|
Last 7 days
Post-peak trend in inorganic chlorine (Cly) from Jungfraujoch, ACE-FTS and HALOE infrared solar observationsMahieu, Emmanuel ![]() Conference (2012, October 17) Rencent trend in inorganic chlorine are derived from ground-based and satellite occultation measurements performed in the infrared at Northern mid-latitudes. The consistent slowing down in the rate of ... [more ▼] Rencent trend in inorganic chlorine are derived from ground-based and satellite occultation measurements performed in the infrared at Northern mid-latitudes. The consistent slowing down in the rate of decrease of hydrogen chloride (HCl) and inorganic chlorine (Cly) is presented and possible causes are discussed. [less ▲] Detailed reference viewed: 38 (4 ULg) Single-cell activity and local field potentials in the ventral tegmental area of awake, freely moving rats; Dethier, Julie ; et alPoster (2012, October 16) The ventral tegmental area (VTA) is known to be involved in reward analysis and detection of salience of events. It contains dopaminergic (DA), GABAergic and perhaps other neurons. Much is known about the ... [more ▼] The ventral tegmental area (VTA) is known to be involved in reward analysis and detection of salience of events. It contains dopaminergic (DA), GABAergic and perhaps other neurons. Much is known about the activity of DA neurons in anaesthetized animals and brain slices. However, there is a clear lack of data on their dynamic regulation in awake animals, although their reactivity to drugs of abuse, for example, is dramatically different in these different conditions (Koulchitsky et al., 2012). Moreover, little is known about the network activity of the VTA. <br /><br />Using a telemetric recording system and 8-microelectrode-arrays, spanning most of the extent of the VTA, we observed both single cell activity and local field potentials (LFPs), as recently described by others (Fujisawa and Buzsáki, 2011). Neurons were considered as being DA when their firing rate was decreased by more than 50% by an i.p. injection of 100 µg/kg of quinpirole. <br /><br />The firing rate of individual DA neurons was very variable over time, as was the spectrum of LFPs. In many cases, sharp changes in the firing rate/bursting of some DA neurons correlated with an increase in the amplitude of the theta band (~5-8 Hz). They were also coherent to the locomotor activity of the animals. However, the extent to which the firing rate of individual neurons within a rat correlated with the increased theta rhythm was very variable, suggesting that the functional connectivity of different DA neurons at a given moment is quite heterogenous. We are currently attempting to use our recordings to infer a “functional topography” of the VTA. [less ▲] Detailed reference viewed: 64 (21 ULg) Dynamique spatio-temporelle de Cryptosporidium et de Giardia dans un réservoir d'eau potable et son bassin versant: cas des lacs de barrage de la Haute-Sûre (Luxembourg)Burnet, Jean-Baptiste ![]() Doctoral thesis (2012) Detailed reference viewed: 28 (5 ULg) Vers un système de prédiction du rendement en temps réelDumont, Benjamin ; Ferrandis Vallterra, Salvador ; Leemans, Vincent et alPoster (2012, October 16) L'objectif de cette recherche est le développement d'un outil capable de prédire les rendements d'une culture de blé en temps réel, au fur et à mesure que la saison avance. Pour atteindre cet objectif ... [more ▼] L'objectif de cette recherche est le développement d'un outil capable de prédire les rendements d'une culture de blé en temps réel, au fur et à mesure que la saison avance. Pour atteindre cet objectif, nous avons développé une méthodologie qui repose sur l'adjonction des éléments suivants : (i) le modèle de culture STICS (INRA, France), (ii) un réseau de capteurs sans fil pour le monitoring des variables agro-environnementales (éKo system, The Crossbow technologies, USA) et (iii) une base de données météorologiques. [less ▲] Detailed reference viewed: 33 (11 ULg) Allégorie des médias dans Le Comte de Monte-Cristo : les figures du télégrapheDurand, Pascal ![]() Scientific conference (2012, October 16) Detailed reference viewed: 52 (11 ULg) Qu'est-ce q'un alicament? Débat scientifique et étranges familiaritésHendrickx, Kim ![]() Scientific conference (2012, October 16) Detailed reference viewed: 27 (0 ULg) Comparison of in-line active content determination of polymeric implant by near infrared spectroscopy and Raman spectroscopyKrier, Fabrice ; ; Ziemons, Eric et alPoster (2012, October 16) Detailed reference viewed: 52 (18 ULg) A multiaxial constitutive model for concrete in the fire situation including transient creep and cooling down phasesGernay, Thomas ![]() Doctoral thesis (2012) Purpose - The present thesis aims to develop an efficient and reliable multiaxial concrete model for implementation in finite elements softwares dedicated to the analysis of structures in fire. The need ... [more ▼] Purpose - The present thesis aims to develop an efficient and reliable multiaxial concrete model for implementation in finite elements softwares dedicated to the analysis of structures in fire. The need for proper concrete model remains a very challenging task in structural (fire) engineering because of the complexity of the concrete mechanical behavior characterization and the severe requirements for the material models raised by the development of performance-based design. Methodology - The thesis opted for a phenomenological approach for modeling the thermo-mechanical behavior of concrete. The specifications of the model are based on the study of published experimental data of concrete samples tests and on the specific needs related to the applications in structural fire engineering. With these specifications in mind, a state of the art review of concrete models is conducted in order to choose the general theoretical framework that best fits the criteria for the development of the new model. The thesis presents the theoretical development of the model and its numerical implementation in a finite elements software. Numerical simulations of experimental tests are then performed to verify that the model satisfy the specifications. Findings - The combination of elastoplasticity theory and damage theory allows to develop a phenomenological model suitable for concrete behavior modeling within the pragmatic and robust theoretical framework of continuum constitutive models based on smeared crack approach. The state of damage in concrete, assumed isotropic, is modeled by means of a fourth order damage tensor to capture the unilateral effect. When complex performance-based situations are considered, the effect of transient creep strain at high temperature must be taken into account by an explicit term in the strain decomposition. A generic transient creep model is therefore developed based on experimental data and the model is calibrated to yield the same results as the Eurocode implicit model in simple prescriptive situations. The concrete model comprises a limited number of parameters that can be identified by three simple tests; besides, a standard set of values to be used in predictive calculations is clearly defined for these parameters. Numerical simulations can deal with all stress states as the model is developed as fully three-dimensional. A large number of examples highlight the capabilities of the model that range from the modeling of sample tests to the modeling of large scale composite structures developing membrane action. Limitations – Due to the assumption that damage and plasticity are driven by the same internal variables in the model, a limitation appears for capturing the concrete post-peak behavior in highly confined stress states. This assumption allows for reducing the number of parameter but it restrains the domain of applicability of the model; it is suggested to adopt a different approach if the behavior in multiaxial compression at high confinement level has to be accurately captured. Another limitation of the model is related to the localization issue, which is only partly addressed in this work by means of the regularization of the crack energy. Further works should bring a more elaborated response while considering the case of reinforced concrete structures, in which numerous cracks develop. Finally, several simplifying assumptions have been adopted to restrain the scope of the research; for instance, the phenomenon of spalling has not been considered. Practical implications - The thesis includes implications for the development of advanced numerical tools for the simulation of concrete structures at ambient temperature and at high temperature. The use of such advanced tools in the design may lead to significant reduction in the building costs and to improved robustness of the structures. Value – The thesis contributes to fulfil an identified need to make available proper constitutive concrete model for implementation