Philippe; Cunge, Jean; Caignaert, Guy (Eds.) Advances in Hydroinformatics (2013)

Handling uncertainties in dam break flow modelling is of primary interest. Therefore, a procedure is presented here to conduct systematic analysis of the uncertainties resulting from the roughness ... [more ▼]

Handling uncertainties in dam break flow modelling is of primary interest. Therefore, a procedure is presented here to conduct systematic analysis of the uncertainties resulting from the roughness coefficient, the breaching hydrograph and topographic data. The flow simulations have been conducted with the model WOLF 2D developed at the University of Liege. This two-dimensional flow model is computationally too costly to perform a high number of repeated runs, as needed for Monte Carlo simulations. Therefore, a “reduced complexity model” has been set up, in the form of multidimensional Hermite polynomials. This method, developed by Isukapalli et al. (2004) and first applied to dam break flow by Niemeyer (2007), involves a reduced number of runs of the complete model to calibrate the polynomials. This paper shows the applicability and efficiency of the methodology, but it also discusses previously unreported shortcomings of the approach, together with hints to overcome them. Results of such uncertainty analysis for dam break flow modelling disclose crucial information for practical risk management. In particular, they reveal that the uncertainty ranges on maximum water depth and time of arrival of the front are not symmetric (overestimation vs. underestimation) and very unevenly distributed in space. [less ▲]

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See detailComparison of three NDT techniques for the inspection of aeronautic composite structures
Dubé, Robin; Scheed, Laurent; Lewandoswki, Jacques et al

Conference (2013, July 28)

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See detailEquivalence of weighted likelihood and Jeffreys modal estimation of proficiency under polytomous item response models
Magis, David ULg

Conference (2013, July 23)

This talk focuses on two proficiency level estimators in item response theory (IRT) framework: the weighted likelihood estimator (WLE) and the Jeffreys modal estimator (JME), that is, the usual Bayes ... [more ▼]

This talk focuses on two proficiency level estimators in item response theory (IRT) framework: the weighted likelihood estimator (WLE) and the Jeffreys modal estimator (JME), that is, the usual Bayes modal estimator with Jeffreys’ non-informative prior. With dichotomously scored items, the WLE and the JME are completely equivalent under the two-parameter logistic model, while remarkable relationships were established under the three-parameter logistic model. The purpose of this talk is to extend such comparison to polytomously scored items. It is shown that both WLE and JME are also equivalent for two broad classes of polytomous IRT models, including, among others, the (modified) graded response model, the (generalized) partial credit model, the rating scale model and the nominal response model. Parallelisms with dichotomously scored items are drawn. An example from a real data set is used to illustrate this finding. [less ▲]

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See detailFranz Thedieck (1900-1995): Zur Biographie eines "rationalen Propagandisten" im 20. Jahrhundert
Brüll, Christoph ULg

Scientific conference (2013, July 17)

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See detailEpigenetic regulation of angiogenesis
Shiva Shankar, Thammadihalli Veerasangaiah ULg

Doctoral thesis (2013)

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See detailAnalysis of solar air-conditioning systems and their integration in buildings
Thomas, Sébastien ULg

Doctoral thesis (2013)

Due to economical and environmental concerns, the energy e fficiency of buildings nowadays has proven to play an increasingly important role. To satisfy the occupants comfort, the cooling of buildings ... [more ▼]

