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See detailADAM28 - Generation of a conditional ADAM28 knock-out mouse Implication of ADAM28 in metastasis dissemination
Gérard, Catherine ULg; Rocks, Natacha ULg; Carnet, Oriane ULg et al

Poster (2016, October)

Introduction: ADAMs (a disintegrin and metalloproteinase) and ADAMTS proteinases (a disintegrin and metalloproteinase with thrombospondin motifs) are MMP (matrix metalloproteinase) -related enzymes ... [more ▼]

Introduction: ADAMs (a disintegrin and metalloproteinase) and ADAMTS proteinases (a disintegrin and metalloproteinase with thrombospondin motifs) are MMP (matrix metalloproteinase) -related enzymes, bearing a multi-domain structure. ADAM28 is a multipotent membrane-bound proteinase and its expression in tissues derived from the foregut in embryonic tissues suggests its involvement in the organogenesis of the respiratory tract. Moreover, ADAM28 is highly overexpressed in non-small-cell lung cancer samples. Notably through a global proteomic approach, we recently identified an upregulation of ADAM28 after induction of lung inflammation in a mouse model of asthma. In addition to data published in the literature and to our findings about ADAM28 expression in various pathological tissues, intrinsic characteristics of this proteinase argue for considering it as a potential regulator of cellular signalling pathways leading to an inflammatory pulmonary microenvironment and, eventually, to carcinogenesis. Indeed, ADAM28 bears an active catalytic domain and interacts in a non-proteolytic manner with some integrins (α4β1) and some P-selectin ligands involved in inflammatory cell migration. ADAM28 was also reported to display the capacity to cleave key mediators such as Von Willebrand factor, IGFBP3 (Insulin-like growth factor-binding protein 3) and CTGF (Connective Tissue Growth Factor). Very recently, ADAM28 was shown to shed pro-TNF-alpha suggesting an important role in tumour control. The present project aims at characterizing molecular mechanisms leading to tumour development in lungs. In the first part of this work, we intend to characterize the effects of ADAM28 depletion on physiological and pathological processes such as tumor development and metastatic dissemination in ADAM28 conditional knock-out mice. Methods: To understand the implication of ADAM28 in lung tumour development we instillated lungs of mice displaying a full knock-out genotype for ADAM28 with Lewis Lung Carcinoma cells and B16K1 melanoma cells. ADAM28 KO mice were also injected intravenously and a subcutaneously with these tumour cells. Results: There is no spontaneous phenotype for ADAM28 full knock-out animals. Preliminary results show an impaired lung tumors engrafment in ADAM28 wild type animals when compared to heterozygous or knock out littermates. Conclusion: This unique mouse strain provides a very precious tool to further investigate ADAM28 implication in various disease models including tumour growth and dissemination. The role of ADAM28 as a pro-tumor factor is widely described in the literature whereas our results suggest that ADAM28 has an anti-tumor function. [less ▲]

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See detailTempus fugit
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailL’évaluation de la formation : comment la rendre utile pour les participants ? Constats et proposition de cinq stratégies d’évaluation partenariale
Faulx, Daniel ULg; Danse, Cédric ULg

in Evaluer : Journal International de Recherche en Education et Formation (2016), 2(1), 37-52

L’évaluation de la formation par les participants est une pratique courante aujourd’hui, portée à la fois par des exigences de rentabilité et de qualité. Cependant, cet exercice, qui se présente ... [more ▼]

L’évaluation de la formation par les participants est une pratique courante aujourd’hui, portée à la fois par des exigences de rentabilité et de qualité. Cependant, cet exercice, qui se présente souvent sous la forme de questionnaires individuels remis à la fin de la formation, peut être vécu par ceux qui les remplissent comme un rituel obligé mais présentant peu d’intérêt. C’est dans l’intention de proposer une alternative à cette situation que cet article a été rédigé. Dans un premier temps, nous faisons le point sur les modes les plus habituels d’évaluation de la formation par les participants. Nous identifions les récurrences de ce genre de pratique et les questions qu’elles posent. Ensuite, nous avançons cinq manières de procéder à une évaluation de telle sorte qu’elle soit bénéfique tant aux apprenants qu’au formateur. Les propositions sont réparties en deux familles (centrée sur l’activité de l’apprenant et centrée sur le processus de formation). Elles visent, au contraire de ce qui est pratiqué habituellement, à mettre au travail chacun des acteurs, formateur comme apprenants, afin que le moment de l’évaluation constitue une occasion de continuer à apprendre. Cette approche est aussi potentiellement transférable en contexte scolaire lors de l’évaluation des enseignants (ou des enseignements) par les élèves/étudiants. [less ▲]

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See detailLes soins en hôpital de jour : du trou de serrure au jeu de clés…
REUTER, Benjamin ULg; TIBERGHIEN, Céline; Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2016), 18

