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See detail« Oiseaux blessés. Avec les stagiaires d’Article 23 »
Melice, Anne ULg

in Centre Franco Basaglia – Liège, Mouvement pour une psychiatrie démocratique dans le milieu de vie. (2016)

Après une synthèse de récits de vie recueillis auprès de stagiaires rencontrés au sein des ateliers de l’Asbl Article 23 (Horeca et Bâtiment), ce texte décrit l’accueil qu’ils m’y ont réservé. Ce récit se ... [more ▼]

Après une synthèse de récits de vie recueillis auprès de stagiaires rencontrés au sein des ateliers de l’Asbl Article 23 (Horeca et Bâtiment), ce texte décrit l’accueil qu’ils m’y ont réservé. Ce récit se prolongera dans le texte suivant intitulé « ‘’Je te porte dans moi comme un oiseau blessé’’ (Aragon) », qui se fera l’écho de mon observation de l’hospitalité propre aux ateliers d’Article 23. [less ▲]

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See detailChanges in crop yields, soil organic carbon and soil nitrogen content under climate change and variable management practices"
Dumont, Benjamin ULg; Basso, Bruno; Shcherbak, Iurii et al

Conference (2016, September)

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See detailA new method for identifying experimental and Palaeolithic hafting adhesives using GC×GC-HRTOFMS
Cnuts, Dries ULg; Perrault, Katelynn ULg; Dubois, Lena ULg et al

Poster (2016, September)

Hafting adhesives can be seen as an indication of the cognitive and technical capabilities of the manufacturers and therefore play a key role in the debate on human evolution [1], [2]. These adhesives are ... [more ▼]

Hafting adhesives can be seen as an indication of the cognitive and technical capabilities of the manufacturers and therefore play a key role in the debate on human evolution [1], [2]. These adhesives are mainly from plant origin (resins, gums or tar) and are often mixed with beeswax and other additives in order to make them less brittle. Archaeological evidence indicates that these adhesives were already in use in the Paleolithic from at least 120.000 years ago [3]. Discoveries for this period are however very rare and only become abundant from the Neolithic onwards [4]. Their longer exposure to biochemical alteration processes limits the chance of survival in the archaeological record. If they are present on Paleolithic stone tools, they appear often in such small quantities that they are challenging to identify by traditional gas chromatography – mass spectrometry (GC-MS) or even to remove them effectively from the stone tool. The destructive nature of traditional GC-MS analysis can damage these rare samples for other analyses. Our study aims to overcome this problem by using headspace solid phase microextraction (HS-SPME) for sample extraction and analysis by comprehensive two-dimensional gas chromatography –high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS), which has the benefit of analyzing the volatile organic compound (VOC)s from the substance and it does not destroy the complete matrix of the adhesive. We present the results of a pilot study intended to examine the potential of this technique for analyzing Palaeolithic adhesives. The study involved (1) an examination of experimental compound adhesives (containing pine and spruce resin, acacia gum and birch tar; beeswax and additives like charcoal, flax or ochre), (2) a blind test on experimental samples to test the reliability of the method and to determine the minimal quantity necessary for analysis, and (3) the analysis of different Palaeolithic adhesives and of experimental samples of at least 15 years old. The analysis was done on extracted and non-extracted adhesives. A unique chromatographic fingerprint was obtained for all experimental adhesive samples. The VOC profile of these adhesives proved to be extremely complex and therefore benefitted significantly from multidimensional separation techniques. GC×GC-HRTOFMS provided an optimal chromatographic separation of adhesive components. HRTOFMS data was used in order to obtain high-resolution mass spectral data to contribute to compound identification. Our study demonstrates that GC×GC-HRTOFMS is a well suited method for identifying small quantities of compound adhesives with significant potential for Palaeolithic contexts. The additional sensitivity afforded by this technique in comparison to traditional GC-MS is a substantial benefit for these quantities. Furthermore, by only analyzing the VOCs of the adhesives, these rare archeological samples are not destroyed and can still be used for other types of analysis. [1] L. Wadley, ‘Compound-Adhesive Manufacture as a Behavioral Proxy for Complex Cognition in the Middle Stone Age’, Curr. Anthropol., vol. 51, no. s1, pp. S111–S119, Jun. 2010. [2] L. Barham, From Hand to Handle: The First Industrial Revolution. Oxford: Oxford University Press, 2013. [3] P. P. A. Mazza, F. Martini, B. Sala, M. Magi, M. P. Colombini, G. Giachi, F. Landucci, C. Lemorini, F. Modugno, and E. Ribechini, ‘A new Palaeolithic discovery: tar-hafted stone tools in a European Mid-Pleistocene bone-bearing bed’, J. Archaeol. Sci., vol. 33, no. 9, pp. 1310–1318, Sep. 2006. [4] M. Regert, ‘Investigating the history of prehistoric glues by gas chromatography-mass spectrometry.’, J. Sep. Sci., vol. 27, no. 3, pp. 244–54, Feb. 2004. [less ▲]

