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See detailWASP-157b, a Transiting Hot Jupiter Observed with K2
Močnik, T.; Anderson, D. R.; Brown, D. J. A. et al

in Publications of the Astronomical Society of the Pacific (2016), 970

We announce the discovery of the transiting hot Jupiter WASP-157b in a 3.95-d orbit around a V = 12.9 G2 main-sequence star. This moderately inflated planet has a Saturn-like density with a mass of $0.57 ... [more ▼]

We announce the discovery of the transiting hot Jupiter WASP-157b in a 3.95-d orbit around a V = 12.9 G2 main-sequence star. This moderately inflated planet has a Saturn-like density with a mass of $0.57 \pm 0.10$ M$_{\rm Jup}$ and a radius of $1.06 \pm 0.05$ R$_{\rm Jup}$. We do not detect any rotational or phase-curve modulations, nor the secondary eclipse, with conservative semi-amplitude upper limits of 250 and 20 ppm, respectively. [less ▲]

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See detailCan regional blocs (still) talk with each other? The Euro-Mercosur relationship
Santander, Sébastian ULg

in World Affairs (2016), 2/33 (459)

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See detailHistoire politique de la construction européenne
Grandjean, Geoffrey ULg

Learning material (2016)

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See detailAttack-Prevention and Damage-Control Investments in Cybersecurity
Lam, Wing Man Wynne ULg

Scientific conference (2016, December)

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See detailEarly prediction of on-going hemorrhage in severe trauma: presentation of the existing scoring systems.
TONGLET, Martin ULg

in archives of trauma research (2016), 5(4),

Early prediction of ongoing hemorrhage may reduce mortality via the earlier delivery of blood products, adequate orientation of the patient in a dedicated highly specialized and trained infrastructure ... [more ▼]

Early prediction of ongoing hemorrhage may reduce mortality via the earlier delivery of blood products, adequate orientation of the patient in a dedicated highly specialized and trained infrastructure, and by earlier correction of acute traumatic coagulopathy. We identified 14 scores or algorithms developed for the prediction of ongoing hemorrhage and the need for massive transfusion in severe trauma patients. [less ▲]

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See detailRéflexion relative à une fiscalité du logement territorialement plus efficiente
Bianchet, Bruno ULg; Copée, Pierre ULg; Xhignesse, Guillaume ULg

in Echos du Logement (2016), 118

Le logement est susceptible d’être frappé par différents impôts, tant au niveau de sa possession que de sa cession. L’ensemble de ces mécanismes apparaît très complexe. De plus, ces dfférentes taxes ... [more ▼]

Le logement est susceptible d’être frappé par différents impôts, tant au niveau de sa possession que de sa cession. L’ensemble de ces mécanismes apparaît très complexe. De plus, ces dfférentes taxes présentent des répercussions directes sur l’organisation du territoire puisqu’elles influencent certains choix et comportements des individus. C’est pourquoi la Conférence Permanente du Développement Territorial (CPDT) a été sollicitée pour étudier les incidences de ces mécanismes et émettre des recommandations à ce propos. Nous nous sommes plus particulièrement penchés sur la fiscalité relative à la transaction et la propriété d’un logement, à savoir le droit d’enregistrement et le précompte immobilier, ce qui nous a permis d’aborder la base soit relative à l’octroi de réduction, soit relative au calcul de l’impôt : le revenu cadastral. Or, celui-ci apparait critiquable à différents points de vue. Notre réflexion s’inscrit dans le contexte de la sixième réforme de l’État (loi spéciale du 6 janvier 2014) qui octroie aux Régions davantage d’autonomie fiscale, mais leur impose aussi de nouvelles contraintes et responsabilités. Dès lors, la Wallonie est devenue suffisamment autonome que pour développer sa propre fiscalité immobilière, en fonction de ses contraintes et objectifs. [less ▲]

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See detailValidity and reliability of the French translation of the VISA-A questionnaire for Achilles tendinopathy
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Disability & Rehabilitation (2016), 38(26), 2593-2599

Purpose The Victorian Institute of Sport Assessment – Achilles tendinopathy questionnaire (VISA-A) evaluates the clinical severity of Achilles tendinopathy. The aim of this study was to translate the VISA ... [more ▼]

Purpose The Victorian Institute of Sport Assessment – Achilles tendinopathy questionnaire (VISA-A) evaluates the clinical severity of Achilles tendinopathy. The aim of this study was to translate the VISA-A into French and to study the reliability and validity of this French version, the VISA-AF. Method The VISA-A was translated into French to produce the VISA-AF using a validated methodology in six steps. Thereafter, several psychometric properties of this French version such as test–retest reliability, internal consistency, construct validity and floor and ceiling effects were evaluated. Therefore, we recruited 116 subjects, distributed into 3 groups: pathological patients (n¼31), at-risk athletes (n¼63) and healthy people (n¼22). Results The final version of the VISAAF was approved by an expert committee. On a scale ranging from 0 to 100, the average scores of the VISA-AF obtained were 59 (± 18) for the pathological group, 99 (± 1) for the healthy group and 94 (± 7) for the at-risk group. The VISA-AF shows excellent reliability, low correlations with the discriminant subscales of the SF-36 and moderate correlations with the convergent subscales of the SF-36. Conclusions The French version of the VISA-A is equivalent to its original version and is a reliable and valid questionnaire for French-speaking patients with Achilles tendinopathy. [less ▲]