in finite elements softwares dedicated to the analysis of structures in fire. Special care is given to the numerical robustness of the model and to the clear definition of the material parameters as the model is intended to be used by structural (fire) engineers in real applications. [less ▲] Detailed reference viewed: 73 (29 ULg) Impact du stress sur la justesse d’une performance vocale chez des étudiants de conservatoireLarrouy, Pauline ; Morsomme, Dominique ![]() Conference (2012, October 15) Un haut niveau d’anxiété entraîne des symptômes physiques et cognitifs. Cet état émotionnel peut se répercuter sur les caractéristiques acoustiques de la voix. Cette étude vise à observer l’impact d’une ... [more ▼] Un haut niveau d’anxiété entraîne des symptômes physiques et cognitifs. Cet état émotionnel peut se répercuter sur les caractéristiques acoustiques de la voix. Cette étude vise à observer l’impact d’une situation stressante sur la justesse d’une performance vocale. 31 étudiants (deux niveaux différents) recrutés au sein des Conservatoires Royaux de Belgique ont chanté une mélodie à trois moments de l’année : deux fois en situation calme (T1 et T3) et une fois en situation anxiogène (T2), c’est à dire le jour de l’examen. Nous avons contrôlé le degré d’anxiété par la mesure de la fréquence cardiaque. Un questionnaire nous renseigne sur l’intensité des symptômes cognitifs et somatiques perçus par les étudiants et leur direction (altérant ou facilitant). La précision des intervalles et le maintien de la tonalité ont été mesurés pour chaque production. Nous comparons les scores obtenus lors d’une situation calme et lors de l’examen. Nous observons que la fréquence cardiaque augmente significativement en situation anxiogène (F(2,90) = 12.60 ; p < .001). L’intensité des symptômes cognitifs et somatiques est plus élevée lors de la situation anxiogène mais l’évolution des symptômes somatiques entre T3 et T2 est plus importante pour les étudiants de 2ème année par rapport aux étudiants de 1ère année. Concernant la justesse, les résultats indiquent qu’un état de stress induit une meilleure précision des intervalles chez les étudiants de 1ère année (p = .02) mais altère le maintien de la tonalité chez les élèves de 2ème année (p = .01). En conclusion, une situation d’examen entraîne une augmentation de la fréquence cardiaque mais l’interprétation des symptômes somatiques dépendrait du niveau d’étude. Les conséquences d’une situation anxiogène, tel un examen de solfège, sur la justesse d’une performance vocale, peuvent être bénéfiques mais sont négatives lorsque l’enjeu est important. [less ▲] Detailed reference viewed: 39 (5 ULg) Cumulative time in band (cTIB): glycemic level, variability and patient outcome all in onePenning, Sophie ; ; et alConference (2012, October 15) Detailed reference viewed: 19 (1 ULg) Clinical aspects of alfaxalone use in rabbits. Partial results.Tutunaru, Alexandru-Cosmin ; ; Drion, Pierre et alin BCLAS, ESLAV (Ed.) Proceedings BCLAS, ESLAV & ECLAM Scientific Meeting (2012, October 15) Alfaxalone, a synthetic neuroactive steroid, has been shown to induce smooth general anesthesia in wild and companion rabbits. The aim of the study was to test the effect of alfaxolone in experimental ... [more ▼] Alfaxalone, a synthetic neuroactive steroid, has been shown to induce smooth general anesthesia in wild and companion rabbits. The aim of the study was to test the effect of alfaxolone in experimental rabbits without concomitant oxygen supplementation.Respiratory status was assessed by measuring the duration of the post-induction apnea, the respiratory rate, the oxygen saturation of hemoglobin in the peripheral blood (SpO2) and the end-tidal CO2 (EtCO2) Cardiac function was assessed by monitoring heart rate using a pulse oximeter. The degree of anesthesia was monitored by evaluating ear and paw pinch reflex, as well as ocular signs such as nystagmus, exophtalmia and the loss of palpebral and corneal reflexes. [less ▲] Detailed reference viewed: 67 (17 ULg) A New Approach for Detection Improvement of the Creutzfeldt-Jakob Disorder through a Specific Surface Chemistry Applied onto Titration Wel; ; Zorzi, Willy et alin Biosensors (2012), 2(4), 433-447 This work illustrates the enhancement of the sensitivity of the ELISA titration for recombinant human and native prion proteins, while reducing other non-specific adsorptions that could increase the ... [more ▼] This work illustrates