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See detailAn Affective Account of Distance Estimation Biases
Dumitru, Magdalena ULg

Conference (2017, March 25)

Dumitru and Joergensen (2016) employed a task designed to probe social attitudes to covertly investigate the magnitude estimation of digit-word expressions (e.g., ‘8 ants’). Here we employed a task ... [more ▼]

Dumitru and Joergensen (2016) employed a task designed to probe social attitudes to covertly investigate the magnitude estimation of digit-word expressions (e.g., ‘8 ants’). Here we employed a task designed to elicit affective states to gain insights into distance underestimation and boundary extension biases. [less ▲]

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See detailCorps et virtualité : Psychopathologie du sujet borderline
Englebert, Jérôme ULg

Scientific conference (2017, March 24)

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See detailThe implicit transformation of national administrative authorities in the service of supranational ‘fair trial’ rights
Van Cleynenbreugel, Pieter ULg

Scientific conference (2017, March 24)

This presentation analyses to what extent the fundamental right to a fair trial has been instrumental in shaping or modifying the structure of national competition and financial market authorities in five ... [more ▼]

This presentation analyses to what extent the fundamental right to a fair trial has been instrumental in shaping or modifying the structure of national competition and financial market authorities in five States (the United Kingdom, France, Germany, the Netherlands and Belgium). Submitting that the ECtHR and the CJEU have succeeded in imposing a limited number of administrative organisation templates on administrative authorities and uncovering the limits of that approach, it will call for a more fundamental reflection on the risks and opportunities associated with inter- and supranational courts establishing, in a bottom-up fashion, administrative organisation templates subsequently imposed on States. [less ▲]

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See detailAnosognosia for behavioral disorder is related to confidence for false self-related memories in Alzheimer’s disease
Mélon, Marlène; Collette, Fabienne ULg; Salmon, Eric ULg et al

Poster (2017, March 24)

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and ... [more ▼]

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and memory cognitive systems in AD, reducing cognitive advantages of self-related memories (i.e. decreasing self reference effect, SRE) in these patients. However, how anosognosia relates to impaired metacognitive monitoring in AD, particularly for self-related memories, is still an open question. To investigate this question, an ecological memory task based on face-name associations was administrated to 20 healthy older controls (HC) and 20 mild AD patients. The influence of self-reference at encoding was assessed on subsequent name recall and recollective experience, as well as on predictive (feeling-of-knowing, FOK) and postretrieval (judgments-of-confidence, JOC) metacognitive judgments on name recognition in all participants. Furthermore relationships between metacognitive outcomes and awareness of daily cognitive and behavioral impairment was examined in AD. Altered SRE was evidenced in name recall and recollective experience in AD. Patients also showed impaired FOK and JOC, as well as lower awareness of their daily functioning impairment (anosognosia). Nevertheless, differential effect of self on metacognitive judgment in AD and HC was only observed on JOC for false memories. Importantly, anosognosia for behavioral disorders was related to post-retrieval confidence for false recognition of self-related items in AD patients. Thus, anosognosia concerning behavioral disorder and altered post-retrieval monitoring of self-related memories appear to be related in AD. We hypothesized that impaired monitoring of personal false memories may lead AD patients to rely on distorted recent reality when providing judgment about their everyday behavioral functioning. [less ▲]

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See detailInactivation of DNA damage repair provides additional efficacy to the treatment of thyroid cancer
Neelature Sriramareddy, Sathyanarayana ULg

Doctoral thesis (2017)

Incidence of thyroid cancer has increased steadily over the last several decades. This type of neoplasm accounts for the majority of deaths due to endocrine cancers. The most frequent form, well ... [more ▼]

Incidence of thyroid cancer has increased steadily over the last several decades. This type of neoplasm accounts for the majority of deaths due to endocrine cancers. The most frequent form, well-differentiated thyroid cancer, is characterized by disease persistence, recurrence and a lack of response to radioiodine-131. With survival rates of 9 weeks to 5 months, anaplastic thyroid cancer has very poor prognosis. To provide additional efficacy to the treatment of thyroid cancer, we investigated the mechanisms of DNA damage and repair. We found that thyroid cancer cells undergo mitosis in presence of unrepaired DNA damage. To proliferate and survive, these cells repair DNA lesions very efficiently using homologous recombination (HR) and non-homologous end joining (NHEJ). Pharmacological inhibition of these pathways significantly increases apoptosis of thyroid cancer cells. This thesis thus demonstrates that targeting DNA damage repair pathways might have therapeutic value in relapsing and advanced thyroid cancers. [less ▲]

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See detailMonitoring Lions (Panthera leo) using Digital 3D Models of their Tracks
Marchal, Antoine ULg