Due to economical and environmental concerns, the energy e fficiency of buildings nowadays has proven to play an increasingly important role. To satisfy the occupants comfort, the cooling of buildings generally involves a considerable consumption of electricity. Solar radiation, which is a free and renewable resource, is linked to the cooling needs of buildings. This work consists in the evaluation, from an energy-saving and economical point of view, of a potential use of solar energy for air-conditioning in residential and o ffice buildings. It includes an integral approach of solar air-conditioning, involving the analysis of the buildings cooling needs, the cold production devices, the solar collector fields and climates. This analysis is supported by simulations and experimental setups. The study of solar air-conditioning systems already available on the market or in laboratories reveals their operational principles as well as their main performance indicators. Two main solar cooling paths are investigated: a thermal and a photovoltaic conversion of solar energy. Besides this, the performance of the entire air-conditioning system broadens the question of the energy performance to the interactions between the diff erent parts of the system. The building thermal loads (heating, cooling, domestic hot water) of some theoretical residential and o ffice buildings are computed in a part of this work dealing with the influence of the comfort model, the building energy performance level and the climate. What comes across through this analysis is that, the location of the buildings put aside, the cooling load is greatly influenced by the envelope thermal performance and the internal gains. The cooling systems involving absorption or adsorption or vapour compression chiller cooling machines are simulated for the previously defi ned building cases. The use of solar energy through thermal collectors for heating meets higher primary energy savings than for cooling. In all cases, the thermally driven system achieves a lower energy and economical performance than a vapour compression chiller partially supplied with a photovoltaic field. Some real scale testing of solar air-conditioning systems was carried out in Arlon (Belgium). A thermally driven adsorption chiller and a vapour compression chiller with a photovoltaic grid-connected fi eld were operated during the cooling season. The measurements made during this experiment and their analysis manage to discover every thermal and electrical energy flows of the systems leading to a new adsorption chiller model. Concerning the comparison with the simulations, the main point of interest is the consumption of electricity dedicated to thermally driven systems, which is two times higher in real scale conditions. The results obtained from the monitoring campaigns corroborate the simulation results about system comparison. [less ▲]

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See detail3D Modeling of Thin Resistive Sheets in the Discontinuous Galerkin Method for Transient Scattering Analysis
Boubekeur, Mohamed; Kameni, Abelin; Bernard, Laurent et al

in Proceedings of the 19th Conference on the Computation of Electromagnetic Fields (COMPUMAG 2011) (2013, July 03)

This papers presents a modeling of thin resistive sheets. An interface condition is used to avoid the fine mesh. The electromagnetic fields are computed with a time domain Discontinuous Galerkin method in ... [more ▼]

This papers presents a modeling of thin resistive sheets. An interface condition is used to avoid the fine mesh. The electromagnetic fields are computed with a time domain Discontinuous Galerkin method in order to evaluate the shielding effectiveness. A 3D cavity is treated to illustrate the efficiency of the condition. [less ▲]

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See detailOptimalisation de la radiosynthèse et production au niveau de la curie d'acides aminés aromatiques marqués au fluor-18
Libert, Lionel ULg

Doctoral thesis (2013)

6-[18F]fluoro-L-dopa (FDOPA) and 2-[18F]fluoro-L-tyrosine (FTYR) are useful radiopharmaceuticals for evaluation by positron emission tomography (PET) of the dopaminergic function and oncological studies ... [more ▼]

