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See detailA Few Recent Publications Around the Centenary of the Armenian Genocide
Grandjean, Geoffrey ULg

in Social History (2016), 49(100), 659-661

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See detailBurgerwetenschap na Fukushima
Van Oudheusden, Michiel ULg

Conference (2016, November 14)

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See detailFragmentation politico-administrative des régions intermédiaires en Europe
Breuer, Christophe ULg

Scientific conference (2016, November 14)

Analyse européenne de la fragmentation politico-administrative locale des régions urbaines intermédiaire : objectifs, méthodologie, indicateurs de fragmentation, lien entre ces indicateurs et le contexte ... [more ▼]

Analyse européenne de la fragmentation politico-administrative locale des régions urbaines intermédiaire : objectifs, méthodologie, indicateurs de fragmentation, lien entre ces indicateurs et le contexte territorial. [less ▲]

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See detailTouch of Evil - Touch of Neo-noir. Du film noir hollywoodien au néo-noir contemporain.
Tomasovic, Dick ULg

Scientific conference (2016, November 14)

Cette conférence interroge les présupposés esthétiques et idéologiques qui ont fondé la catégorie du néo-noir dans le cinéma hollywoodien des dernières décennies.

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See detailLe soutien fiscal à la propriété-occupation à la lumière du cas belge
Xhignesse, Guillaume ULg

Scientific conference (2016, November 14)

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See detailStudying the genetics of Mendelian and complex traits with high-throughput genotyping and sequencing in cattle
Li, Wanbo ULg

Doctoral thesis (2016)

Background For decades, identifying genes and mutations underlying inherited diseases and economically import traits has been at the core of genetic studies in domestic animals. The initial arduous task ... [more ▼]

Background For decades, identifying genes and mutations underlying inherited diseases and economically import traits has been at the core of genetic studies in domestic animals. The initial arduous task of gene mapping with microsatellites or low-density SNP panels was then followed by a often fruitless and tedious attempt to isolate the causative mutations for both monogenic and polygenic traits. The availability of high-density SNP arrays considerably accelerated the gene mapping process. More recently, advances in second-generation high-throughput sequencing (HTS) including whole genome, exome, and RNA sequencing have brought tremendous efficiency into dissecting the genetic underpinnings of phenotypes of interest. In this thesis, we describe the use of these new technologies to decipher the genetic basis of several monogenic and polygenic traits, in both forward and reverse genetic settings. Results We first describe the use of medium-density SNP arrays to dissect genetic basis of a monogenic disease (Crooked Tail Syndrome, CTS), as well as of complex phenotypes related to meiotic recombination in cattle. With regards to CTS, we first demonstrate that a common 2bp-deletion in the MRC2 gene causes the condition in Belgian Blue cattle (BBC), and that the frequency of the condition is due to a pleiotropic effect of the mutation on muscle mass. We discover a second loss-of-function mutation in the same gene MRC2, supporting the hypothesis of pleiotropy and balancing selection. With regards to recombination, we report that genetic variants in REC8 and RNF212 affect the genome-wide recombination rate in cattle. The RNF212 gene has also been shown to be associated with genome-wide recombination rate in humans, however REC8 is not supported as a candidate gene by newer data. We also demonstrated that several variants in the zinc-finger domain of a gonosomal PRDM9 paralogue influence hotspot usage in cattle, reminiscent of previous findings in human and mice. The subsequent application of HTS technology in forward genetic analyses, allowed us to identify: i) an intronic mutation in the PIGH gene that causes the skipping of exon 2, and is the cause of arthrogryposis in BBC, ii) a 3.3 kb deletion removing exons 25-27 of the FANCI gene, that causes brachyspina in Holstein-Friesian cattle. We finally used a reverse genetic approach to identify embryonic lethal (EL) mutations compromising fertility in beef (BBC) and dairy cattle (Holstein-Friesian and Jersey). We mined whole genome and exome sequence data from more than 500 animals for candidate embryonic lethal variants corresponding to loss-of-function (stop gain, frameshift and splice site variants) and disruptive missense variants. By doing so we demonstrate that against expectations domestic Bos taurus cattle are genetically more variable than humans including Africans, however, that their burden of disruptive variants is similar, amounting to ∼100 such variants per individual. We interpret this as resulting from more effective purifying selection in recent times as a result of increased inbreeding. We have genotyped thousands of animals for thousands of EL candidates, and estimate – from the observed depletion in homozygotes - that no more ∼15% of those are developmentally essential. We do not find evidence for synthetic epistasis between candidate EL mutations. By evaluating the departure from Mendelian expectations in matings between carrier sires and dams, we unambiguously demonstrate the embryonic lethal nature of nine relatively common candidate EL variants. All of them affect genes that are involved in basic cellular processes. We demonstrate that only one of these would have been detected using the haplotype-based approach that were applied thus far. The established list of loss-of-function variants is being mined for putative non-lethal, yet major phenotypic effects of medical relevance. Among these, we uncovered a 10-bp deletion in the MLPH gene, which results a premature stop codon, that causes diluted color – ‘cool gray’ – in BBC. Conclusions and Perspectives Due to the intensive use of some elite sires by means of artificial insemination in cattle, several outbursts of genetic defects have been observed in recent years. We herein demonstrate that uncovering the genetic basis of such Mendelian disorders can be very effective when integrating high-throughput genotyping and sequencing technology. Fertility in cattle and other domestic animals has declined over the last decades. Our discovery of a number of embryonic lethal variants segregating in cattle provide a complementary explanation for the decline in fertility, in addition to the theory of negative energy balance of high producing cows. The reverse genetic approach we developed for screening EL variants has at least two advantages. First, our approach also works in small sized populations. Second, our approach has higher sensitivity than the haplotype-based approach. It has been suspected for some time that most of the variants underlying complex traits map to noncoding regions. Deciphering the functional consequence of these regulatory variants has proven challenging. The ENCODE projects in human and mice provide good examples of how high-throughput functional assays based on NGS technology may enhance our knowledge of the non-coding regions of the genome. It is reasonable to anticipate that the release of ENCODE-like data in the animal research field will assist in the discovery of the genetic basis of complex traits at an unprecedented pace. [less ▲]