Doctoral thesis (2017)

As the Earth may be entering a new human-influenced geological time, the Anthropocene, the pressure on biodiversity due to increasing human populations and activities is unprecedented. Monitoring animal ... [more ▼]

As the Earth may be entering a new human-influenced geological time, the Anthropocene, the pressure on biodiversity due to increasing human populations and activities is unprecedented. Monitoring animal populations is essential to gain demographic data and assess their viability. Because of the difficulties linked to invasive methods that involve direct observation or handling, many researchers have explored alternative approaches such as using tracks. Tracks are the material by-product of the interaction between terrestrial animals and their physical environment due to gravity. The interpretation of tracks exists since the dawn of mankind and is a crucial factor for human evolution. As an integral part of hunting, the art of tracking involves cognitive thinking that may well be part of the origin of science. However, monitoring species through their tracks is controversial due to several reasons: unreliable recording techniques limited to two-dimensions, manipulator bias, substrate variation, misidentification of the foot from which each track originates, and subjective identification of the age, sex and/or individual. The aim of this thesis was to evaluate the possibility of monitoring lions Panthera leo through digital three-dimensional (3D) models of their tracks. The first step was to assess close-range digital photogrammetry as a low-cost, rapid, practical and reliable field technique for the digital 3D modelling of lion paws, tracks and trails. A trail, that is a continuous sequence of tracks made by the same individual, reflects the morphology and kinematics of that individual. The use of traditional morphometrics enabled the extraction of variables such as distances, angles and areas from the digital 3D trails originating from individuals of known age, sex and/or identity. When comparing adult lions walking at the same gait (i.e. same kinematics), the trail variables provided sufficient information to identify the sex and individual. The digital solution permitted the extraction of more variables than the usual pace, stride and straddle. These additional variables enabled a better discrimination between the sexes and individuals. As for the paw and track morphology, traditional morphometrics conveys limited information about the geometric structure, and fails to quantify the shape variations along curves and surfaces. To overcome these drawbacks, geometric morphometrics allowed the extraction of the form (i.e. size and shape) by means of superimposed fixed landmarks, and curve- and surface-slider semi-landmarks. Using fixed landmarks, the paws and tracks presented enough shape variation to identify their position along the anteroposterior (front or hind) and mediolateral (right or left) axes. We used fixed landmarks, with and without curve- and surface-sliders, on paws and tracks from lions of known age, sex and/or identity. The identification of the age and sex from the paws, and the age, sex and individual from the tracks achieved higher accuracies when using size and shape variables together rather than independently. The information from curves and surfaces offered an advantage for the identification from the tracks but not from the paws. Due to the variation in anatomy, paw morphology and individuality in walking, tracks and trails contain information about the individual lion that created them. Recent advances in digital close-range photogrammetry and geometric morphometrics allow the recording and extraction of that information, which can then provide data to help monitor lion populations using a non-invasive approach. [less ▲]

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See detailRecollection versus familiarity in normal aging and in mild cognitive impairment: Impact of test format
Simon, Jessica ULg; Gilsoul, Jessica ULg; SALMON, Eric ULg et al

Poster (2017, March 24)

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to ... [more ▼]

If familiarity is better preserved than recollection in aging and in the early stage of Alzheimer's disease (Koen & Yonelinas, 2014), the experimental conditions promoting its use should be beneficial to these populations. One condition influencing the relative contribution of recollection and familiarity during recognition is the format of the test. The aim of this study was to investigate the impact of test format on recollection and familiarity in normal aging and in MCI in two tasks where the level of performance is equalized. Seventy young participants, 70 younger-old (55-69 years old), 69 older-old (70-85 years old), and 13 MCIs were presented with forced-choice and yes/no visual recognition memory tasks with the Remember/Know/ Guess paradigm. Young participants had better recognition memory performance than younger-old, who performed better than older-old and MCIs. Recollection and familiarity declined progressively in healthy aging. In MCI, recollection was more affected than familiarity, but patients demonstrated a more liberal use of familiarity. Finally, test format did not influence strongly the results. Young people used recollection more often in the forced-choice task compared to the yes/no task. [less ▲]

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See detailDepression is a heterogeneous condition: A cluster-analysis approach
Wagener, Aurélie ULg; Baeyens, Céline; Van der Linden, Martial ULg et al

Poster (2017, March 24)

The heterogeneity of depression (i.e., symptomatology profiles, treatment responsiveness) is more and more evidenced. From a clinical perspective, having a clearer overview of the symptoms’ heterogeneity ... [more ▼]