6-[18F]fluoro-L-dopa (FDOPA) and 2-[18F]fluoro-L-tyrosine (FTYR) are useful radiopharmaceuticals for evaluation by positron emission tomography (PET) of the dopaminergic function and oncological studies, respectively. In comparison to electrophilic synthesis, the no-carrier-added (nca) nucleophilic preparation of these 2 radiopharmaceuticals, described in 2004 by Lemaire et al, has several advantages such a high batch yield and high specific activity. However, this nca enantioselective synthesis using a chiral phase-transfer catalyst requires some chemicals (i.e. corrosive HBr gas) arduous to handle and store and reactions at low and high temperature (0°C, 200°C) difficult to implement into a commercially available synthesizer. Important chemical improvements, realized during this PhD thesis, having resulted in straightforward automation of FDOPA and FTYR synthesis, in a commercially available FASTLab module (GE healthcare) are presented. The first significant improvement to the synthesis has consisted in the development of a fast and reliable method suitable for the preparation of (substituted) [18F]fluorobenzyl halides from several [18F]fluorobenzaldehydes. Aromatic nucleophilic substitution of trimethylammonium benzaldehyde triflate and nitro precursors were realized with nca [18F]fluoride. After labeling, [18F]fluorobenzaldehydes were trapped on a Solid Phase Extraction (SPE) cartridge and the subsequent conversion (reduction and halogenation) into benzyl halides was directly realized, on-line, on the support. Reduction of the aldehydes and the following halogenation step were performed with an aqueous solution of NaBH4 and aqueous solutions of concentrated acid (HI, HBr, HCl), respectively. These two near-quantitative reactions proceed at room temperature within 2 minutes at high yields. The second improvement of the nca synthesis of FDOPA and FTYR has consisted in the enantioselective formation of a new carbon-carbon bond by phase-transfer catalysis in presence of a chiral phase-transfer catalyst (PTC) at RT rather than at 0°C. Seven chiral phase-transfer catalysts with a potential high enantioselectivity, at room temperature, for the asymmetric alkylation of a N-(diphenylmethylene)glycine tert-butyl ester have been prepared. Two of these catalysts affords high enantiomeric excess in FDOPA and FTYR (e.e. ≥ 95%) at room temperature and even at 75°C (e.e. ≥ 90%). One is readily available from a cinchona alkaloid and the other one from a biphenyl substrate. The third improvement concerned the hydrolysis step (200°C, 20 min). Different starting precursors with more labile protective groups than the methoxy were synthesized and evaluated. Among these compounds, the isopropyl ether protective group seems the more advantageous. By exploiting the advantages of the improvements to the chemistry described in this work and the potential of the nca approach, the synthesis of FDOPA and FTYR was automated in a FASTlab module with GMP single use cassettes. After 100 min of bombardment (167 GBq) and 63 min of synthesis, more than 50 GBq (1,35 Ci) of 6-[18F]fluoro-L-dopa (e.e. ≥ 96,3%) with a specific activity in excess of 0.75 TBq/µmol are routinely produced. For FTYR, slightly higher yield was obtained. With such reliable production, 6-[18F]fluoro-L-dopa and 2-[18F]fluoro-L-tyrosine are now available for clinical investigation. [less ▲]

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See detailProtein Identification and Quantification in Mixtures of highly-modified Proteins
Dobson, Rowan ULg

Doctoral thesis (2013)

The identification and quantification of proteins in highly-modified mixtures using proteomics has been performed. Two research projects have been undertaken which fulfil this aim. The first comprised the ... [more ▼]

The identification and quantification of proteins in highly-modified mixtures using proteomics has been performed. Two research projects have been undertaken which fulfil this aim. The first comprised the development of quantitative methods to detect trace amounts of hazelnut and soy in complex mixtures. A method for the detection and absolute quantification of Cor a 9, a major hazelnut (Corylus avellana) allergen was developed based on mass spectrometry. One hundred and ten hazelnut proteins were detected, five of which were allergens. The peptide chosen for quantification was from Cor a 9 (11S globulin-like protein). Two specific fragmentation reactions were chosen in multiplexed Selected Reaction Monitoring (SRM). Forty three hazelnut food processing imitation samples, varying a range of factors, such as the temperature and incubation time were analysed. A calibration curve was made for cookies. The developed method was for home-made cookies, shop-bought cookies and chocolate. The quantities of Cor a 9 in each sample were determined from the quantification of the target peptide using isotopic dilution with a heavy isotopically labelled peptide. A second peptide with two transitions was also proven to be a possible alternative as a detection method for hazelnut. The presence of soybean allergens in processed food can be detected using the mass spectrometric identification of a soybean peptide which is resistant to the heating and chemical reactions associated with food processing. The proteomic analysis of soybeans allowed the identification of 11 allergens. A method using a peptide (VFDGELQEGR) from glycinin G1 (Gly m 6.0101) was developed for the detection and semi-quantification of the allergen in food samples. Two specific fragmentation pathways were chosen in selected reaction monitoring for unambiguous identification of glycinin G1 and were: 575.3 903.4 Da and 575.3 788.4 Da. Sixteen imitation samples of processed food spiked with soybean were analyzed, where factors such as temperature and incubation time were varied, and the chosen transitions were detected. The developed method was specific for home-made cookies and a shop-bought biscuit. Semi-quantification from both cooked and uncooked cookies was demonstrated. The second comprised the identification and quantification of conotoxins in the venom of Conus textile by the use of isotope coded affinity tagging (ICAT) and label-free quantification. The extreme variety and complexity of the conotoxins has been insufficiently documented and this research demonstrates the varied nature of conotoxins found in different parts of the venom duct and their patterns of expression. Fifteen conotoxins, several with different post-translational modifications (PTMs), were identified and quantified. Distinctive patterns emerged, with the largest group of conotoxins increasing, then peaking in the central6 proximal part, before decreasing; whilst the second largest group peaked in the distal region, generally displaying nothing in the first parts. A new conotoxin, PCCSKLHDNSCCGL*, was sequenced. [less ▲]