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See detailSIMULATION AND ANALYSIS OF RECEPTOR DYNAMICS IN A BMP REGULATORY NETWORK
Germain, Morgan ULg; Bolander, Johanna; Ji, Wei et al

Poster (2016, September)

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See detailSOLINDIC : Etude de l’activité biologique du système « Sol-Plante » en vue de préserver les fonctionnalités des sols agricoles
Blondel, Alodie; Durenne, B.; Mingeot, D. et al

Report (2016)

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See detailPar-delà les mots : les politiques d'activation face à leurs limites
Vrancken, Didier ULg

Article for general public (2016)

Au cours des dernières décennies, sur fond de crise économique, ont émergé des politiques sociales d' "activation" visant à mobiliser les individus les plus fragiles, à les autonomiser et les ... [more ▼]

Au cours des dernières décennies, sur fond de crise économique, ont émergé des politiques sociales d' "activation" visant à mobiliser les individus les plus fragiles, à les autonomiser et les responsabiliser davantage. Initialement déployées sur le terrain de la (re)mise à l'emploi, ces politiques se sont peu à peu étendues à d'autres champs comme la santé, les retraites, le socio-pénal, les politiques de la ville, le vieillissement actif, l'aide sociale... Un véritable projet anthropologique misant sur le travail sur Soi semble s'être dessiné... [less ▲]

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See detailUtilisation of CO2 from an Industrial source for Methanol production
Font-Palma, Carolina; Douven, Sigrid ULg; Léonard, Grégoire ULg

Conference (2016, September)

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See detailCutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients
Jurczyszyn, A.; Olszewska-Szopa, M.; Hungria, V. et al

in Leukemia & Lymphoma (2016), 57(9 2071-6), 2071-6

Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical ... [more ▼]

Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS. [less ▲]

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See detailL'applicabilité des droits humains à l'action de la Cour pénale internationale
Deprez, Christophe ULg

Book published by Bruylant (2016)

Entre instrument de protection des libertés fondamentales et menace à l’égard des mêmes libertés, l’activité pénale est un phénomène cerné de paradoxes. Les règles de protection des droits humains ont ... [more ▼]

Entre instrument de protection des libertés fondamentales et menace à l’égard des mêmes libertés, l’activité pénale est un phénomène cerné de paradoxes. Les règles de protection des droits humains ont notamment pour ambition de contenir ces paradoxes : en encadrant le pouvoir de contrainte que l’autorité répressive peut exercer sur les individus, ces normes essentielles doivent permettre de garantir une justice pénale qui demeure fidèle aux principes qu’elle entend défendre. Mais, dès lors que le droit international des droits humains a été pensé et conçu pour circonscrire l’autorité des États, qu’en reste-t-il lorsqu’on cherche à l’appliquer à la Cour pénale internationale ? Dans quelle mesure et sur la base de quel(s) fondement(s) juridique(s) cet acteur répressif d’un genre nouveau est-il tenu au respect de règles auxquelles il n’a pas expressément souscrit ? Les spécificités de la justice pénale internationale – telles que la gravité des crimes ayant favorisé son émergence – réclament-elles une adaptation du niveau de protection accordé aux suspects et accusés internationaux ? Cet ouvrage vise à apporter un éclairage sur ces questions et, ainsi, à cerner les contours de l’applicabilité des droits humains à l’action de la Cour pénale internationale. [less ▲]