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See detailSoutenir le développement langagier en maternelle : Développement d’un outil d’observation et de soutien pour les enseignant.e.s en Belgique francophone
Bergeron-Morin, Lisandre ULg; Leroy, Sandrine ULg; Maillart, Christelle ULg

Conference (2016, November 14)

Les effets positifs des contextes éducatifs préscolaires sur le développement langagier des en-fants et par conséquent sur leur réussite éducative subséquente sont maintenant reconnus, particulièrement ... [more ▼]

Les effets positifs des contextes éducatifs préscolaires sur le développement langagier des en-fants et par conséquent sur leur réussite éducative subséquente sont maintenant reconnus, particulièrement auprès des enfants provenant de milieux vulnérables sur le plan socio-économique (Dickinson, 2011). En effet, les enfants ont l’occasion d’y expérimenter de façon quotidienne des interactions riches et diversifiées avec les enseignant.es, susceptibles d’étayer leur langage (Pence et al., 2008). Or, la qualité du soutien au développement langagier offert, qui dépend entre autres de la capacité de l’enseignante à observer et à ainsi s’adapter au niveau de développement langagier de chaque enfant, est très hétérogène d’une groupe à l’autre (Bou-chard et al., 2010; Girolametto et al., 2002). En Belgique francophone, où l’orthophonie dite préventive est encore peu développée, les ensei-gnantes de maternelle font état d’un manque d’outils et de connaissances pour observer le déve-loppement langagier des enfants. L’outil SOLEM (Soutenir et Observer le Langage des Enfants en Maternelle) a été développé pour répondre à ce besoin. MÉTHODE Quatre groupes nominaux ont été réalisés auprès de 39 enseignants, agents psycho-médico-sociaux et directions d’écoles afin d’identifier leurs besoins. Un prototype de l’outil d’observation a été développé et mis à l’essai dans 10 classes pilotes, afin d’en valider la forme et le contenu. 4 enfants par groupe ont été évalué de façon parallèle avec l’Évaluation du Langage Oral (ELO), afin de faire état de la validité concurrente de l’outil SOLEM. RÉSULTATS SOLEM a été développé à partir de constats issus des groupes nominaux : accorder de l’importance aux aspects moins formels du langage, avoir une démarche en arborescence adap-tée à chaque enfant, qui mène à des pistes d’actions adaptées. Les premières mises à l’essai semblent confirmer que SOLEM répond au besoin exprimé par les enseignants.es : identifier les enfants qui ont besoin d’un soutien spécifique sur le plan du développement langagier et obser-ver leur communication pour y ajuster le soutien offert. Les résultats permettent d’aborder une réflexion sur comment l’observation du développement langagier des enfants par l’enseignant.e peut introduire la mise en place de pratiques de soutien aux habiletés langagières dans les groupes de maternelle. [less ▲]

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See detailPrix fonciers et fonctionnement des marchés immobiliers
Halleux, Jean-Marie ULg

Conference given outside the academic context (2016)

