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See detailOne-year outcomes in 1,010 unselected patients treated with the PROMUS Element everolimus-eluting stent: the multicentre PROMUS Element European Post-Approval Surveillance Study
Thomas, MR; Birkemeyer, R; Schwimmbeck, P et al

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2015), 10

Aims: The PROMUS™ Element™ European Post-Approval Surveillance Study (PE-Prove) is a prospective, open-label, multicentre observational study designed to assess outcomes following PROMUS Element ... [more ▼]

Aims: The PROMUS™ Element™ European Post-Approval Surveillance Study (PE-Prove) is a prospective, open-label, multicentre observational study designed to assess outcomes following PROMUS Element everolimus-eluting stent implantation in an unselected patient population. Methods and results: A total of 1,010 patients were enrolled at 40 clinical sites in Europe, including 24.9% with medically treated diabetes, 50.0% with Type B2/C lesions, 6.1% with chronic total occlusion, 17.8% with acute myocardial infarction (MI ≤24 hours pre-procedure), and 20.1% with unstable angina. The target lesion was the culprit for ST-segment elevation MI in 7.3% of patients. The one-year, per patient target vessel failure rate was 6.2% (60/975), 3.4% (33) being related to the PROMUS Element stent. Rates of cardiac death, MI, and Academic Research Consortium (ARC) definite/probable stent thrombosis were 1.7%, 3.5%, and 0.6%, respectively. The target vessel revascularisation rate was 3.2% (31/975), 2.1% (20) being related to the PROMUS Element stent. Conclusions: In a large and relatively complex group of “real-world” patients, coronary artery revascularisation with the PROMUS Element everolimus-eluting stent provides favourable results with low event rates consistent with those reported for other contemporary drug-eluting stents. [less ▲]

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See detailAtlas des énergies mondiales. Quels choix pour demain?
Barré, Bertrand; Merenne-Schoumaker, Bernadette ULg

Book published by Autrement - Troisième édition (2015)

Ouvrage organisé en cinq parties : 1. Une consommation énergétique contrainte; 2. Les grandes énergies traditionnelles; 3. Les énergies renouvelables au coeur de la transition énergétique; 4. Géopolitique ... [more ▼]

Ouvrage organisé en cinq parties : 1. Une consommation énergétique contrainte; 2. Les grandes énergies traditionnelles; 3. Les énergies renouvelables au coeur de la transition énergétique; 4. Géopolitique de l'énergie; 5. Le temps de l'action [less ▲]

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See detailAtlas mondial des matières premières. Des besoins croissants, des ressources limitées
Merenne-Schoumaker, Bernadette ULg

Book published by Autrement - Deuxième édition (2015)

Une publication organisée en cinq parties : 1. Les produits miniers et énergétiques; 2. Les autres matières premières; 3. Des produits plus stratégiques que jamais; 4. Des enjeux économiques majeurs; 5 ... [more ▼]

Une publication organisée en cinq parties : 1. Les produits miniers et énergétiques; 2. Les autres matières premières; 3. Des produits plus stratégiques que jamais; 4. Des enjeux économiques majeurs; 5. Une gageure géopolitique pour l'avenir. [less ▲]

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See detailEvolution et extinctions des ichthyosaures
Fischer, Valentin ULg

in L'écho des falaises (2015), 19

lchthyosaurs are marine reptiles that colonized numerous ecological niches during the Mesozoic. ln addition to their morphology similar to that of fast swimming sharks and teleosts, ichthyosaurs have the ... [more ▼]

lchthyosaurs are marine reptiles that colonized numerous ecological niches during the Mesozoic. ln addition to their morphology similar to that of fast swimming sharks and teleosts, ichthyosaurs have the particularity to go extinct before the CretaceousPalaeogene boundary, during the Cenomanian (early Late Cretaceous). Although many ichthyosaur-rich localities have been known for a long ti me, the extinction phases that marked the ir history were analysed and quantified in detail only recently. This article summarizes the evolutionary history of ichthyosaurs, with a focus on these extinctions phases. [less ▲]