During a new period of disruption with the hospital-tradition of psychiatric care, the specificity and originality of the Day Hospital remains to be defined. The metaphoric dimension of the therapeutic ... [more ▼]

During a new period of disruption with the hospital-tradition of psychiatric care, the specificity and originality of the Day Hospital remains to be defined. The metaphoric dimension of the therapeutic “passe-partout”, could be appliqued to hospitals which are to this day, part of institutional therapy story: The care teams have effectively replaced the walls to accommodate the most complex mental diseases. Several therapeutic “keys” are well produced and co-constructed with the fundamental goal of allowing the patient to (re) gain freedom-bridges lost under the weight of his psychopathology. Even though in 40 years the Day Hospital continues to evolve and reinvent, it interestingly gets through crises. This ability to overcome crises is seen in the deinstitutionalization crisis where it was handled with stability due to its originality. Stability does not mean stagnation: the daily questioning of the therapeutic work group leads us… Thanks to this article, we will specifically highlight the therapeutic effect observed across the different support models to the Day Hospital. [less ▲]

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See detailGuide du post-partum
Emonts, Patrick ULg

Book published by deboeck (2016)

Guide of the post-partum drafted for the attention of all the persons receiving benefits of care involved in the post-partum. Daily reference tool for all the professionals of French language. Guide du ... [more ▼]

Guide of the post-partum drafted for the attention of all the persons receiving benefits of care involved in the post-partum. Daily reference tool for all the professionals of French language. Guide du post-partum rédigé à l'attention de tous les prestataires de soins impliqués dans le post-partum. Outil de référence quotidien à l'usage de tous les professionnels de langue française. [less ▲]

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See detailA case of added value of 123I-mIBG SPECT/CT imaging in the diagnosis of a pheochromocytoma extending into the left adrenal vein
PAQUES, Florence ULg; HAMOIR, Etienne ULg; LOVINFOSSE, Pierre ULg et al

in Acta Chirurgica Belgica (2016)

We present the case of a 48-year-old patient with a left adrenal incidentaloma found on computed tomography (CT) for which the diagnosis of pheochromocytoma was confirmed by a 24-hour urinary dosage of ... [more ▼]

We present the case of a 48-year-old patient with a left adrenal incidentaloma found on computed tomography (CT) for which the diagnosis of pheochromocytoma was confirmed by a 24-hour urinary dosage of norepinephrine. The 123I-mIBG scintigraphy showed a high uptake of 123I-mIBG in the left adrenal gland and, additionally, the single photon emission computed tomography combined with a low-dose CT (SPECT/CT) suggested the extension into the adrenal vein. The diagnostic CT and magnetic resonance images agreed with these findings and the subsequent surgery confirmed the vascular invasion. [less ▲]

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See detailIntroduction à AquaCrop: élaboration de calendriers d'irrigation
Wellens, Joost ULg

Scientific conference (2016, October)

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See detailUnexpected high levels of Cobalamin (Vitamin B12): Numerous interferences are decreased by PEG treatment.
LADANG, Aurélie ULg; VRANKEN, Laura ULg; CAVALIER, Etienne ULg

Poster (2016, October)

Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies ... [more ▼]

Cobalamin (Vitamin B12) deficiency is a common cause of anemia. High levels of serum cobalamin is mainly due to cobalamin supplementation. It has also been associated with hematological malignancies, liver or renal diseases. Cobalamin is sometimes found elevated in autoimmune disorders and infectious diseases but concerns are raised on the fact that those serum increases might be due to interference with immunoassays. Those data’s shed the lights on the high prevalence of interference in patients with unexpected high cobalamin level. Precipitation with PEG appears to be an easy and costless method to increase the reliability of cobalamin dosage. In accordance with our results, we recommand to treat systematically every serum with a cobalamin >1500 ng/L. [less ▲]

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See detailLong-Term Results of 18 Fat Injections in Unilateral Vocal Fold Paralysis
PAGANO, Rémi ULg; Morsomme, Dominique ULg; CAMBY, Séverine ULg et al

in Journal of Voice (2016)

Summary: Objective. The purposes of this study were to assess the long-term efficacy of medialization laryngo- plasty via injection of autologous fat in patients with unilateral laryngeal paralysis, and ... [more ▼]