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See detailEvaluation of adaptive facades: Case study, Al Bahar Towers, UAE
Attia, Shady ULg

in Amato, Alex (Ed.) TOGETHER LET’S BUILD A SUSTAINABLE FUTURE (2016, November 13)

The assessment of adaptive facades presents a barrier in light of the fact that there is no settled assessment technique se to systematically reach this goal. Many of the available façade performance ... [more ▼]

The assessment of adaptive facades presents a barrier in light of the fact that there is no settled assessment technique se to systematically reach this goal. Many of the available façade performance evaluation systems or frameworks have restricted applicability for such advanced building facades. The complexity of adaptive or dynamic facades evaluation is related to the performance evaluation of façade elements, systems and overall building performance coupled to occupant behavior and occupant satisfaction. In this context, we present\s a case study for an adaptive sunscreens façade and evaluate its performance and occupant behavior. The evaluation focuses mainly on pre and post construction phase of adaptive facades: The design assist phase (including the durability test, visual mockup, onsite mashrabiya mounting and weather stripping), the commissioning phase (field verification and performance testing) and the monitoring phase. The selected project is a 150 meters high twin tower that stands with honey-comb inspired structure and automated dynamic solar screen that responds to the sun’s movement. These solar screens respond dynamically and automatically to the angle of the sun which improves the control over energy consumption, solar radiation and glare with the ability to admit natural light into the building. The paper is part of the research activities of working group 3 of the European COST Action 1403 on “Adaptive Facades “. Different methods were used for evaluation, this include: interviews with the architect and façade engineer and technical control specialist, occupants, reviews of standard and codes, review of energy models and a systematic design process mapping. A documentation of the case study describing the post construction occupant comfort, and façade operation was prepared. This paper’s audience is mainly project managers, architects, building façade engineers together with facility managers concerned with the process of design, construction and operation of adaptive sunscreens facades. The outcome of this study identifies quantifiable performance indicators and effective strategies for the design and performance evaluation of optimal adaptive facades. [less ▲]

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See detailThe freedom to receive trade union services: a stepping stone for worker protection in the EU internal market?
Van Cleynenbreugel, Pieter ULg

Scientific conference (2016, November 12)

This conference paper/presentation explores to what extent workers can receive trade union services in a cross border context and how this possibility can be used as a starting point for a better tailored ... [more ▼]

This conference paper/presentation explores to what extent workers can receive trade union services in a cross border context and how this possibility can be used as a starting point for a better tailored reflection on the future of harmonised worker protection across the European Union. [less ▲]

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See detailLa pollution atmosphérique enregistrée dans les stalagmites de Han-sur-Lesse
Allan, Mohammed ULg; Fagel, Nathalie ULg; Verheyden, sophie

Conference (2016, November 12)

Les spéléothèmes sont maintenant considérées comme précieuses archives climatiques et environnementales sur les continents, offrant un certain nombre d'avantages par rapport à d'autres archives ... [more ▼]

Les spéléothèmes sont maintenant considérées comme précieuses archives climatiques et environnementales sur les continents, offrant un certain nombre d'avantages par rapport à d'autres archives continentales (les sédiments lacustres, les carottes de glace….). Cette archive peut être aisément datables (U/Th, comptage de lamines et 14C), et présentent une haute résolution temporelle (décennale à saisonnière). Cependant, leur potentiel pour l'enregistrement de la pollution de l'environnement est largement inexploré et principalement axé sur la quantification des contributions d'aérosols dans des grottes touristiques. Cette étude est un des premières études qui utilise les spéléothèmes pour retracer la pollution atmosphérique. Basé sur deux spéléothèmes collectées dans la grotte de Han-sur-Lesse (S-Belgique), ce travail a deux objectifs : 1) le premier est de quantifier la concentration du Pb pour la dernière 250 ans, 2) le second objectif est de définir les sources anthropiques prédominantes de Pb en utilisant les rapports isotopiques du Pb et en basant sur les comparaisons avec les données historiques des activités anthropogéniques en Europe et la Belgique. Les concentrations en éléments traces (Al et Pb) (mesurées par LA-ICP-MS et ICP-MS) et les rapports isotopiques du Pb (mesurées par MC-ICP-MS) permettent d'identifier trois intervalles caractérisés par un enrichissement particulier en Pb : de 1880 à 1905 AD, de 1945 à 1965 AD, et de 1975 à 1990 AD. Les spéléothèmes montrent des changements similaires au niveau historique de la pollution atmosphérique connu en Belgique. Les rapports isotopiques du Pb distinguent clairement les sources de Pb et confirment que le charbon et la combustion de l'essence combinée avec des activités métallurgiques régionales étaient les sources prédominantes de la pollution au cours des 250 dernières années. Cette étude met l'accent sur la capacité des spéléothèmes d’enregistrer la pollution atmosphérique. [less ▲]

