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See detailMolecular dynamics study of micelle proeprties according to their size
Lebecque, Simon ULg; Crowet, Jean-Marc ULg; Nasir, Mehmet Nail ULg et al

in Journal of Molecular Graphics and Modelling (2017)

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have ... [more ▼]

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have notably several applications in many domains, such as drug delivery or membrane protein solubilization. In this context, the study of micelle formation in relation with the structural and physico-chemical properties of surfactants is of great interest to better control their use in the different application fields. In this work, we use the MD approach developed by Yoshii et al. and extend it to surfactants with different structures. We aim to systematically investigate different micellar properties as a function of the aggregates size by a molecular dynamics approach, to get an insight into the micellar organization and to collect some relevant descriptors about micelle formation. For this, we perform short MD simulations of preformed micelles of various sizes and analyze three parameters for each micelle size, namely the eccentricity of the micelles, the hydrophobic/hydrophilic surface ratio and the hydrophobic tails hydration. If these parameters are known descriptors of micelles, they were not yet studied in this way by MD. We show that eccentricity, used as “validator” parameter, exhibits minimal values when the aggregate size is close to the experimental aggregation number for surfactants that are known to form spherical micelles. This hence indicates that our methodology gives consistent results. The evolution of the two descriptors follows another scheme, with a sharp increase and decrease, respectively, followed by a leveling-off. The aggregate sizes at which this stabilization starts to occur are close to the respective aggregation number of each surfactant. In our approach, we validate the use of these descriptors to follow micelle formation by MD, from “simple” surfactants to more complex structures, like lipopeptides. Our calculations also suggest that some peculiar behavior, like that of TPC, can be highlighted by our approach. In the context of peptidic surfactants, our methodology could further help to improve computer simulations combined to molecular thermodynamic models to predict micellar properties of those more complex amphiphilic molecules. [less ▲]

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See detailIdentifying tissue specific gene expression using RNAseq data from multiple porcine tissues
Huang, Jianzhen; Schroyen, Martine ULg; Gabler, Nick et al

Poster (2017)

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See detailNeurobiologische Korrelate von exekutiver Kontrolle im alternden Gehirn
Overhage, Sina; Eickhoff, Simon; Jockwitz, Christiane et al

Poster (2017)

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See detailExposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.
Sabatel, Catherine ULg; Radermecker, Coraline ULg; Fievez, Laurence ULg et al

in Immunity (2017), 46(3), 457-473

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major ... [more ▼]

Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective effects, suggesting a major contribution of CpG to microbe-induced asthma resistance. However, how CpG confers protection remains elusive. We found that exposure to CpG expanded regulatory lung interstitial macrophages (IMs) from monocytes infiltrating the lung or mobilized from the spleen. Trafficking of IM precursors to the lung was independent of CCR2, a chemokine receptor required for monocyte mobilization from the bone marrow. Using a mouse model of allergic airway inflammation, we found that adoptive transfer of IMs isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. IM-mediated protection was dependent on IL-10, given that Il10-/- CpG-induced IMs lacked regulatory effects. Thus, the expansion of regulatory lung IMs upon exposure to CpG might underlie the reduced risk of asthma development associated with a microbe-rich environment. [less ▲]

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See detailOptimized Schwarz Domain Decomposition Methods for Scalar and Vector Helmholtz Equations
Antoine, Xavier; Geuzaine, Christophe ULg

in Lahaye, Domenico; Tang, Jok; Vuik, Kees (Eds.) Modern Solvers for Helmholtz Problems (2017)

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See detailP-301 High Concentration Multistrain Probiotic Produced at Different Manufacturing Sites: Comparative Analysis.
Lombardi, Francesca; La Torre, Cristina; Giusti, Ilaria et al

in Inflammatory Bowel Diseases (2017), 23

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See detailTime course of familiarity and novelty decisions in aging
Delhaye, Emma ULg; Bastin, Christine ULg; Moulin, Christopher et al

Conference (2017)

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See detailHigh-throughput strategies for the discovery and engineering of enzymes for biocatalysis
Jacques, Philippe ULg; Béchet, M.; Bigan, M. et al

in Bioprocess and Biosystems Engineering (2017), 40(2),

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See detailSouche bactérienne génétiquement modifiée produisant de la kurstakine dans le milieu de culture
Lereclus, D.; Jacques, Philippe ULg; Gohar, M. et al

Patent (2017)

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See detailExploring the effects of seismicity on landslides and catchment sediment yield: An Italian case study
Vanmaercke, Matthias ULg; Ardizzone, F.; Rossi, M. et al

in Geomorphology (2017), 278

Recent studies showed that contemporary average catchment sediment yields (SY, [t km− 2 y− 1]) at regional and continental scales are often strongly correlated to spatial patterns of seismic activity ... [more ▼]