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See detailSingle molecule measurements of synthetic molecular machines at work
Duwez, Anne-Sophie ULg

in Joachim, Christian; Rapenne, Gwenael (Eds.) Single molecular machines and motors (2015)

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See detailZebrafish bone and general physiology are differently affected by hormones or changes in gravity.
Aceto, Jessica ULg; Nourizadeh-Lillabadi, Rasoul; Marée, Raphaël ULg et al

in PLoS ONE (2015), 10(6), 1-42

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire ... [more ▼]

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire organism is still incomplete. We used altered gravity and drug treatment experiments to evaluate their effects specifically on bone formation and more generally on whole genome gene expression. By combining morphometric tools with an objective scoring system for the state of development for each element in the head skeleton and specific gene expression analysis, we confirmed and characterized in detail the decrease or increase of bone formation caused by a 5 day treatment (from 5dpf to 10 dpf) of, respectively parathyroid hormone (PTH) or vitamin D3 (VitD3). Microarray transcriptome analysis after 24 hours treatment reveals a general effect on physiology upon VitD3 treatment, while PTH causes more specifically developmental effects. Hypergravity (3g from 5dpf to 9 dpf) exposure results in a significantly larger head and a significant increase in bone formation for a subset of the cranial bones. Gene expression analysis after 24 hrs at 3g revealed differential expression of genes involved in the development and function of the skeletal, muscular, nervous, endocrine and cardiovascular systems. Finally, we propose a novel type of experimental approach, the "Reduced Gravity Paradigm", by keeping the developing larvae at 3g hypergravity for the first 5 days before returning them to 1g for one additional day. 5 days exposure to 3g during these early stages also caused increased bone formation, while gene expression analysis revealed a central network of regulatory genes (hes5, sox10, lgals3bp, egr1, edn1, fos, fosb, klf2, gadd45ba and socs3a) whose expression was consistently affected by the transition from hyper- to normal gravity. [less ▲]

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See detailDo Animals Work? Creating Pragmatic narrative
Despret, Vinciane ULg

in Senior, Matthew; Clark, David; Freccero, Carla (Eds.) Animots: Postanimality in French Thought (2015)

Do animals work? The way in which we answer this question could bear either the best or the worst consequences for animals. This indicates the pragmatism of such an inquiry. Acknowledging the cooperation ... [more ▼]

Do animals work? The way in which we answer this question could bear either the best or the worst consequences for animals. This indicates the pragmatism of such an inquiry. Acknowledging the cooperation and involvement of lab animals in the workload, as proposed by pharmacologist Michael Robin Chance in the 40s, could have changed the entire story. However, what does “work” mean? Donna Haraway defines “work” as a process that crafts identities and “response-abilities.” She writes: “animals as workers in labs, animals in all their worlds, are response-able in the same sense people are; that is, responsibility is a relationship crafted into intra-action through which entities, subjects and objects, come into being.” Sociologists and anthropologists have been reluctant to consider the idea that other beings could claim to work, apart from a few specific cases such as herding dogs, guide dogs, etc. My colleague, the French sociologist Jocelyne Porcher believes that breeding animals actively collaborate with their breeders. In her previous surveys, she heard anecdotes that suggested that cows and pigs deliberately ease the workload, taking initiative and subjectively getting involved in the work. However, when questioned on the issue, breeders adhere to common beliefs that only humans work, not animals. Looking deeper into the issue, we have discovered that the answer to this question fluctuates depending upon the way the question is posed and to whom the question is directed. [less ▲]

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See detailThe Tax Disputes and Litigation Review - Belgium
Docclo, Caroline ULg

in Whitehead, Simon (Ed.) The Tax Disputes and Litigation Review (2015)

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See detailLe droit des Etats-Unis
Albert, Joanne ULg

Learning material (2015)