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See detailLike human adipose tissue and dermis, human bone marrow harbor cells with neural crest-associated characteristics.
Wislet, Sabine ULg

Conference (2016, November 12)

Adult neural crest stem cells (NCSC) are of extraordinary high plasticity and promising candidates for a use in regenerative medicine. Several locations like skin, adipose tissue, dental pulp or bone ... [more ▼]

Adult neural crest stem cells (NCSC) are of extraordinary high plasticity and promising candidates for a use in regenerative medicine. Several locations like skin, adipose tissue, dental pulp or bone marrow have been described in rodent. However, very few information is available concerning their correspondence in human tissues. The main objective of this study was therefore to characterize NCSC from adult human bone marrow. In this purpose, we compared human bone marrow stromal cells to human adipose tissue and dermis, already described for containing NCSC. We performed comparative analyses in terms of gene and protein expression, as well as functional characterizations. It appeared that human bone marrow, similarly to adipose tissue and dermis contains NESTIN+ / SOX9+ / TWIST+ / SLUG+ / P75NTR+ / BRN3A+/ MSI1+/ SNAIL1+ cells and were able to differentiate into melanocytes and Schwann cells. Moreover, when injected into chicken embryos, all those cells were able to migrate and follow endogenous neural crest migration pathways. Altogether, the phenotypic characterization and migration abilities strongly suggest the presence of neural crest-derived cells in human adult bone marrow. [less ▲]

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See detailImages et figures. Dispositifs de re-découpage du sensible (Rancière)
Hagelstein, Maud ULg

Conference (2016, November 12)

Dans son historiographie critique (Les noms de l’histoire, 1992 / Figures de l’histoire, 2012), J. Rancière définit pour l’époque contemporaine des formes alternatives de poétique, de mise en récit et de ... [more ▼]

Dans son historiographie critique (Les noms de l’histoire, 1992 / Figures de l’histoire, 2012), J. Rancière définit pour l’époque contemporaine des formes alternatives de poétique, de mise en récit et de mise en visibilité de l’histoire, qui auraient pour effet de mieux prendre en compte les anonymes et de découper autrement le sensible. Dans de nombreux textes (cf. par ex. Le destin des images, sur la « phrase-image »), Rancière étudie les formes d’accompagnement entre images et mots, et pense la figurabilité comme articulation de deux pouvoirs expressifs en un agencement spécifique. Pour échapper au débat stérile sur la préséance de l’image sur le langage (ou vice-versa), on envisagera avec Rancière l’idée selon laquelle l’image serait une « manière dont les choses parlent et se taisent ». L’image ne dit pas mieux les intensités que les mots, mais elle aménage un lieu inédit pour la mise en fiction des paroles de l’histoire. En ce sens spécifique, la figurabilité, comme mise en scène des mots et des images, doit pouvoir compter sur le travail de l’indétermination – comme on le montrera avec quelques exemples cinématographiques. [less ▲]

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See detailElektrodynamische Fragmentierung von Elektroschrott
Iseli, Cédric; Streicher-Porte, Martin; Martino, Rémi ULg et al

Poster (2016, November 11)

Untersuchungen dazu werden in diesem Bericht am Beispiel von WEEE und speziell an Leiter-platten aufgezeigt. Die Versuche zeigen, dass EDF für verschiedenste Arten von Elektroschrott eingesetzt werden ... [more ▼]

Untersuchungen dazu werden in diesem Bericht am Beispiel von WEEE und speziell an Leiter-platten aufgezeigt. Die Versuche zeigen, dass EDF für verschiedenste Arten von Elektroschrott eingesetzt werden kann. Verschweisste Kompaktgeräte können zum Beispiel so weit geöffnet werden, dass die ge-wünschte Komponente freigelegt und entfernt werden kann. Leiterplatten haben die Eigenschaft, dass bei kontinuierlich steigendem Energieeintrag zuerst die aufgebrachten Komponenten abgetrennt werden, bevor die Cu-Bahnen freigelegt werden. Bei noch höherem Energieeintrag wird die Leiterplatte schlussendlich zerkleinert und vollständig zer-stört. Durch diese Entfrachtung der Leiterplatte kann ein metallreiches Konzentrat hergestellt werden. [less ▲]

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See detail3D and stereoscopy
Verly, Jacques ULg; Grogna, David ULg; Lejeune, Antoine ULg

Conference given outside the academic context (2016)

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See detailTraining researchers to ethics in research
Halleux, Isabelle ULg

