Intervention à la Nuit Sartre - Les biographies existentielles

Conference (2013, June 07)

Innovative Methodology for the Definition of Design Spaces of Chromatographic Methods

Conference (2013, June 06)

As defined by ICH [1] and FDA, Quality by Design (QbD) stands for “a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process ... [more ▼]

As defined by ICH [1] and FDA, Quality by Design (QbD) stands for “a systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quality risk management”. A risk–based QbD–compliant approach is proposed for the robust development of analytical methods. This methodology based on Design of Experiments (DoE) to study the experimental domain models the retention times at the beginning, the apex and the end of each peak corresponding to the compounds of a mixture and uses the separation criterion (S) rather than the resolution (RS) as a Critical Quality Attribute. Stepwise multiple linear regressions are used to create the models. The estimated error is propagated from the modelled responses to the separation criterion (S) using Monte Carlo simulations in order to estimate the predictive distribution of the separation criterion (S) over the whole experimental domain. This allows finding ranges of operating conditions that will guarantee a satisfactory quality of the method in its future use. These ranges define the Design Space (DS) of the method. In chromatographic terms, the chromatograms processed at operating conditions within the DS will assuredly show high quality, with well separated peaks and short run time, for instance. This Design Space can thus be defined as the subspace, necessarily encompassed in the experimental domain (i.e. the knowledge space), within which the probability for the criterion to be higher than an advisedly selected threshold is higher than a minimum quality level. Precisely, the DS is defined as “the multidimensional combination and interaction of input variables (e.g., material attributes) and process parameters that have been demonstrated to provide assurance of quality” [1]. Therefore, this DS defines a region of operating conditions that provide prediction of assurance of quality rather than only quality as obtained with traditional mean response surface optimisation strategies. For instance, in the liquid chromatography there is a great difference in e.g. predicting a resolution (RS) higher than 1.5 vs. predicting that the probability for RS to be higher than 1.5 (i.e. P(RS> 1.5)) is high. The presentation of this global methodology will be illustrated for the robust optimisation and DS definition of several liquid chromatographic methods dedicated to the separation of different mixtures: pharmaceutical formulations, API and impurities/degradation products, plant extracts, separation of enantiomers, … [less ▲]

Bandgap Measurement by Spectroscopic Ellipsometry for Strained Ge1-xSnx

Conference (2013, June 04)

Composition and Thickness Dependence of GeSn Growth by Chemical Vapor Deposition

Conference (2013, June 04)

Numerical Simulation of Double Cup Extrusion Test using the Arbitrary Lagrangian Eulerian Formalism

in Proceedings of Coupled Problems 2013 (2013, June)

Over een toiletartikel: Hendrik van Veldekes 'Sente Servaes' en Camille Huysmans

in Spiegel der Letteren (2013), 55(2), 189-200

In 1858 J.H. Bormans published the first edition of Hendrik van Veldeke’s legend of Saint Servatius which had only just come to light. Nearly forty years later, Camille Huysmans supplied additional ... [more ▼]

In 1858 J.H. Bormans published the first edition of Hendrik van Veldeke’s legend of Saint Servatius which had only just come to light. Nearly forty years later, Camille Huysmans supplied additional information about the work’s discovery. In a humorous letter printed in the Limburgsch jaarboek (1895-1896) he revealed how one of his former teachers, during a visit to a friend’s house, had stumbled upon the fifteenth-century manuscript in the toilet, ready to be used as toilet paper. Only recently have scholars begun to cast doubt on Huysmans’s story. A closer look at Huysmans’s student career in Liège and his involvement in the association Onze Taal (Our Language) may shed new light on the origins and veracity of his account. [less ▲]

Enjeux techniques, symboliques et politiques de la mesure de la diversité dans les entreprises et les organisations?

in Management International = International Management = Gestión Internacional (2013)

Brain metabolic dysfunction in Capgras syndrome during Alzheimer’s disease: a positron emission tomography study

Poster (2013, June)

Intact procedural motor sequence learning in developmental coordination disorder

in Research in Developmental Disabilities (2013), 34(6), 1974-1981

The purpose of the present study was to explore the possibility of a procedural learning deficit among children with developmental coordination disorder (DCD). We tested 34 children aged 6–12 years with ... [more ▼]

The purpose of the present study was to explore the possibility of a procedural learning deficit among children with developmental coordination disorder (DCD). We tested 34 children aged 6–12 years with and without DCD using the serial reaction time task, in which the standard keyboard was replaced by a touch screen in order to minimize the impact of perceptuomotor coordination difficulties that characterize this disorder. The results showed that children with DCD succeed as well as control children at the procedural sequence learning task. These findings challenge the hypothesis that a procedural learning impairment underlies the difficulties of DCD children in acquiring and automatizing daily activities. We suggest that the previously reported impairment of children with DCD on the serial reaction time task is not due to a sequence learning deficit per se, but rather due to methodological factors such as the response mode used in these studies. [less ▲]

Determination of activation yield curves for fusion escaping particle diagnostics

Conference (2013, June)