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See detailEvaluation ENMG du plexus brachial
WANG, François-Charles ULg

in Lettre du Neurologue: le Courrier du Spécialiste (2016), XX(10), 334-344

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See detailTriclosan exposure results in alterations of thyroid hormone status and retarded early development and metamorphosis in Cyprinodon variegatus
Schnitzler, Joseph ULg; Frederich, Bruno ULg; Dussenne, Mélanie ULg et al

in Aquatic Toxicology (2016), 181

Thyroid hormones are critically involved in somatic growth, development and metamorphosis of vertebrates. The structural similarity between thyroid hormones and triclosan, an antimicrobial compound widely ... [more ▼]

Thyroid hormones are critically involved in somatic growth, development and metamorphosis of vertebrates. The structural similarity between thyroid hormones and triclosan, an antimicrobial compound widely employed in consumer personal care products, suggests triclosan can have adverse effects on the thyroid system. The sheepshead minnow, Cyprinodon variegatus, is now used in ecotoxicological studies that have recently begun to focus on potential disruption of the thyroid axis by endocrine disrupting compounds. Here, we investigate the in vivo effects of exposure to triclosan (20, 50, and 100 μg L−1) on the thyroid system and the embryonic and larval development of C. variegatus. Triclosan exposure did not affect hatching success, but delayed hatching time by 6–13 h compared to control embryos. Triclosan exposure affected the ontogenetic variations of whole body thyroid hormone concentrations during the larval phase. The T3 peak around 12–15 dph, described to be indicative for the metamorphosis climax in C. variegatus, was absent in triclosan-exposed larvae. Triclosan exposure did not produce any deformity or allometric repatterning, but a delayed development of 18–32 h was observed. We conclude that the triclosan-induced disruption of the thyroid system delays in vivo the start of metamorphosis in our experimental model. We observed a global developmental delay of 24–45 h, equivalent to 4–7% prolongation of the developmental time in C. variegatus. The costs of delayed metamorphosis can lead to reduction of juvenile fitness and could be a determining factor in the outcome of competitive interactions. [less ▲]

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See detailJAMES BOOKER The Bayou Maharajah - Portrait
Sacré, Robert ULg

in ABS Magazine (2016), (52), 16-25

Carrière du pianiste James Booker (1939-1983) , originaire de la Nouvelle Orleans, LA, USA

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See detailLes fondements dogmatiques du droit chez Leibniz
Paksy, Máté ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), LXI(3), 587-597

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See detailCellwise Robust regularized discriminant analysis
Aerts, Stéphanie ULg; Wilms, Ines

E-print/Working paper (2016)

Quadratic and Linear Discriminant Analysis (QDA/LDA) are the most often applied classification rules under normality. In QDA, a separate covariance matrix is estimated for each group. If there are more ... [more ▼]

Quadratic and Linear Discriminant Analysis (QDA/LDA) are the most often applied classification rules under normality. In QDA, a separate covariance matrix is estimated for each group. If there are more variables than observations in the groups, the usual estimates are singular and cannot be used anymore. Assuming homoscedasticity, as in LDA, reduces the number of parameters to estimate. This rather strong assumption is however rarely verified in practice. Regularized discriminant techniques that are computable in high-dimension and cover the path between the two extremes QDA and LDA have been proposed in the literature. However, these procedures rely on sample covariance matrices. As such, they become inappropriate in presence of cellwise outliers, a type of outliers that is very likely to occur in high-dimensional datasets. In this paper, we propose cellwise robust counterparts of these regularized discriminant techniques by inserting cellwise robust covariance matrices. Our methodology results in a family of discriminant methods that (i) are robust against outlying cells, (ii) cover the gap between LDA and QDA and (iii) are computable in high-dimension. The good performance of the new methods is illustrated through simulated and real data examples. As a by-product, visual tools are provided for the detection of outliers. [less ▲]

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See detailDroit et dystopies
Pironnet, Quentin ULg

in Revue Interdisciplinaire d'Etudes Juridiques [= RIEJ] (2016), 77

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See detailShort-lived subduction and exhumation in Western Papua (Wandamen peninsula): Co-existence of HP and HT metamorphic rocks in a young geodynamic setting
François, Camille ULg; de Sigoyer, Julia; Pubellier, Manuel et al

in Lithos (2016), 266-267

Understanding processes of formation of accretionary wedges requires studying young and well preserved examples. The Lengguru wedge (West Papua) is younger than 10 Myr and is a result of oblique and fast ... [more ▼]