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See detailStratégies et représentations de l'apprentissage du français langue étrangère chez des lycéens vietnamiens : description et étude de leur rapport avec les compétences linguistiques
Nguyen, Huu Binh ULg

Doctoral thesis (2013)

Strategies that language learners use and their beliefs about language learning are fields that have interested many researchers in recent years. So, what are language learning strategies used by ... [more ▼]

Strategies that language learners use and their beliefs about language learning are fields that have interested many researchers in recent years. So, what are language learning strategies used by Vietnamese learners of French as foreign language? What are their beliefs concerning language learning? Is there any relationship between these elements and proficiency? This is what we propose to study in this doctoral work using quantitative approach with three main research tools: the Strategy Inventory for Language Learning (Oxford, 1990), the Beliefs About Language Learning Inventory (Horwitz, 1988) and a linguistic test. We start this research by meeting the important requirement of the cross-cultural validation of the adopted questionnaires. Then, statistical analysis (descriptive and inferential) will allow us to answer to research questions. The results show that Vietnamese learners have limited and varied strategy use and they have different beliefs about the learning of French as a foreign language. Furthermore, the relationship between strategy use and representations, on the one hand, and between these elements and proficiency, on the other hand, is statistically significant. However, it is fairly complex. To conclude this thesis, we will try to provide possible explanations and point out implications. This discussion will lead to some recommendations aimed at different players involved in the teaching/learning of French in Vietnam. [less ▲]

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See detailPlatelet-rich plasma (PRP) to treat chronic upper patellar tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in British Journal of Sports Medicine (2013, July), 47(10 (e3)), 15

Background: Upper patellar tendinopathies remain often chronic and rebel to a thorough conservative treatment. Moreover, the option of a surgical treatment could be disappointing. New treatments are being ... [more ▼]

Background: Upper patellar tendinopathies remain often chronic and rebel to a thorough conservative treatment. Moreover, the option of a surgical treatment could be disappointing. New treatments are being developed. Injection of PRP is one of these. Platelets contain lot of growth factors which would have the potentiality to enhance the healing process of tendons. Even if in vitro and animal experiments have demonstrated this stimulation of tendon healing process1, clinical series are subject to controversy2. Methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments [VAS, clinical examination with an algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and Optojump) and imagery (ultrasounds and MRI)]were made before infiltration of PRP, and 6 weeks and 3 months after. The PRP was obtained by an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a 6-week standardised sub-maximal eccentric reeducation. Results: We observed a very significant improvement of the algofunctional status as soon as 6 weeks after the infiltration of PRP, and continued to a lesser extent up to 3 months. During functional evaluation, pain decreased as well, but without significant improvement of performances. No significant improvements in the imagery were observed. Interestingly, patients who had a VAS equal or below 1 after 3 months post-infiltration were younger (24.7 vs 32.2 y.o.). Moreover, these younger patients had a significant increase of the IKDC score (p=0.003), a significant improvement of pain during isokinetic evaluations (p<0.05), and during Optojump assessments (p=0.01). Seventy-five percent of subjects were able to return to sport, even if only half of these patients recovered the same level than before the tendinopathy. Discussion / Conclusions: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol is efficient to improve symptoms of chronic upper patellar tendinopathies, non-responsive to classical conservative treatments. However, up to now, there is no consensus on the method to prepare the PRP. Indeed, each technique could provide a very different PRP (variations in the platelet concentrations and of the amount of red and white cells). [less ▲]