the enhancement of the sensitivity of the ELISA titration for recombinant human and native prion proteins, while reducing other non-specific adsorptions that could increase the background signal and lead to a low sensitivity and false positives. It is achieved thanks to the association of plasma chemistry and coating with different amphiphilic molecules bearing either ionic charges and/or long hydrocarbon chains. The treated support by 3-butenylamine hydrochloride improves the signal detection of recombinant protein, while surface modification with the 3,7-dimethylocta-2,6-dien-1-diamine (geranylamine) enhances the sensitivity of the native protein. Beside the surface chemistry effect, these different results are associated with protein conformation. [less ▲] Detailed reference viewed: 10 (0 ULg) Allergies alimentaires : quel bilan ? Perturbations du comportement alimentaire liées à des résultats d'analyses IgE/IgG alimentairesGADISSEUR, Romy ![]() Conference (2012, October 15) Detailed reference viewed: 14 (1 ULg) Liège entre la France et l'Allemagne : influences et échanges culturelsBrüll, Christoph ; Lanneau, Catherine ![]() Conference (2012, October 13) Detailed reference viewed: 11 (4 ULg) Determination of the molecular players of adaptation to anti-angiogenic therapy in breast cancer by quantitative proteomic and high molecular MALDI Imaging.Cimino, Jonathan ; Sounni, Nor Eddine ; Calligaris, David et alPoster (2012, October 13) Breast carcinoma is the most common and second leading cause of cancer mortality in women. The recognition of the “angiogenic switch” as a rate-limiting secondary step in tumorigenesis led to extensive ... [more ▼] Breast carcinoma is the most common and second leading cause of cancer mortality in women. The recognition of the “angiogenic switch” as a rate-limiting secondary step in tumorigenesis led to extensive pre-clinical researches on angiogenesis and finally the approval of VEGF-neutralizing antibodies (bevacizumab) and VEGF receptor tyrosine kinase inhibitors (RTKs:Sunitinib). The Sunitinib has been used clinically in patients with breast cancer refractory to other therapeutic agents. Unfortunately, like the cytotoxic therapies, these drugs do not produce lasting effects and resistance to treatment appeared clinically. Questions have emerged about the failure of anti-angiogenic therapy in clinic and the limitations of predictive preclinical models, and also about the molecular assessment of all stages of tumor adaptation and me<x>tastatic disease. To this end, we applied quantitative proteomics and imaging mass spectrometry tools to visualize and study the profiles of proteins and small molecules associated with tumor treated or not with Sunitinib using a novel preclinical model of breast carcinoma cells. In this project, we first developed a reproducible model of resistance to Sunitinib of human triple negative breast cancer MDA-MB-231 cells expressing luciferase gene. Cells were subcutaneously injected into mice RAG1-/- and divided into four experimental groups including, control mice treated with vehicle or Sunitinib for 30 days and sacrificed 1 days after treatment withdrawal or when tumor reached a volume of 300 mm3. In the second step. Tumors were analyzed using a nanoAcquity UPLC Synapt TM HDMS TM G1 (Waters, Manchester,UK) and Mass Spectrometry Imaging. For quantitative proteomic analyses of tumors, a bioinformatics analysis was used with the Protein lynx global server 2.2.5 software. Imaging mass spectrometry was performed on tissue sections of tumors and organs subsequently colonized by me<x>tastases. Matrix sublimation was used to coat tumor sections (14 µm-tick) with 1.5 Diaminonaphthalene for lipids analysis and Sinapinic acid for entire proteins analysis. Ion cartographies were recorded with a Solarix 9.4T FTMS instrument for lipids and with an Ultraflex II TOF-TOF instrument for entire proteins (Bruker Daltonics, Germany) with a spatial resolution of 100 µm. Global protemic revealed different protein profiles between tumor treated or not with Sunitinib. The Mass Spectrometry Imaging detected differences in intensity and location of some proteins and lipids are also associated with some histological features including inflammatory, necrotic and angiogenic areas. Bioinformatics analysis will be applied to ensure the integration of all data in order to provide the basis for identifying molecular pathways activated during the acquisition of refractoriness