Understanding processes of formation of accretionary wedges requires studying young and well preserved examples. The Lengguru wedge (West Papua) is younger than 10 Myr and is a result of oblique and fast subduction (11cm/yr) of the Bird’s Head (a part of the Australian margin beneath the Melanesian Arc). Thus, the rapid formation of this wedge (actually a Fold and Thrust Belt) may be attributed to a single tectonic event. High pressure (HP) metabasic and metasedimentary rocks have been discovered in the core of the wedge in the Wandamen peninsula. Locally, these rocks are overprinted by migmatization during the decompression. Field relationships indicate that migmatites and anatectic leucogranite crosscut the HP metamorphic rocks. This paper reports characterization of petrology and thermobarometry of metasediments and metabasic samples, all included in a former mélange-type rock association, as well as geochronology of metasediments. Pressure-Temperature (PT) conditions highlight two stages of metamorphism within a small time bracket. In metasediments, a first stage of relatively HP (~13-17 kbar) is observed as attested by a first paragenesis of garnet-kyanite-phengite. Garnet, kyanite and phengite are then destabilized in favor of biotite during the decompression (5-12 kbar and > 550°C). Late fractures filled with chlorite and a second generation of white mica crosscut the foliation (< 7 kbar and 500-600°C). In metabasic rocks, the peak of pressure is reached from 15 to 23 kbar and from 525 to 650°C. Geochronological study was conducted using U-Pb dating (LA-MC-ICPMS) on zircons from the metasedimentary and migmatitic rocks. Some zircon cores often present high Th/U ratio typical for magmatic origin, as confirmed by trace element signature of metasediments, and recorded ages older than 300 Ma, witness of the activity of a volcanic arc on the former margin of the Australian craton. Most others zircons presents a low Th/U ratio attesting their metamorphic origin, confirmed by inclusions of kyanite. The metamorphic zircons are dated between 5.61 ± 0.04 Ma and 8.1 ± 1.1 Ma. These very young metamorphic ages attest for a rapid subduction and exhumation event. [less ▲]

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See detailMachine Learning based Prediction of Internet Path Dynamics
Wassermann, Sarah ULg; Casas, Pedro; Donnet, Benoît ULg

in ACM CoNEXT Student Workshop: Irvine 12 décembre 2016 (2016, December)

We study the problem of predicting Internet path changes and path performance using traceroute and machine-learning techniques. Path changes are frequently linked to path inflation and performance ... [more ▼]

We study the problem of predicting Internet path changes and path performance using traceroute and machine-learning techniques. Path changes are frequently linked to path inflation and performance degradation. Therefore, predicting their occurrence could improve the analysis of path dynamics using traceroute. By relying on neural networks and using empirical distribution based input features, we show that we are able to predict (i) the remaining life time of a path before it actually changes, and (ii) the number of path changes in a certain time slot with relatively high accuracy. We also show that it is possible to predict path performance in terms of latency, opening the door to novel, machine-learning-based approaches for RTT prediction. [less ▲]

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See detailEtude de l’évolution de la pathologie arthrosique et des propriétés mécaniques du cartilage sur un modèle d’arthrose spontanée chez le cobaye Dunkin-Hartley
Legrand, Catherine ULg

Poster (2016, December)

Dans les modèles animaux, la gravité des lésions du cartilage est appréciée grâce à des scores histologiques évaluant la structure, le contenu en protéoglycane, l’intégrité de la tidemark, la cellularité ... [more ▼]

Dans les modèles animaux, la gravité des lésions du cartilage est appréciée grâce à des scores histologiques évaluant la structure, le contenu en protéoglycane, l’intégrité de la tidemark, la cellularité, ainsi que les ostéophytes. Parallèlement à ces analyses histologiques, nous avons étudié les propriétés mécaniques du cartilage à différents stades d’évolution de la maladie chez le cobaye Dunkin-Hartley. Nous avons également corrélé la sévérité des lésions histologiques avec les propriétés mécaniques du cartilage. [less ▲]

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See detailDevelopment and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs
Karim, Reatul ULg; Palazzo, Claudio ULg; Laloy, Julie et al

Poster (2016, December)

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site ... [more ▼]

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility. [less ▲]

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See detailIntramolecular continuous-flow strategy towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

Poster (2016, December)

threo-Methylphenidate hydrochloride is the most widely prescribed drug to treat attention deficit hyperactivity disorder (ADHD). Herein we present the batch-to-flow translation of a carbene-based ... [more ▼]

threo-Methylphenidate hydrochloride is the most widely prescribed drug to treat attention deficit hyperactivity disorder (ADHD). Herein we present the batch-to-flow translation of a carbene-based intramolecular strategy for the diastereoselective preparation of this active pharmaceutical ingredient. The process relies on the thermal generation and decomposition of a hazardous diazospecies, its thermal intramolecular C-H insertion reaction yielding an intermediate β-lactam, and its subsequent acidic methanolysis, giving enriched threo-methylphenidate hydrochloride in 70% isolated yield. The automated microfluidic setup telescopes 2 chemical transformations, 1 intermediate in-line purification and sustains a daily productivity of 20.4 g/day of methylphenidate hydrochloride. The preparation of the β-lactam is implemented on mesoscale in a pilot-scale continuous-flow reactor, providing 4.25 kg of this key intermediate per day. [less ▲]

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