The heterogeneity of depression (i.e., symptomatology profiles, treatment responsiveness) is more and more evidenced. From a clinical perspective, having a clearer overview of the symptoms’ heterogeneity of depression will help (1) to deeper understand its underlined psychological processes and (2) to tailor clinical treatments (i.e., psychological interventions and/or antidepressant medications). In order to so, an effort to determine subtypes of depression has been developed through a cluster-analysis approach. Andreasen et al. (1980) identified three clusters of depressed patients based on the Schedule for Affective Disorders and Schizophrenia; Schacht et al. (2014) evidenced five clusters based on the Hamilton Depression Rating Scale (i.e., lack of insight, sleep/sexual/somatic, typical MDD, gastrointestinal/weight loss, mild MDD); Hybels et al. (2012) found three clusters of depressive patients based on the Center for Epidemiologic Studies-Depression Scale in community seniors; and Guidi et al. (2011) found two clusters of depressives in medically ill patients based on the Structured Clinical Interview for DSM-IV (i.e., depressed somatizers, irritable/anxious depression). The current study aims at replicating and extending these previous findings in adults presenting depressive symptoms through a cluster-analysis approach. Unlike previous studies, the highlighting of the clusters will be based on the most frequently used assessment of depression, the Beck Depression Inventory-Second Edition (BDI-II). Further, the definition of the clusters will be based on the presence of the depressive symptoms rather than on their severity because symptoms’ severity on the BDI-II can be misrepresentative of the phenomenology of depressive symptoms’ clusters. A sample of 619 adults from community and mental healthcare centers has been recruited. Inclusion criteria were as follows: being a French-speaking adult aged between 18 and 60 years and presenting at least five symptoms on the BDI-II, irrespective of their severity. Data grouping was achieved through a combination of hierarchical (Ward’s method with squared Euclidian distance measurement) and nonhierarchical procedures (K-means cluster analysis), as recommended by recent theoretical trends. A six-cluster solution was evidenced: heavy sleepers (high levels of tiredness, loss of energy and increase of sleep), cognitive depressives (high levels of pessimism, past failures, guilty feelings, self-dislike and worthlessness), affective-somatic depressives (high levels of affective symptoms - loss of interest and pleasure - and somatic symptoms - increase of appetite and sleep, irritability), mild depressives (mild levels of all symptoms), sleepless depressives (high levels of decrease of sleep and tiredness), typical depressives (high levels of all symptoms). Results evidenced the heterogeneity of depressive symptoms, as six different clusters of depressive adults have been found. Two of the clusters identified in the current study are similar to two clusters identified by Schacht et al. (2014) (sleepless depressives are similar to the cluster “sleep/sexual/somatic” because their profile are highly characterized by symptoms related to insomnia and tiredness; mild depressives are similar to the cluster “mild MDD/symptoms” because their profile are characterized by low to average levels on all symptoms). The take-home message of this study is that depression is a heterogeneous condition. Consequently, it is necessary to consider this heterogeneity in order to tailor the psychological intervention. [less ▲]

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See detailOLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages
QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg; Bertrand, Virginie ULg et al

in Clinical Proteomics (2017), 24(9),

Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages ... [more ▼]

Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient’s survival. Methods: We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohisto‑ chemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages. Results: Out of 5258 proteins identified, we obtained 561 proteins with a significant differential distribution among groups of patients and controls. KNG1, OLFM4 and Sec24C distributions were validated in tissues and showed differ‑ ent expression levels especially in the two early CRC stages compared to normal and preneoplastic tissues. Conclusion: We highlighted three proteins that require further investigations to better characterise their role in early CRC carcinogenesis and their potential as early CRC markers. [less ▲]

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See detailAmok. De quelques perdants radicaux chez Hans Magnus Enzensberger.
Hamers, Jérémy ULg; Cormann, Grégory ULg

Conference (2017, March 23)

En 2006, l’écrivain et essayiste allemand Hans Magnus Enzensberger publie Le perdant radical, un « essai sur les hommes de la terreur », conformément au sous-titre de cet ouvrage d’une soixantaine de ... [more ▼]