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See detailPenser par le milieu, cultiver l'équivocation
Despret, Vinciane ULg

in Büttgen, Phillipe; Gendreau-Massaloux, Michèle; North, Xavier (Eds.) Les pluriels de Barbara Cassin, ou le partage des équivoques (2015)

« Gorgias, écrivait Barbara Cassin, montre comment le Poème de Parménide, loin de partir, comme il le prétend, d'un “il y a” de être (esti : es gibt Sein, dit Heidegger), fabrique bien plutôt l'être en le ... [more ▼]

« Gorgias, écrivait Barbara Cassin, montre comment le Poème de Parménide, loin de partir, comme il le prétend, d'un “il y a” de être (esti : es gibt Sein, dit Heidegger), fabrique bien plutôt l'être en le disant, le fait être ; on ne va pas de l'être au dire de l'être, en toute fidélité et adéquation, mais, à l'inverse, l'être est un effet de dire, un produit du poème, la conséquence d'une performance discursive. C'est de là que je suis repartie. » Au cœur de sa réflexion sur la performativité du langage se déploie, chez Cassin, la question de l’efficace créatif de la traduction. Cette question peut être mise en rapport avec la notion développée par l’anthropologue Eduardo Viveiros de Castro sous le terme d’« équivocation ». Traduire, dit-il, c’est présumer qu’une équivocation existe toujours ; c’est communiquer par différences, différences dans sa langue — sous le même terme, quantité de choses peuvent revendiquer répondre de ce terme—, différences dans la langue de l’autre, et différences dans l’opération même de traduction— car les deux équivocités ne sont pas superposables. C’est ce qui conduit Viveiros de Castro à dire que « la comparaison est au service de la traduction », et non l’inverse. On ne traduit pas pour comparer, on compare à la seule fin de réussir à traduire. Et on compare des différences, des équivoques, des homonymes. L’équivocation est, en ce sens, le déploiement des versions. Dans une traduction, explique Cassin, non seulement chaque terme et chaque opération syntaxique de la langue source peuvent recevoir plusieurs sens, mais ils vont être traduits, dans la langue d’arrivée par des termes et des opérateurs syntaxiques qui, eux-mêmes, peuvent en avoir plusieurs. La version cultive ces divergences et ces bifurcations, de manière contrôlée— mais comme on dit que marcher est une manière contrôlée de tomber. Cette pratique de l’équivocation comme volonté de maintien de la contradiction est à l’œuvre dans les travaux les plus divers de la philosophe. Je m’attacherai plus particulièrement à la partie plus littéraire de ceux-ci. Au départ de la nouvelle « Les mots de tous les jours et l’orchidée de la nuit », que je mettrai en rapport avec une analyse de la thématique de la transmission, de l’identité et du deuil proposée par le psychanalyste Jean Allouch, je souhaiterais dégager les effets pragmatiques et féconds d’une traduction assumant et cultivant la possibilité de faire tenir des traductions divergentes et contradictoires d’un même énoncé. [less ▲]

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See detailWhy i"I had not read Derrida": Often too close, Always too far away
Despret, Vinciane ULg

in Mackenzie, Lousa; Posthumus, Stephanie (Eds.) French Thinking about Animals (2015)

Ce chapitre se propose d'envisager les manières de réguler la distance avec l'animal, dans les pratiques philosophiques. Nous avons été, ceux de ma génération de chercheurs continentaux dont moi-même ... [more ▼]

Ce chapitre se propose d'envisager les manières de réguler la distance avec l'animal, dans les pratiques philosophiques. Nous avons été, ceux de ma génération de chercheurs continentaux dont moi-même, pris entre d'une part, cette tendance très francophone de n'envisager l'animal que comme support de représentations (en maximalisant la distance), et d'autre part le sentiment qu'il était nécessaire de prendre position ( et donc de réduire cette distance), en essayant de trouver des modes compatibles avec le rejet que cette attitude ne manquerait pas de provoquer. Bruno Latour et Isabelle Stengers ont apporté, à cet égard, des outils précieux, et notamment en ouvrant la question de la sociologie des sciences à la normativité, par le biais, pour le premier, de la notion d'amateur, pour la seconde de celle de "récalcitrance". L'influence de Donna Haraway, ce sera mon hypothèse, en quelque sorte prolonge (et repose sur) cette veine ouverte et nous offre une manière encore différente de travailler et de repenser la distance. [less ▲]