Recent studies showed that contemporary average catchment sediment yields (SY, [t km− 2 y− 1]) at regional and continental scales are often strongly correlated to spatial patterns of seismic activity. Nonetheless, we currently have little insights into the mechanisms that explain these correlations. We investigated how spatial patterns of SY in Italy are linked to patterns of seismic activity. For a dataset of 103 Italian catchments with average SY measured over a period of years to decades, we extracted tectonic and none-tectonic variables that potentially explain observed differences in SY. These include proxies for vertical uplift rates and cumulative seismic moments (CSM) associated with historic earthquakes of different ranges of magnitude. Results showed that also across Italy, SY is significantly correlated to seismicity. However, SY showed much stronger correlations with proxies of seismicity relating to small but frequent earthquakes (2 ≤ Mw < 4) than with proxies relating to tectonic uplift or large, potentially landslide-triggering earthquakes (Mw ≥ 4). Analyses of a dataset of about 500,000 landslides across Italy showed very comparable trends: spatial patterns of landslides within similar lithological units generally show a significant positive correlation with CSM of weak but frequent seismicity and generally not with CSM of large earthquakes. These results suggest that, on a decadal time scale and at a regional/continental spatial scale, frequent but relatively weak seismicity may exert a more important geomorphic impact than large earthquake events or tectonic uplift. © 2016 Elsevier B.V. [less ▲]

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See detailExploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and Characterization of Inorganic Nanoparticles
Emmanuel, Noémie ULg; Emonds-Alt, Gauthier ULg; Lismont, Marjorie et al

in Journal of Chemical Education (2017)

Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic ... [more ▼]

Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic setups based on PFA capillary coils and standard HPLC connectors in upper undergraduate chemistry labs. Fundamental principles and concepts, as well as practical tips for the rapid deployment of microfluidics are presented. In-line membrane separation, segmented-flow regime, high temperature experiments, and in-line analytical techniques are illustrated with the preparation of inorganic nanoparticles (silver, gold, cadmium selenide or telluride) in microreactors. Besides microfluidics, analytical techniques for nanoparticle analysis are also illustrated. [less ▲]

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See detailGuidance Document on Measurement Uncertainty for Laboratories performing PCDD/F and PCB analysis using Isotope Dilution Mass Spectrometry
Eppe, Gauthier ULg; Schaechtele, Alexander; Haedrich, Johannes et al

Report (2017)

This document on measurement uncertainty was developed within the network of the European Union Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food and the respective National Reference ... [more ▼]

This document on measurement uncertainty was developed within the network of the European Union Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food and the respective National Reference Laboratories (NRLs) of member states. Detailed guidance is given on the evaluation of measurement uncertainty in the quantitative analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs), to assist laboratories performing official feed and food control within the European Union, especially National Reference Laboratories (NRLs) and Official Laboratories (OFLs). It provides useful key elements contributing to further harmonization of compliance assessment and outlines practical aspects related to measurement uncertainty estimation. A new concept placing special emphasis on the inclusion of current method performance data is presented. The concept covers the full analytical process from sample receipt at the laboratory through sample storage, preparation and analysis, to data processing and reporting. In particular, it focuses on the role of analytical variability generally known as "measurement uncertainty" (MU) in the interpretation of analytical results for assessment of their compliance with a specification. Effects from sampling [EURACHEM/CITAC 2007, /18/] and transport also contributing to MU are acknowledged but not treated within the scope of this document. Two selected approaches for measurement uncertainty estimation are proposed for the determination of PCDD/Fs and PCBs in food and feed by gas chromatography-mass spectrometry (GC-MS) using internal standard stable isotope labelled analogues. An empirical, or “top-down”, approach combines contributions from intermediate (intra-laboratory) precision and trueness (expressed as bias) to estimate measurement uncertainty, both for individual congeners and for sum parameters. The working group recommends the use of the empirical approach as described in this document as the main option for MU estimation, because it is designed and developed to cover the whole analytical process and also includes the opportunity to reassess or update MU on a regular basis. However, an alternative methodology based on a semi-empirical approach following the EURACHEM/CITAC guide [EURACHEM/CITAC 2012, /12/] is also presented. It has been designed for laboratories new to this type of analysis that have generated data from initial validation studies. In this case the semi-empirical approach may be a good starting point, however the authors recommend implementing the empirical or top-down approach once enough data have been gathered. [less ▲]

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See detailModelling Future EU Power Systems Under High Shares of Renewables: The Dispa-SET 2.1 open-source model
Quoilin, Sylvain ULg; Hidalgo Gonzalez, Ignacio; Zucker, Andreas

Book published by Publications Office of the European Union (2017)

The increase in the share of renewable sources leads to new needs in terms of flexibility. This evolution of the power system requires proper simulation tools. The Dispa-SET model simulates with a high ... [more ▼]

