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See detailEccentric training for tendon healing after lesion: a rat model
Kaux, Jean-François ULiege; Libertiaux, Vincent ULiege; Leprince, Pierre ULiege et al

in American Journal of Sports Medicine (2017), 45(6), 1440-1446

BACKGROUND:The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore ... [more ▼]

BACKGROUND:The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore, eccentric exercise seems to improve the mechanical quality of the tendon. HYPOTHESIS:A combination of PRP injection and eccentric training might be more effective than either treatment alone. STUDY DESIGN:Controlled laboratory study. METHODS:Adult male rats were anesthetized, an incision was performed in the middle of their left patellar tendon and an injection of physiological fluid (PF) or homologous PRP was randomly made at the lesion level. The rats were then divided into 2 groups: the eccentric group, undergoing eccentric training 3 times a week, and the untrained group, without any training. Thus, 4 groups were compared. After 5 weeks, the tendons were removed and their ultimate tensile strength and energy were measured. Tendons were frozen for proteomic analyses when all biomechanical tests were completed. Statistical analysis was performed with linear mixed effect models. RESULTS:No significant difference was found between the treatments using PF injection or PRP injection alone. However, the value of the ultimate tensile force at rupture was increased by 4.5 N (108% of control, P = .006) when eccentric training was performed. An intragroup analysis revealed that eccentric training significantly improved the ultimate force values for the PRP group. Proteomic analysis revealed that eccentric training led to an increase in abundance of several cytoskeletal proteins in the PF group, while a decrease in abundance of enzymes of the glycolytic pathway occurred in the PRP treated groups, indicating that this treatment might redirect the exercise-driven metabolic plasticity of the tendon. CONCLUSION: Eccentric training altered the metabolic plasticity of tendon and led to an improvement of injured tendon resistance regardless of the treatment injected (PF or PRP). CLINICAL RELEVANCE:This study demonstrates the necessity of eccentric rehabilitation and training in cases of tendon lesion regardless of the treatment carried out. [less ▲]

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See detailIntergroup variation in robbing and bartering by long-tailed macaques at Uluwatu Temple (Bali, Indonesia)
Brotcorne, Fany ULiege; Giraud, Gwennan; Gunst, Noelle et al

in Primates : Journal of Primatology (2017)

Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the ... [more ▼]

Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the macaques appear to use them as tokens, returning them to humans in exchange for food. While extensively studied in captivity, our research is the first to investigate the object/food exchange between humans and primates in a natural setting. During a 4-month study in 2010, we used both focal and event sampling to record 201 RB events in a population of long-tailed macaques (Macaca fascicularis), including four neighboring groups ranging freely around Uluwatu Temple, Bali (Indonesia). In each group, we documented the RB frequency, prevalence and outcome, and tested the underpinning anthropogenic and demographic determinants. In line with the environmental opportunity hypothesis, we found a positive qualitative relation at the group level between time spent in tourist zones and RB frequency or prevalence. For two of the four groups, RB events were significantly more frequent when humans were more present in the environment. We also found qualitative partial support for the male-biased sex ratio hypothesis [i.e., RB was more frequent and prevalent in groups with higher ratios of (sub)adult males], whereas the group density hypothesis was not supported. This preliminary study showed that RB is a spontaneous, customary (in some groups), and enduring population-specific practice characterized by intergroup variation in Balinese macaques. As such, RB is a candidate for a new behavioral tradition in this species. [less ▲]

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See detailChapter 35: Immune Reconstitution and Tolerance
Belle, Ludovic ULiege; Drobyski, William R.

in Abutalib, Syed; Parameswaran, Hari (Eds.) Clinical Manual of Blood and Bone Marrow Transplantation (2017)

Hematopoietic cell transplantation (HCT) remains the only curative treatment option for many patients with hematological malignancies and genetic disorders. Recipients can receive either an autologous or ... [more ▼]

Hematopoietic cell transplantation (HCT) remains the only curative treatment option for many patients with hematological malignancies and genetic disorders. Recipients can receive either an autologous or allogeneic graft, which is often dependent upon the primary disease for which transplantation is contemplated. One of the major goals of transplantation is the development of a fully functional immune system. Patients undergoing allogeneic hematopoietic cell transplantation (alloHCT), in particular, have the highest rate of transplantrelated mortality (TRM) due to complications that can result from immunodeficiencies or immune dysregulation that occurs as a consequence of the procedure. These include, but are not limited to, infections, graft‐versus‐host disease (GvHD), autoimmune disorders, and secondary malignancies. Recovery of a fully functional immune system is thus critical for HCT success and improving immune reconstitution is of great clinical interest. This chapter will focus on immune reconstitution following allo‐HCT since immune recovery is more complicated in this setting due to the underlying HLA disparity between the donor and the recipient. [less ▲]