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See detailFonctionnement exécutif et attentionnel consécutif à des lésions cérébrales acquises : une analyse de cas multiples
Hogge, Michael; Salmon, Eric ULg; Collette, Fabienne ULg

in Revue de Neuropsychologie, Neurosciences Cognitives et Cliniques (2015), 7(2), 71-99

Le fonctionnement exécutif a été conceptualisé comme un ensemble de processus cognitifs de haut niveau pouvant être clairement distingués, et dont le substrat cérébral se situerait au sein des régions ... [more ▼]

Le fonctionnement exécutif a été conceptualisé comme un ensemble de processus cognitifs de haut niveau pouvant être clairement distingués, et dont le substrat cérébral se situerait au sein des régions frontales. Un certain nombre de données obtenues notamment chez des patients présentant des lésions cérébrales acquises sont toutefois venues remettre en question cette conceptualisation. Dans ce contexte, nous avons administré une large batterie d’épreuves exécutives et attentionnelles à un petit groupe de patients cérébro-lésés (N=9) afin de déterminer, au moyen d’analyses de cas multiples, l’influence de la localisation et de l’étendue des lésions, ainsi que l’influence de difficultés attentionnelles, sur la survenue d’un syndrome dysexécutif. Les analyses de profils individuels semblent indiquer qu’un mauvais transfert d’information entre régions cérébrales antérieures et postérieures serait responsable de la survenue de troubles exécutifs, et que, dans certains cas, ce soient des difficultés attentionnelles qui déterminent ces déficits. Toutefois, il se pourrait également que l’atteinte de certaines régions clés (relativement focalisées) sous-tendant des processus cognitifs impliqués dans un large éventail de tâches exécutives soit responsable de la survenue d’un dysfonctionnement exécutif massif. [less ▲]

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See detailThe retirement of the migrant labor force: pension portability and beyond
Jousten, Alain ULg

in CESifo Economic Studies (2015), 61(2), 416-437

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – ... [more ▼]

The specificities of the workforce with a migrant background are often neglected in studies of retirement. Similarly, many studies of migration’s impact on pensions often focus on aggregate outcomes – system sustainability or distributive characteristics. The present paper provides a fresh look at the nexus between these two literatures. It discusses the impact of the European social security coordination mechanisms on individual decision-making and on the functioning of social security systems – with a focus on retirement. The paper argues that such effects are non-negligible and are likely to have major policy consequences. [less ▲]

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See detailHigh‐k Gate Stacks on Low Bandgap Tensile Strained Ge and GeSn Alloys for Field-Effect Transistors
Wirths, Stephan; Stange, Daniela; Pampillon, Maria-Angela et al

in ACS Applied Materials and Interfaces (2015), 7

We present the epitaxial growth of Ge and Ge0.94Sn0.06 layers with 1.4% and 0.4% tensile strain, respectively, by reduced pressure chemical vapor deposition on relaxed GeSn buffers and the formation of ... [more ▼]

We present the epitaxial growth of Ge and Ge0.94Sn0.06 layers with 1.4% and 0.4% tensile strain, respectively, by reduced pressure chemical vapor deposition on relaxed GeSn buffers and the formation of high-k/metal gate stacks thereon. Annealing experiments reveal that process temperatures are limited to 350 °C to avoid Sn diffusion. Particular emphasis is placed on the electrical characterization of various high-k dielectrics, as 5 nm Al2O3, 5 nm HfO2, or 1 nm Al2O3 / 4 nm HfO2, on strained Ge and strained Ge0.94Sn0.06. Experimental capacitance− voltage characteristics are presented and the effect of the small bandgap, like strong response of minority carriers at applied field, are discussed via simulations. [less ▲]