The increase in the share of renewable sources leads to new needs in terms of flexibility. This evolution of the power system requires proper simulation tools. The Dispa-SET model simulates with a high level of detail the short-term operation of large-scale power systems, solving the unit commitment and optimal dispatch problems. The model is an open-source tool and comes with an open dataset for testing purposes. It can therefore be freely re-used or modified to fit the needs of a particular case study. [less ▲]

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See detailAnalyse des transformations du secteur des ONG belges de développement : vers une professionnalisation.
Contor, Justine ULg

Conference (2017)

Cette communication revient sur le processus de transformation à l’œuvre dans le secteur des ONG observée depuis quelques années. Cette transformation porte à la fois sur l'organisation et sur le ... [more ▼]

Cette communication revient sur le processus de transformation à l’œuvre dans le secteur des ONG observée depuis quelques années. Cette transformation porte à la fois sur l'organisation et sur le travailleur. En effet, il semblerait que nous sommes face à une nouvelles génération d'ONG, "gestionnaire", dans laquelle de nouveau profil de travailleur (marketing, gestion, communication) coexiste avant d'autres travailleurs avec des profils plus techniques et souvent plus engagés aussi. [less ▲]

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See detailVaginocutaneous fistula and buttock abscess formation 7 years after polypropylene transobturator tape insertion.
ABDALLAH, Alain; NISOLLE, Michelle ULg; DE LANDSHEERE, Laurent ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2017), 46

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including ... [more ▼]

Surgical treatment for stress urinary incontinence (SUI) using transobturator tape insertion is widely accepted. However several postoperative complications were reported in the literature including infections, abscess and fistula formation. Here we report a case of 57 year old female who presented with abscess and left vaginocutaneous buttock fistula 7 years after transobturator polypropelene tape insertion. Treatment included abscess drainage with dissection of the fistulous tract and removal of the left arm of the transobturator tape along with antibiotic coverage. Sinus drainage stopped after 3 days. Stress urinary incontinence didn't recur. Suspicion of fistula formation should rise in patients presenting with bothersome vaginal or cutaneous discharge after transobturator tape insertion. This case is particular since it describes a fistula complication with polypropelene tape which is unusual with this type of tapes. Treatment of such complication should always consist of surgical removal of the mesh to allow closure of the fistulous tract. [less ▲]

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See detailInfrared imaging of high density protein arrays.
De Meutter, Joelle; Vandenameele, Julie ULg; Matagne, André ULg et al

in Analyst (2017)

We propose in this paper that protein microarrays could be analysed by infrared imaging in place of enzymatic or fluorescence labelling. This label-free method reports simultaneously a large series of ... [more ▼]

We propose in this paper that protein microarrays could be analysed by infrared imaging in place of enzymatic or fluorescence labelling. This label-free method reports simultaneously a large series of data on the spotted sample (protein secondary structure, phosphorylation, glycosylation, presence of impurities, etc.). In the present work, 100 mum protein spots each containing about 100 pg protein were deposited to form high density regular arrays. Using arrays of infrared detectors, high resolution images could be obtained where each pixel of the image is in fact a full infrared spectrum. With microarrays, hundreds of experimental conditions can be tested easily and quickly, with no further labelling or chemistry of any kind. We describe how the noise present in the infrared spectra can be split into image noise and detector noise. We also detail how both types of noise can be most conveniently dealt with to generate very high quality spectra of less than 100 pg protein. Finally, the results suggest that the protein secondary structure is preserved during microarray building. [less ▲]

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See detailTowards an Australian Philosophy: Constructive Appropriation of Enlightenment Thinking in Murray Bail's The Pages
Herbillon, Marie ULg

in Tunca, Daria; Wilson, Janet (Eds.) Postcolonial Gateways and Walls: Under Construction (2017)

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See detailIntegrating production scheduling and vehicle routing decisions at the operational decision level: A review and discussion
Moons, Stef; Ramaekers, Katrien; Caris, An et al

in Computers & Industrial Engineering (2017), 104

Production scheduling and vehicle routing are two well-studied problems in literature. Although these supply chain functions are interrelated, they are often solved sequentially. This uncoordinated ... [more ▼]

Production scheduling and vehicle routing are two well-studied problems in literature. Although these supply chain functions are interrelated, they are often solved sequentially. This uncoordinated approach can lead to suboptimal solutions. In the current competitive business environment, companies are searching for methods to save costs and improve their service level. Integrating production and distribution scheduling operations can be an approach to improve the overall performance. This paper focuses on integrated production-distribution operational level scheduling problems, which explicitly take into account vehicle routing decisions of the delivery process. Existing literature on integrated production scheduling and vehicle routing problems is reviewed and classified. Both the problem characteristics of mathematical models and the accompanying solution approaches are discussed to identify directions for further research. [less ▲]

Detailed reference viewed: 43 (2 ULg)