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See detailTwo-qubit entangling gates between distant atomic qubits in a lattice
Cesa, Alexandre ULiege; Martin, John ULiege

in Physical Review A (2017), 95

Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two ... [more ▼]

Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two-qubit conditional gates between nearest-neighbor qubits in the array can be implemented by exploiting the Rydberg blockade mechanism, as was shown by D. Jaksch et al. [Phys. Rev. Lett. 85, 2208 (2000)]. However, the energy shift due to dipole-dipole interactions causing the blockade falls off rapidly with the interatomic distance, and protocols based on direct Rydberg blockade typically fail to operate between atoms separated by more than one lattice site. In this work, we propose an extension of the protocol of Jaksch et al. for controlled-Z and controlled-NOT gates which works in the general case where the qubits are not nearest neighbors in the array. Our proposal relies on the Rydberg excitation hopping along a chain of ancilla noncoding atoms connecting the qubits on which the gate is to be applied. The dependence of the gate fidelity on the number of ancilla atoms, the blockade strength, and the decay rates of the Rydberg states is investigated. A comparison between our implementation of a distant controlled-NOT gate and one based on a sequence of nearest-neighbor two-qubit gates is also provided. [less ▲]

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See detailEmmanuel Todd ou l'âme des peuples
Coutiez, Dimitri ULiege; Jacquemain, Marc ULiege

Article for general public (2017)

L'article expose la théorie fondamentale d'Emmanuel Todd qui défend l'influence persistante des structures familiales sur le mode d'organisation économique et politique des sociétés contemporaines. Le ... [more ▼]

L'article expose la théorie fondamentale d'Emmanuel Todd qui défend l'influence persistante des structures familiales sur le mode d'organisation économique et politique des sociétés contemporaines. Le texte montre comment le livre "Qui est Charlie" consacré à la mobilisation après les attentats contre Charlie Hebdo tout début 2015 connecte l'analyse de la conjoncture politique à la logique séculaire qu'Emmanuel Todd met en évidence dans ses travaux de démographe et d'anthropologue; [less ▲]

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See detailCan any possible combination of modes improve intermodal attractiveness?
Mostert, Martine ULiege; Caris, An; Limbourg, Sabine ULiege

in Proceedings of the BIVEC-GIBET Transport Research Days 2017 (2017, May)

In its White Paper on Transport, the European Commission recognizes intermodal transport as an alternative solution to road transport. In practice, intermodal transport can be constituted by any ... [more ▼]

In its White Paper on Transport, the European Commission recognizes intermodal transport as an alternative solution to road transport. In practice, intermodal transport can be constituted by any combination of modes, while in the literature, intermodal transport is often modeled as a combination of modes in the order “road-rail/inland waterway-road”. This work develops a new intermodal allocation model which allows choosing between any direct (road, rail and inland waterways) transport and any intermodal transport chain constituted by up to three modes of transport. Intermodal solutions can pass through one or two intermodal terminals. Applied on experimental data at the European level, the model gives insight on the optimal flow distribution for economic objectives (optimization of transport operational costs) and environmental objectives (optimization of transport CO2 emissions and air pollution external costs). Results highlight that the traditional modeling of intermodal transport as a “road-rail/inland waterway-road” combination better fits economic than environmental objectives. [less ▲]

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See detailGBM cells from the tumour mass versus the subventricular zone: molecular and functional characterisation
Di Gregorio, Marina ULiege; willems, Estelle; Dedobbeleer, Matthias ULiege et al

Poster (2017, May)

Life expectancy after diagnosis of glioblastoma (GBM) remains poor even with the best available treatment. This catastrophic survival is the direct consequence of systematic tumour recurrence. It has ... [more ▼]

Life expectancy after diagnosis of glioblastoma (GBM) remains poor even with the best available treatment. This catastrophic survival is the direct consequence of systematic tumour recurrence. It has previously been demonstrated that the subventricular zone (SVZ, a neurogenic niche of the adult central nervous system) attracts and harbours GBM cells, expressing stem cell biomarkers that act like glioblastoma-initiating cells. These cells hosted in the SVZ may be responsible for tumour recurrence. To better understand the difference between cells from the tumour mass (TM) and those migrating to the SVZ, this project will focus on two axes. First, a proteomic and transcriptomic approach will be used to identify one or more biomarkers that might help to establish if recurrences originate from the TM or the SVZ. The second aim of the project is to compare these two populations of cells from a functional point of view. Some functional differences have already been observed: cells derived from SVZ form more spheroids than those derived from TM (1). U87MG cells from SVZ also form tumours more easily in mice compared to cells derived from the TM (2). However, preliminary results in chemo- and radioresistance assays on the cultured cells (U87MG) do not show significant differences between the two populations. Therefore, it might be the SVZ environment that plays a key role in therapeutic resistance, rather than intrinsic biological differences of cells from the TM versus the SVZ. [less ▲]