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See detailProduction at the Curie Level of No-Carrier-Added 6-18F-Fluoro-L-Dopa
Libert, Lionel ULg

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (2013), 54(7),

6-18F-fluoro-L-dopa (18F-FDOPA) has proven to be a useful radiopharmaceutical for the evaluation of presynaptic dopaminergic function using PET. In comparison to electrophilic synthesis, the no-carrier ... [more ▼]

6-18F-fluoro-L-dopa (18F-FDOPA) has proven to be a useful radiopharmaceutical for the evaluation of presynaptic dopaminergic function using PET. In comparison to electrophilic synthesis, the no-carrier-added (NCA) nucleophilic method has several advantages. These include much higher available activity and specific activity. Recently, we have described an NCA enantioselective synthesis using a chiral phase-transfer catalyst. However, some chemicals were difficult to implement into a commercially available synthesizer, restricting access to this radiopharmaceutical to only a few PET centers. Methods: In this paper, 2 important chemical improvements are proposed to simplify production of 18F-FDOPA, resulting in straightforward automation of the synthesis in a commercially available module. Results: First, a fast, simple, and reliable synthesis of 2-18F-fluoro-4,5-dimethoxybenzyl iodide on a solid phase support was developed. Second, a phase-transfer catalyst alkylation of a glycine derivative at room temperature was used to enable enantioselective carbon–carbon bond formation. After hydrolysis and high-performance liquid chromatography purification, a high enantiomeric excess of 18F-FDOPA (~97%) was obtained using a chiral catalyst available from a biphenyl 3 substrate. The total synthesis time was 63 min, and the decay-corrected radiochemical yield was 36% +/- 3% (n = 8). Conclusion: By exploiting the advantages of this NCA approach, using a starting activity of 185 GBq of NCA 18F-fluoride, high activities of 18F-FDOPA (> 45 GBq) with high specific activity (>753 GBq/mmol) are now available at the end of synthesis for use in clinical investigations. [less ▲]

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See detailInvestigation on a ventilation heat recovery exchanger: Modeling and experimental validation in dry and partially wet conditions
Gendebien, Samuel ULg; Bertagnolio, Stéphane ULg; Lemort, Vincent ULg

in Energy & Buildings (2013), 62

The present paper focuses on the development and experimental validation of a model of air-to-air heat exchanger dedicated to domestic mechanical heat recovery ventilation. The proposed model describes ... [more ▼]

The present paper focuses on the development and experimental validation of a model of air-to-air heat exchanger dedicated to domestic mechanical heat recovery ventilation. The proposed model describes dry and partially wet regimes. The first part of the paper presents a semi-empirical model based on the physical characteristics of the heat recovery device and relying on empirical correlations available in the literature for the convective heat transfer coefficients. In the case of partially wet regime, a moving boundary model is applied in order to predict sensible and latent heat transfer rates. A model developed with friction factor coefficients estimated by correlations from the literature is also presented in order to predict the hydraulic performance in dry conditions. The second part of the paper describes the experimental investigation conducted on an off-the-shelf heat exchanger. Experimental data are used to tune correlations for the determination of the convective heat transfer coefficient and validate the proposed simulation model of the ventilation heat recovery exchanger in partially wet conditions. The model developed to determine the hydraulic performance with existing correlations for the friction factor coefficient does not require a calibration. Finally, examples of use of the developed model are presented, which includes coupling the model with a building simulation model, a study of the influence of the humidity on the evolution of the latent and sensible heat transfer rates and strategies to avoid freezing in the heat exchanger. [less ▲]