Learning material (2016)

This document is provided as a support for training researchers on Ethical Decision Making, and Ethics and Quality in Research. It was presented to the Re@WBC meeting in Kragujevac, Serbia. It can be used ... [more ▼]

This document is provided as a support for training researchers on Ethical Decision Making, and Ethics and Quality in Research. It was presented to the Re@WBC meeting in Kragujevac, Serbia. It can be used in a "train the trainer" context. Duration: 1 day. A very active participation is expected from participants. [less ▲]

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See detailE-health y sus implicaciones jurídicas: el marco europeo e italiano
Colussi, Ilaria Anna ULg

Scientific conference (2016, November 11)

The conference focused on the right to health and its legal and ethical implications. The speech gave a framework on health policies in the European Union, and in particular on the use of technologies for ... [more ▼]

The conference focused on the right to health and its legal and ethical implications. The speech gave a framework on health policies in the European Union, and in particular on the use of technologies for health reasons. The Italian framework is also considered, in order to check the implementation of EU policies inside one National State and develop comparative analysis at that regard. [less ▲]

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See detailLeibniz and the Polyp, or the Metaphysical Puzzle of Life
Dony, Arthur ULg

Conference (2016, November 11)

In this paper, I propose to explore the link between experience and reason in the problem of the apprehension of life. My general claim is that philosophical issues are necessarily involved in a theory of ... [more ▼]

In this paper, I propose to explore the link between experience and reason in the problem of the apprehension of life. My general claim is that philosophical issues are necessarily involved in a theory of living organisms, since identifying a certain entity as a living being is to go beyond its manifestations. In part I, I argue that the empirical approach of the natural sciences cannot fully account for the peculiarity of life. In particular, I argue that the different criteria used to distinguish the living from the non-living, as those proposed in biology, are inadequate, both de facto and de jure. Indeed, they are constantly challenged by inventions of machines displaying features commonly regarded as specific to livings, and also by discoveries of new organisms whose unexpected features overcome the boundaries of our categories. More fundamentally, I hold that these criteria fail to provide sufficient conditions for qualifying beings as living, as long as the external appearances of life can, in principle, be reproduced by lifeless automatons. Therefore the phenomenological aspect of life, which cannot be accessed in a third person point of view (as the perception itself), turns out to be crucial. In the second part, I elaborate on these issues by focusing on the leibnizian theory of living beings. According to Leibniz, the distinctive feature of life is to have of a real unity, which must be conceived as the one to be found in a perceiving soul. After a brief survey on the foundations of this theory, I will emphasize how Leibniz’s attempt to account for the true unity of living beings – as opposed to the accidental unity of non-living things – exemplifies the problematic relationship between the observable properties of organized matter and the inner (or metaphysical) properties of the living as such. In Leibniz’s case indeed, the lack of empirical evidence forces him to resort to philosophical postulates, namely the principle of analogy and the principle of continuity. This latter principle allows him to qualify plants as living beings and to predict the existence of “borderline” organisms as the polyp. Finally, I will propose to consider the discovery of the polyp in the eighteenth century as a case of particular interest and a challenge to the classical conceptions of the living. Among its numerous outstanding properties, the polyp has the faculty to regenerate when cut into pieces, each of them becoming a whole new organism, and to breed by budding. Moreover, a polyp is constituted as a colony of self-contained, smaller polyps. Because of that, it is difficult to determine what the living organism exactly is: is it the colony as a whole or each of its members? And if the whole constitutes a real organism, how shall we explain its oneness? These issues raise the crucial questions of unity and individuality, which are of tremendous importance with regard to the ontological status of life. [less ▲]

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See detailReducing the global burden of HTLV-1 infection: An agenda for research and action
Willems, Luc ULg; Hasegawa, Hideki; Accolla, Roberto et al

in Antiviral Research (2016), 137(2017), 41-48

Even though an estimated 10e20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has ... [more ▼]

Even though an estimated 10e20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has been made to reduce its prevalence. In response to this situation, the Global Virus Network launched a taskforce in 2014 to develop new methods of prevention and treatment of HTLV-1 infection and promote basic research. HTLV-1 is the etiological agent of two life-threatening diseases, adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis, for which no effective therapy is currently available. Although the modes of transmission of HTLV-1 resemble those of the more familiar HIV-1, routine diagnostic methods are generally unavailable to support the prevention of new infections. In the present article, the Taskforce proposes a series of actions to expand epidemiological studies; increase research on mechanisms of HTLV-1 persistence, replication and pathogenesis; discover effective treatments; and develop prophylactic and therapeutic vaccines. [less ▲]

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