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See detailNon-Invasive Analysis of Mural Painting from a Late-Republican House (1st century B.C.) in Ostia
Strivay, David ULiege; Herens, Elodie ULiege; Morard, Thomas ULiege et al

Conference (2017, May)

This paper is a comprehensive analytical study of the murals belonging to an ancient Roman house through the characterization of materials. The project focuses on the wall paintings of the Domus dei ... [more ▼]

This paper is a comprehensive analytical study of the murals belonging to an ancient Roman house through the characterization of materials. The project focuses on the wall paintings of the Domus dei bucranes, a house of the end of the Republican era discovered on the site of the Schola of Trajan in Ostia. This Domus has undergone several phases of development in the 1st century BC before being destroyed around 20 BC. A new house was immediately rebuilt after a major change from the ground, which allowed exceptional preservation of the decoration system. The results complement our knowledge of Roman painting techniques during the 1st century BC and also provide a comprehensive multidisciplinary approach to the problem of conservation of wall paintings. These two related objectives have been studied using non-destructive testing methods (MA-XRF, FTIR and Raman spectroscopy). The analyzes have been performed in situ using our mobile systems. The different set-ups had to be modified in order to be able to work on horizontal surfaces, specially our XRF scanner. The study of the pictorial layers address various issues in the field of archaeology: what technique has been implemented? Does the same technique was used in both phases of the development of Domus? Do they correspond to the techniques described by ancient writers? These responses are compared to those observed in other sets of murals dating from the 1st century BC. [less ▲]

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See detailUltrasonic roll bite measurements in cold rolling: Contact length and strip thickness
Carretta, Yves; Hunter, Andrew; Boman, Romain ULiege et al

in Proceedings of the Institution of Mechanical Engineers - Part J - Journal of Engineering Tribology (2017)

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, online process measurements are usually carried out; such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring strip thickness variations as well as roll bite length in situ and in real time. The sensor emits ultrasonic pulses that reflect from the interface between the roll and the strip. Both the time-of-flight of the pulses and the reflection coefficient (the ratio of the amplitude of the reflected signal to that of the incident signal) are recorded. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under several lubrication conditions. Strip thickness variation and roll-bite length obtained from the experimental data agree well with numerical results computed with a cold rolling model in the mixed lubrication regime. [less ▲]

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See detailEtude expérimentale et numérique d'un échangeur destiné à la récupération de chaleur fatale sur bancs d'essais de moteurs aéronautiques
Gendebien, Samuel ULiege; Guillaume, Ludovic ULiege; Bellolio Domke, Sebastian Andres ULiege et al

in Colloque Inter-universitaire Franco-Québécois (CIFQ 2017), 22-24 mai 2017, Saint-Lô, France (2017, May)

Aujourd’hui, d’importants efforts sont réalisés dans divers secteurs afin de diminuer la consommation en énergie. En ce qui concerne le secteur aéronautique, de nombreux tests sont réalisés sur les ... [more ▼]

Aujourd’hui, d’importants efforts sont réalisés dans divers secteurs afin de diminuer la consommation en énergie. En ce qui concerne le secteur aéronautique, de nombreux tests sont réalisés sur les moteurs afin d’assurer la sécurité du transport aérien. Dans ce contexte, il a été envisagé de récupérer, recycler et valoriser l’énergie produite par le moteur au moyen d’un échangeur placé dans la cheminée d’évacuation des gaz. Pour ce faire, un prototype de modèle réduit d’échangeur récupératif sur gaz de combustion (gaz/eau ou gaz/huile) a été conçu, fabriqué et testé. Ce papier présente les caractéristiques du modèle réduit de l’échangeur développé spécifiquement pour cette application. L’ensemble du banc d’essais et le système de mesure mis en place afin de caractériser les performances de l’échangeur sont décrits. Une analyse des résultats expérimentaux est présentée. Les tests sont notamment divisés en deux parties : établissement des performances en régime monophasique et diphasique. Notons également que les performances hydrauliques de l’échangeur ont été expérimentalement déterminées. Un modèle numérique de type semi-empirique est proposé pour prédire les performances de l’échangeur. Ce dernier nécessite un calibrage des paramètres au moyen des données expérimentales afin de prédire les performances de l’échangeur sous une grande plage de conditions opératoires. Une comparaison entre résultats numériques et expérimentaux est finalement présentée. [less ▲]

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See detailMODELISATION D’UN ECHANGEUR A THERMOSIPHONS POUR LA RECUPERATION DE CHALEUR
Le, Van Long ULiege; Dumas, Xavier; Ferrand, Ludovic et al

in XIIIème Colloque Interuniversitaire Franco-Québécois sur la Thermique des Systèmes (2017, May)