Summary: Objective. The purposes of this study were to assess the long-term efficacy of medialization laryngo- plasty via injection of autologous fat in patients with unilateral laryngeal paralysis, and to discuss the results based on the volume of fat injected and the size of the initial glottic gap. Study design. This was a retrospective study with clinical reevaluation of 18 patients treated for unilateral laryn- geal paralysis at Liège University Hospital between April 1, 2011, and December 1, 2014. Method. The voice examination included subjective scales (GRBAS and the Voice Handicap Index), a report on acous- tic and aerodynamic voice parameters, and laryngostroboscopic assessment of glottic closure and mucosal wave (T0: preoperative; T1: immediate postoperative; T2: >1 year). Results. The median follow-up duration was 19 months. We observed a significant improvement in maximum pho- nation time; mean flow rate; jitter; the Voice Handicap Index; the G, R, B, and A subscales of the GRBAS-I; and glottic closure at T1. These parameters remained stable over time, without any significant difference except for shimmer and glottic closure between T1 and T2. Regardless of the volume of fat injected and the magnitude of the initial glottic gap, we did not see any significant difference from one assessment time to another. Conclusion. Medialization laryngoplasty by means of the injection of autologous fat is a safe, effective surgical tech- nique for patients with unilateral laryngeal paralysis regardless of the size of the initial glottic gap. The results are maintained longer than 1 year, and no evidence of significant resorption of the fat was found in our study over a period of 12–58 months. The volume of fat injected does not seem to affect the functional results. Key Words: Glottic insufficiency–Glottic closure–Glottic gap–Laryngeal paralysis–Vocal fold paralysis–Laryngoplasty– Autologous fat–Fat injection. [less ▲]

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See detailStudy of the SV2A protein role in Epilepsy.
Bartholomé, Odile ULg; Van Den Ackerveken, Priscilla ULg; Wislet, Sabine ULg et al

Poster (2016, October)

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See detailUsing images to analyze images. Semiotics meets Cultural Analytics
Dondero, Maria Giulia ULg

in Reyes-Garcia, Everardo; Châtel-Innocenti, Pierre; Zreik, Khaldoun (Eds.) Archiving and Questioning Immateriality - Proceedings of the 5th Computer Art Congress (2016, October)

In our text we examine image visualizations generated from big collections of archived images produced by Lev Manovich and his team in the field of Cultural Analytics. Our aim is to examine how these ... [more ▼]

In our text we examine image visualizations generated from big collections of archived images produced by Lev Manovich and his team in the field of Cultural Analytics. Our aim is to examine how these image visualizations function as analysis-images from two correlated perspectives of one semiotic approach: 1. Enunciation. What point of view is conveyed by the image visualizations about the computer-manipulated archive images? 2. Rhetorical/mereological composition: What is the mereological relation between the final visualization and the multitude of images that it contains, filters, or manipulates? [less ▲]

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See detailInterview d'Hassan Bousetta, Chercheur FNRS au CEDEM
Bousetta, Hassan ULg

Article for general public (2016)

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See detailL'image peut-elle nier?
Dondero, Maria Giulia ULg; Badir, Sémir ULg

Book published by presses universitaires de Liège (2016)

L’image peut-elle nier ? La question est en apparence toute simple et attendrait une réponse catégorique, oui ou non. Si pourtant, dans le présent ouvrage, des linguistes, des sémioticiens, des ... [more ▼]

L’image peut-elle nier ? La question est en apparence toute simple et attendrait une réponse catégorique, oui ou non. Si pourtant, dans le présent ouvrage, des linguistes, des sémioticiens, des philosophes, des spécialistes des arts visuels et audiovisuels se sont penchés sur cette question, c’est qu’en réalité tout fait problème en elle. Car répondre à une telle question, cela consisterait d’abord à déterminer les conditions dans lesquelles elle se pose. Qu’appelle-t-on « nier » et qu’appelle-t-on « image » ? Et selon quel corpus d’images ? Peut-on donner une réponse unique à la diversité de ses domaines d’usage : les arts, les religions et les sciences, ainsi que de ses genres (portrait, nature morte, etc.) ? Les contributeurs du présent volume explorent différentes sortes de supports médiatiques et d’objets visuels : expériences picturales contemporaines, photographie, films, peinture chinoise, mais aussi peinture religieuse médiévale, pictographies esquimaudes de la fin du XIXe siècle ou hiéroglyphes égyptiens. Une première partie, intitulée « L’énonciation en image », explore les relations entre la négation dans l’image et la théorie de l’énonciation comme celle-ci est revisitée par la sémiotique contemporaine. Une seconde, ayant pour titre « Du langage verbal aux images », s’attache à des comparaisons entre les sens de la négation dans différentes langues et grammaires et leurs cultures visuelles respectives. Les comparaisons inévitables avec d’autres lieux d’exercice de la négation — à savoir les langages formels et les langues verbales — et l’examen des transferts conceptuels non moins indispensables que ces comparaisons suscitent mettent ainsi à l’épreuve d’une question le statut ontologique de l’image. [less ▲]