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See detailFrom European Mobility to Military Interoperability - Exchanging young officers, knowledge and know-how
Paile, Sylvain ULg

Book published by Publications Office of the European Union - Luxembourg: Publications Office of the European Union, 2016 (2016)

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See detailRefractive and diffractive contribution of linear chromatic aberration (LCA) on depth-of-focus with trifocal intraocular lenses (IOLs)
Loicq, Jerôme ULg; Gatinel, Damien

Poster (2016, September)

Purpose: To investigate the refractive and diffractive contribution of LCA on depth of focus extension of trifocal IOLs in polychromatic light conditions Setting: University of Liège, Belgium; Fondation ... [more ▼]

Purpose: To investigate the refractive and diffractive contribution of LCA on depth of focus extension of trifocal IOLs in polychromatic light conditions Setting: University of Liège, Belgium; Fondation Ophtalmologique A. de Rothschild, Paris Methods: The LCAs associated with the three focal points of hydrophobic and hydrophilic diffractive FineVision trifocal IOLs (PhysIOL SA, Liège, Belgium), were simulated in an Arizona eye model and experimentally measured on an optical bench at 480, 546 and 650 nm. The effect of Abbe number and aperture on different IOL materials was also evaluated. Based on wavelength–dependent MTF through-focus curves and PSF properties, polychromatic behavior of the trifocal IOLs was assessed under mesopic and photopic conditions. Results: LCA amplitude and sign were different for each of the trifocal IOL focal points. The diffractive LCA for near and intermediate was independent of IOL material (GFree versus hydrophilic acrylic, 26%), while far vision LCA appeared to be controlled by the material Abbe number. Under polychromatic conditions, the LCA contributed to depth of focus extension with different types of lens material, providing maximal visual acuity under white light conditions at all distances. Conclusions: Diffractive trifocal IOLs show chromatic aberrations with an increase in depth of focus under polychromatic light. This effect likely contributes to the extended range of vision. [less ▲]

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See detailClinically relevant optical properties of three types of intraocular lenses
Gatinel, Damien; Loicq, Jerôme ULg

Conference (2016, September)

Purpose: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus (TECNIS Symfony), bifocal (TECNIS ZMB00), and trifocal ... [more ▼]

Purpose: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus (TECNIS Symfony), bifocal (TECNIS ZMB00), and trifocal (FineVision GFree). Setting: Rothschild Foundation Paris, France - Liege Space Center Liège, Belgique Methods: Surface topography was analyzed by optical microscopy. Modulation transfer function (MTF) and spherical aberrations were determined on optical bench for variable pupil apertures and with two cornea models (0 µm and +0.28 µm). United States Air Force target imaging was analyzed for different focal points (near, intermediate, and far). Point spread function (PSF) and halos were quantified and compared. Results: All lenses presented step-like optic topography. For a pupil size of = 3 mm, distinctive MTF peaks were observed for all lenses: two peaks for the extended depth of focus and bifocal lenses with +1.75 and +4.00 diopters (D) addition, respectively, and three peaks for the trifocal lens with +1.75 and +3.50 addition for intermediate and near vision, respectively. The extended depth of focus and bifocal lens had slightly higher MTF at best focus with the +0.28 µm cornea model than with the 0 µm model, whereas the trifocal lens was likely to be more independent of the corneal spherical aberrations. Conclusions: Each lens appears to rely on light diffraction for optical performance, presenting halos with comparable intensities. For small pupil apertures, the MTF peaks for the far and intermediate focal distances of the trifocal and extended depth of focus lenses overlap, but the trifocal lens presented an additional MTF peak for the near focal points. [less ▲]