Le présent travail a pour objectif de modéliser un échangeur à thermosiphons diphasiques pour transporter la chaleur d’un effluent gazeux (c.à.d. gaz de combustion) à haute température (720°C) au système ... [more ▼]

Le présent travail a pour objectif de modéliser un échangeur à thermosiphons diphasiques pour transporter la chaleur d’un effluent gazeux (c.à.d. gaz de combustion) à haute température (720°C) au système ORC (cycle organique de Rankine). Les thermosiphons sont placés dans les gaz de combustion et refroidis par le fluide de travail du système ORC (le Cyclopentane pour le cas actuel). Le débit massique des fumées et la puissance thermique de l’échangeur sont respectivement imposés de 21 kg/s et de 4.022 MWth. Le fluide organique s’évapore à une température de 200°C et quitte l’évaporateur sans surchauffe (vapeur saturée). Le modèle de simulation développé dans le logiciel EES (Engineering Equation Solver) est capable de déterminer le nombre nécessaiare de thermosiphons. L’influence des pas transversaux et longitudinaux de l’échangeur sur le nombre de thermosiphons et la perte de charge des fumées est également examinée pour les dispositions quinconces et alignées des tubes de thermosiphons. [less ▲]

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See detailSustainability Accounting and Control for Smart City - Special Issue - Call for Papers
Crutzen, Nathalie ULiege; Van Bockhaven, Jonas; Schaltegger, Stefan et al

in sustainability accounting, management and policy journal (2017)

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See detailOrigin of the counterintuitive dynamic charge in the transition metal dichalcogenides
Pike, Nicholas ULiege; Van Troeye, Benoit; Dewandre, Antoine ULiege et al

in Physical Review B (2017), 95

Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we ... [more ▼]

Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we investigate their static and dynamic charges. The dynamic charge of the transition metal dichalcogenides with trigonal symmetry are anomalously large, while in their hexagonally symmetric counterparts, we even observe a counterintuitive sign, i.e., the transition metal takes a negative charge, opposite to its static charge. This phenomenon, so far never remarked on or analyzed, is understood by investigating the perturbative response of the system and by investigating the hybridization of the molecular orbitals near the Fermi level. Furthermore, a link is established between the sign of the Born effective charge and the process of π backbonding from organic chemistry. Experiments are proposed to verify the calculated sign of the dynamical charge in these materials. Employing a high-throughput search we also identify other materials that present counterintuitive dynamic charges. [less ▲]

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See detailLes épreuves multiples chez les jeunes. Réflexion sur un programme développemental à long terme.
Jidovtseff, Boris ULiege

Learning material (2017)

Réflexion personnelle sur une proposition de modèle développemental à long terme spécifique aux épreuves multiples en athlétisme.

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See detailRégimes matrimoniaux et effets patrimoniaux des partenariats enregistrés en Europe. Propos introductifs
Wautelet, Patrick ULiege

in Droit de la famille (2017), 22(5), 10-13

Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des ... [more ▼]

Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des questions ouvertes qu'ils posent [less ▲]

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See detailTranscriptome wide analysis of natural antisense transcripts shows potential role in breast cancer
Wenric, Stéphane ULiege; El Guendi, Sonia; CABERG, Jean-Hubert ULiege et al

Poster (2017, May)

Non-coding RNAs (ncRNA) represent at least 1/5 of the mammalian transcript amount, and about 90% of the genome length is actively transcribed. Many ncRNAs have been demonstrated to play a role in cancer ... [more ▼]

Non-coding RNAs (ncRNA) represent at least 1/5 of the mammalian transcript amount, and about 90% of the genome length is actively transcribed. Many ncRNAs have been demonstrated to play a role in cancer. Among them, natural antisense transcripts (NAT) are RNA sequences which are complementary and overlapping to those of protein-coding transcripts (PCT). NATs were punctually described as regulating gene expression, and are expected to act more frequently in cis than other ncRNAs that commonly function in trans. In this work, 22 breast cancers expressing estrogen receptors and their paired healthy tissues were analyzed by strand-specific RNA sequencing. To highlight the potential role of NATs in gene regulations occurring in breast cancer, three different gene extraction methods were used: differential expression analysis of NATs between tumor and healthy tissues, differential correlation analysis of paired NAT/PCT between tumor and healthy tissues, and NAT/PCT read count ratio variation between tumor and healthy tissues. Each of these methods yielded lists of NAT/PCT pairs that were demonstrated to be enriched in survival-associated genes on an independent cohort (TCGA). This work allows to highlight NAT lists that display a strong potential to affect the expression of genes involved in the breast cancer pathology. [less ▲]

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See detailDeciphering the role of dendritic sodium channels on action potential dynamics in substantia nigra dopaminergic neurons
Moubarak, Estelle; Engel, Dominique ULiege; Dufour, Martial et al

Poster (2017, May)

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