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See detailOrganisation du post-partum à la sortie- Besoins spéciaux- Suivi des enfants à risque
RIGO, Vincent ULg

in Barlow, P; Ceysens, G; EMONTS, Patrick (Eds.) et al Guide du post-partum (2016)

Bien que la majorité des enfants ne nécessitent qu’un suivi de médecine préventive classique, différentes situations imposent une attention particulière pour permettre un dépistage et une prise en charge ... [more ▼]

Bien que la majorité des enfants ne nécessitent qu’un suivi de médecine préventive classique, différentes situations imposent une attention particulière pour permettre un dépistage et une prise en charge précoce. La discussion qui précède ne peut évidement être complète, et a pour but de rappeler des conditions fréquentes ou exemplatives. La recherche et la transmission des informations pendant la grossesse favorise la planification et la mise en place du suivi dès avant la naissance. Une communication adéquate entre les équipes anténatales, néonatales, pédiatriques et de post-partum permet d’améliorer l’organisation et l’efficacité des soins. Pour les intervenants du post-partum, la connaissance des conditions qui requièrent une attention particulière permet aussi de rappeler et renforcer les étapes initiales de prise en charge auprès des parents. [less ▲]

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See detailInternational Trade Sanctions related to Dual-Use Goods and Technologies
Colussi, Ilaria Anna ULg

in Athens Journal of Law (2016), 2(4), 237-252

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations when the object of trade is constituted by strategic items, such as dual-use items, which may ... [more ▼]

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations when the object of trade is constituted by strategic items, such as dual-use items, which may have peaceful (civilian/commercial) or non peaceful/military applications. Trade of these categories of goods needs to be controlled, as they can provoke security concerns. Such control is pursued through control lists, licenses, authorizations to stakeholders of the supply chain, information- sharing and cooperation mechanisms, reports, records, declarations, screenings and sanctions as well. The paper aims at focusing on the issue of sanctions, in particular the ones established at the international level: these measures are provided for the violation of trade rules in reference to dual-use items, and/or sanctions have as an object this type of goods. The legal provisions established by the World Trade Organization (WTO) and at the United Nations level are analysed thereafter. Brief observations are offered as regards the EU framework of restrictive measures too. [less ▲]

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See detailPrimary Care Physicians’ Action Plans for Answering to Results of Screening Test based on the Concept of Quaternary Prevention
Bae, Jong Myon; Jamoulle, Marc ULg

in Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi (2016), 49(6), 343-348

Since non-communicable disease (NCD) should be controllable rather than curable, more emphasis is placed on prevention, rather than on treatment. For early detection of diseases, a primary care physician ... [more ▼]

Since non-communicable disease (NCD) should be controllable rather than curable, more emphasis is placed on prevention, rather than on treatment. For early detection of diseases, a primary care physician (PCP) as well as general practitioner and family physician should interpret screening results accurately and provide screenees with appropriate information of prevention and treatment including potential harms. The concept of quaternary prevention (QP), which was introduced by Jamoulle and Roland in 1995 was applied to screening results. This article summarizes situations that PCPs encounter during screening tests according to the concept of QP, and suggests measures to face such different situations. Suggestions for screening tests customized to the characteristics of individuals are substituting suggestions for screening based on guidelines. Since there are some circumstances that screening tests should not be done, further studies based on the concept of prevention level proposed by Jamoulle and Roland are required to draw various and useful prevention strategies to prevent NCDs, including cancers. Thus, applying the concept of QP helps PCPs have better insights on screening tests for preventing NCD and also contributes to improve doctor-patient relationship by helping screenees understand medical uncertainties. Key [less ▲]

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See detailOrganizaciones regionales y diversidad cultural: la diplomacia de la Unión Europea con el Mercosur entre la sombra de Hollywood y la acción intergubernamental
Vlassis, Antonios ULg

in Cuadernos de Información y Comunicación (2016), 21

Abstract. The aim of the article is double: on the one hand, to explore the EU’s ability to conduct a foreign audiovisual policy towards the Mercosur region and to promote the norms of the Convention on ... [more ▼]

Abstract. The aim of the article is double: on the one hand, to explore the EU’s ability to conduct a foreign audiovisual policy towards the Mercosur region and to promote the norms of the Convention on diversity of cultural expressions; on the other hand, to analyze the impact of the EU audiovisual policy model on the development of the Mercosur audiovisual cooperation and to focus on the main forces shaping the Mercosur audiovisual landscape. The article seeks to emphasize why and how the EU pursues an audiovisual foreign policy towards the Mercosur region, for which purposes as well as to highlight the resistances. In this sense, it is more concerned with understanding how the EU’s audiovisual diplomacy interplays with other main factors, such as the governmental action, namely the EU and Mercosur members’ audiovisual diplomacy and the practices of private sector (Hollywood and big media conglomerates). [less ▲]

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