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See detailA multirate approach to combine electromagnetic transients and fundamental-frequency simulations
Plumier, Frédéric ULg; Geuzaine, Christophe ULg; Van Cutsem, Thierry ULg

Conference (2013, July)

Abstract--- A new multi-rate technique is proposed to combine fundamental-frequency simulation (typical of stability studies) with electromagnetic transients simulation. The objective of this hybrid ... [more ▼]

Abstract--- A new multi-rate technique is proposed to combine fundamental-frequency simulation (typical of stability studies) with electromagnetic transients simulation. The objective of this hybrid approach is to obtain more accurate simulations than with the fundamental-frequency approximation, while saving computing time by applying the detailed model to a subsystem only, in some neighbourhood of the disturbance. It also allows to remove some limitations of fundamental-frequency simulation, such as the difficulty of simulating unbalanced faults. A relaxation technique is used to iterate between both models with simple interfacing. Preliminary results obtained with a 74-bus test system are presented, together with a comparison with full electromagnetic transients simulation. [less ▲]

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See detailNarrateur, personnage et lecteur. Pragmatique des subjectivèmes relationnels, des points de vue énonciatifs et de leur dialogisme
Goin, Emilie ULg

in Cahiers de Narratologie (2013)

Les instances internes au récit que sont le narrateur, le personnage et le lecteur virtuel entretiennent des relations, principalement idéologiques et affectives, que l’on peut décrire d’après une ... [more ▼]

Les instances internes au récit que sont le narrateur, le personnage et le lecteur virtuel entretiennent des relations, principalement idéologiques et affectives, que l’on peut décrire d’après une approche pragma-énonciative et rhétorique. Nous proposons une modélisation du système intra-relationnel du récit et une réflexion sur plusieurs problématiques que pose l’analyse de ces relations : le repérage des subjectivèmes relationnels, l’identification de leurs effets pragmatiques, leur assemblage en un point de vue émanant d’un sujet énonciateur particulier, les différentes articulations possibles entre les points de vue du narrateur et du personnage et leurs effets pragmatiques. D’après cette perspective nous proposons une nouvelle analyse et interprétation du récit La Femme de Gilles de Madeleine Bourdouxhe. [less ▲]

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See detailSimulation and optimization of a CHP biomass plant and district heating network
Sartor, Kevin ULg; Quoilin, Sylvain ULg; Dewallef, Pierre ULg

Conference (2013, July)

Biomass Combined Heat and Power (CHP) plants connected to district heating (DH) networks are recognized nowadays as a very good opportunity to increase the share of renewable sources into energy systems ... [more ▼]

Biomass Combined Heat and Power (CHP) plants connected to district heating (DH) networks are recognized nowadays as a very good opportunity to increase the share of renewable sources into energy systems. However, as CHP plants are not optimized for electricity production, their operation is profitable only if a sufficient heat demand is available throughout the year. Most of the time, pre-feasibility studies are based on peak power demand and business plans only assume monthly or yearly consumption data. This approach usually turns out to overestimate the number of operating hours or oversize the plant capacity. This contribution presents a methodology intended to be simple and effective that provides accurate estimations of economical, environmental and energetic performances of CHP plants connected to district heating networks. A quasi-steady state simulation model of a CHP plant combined with a simulation model of the district heating network installed on the Campus of the University in Liège (Belgium) is used as an application framework to demonstrate the effectiveness of the selected approach. Based on the developed model and actual consumption data, several scenarios for energy savings are considered and ranked. The potential energy savings and resulting energy costs are estimated enabling more general conclusions to be drawn on the opportunity of using district heating networks in urban districts for Western Europe countries. [less ▲]

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