En 2006, l’écrivain et essayiste allemand Hans Magnus Enzensberger publie Le perdant radical, un « essai sur les hommes de la terreur », conformément au sous-titre de cet ouvrage d’une soixantaine de pages dans lequel l’auteur décrit les multiples facettes d’un ensemble de figures meurtrières. Du tireur fou dans un lycée américain au combattant islamiste ceinturé d’explosifs, isolé ou organisé en groupe, tout perdant radical répond au même mécanisme : c’est « lorsqu’il aura repris à son compte le jugement des autres, ceux qu’il tient pour les gagnants (…) qu’il pète les plombs. » L’indistinction est frappante : pour Enzensberger, le perdant radical peut sévir seul ou en groupe ; son moteur profond, irréductible à un engagement politique ou religieux, reste le même dans les deux cas. Car pour l’essayiste, rien, pas même une théorie critique de la société, ne permet de rendre compte de la nature du perdant radical, si ce n’est la suppression de l’instinct de conservation. Dans plusieurs textes littéraires – on songe notamment à son poème Zur Frage der Bedürfnisse (1991) et à son entretien autobiographique fictif avec lui-même Erinnerungen an einen Tumult (2014) –, Hans Magnus Enzensberger crée ou recrée des figures de terroristes qui réalisent parfaitement le profil type du perdant radical. Andreas Baader, les jeunes bourgeois d’une secte marxiste en Suède, un terroriste islamiste en fuite, un guérillero sud-américain qui a perdu tout sens de la réalité, autant de figures fictionnelles ou refictionnalisées qui, partant d’une même position d’échec apparemment imposée de l’extérieur et assumée en tant que telle, superposent destruction et autodestruction. L’hypothèse générale à laquelle nous voudrions soumettre ces personnages de terroristes est qu’ils sont les héritiers d’une figure essentielle pour la littérature allemande et anglo-saxonne : l’amok. [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

Detailed reference viewed: 39 (3 ULg)
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See detailPotential uses of pumped urban groundwater. A case study in Sant Adrià del Besòs (Spain)
Jurado Elices, Anna ULg; Vázquez-Suñé; Pujades, Estanislao ULg

in Hydrogeology Journal (2017)

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent ... [more ▼]

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent disuse of groundwater resulted in rising water tables that damage underground structures (e.g., building basements and underground car parks and tunnels), leading to additional pumping in urban areas. This is the case of the underground parking lot of Sant Adrià del Besòs (NE Spain), where large amounts of urban groundwater are pumped to avoid seepage problems. The question that arises here is if this pumped groundwater can be used for other purposes (e.g., drinking water and urban irrigation) instead of wasting this valuable resource. To answer this question, it is necessary to quantify the groundwater recharge and to assess the evolution of ground-water quality in order to properly identify its potential uses. The limiting factor to define the uses of this resource is the groundwater quality because ammonium and some metals (iron and manganese) are present at high concentrations. Hence, further treatment would be needed to meet drinking water requirements. The pumped groundwater could also be used for supplying the ecological river flow and/or for mitigating seawater intrusion problems. Currently, only a small amount of this urban groundwater is used for cleaning public areas and watering public gardens. This situation highlighted the urgent need to manage this resource in a responsible and more efficient manner, especially in moments of high water demand such as drought periods. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULg; Blanpain, Manon ULg; Van Egroo, Maxime ULg et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailConstruction, restauration et ornement: pour une histoire de quelques chantiers "décapants"
Houbart, Claudine ULg; Detry, Nicolas

Conference (2017, March 23)

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See detailInterest of multisite bacterial screening for the diagnosis of congenital listerisosis with negative blood culture: a case report
Snyers, Diane ULg; Thirion, Sophie ULg; Kalenga, Masendu ULg et al

Scientific conference (2017, March 23)

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal ... [more ▼]

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal infections occurs rarely. As a consequence, listeriosis is not always considered for early onset neonatal infection, especially when blood culture is negative. Indeed, identification of listeria in the blood stream by conventional bacteriological methods remains the reference method for diagnosing listeriosis. We report a case of congenital listeriosis with negative blood culture despite typical chorioamnionitis, where the pathogen was cultured in gastric aspirate.Although the disease is rare, congenital listeriosis still remain a possible challenging condition in neonatal practice as revealed by this case report. This also shows the importance of multisite bacterial culture beside conventional blood and CSF culture, in combination with histological examination of the placenta for the diagnosis of congenital listeriosis. [less ▲]

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See detailLe droit de vote en Belgique, 1830-2017
Lanneau, Catherine ULg

Conference given outside the academic context (2017)

Detailed reference viewed: 37 (5 ULg)
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See detailLa Cour pénale internationale et les crimes de guerre
Deprez, Christophe ULg

Scientific conference (2017, March 23)

Ces dias ont servi de support à une présentation introductive sur la compétence de la Cour pénale internationale en matière de crimes de guerre, proposée dans le cadre du séminaire "Guerre & Droit ... [more ▼]

Ces dias ont servi de support à une présentation introductive sur la compétence de la Cour pénale internationale en matière de crimes de guerre, proposée dans le cadre du séminaire "Guerre & Droit" organisé à l'Université catholique de Louvain (2016-2017) [less ▲]

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