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See detailThe finite index basis property
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Journal of Pure and Applied Algebra (2015), 219(7), 25212537

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See detailMaximal bifix decoding
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Discrete Mathematics (2015), 338(5), 725742

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See detailBifix codes and interval exchanges
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Journal of Pure and Applied Algebra (2015), 219(7), 27812798

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See detailAcyclic, connected and tree sets
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Monatshefte für Mathematik (2015), 176(4), 521550

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See detailCell based advanced therapeutic medicinal products for bone repair: Keep it simple?
Leijten, J.; Chai, Y. C.; Papantoniou, I. et al

in Advanced drug delivery reviews (2015), 84

The development of cell based advanced therapeutic medicinal products (ATMPs) for bone repair has been expected to revolutionize the health care system for the clinical treatment of bone defects. Despite ... [more ▼]

The development of cell based advanced therapeutic medicinal products (ATMPs) for bone repair has been expected to revolutionize the health care system for the clinical treatment of bone defects. Despite this great promise, the clinical outcomes of the few cell based ATMPs that have been translated into clinical treatments have been far from impressive. In part, the clinical outcomes have been hampered because of the simplicity of the first wave of products. In response the field has set-out and amassed a plethora of complexities to alleviate the simplicity induced limitations. Many of these potential second wave products have remained "stuck" in the development pipeline. This is due to a number of reasons including the lack of a regulatory framework that has been evolving in the last years and the shortage of enabling technologies for industrial manufacturing to deal with these novel complexities. In this review, we reflect on the current ATMPs and give special attention to novel approaches that are able to provide complexity to ATMPs in a straightforward manner. Moreover, we discuss the potential tools able to produce or predict 'goldilocks' ATMPs, which are neither too simple nor too complex. [less ▲]

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See detailMultifactorial Optimization of Contrast-Enhanced Nanofocus Computed Tomography for Quantitative Analysis of Neo-Tissue Formation in Tissue Engineering Constructs.
Sonnaert, Maarten; Kerckhofs, Greet; Papantoniou, Ioannis et al

in PloS one (2015), 10(6), 0130227

To progress the fields of tissue engineering (TE) and regenerative medicine, development of quantitative methods for non-invasive three dimensional characterization of engineered constructs (i.e. cells ... [more ▼]

To progress the fields of tissue engineering (TE) and regenerative medicine, development of quantitative methods for non-invasive three dimensional characterization of engineered constructs (i.e. cells/tissue combined with scaffolds) becomes essential. In this study, we have defined the most optimal staining conditions for contrast-enhanced nanofocus computed tomography for three dimensional visualization and quantitative analysis of in vitro engineered neo-tissue (i.e. extracellular matrix containing cells) in perfusion bioreactor-developed Ti6Al4V constructs. A fractional factorial 'design of experiments' approach was used to elucidate the influence of the staining time and concentration of two contrast agents (Hexabrix and phosphotungstic acid) and the neo-tissue volume on the image contrast and dataset quality. Additionally, the neo-tissue shrinkage that was induced by phosphotungstic acid staining was quantified to determine the operating window within which this contrast agent can be accurately applied. For Hexabrix the staining concentration was the main parameter influencing image contrast and dataset quality. Using phosphotungstic acid the staining concentration had a significant influence on the image contrast while both staining concentration and neo-tissue volume had an influence on the dataset quality. The use of high concentrations of phosphotungstic acid did however introduce significant shrinkage of the neo-tissue indicating that, despite sub-optimal image contrast, low concentrations of this staining agent should be used to enable quantitative analysis. To conclude, design of experiments allowed us to define the most optimal staining conditions for contrast-enhanced nanofocus computed tomography to be used as a routine screening tool of neo-tissue formation in Ti6Al4V constructs, transforming it into a robust three dimensional quality control methodology. [less ▲]

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