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See detailTraduction inter-culturelle et validation du Kujala Anterior Knee Pain Scale (AKPS) en français
Kaux, Jean-François ULg; Bornheim, Stephen ULg; Remy, Gaël et al

in 9ème Congrès commun SFMES - SFTS (2016, September)

Introduction : Le syndrome fémoro-patellaire est l'un des problèmes de genou les plus répandus qui se caractérise par une douleur antérieure du genou dans des activités mettant en charge l'articulation ... [more ▼]

Introduction : Le syndrome fémoro-patellaire est l'un des problèmes de genou les plus répandus qui se caractérise par une douleur antérieure du genou dans des activités mettant en charge l'articulation fémoro-patellaire. Le Kuala Anterior Knee Pain Scale (Kujala AKPS) est un questionnaire utilisé pour évaluer les symptômes subjectifs, tels que les limitations fonctionnelles et la douleur antérieure du genou. Le questionnaire a déjà été traduit et validé en portugais brésilien, en persan, en chinois, en turque, et en néerlandais. Le but de cette étude est de traduire ce questionnaire en français afin d'en évaluer sa fiabilité et sa validité. Matériel et méthode : La traduction et l’adaptation interculturelle du questionnaire a été adaptée selon les recommandations internationales qui se présentent en 6 étapes : traduction initiale, synthèse des traductions, traduction de retour vers la langue d’origine, comité d'experts, test de la version pré-finale et approbation du comité experts. Une fois la version française obtenue, les participants (n=101) ont remplis 2 fois le Kujula AKPS avec un intervalle de 7 jours, et le Short Form Health Survey (SF-36) afin d'en évaluer les propriétés psychométriques (la cohérence interne, la fidélité test-retest et la validité de construit). Résultats : Le Kujula AKPS montre une fidélité test-retest élevée pour le score total (ICC 0,97). La traduction française possède une cohérence interne élevée (0,87). Le Kujula AKPS possède une corrélation forte avec une partie des sous-échelles convergentes du SF-36 (PF, RP et BP). Il y a une corrélation faible ou modérée avec les sous-échelles divergentes du SF-36 (MH, SF et VT). Il n’y a pas d’effet plancher et plafond. Conclusion : La version française du questionnaire Kujula AKPS étant compréhensible, semble avoir une bonne adaptation interculturelle. Cette étude a démontré que le Kujula AKPS-F est fiable et valide pour les patients francophones souffrant d'un syndrome rotulien. [less ▲]

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See detailImpact d’une réathlétisation précoce sur les performances des sportifs opérés d’une rupture du ligament croisé antéro-externe du genou
Duval, Thomas; Kaux, Jean-François ULg; LEHANCE, Cédric ULg et al

in 9ème Congrès commun SFMES - SFTS (2016, September)

Introduction : La reconstruction du ligament croisé antéro-externe du genou est une chirurgie lourde qui est suivie d’une longue période de rééducation. Le retour au sport après cette opération reste ... [more ▼]