to drug treatments. [less ▲] Detailed reference viewed: 53 (8 ULg) Le mineur en droit médicalNottet, Aurélie ![]() in Genicot, Gilles (Ed.) Nouveaux dialogues en droit médical (2012, October 12) Detailed reference viewed: 32 (6 ULg) Les kératomes: lésions et traitements chez 19 chevauxSalciccia, Alexandra ; de la Rebière de Pouyade, Geoffroy ; Bolen, Géraldine et alConference (2012, October 12) Introduction: Les kératomes, masses hyperplasiques de kératine, croissent entre la phalange distale (P3) et la paroi du sabot et provoquent des boiteries chez le cheval. La littérature comporte de ... [more ▼] Introduction: Les kératomes, masses hyperplasiques de kératine, croissent entre la phalange distale (P3) et la paroi du sabot et provoquent des boiteries chez le cheval. La littérature comporte de nombreux rapports de cas isolés mais peu de séries cliniques. Matériel et méthodes: Les dossiers cliniques des cas de kératomes présentés depuis 2004 à la faculté de médecine vétérinaire de Liège ont été revus. Résultats: Vingt-trois kératomes ont été diagnostiqués sur 19 chevaux boiteux. Un cheval présentait 2 kératomes sur le même pied et 3 chevaux présentaient 2 kératomes sur des pieds différents. Sur les 22 pieds atteints, les lésions observées étaient: un abcès, souvent récidivant (18 cas), une déformation de la muraille (6 cas), une déviation de la ligne blanche (6 cas) et une seime (3 cas). Un kératome était situé sous la sole et 22 sous la muraille. La durée des symptômes variait de 2 semaines à 15 ans (plus d'un an sur 12 pieds). Sur les radiographies, une lyse par compression de P3 était visible en regard de 20 kératomes. Le cheval présentant 2 kératomes sur le même pied a été euthanasié. Trois kératomes ont été traités de manière conservative. Dix-huit kératomes (chez 16 chevaux) ont été excisés chirurgicalement dont 16 par avulsion complète de muraille, 1 par avulsion partielle de muraille et 1 par curetage d'une portion de sole. Aucune complication postopératoire n'a été observée dans 7/18 cas (39%). Les complications rencontrées étaient: une granulation excessive (10 cas), une douleur importante pendant plusieurs jours (5 cas), une légère infection (4 cas), un enfoncement de P3 en regard de la zone avulsée (2 cas) et une récidive (2 cas, dont 1 a été réopéré avec succès ultérieurement). Un cheval est encore en convalescence au moment de cette étude. Le suivi à long terme d’un cheval a été perdu. Des 14 chevaux repris dans l'évaluation postopératoire, 1 a été euthanasié pour une autre raison que le kératome, 3 chevaux ont gardé une boiterie résiduelle au trot et 10 chevaux ont récupéré leur niveau d'activité. Discussion: La littérature décrit les kératomes comme rares1. Or, 21% des chevaux de cette étude (4 chevaux sur 19) présentaient plusieurs kératomes. De plus, dans 54 % des cas, les symptômes duraient depuis plus d’un an. Dès lors, il apparait que les kératomes sont sous diagnostiqués ou le sont souvent tardivement. La chronicité et l’étendue des kératomes de cette étude n’a que très rarement permis leur résection par avulsion partielle de muraille, technique de choix dont les complications postopératoires sont moindres². Un diagnostic précoce par inspection minutieuse des sabots, particulièrement en cas d’abcès de pied récidivant permettrait une excision par une technique moins invasive, qui diminuerait la convalescence et les complications postopératoires. Bibliographie: 1. Sundberg, J.P. et al. Neoplasms of Equidae. Journal of American veterinary medical association, 1977, 170: 150-152. 2. Boys Smith SJ. et al. Complete and partial hoof wall resection for keratoma removal: postoperative complications and final outcome in 26 horses (1994-2004). Equine Veterinary Journal, 2006, 38 (2): 127-133. [less ▲] Detailed reference viewed: 120 (13 ULg) Deciphering Distance-Induced Deceleration of Gait and Ataxia in People with Multiple SclerosisPHAN BA, Remy ; Pierard, Sébastien ; Moonen, Gustave et alPoster (2012, October 12) Detailed reference viewed: 40 (3 ULg) Pierre-François Ladvocat (1791-1854) et l’avènement de l’éditeur littéraire au début du XIXe siècleDurand, Pascal ![]() Scientific conference (2012, October 12) Detailed reference viewed: 17 (3 ULg) Use of MIR spectrometry for technological properties prediction of milk samples from Walloon dairy cowsColinet, Frédéric ; Soyeurt, Hélène ; Gengler, Nicolas et alConference (2012, October 12) Detailed reference viewed: 24 (11 ULg) |
||