Introduction : La reconstruction du ligament croisé antéro-externe du genou est une chirurgie lourde qui est suivie d’une longue période de rééducation. Le retour au sport après cette opération reste toutefois un défi. Plus d’un tiers des athlètes est incapable de reprendre son activité au même niveau. La peur de subir un nouvel accident reste un obstacle majeur à cette reprise sportive et la persistance de déficits fonctionnels est la première cause de récidives de déchirure ligamentaire. Matériels et méthodes : Notre échantillon comprend dix sujets, cinq dans le groupe bénéficiant d’une réathlétisation précoce et cinq dans le groupe témoin. Le premier groupe réalise une séance de réathlétisation précoce hebdomadaire (à raison d’une fois par semaine et ce, durant six mois) associée à la rééducation en kinésithérapie durant une durée de six mois. Le deuxième groupe bénéficie uniquement de séances de kinésithérapie classique respectant un protocole bien défini du CHU de Liège. Nous avons choisi de réaliser, en pré-opératoire, dans les deux groupes, un test isocinétique. En post-opératoire (après six mois), les sujets des deux groupes ont réalisé dans l’ordre suivant : un test isocinétique, un questionnaire de KOOS et enfin des tests fonctionnels (Hop test). Les séances de réathlétisation et de kinésithérapie sont suivies selon un protocole spécifique respectant l’individualisation propre à chaque patient. Résultats : L’analyse des tests isocinétiques et du questionnaire de KOOS, nous a permis de constater des différences entre les deux groupes au niveau des valeurs chiffrées mais qui ne sont cependant pas significatives (P level= 0,07). Par contre, l’analyse des résultats obtenus dans les tests fonctionnels (tests de sauts en longueur évaluant la performance en distance) a montré des différences significatives (P level= 0,04 pour le single hop et le triple hop test, P level= 0,02 pour le cross over hop test) entre les deux groupes et celles-ci sont au bénéfice du groupe ayant bénéficié d’une réathlétisation précoce. Conclusion : Dans cette étude, nous constatons une amélioration globale des performances en faveur du groupe ayant bénéficié d’une réathlétisation précoce. Cependant lors de l’analyse statistique et ce surtout concernant dans le test isocinétique, peu d’éléments évoluent de manière significative voir aucun pour le questionnaire de KOOS. Le faible échantillonnage de cette étude préliminaire intervient certainement dans ce constat. [less ▲]

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See detailTargeted mutagenesis of orphan GPCRs of the SREB family
Laschet, Céline ULg; Dupuis, Nadine ULg; Soni, Arvind ULg et al

Poster (2016, September)

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See detailLa Cour pénale internationale et les entorses aux droits essentiels des personnes privées de liberté
Deprez, Christophe ULg

E-print/Working paper (2016)

Ce texte propose un bref aperçu des faiblesses de la pratique de la Cour pénale internationale en matière de privation de liberté.

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See detailMacro-economic factors influencing the architectural business model shift in the pharmaceutical industry
Dierks, Raphaela Marie Louisa ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg et al

in Expert Review of Pharmacoeconomics & Outcomes Research (2016), First online

Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its ... [more ▼]

Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its underlying business model. Despite significant articles in the press, there is little medical and economic evidence on the rationale driving the transformation from the traditional Research & Development (R&D) model to new alternative business models, such as Mergers & Acquisitions (M&A). The purpose of this review is to understand the macro-economic factors responsible for the revolution of the pharmaceutical business model, by understanding the needs, desires, new behavioral patterns, but also challenges within the industry. Considering these changes will be the key to possessing a competitive advantage over the market players. Areas covered: Existing literature on new macro-economic factors changing the pharmaceutical landscape has been reviewed to present a clear image of the current market environment. Expert commentary: Literature and media sources show that pharmaceutical companies are facing an architectural alteration in their business model, with more M&A deals and collaborations headlining the papers. Although Q1 2016 did show a major slowdown in M&A deals by volume since 2013 (with deal cancellations of Pfizer and Allergan, or the downfall of Valeant) pharmaceutical analysts remain confident that this shortfall was a consequence of the equity market volatility. It seems likely that the shift to an M&A model will become apparent during the remainder of 2016, with deal announcements such as Abbott Laboratories, AbbVie and Sanofi worth USD 45billion [1] showing the appetite of big pharma companies to shift from the fully vertical integrated business model to more horizontal business models. [less ▲]

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See detailIdentification of virulotypes and serotypes of enteropathogenic (EPEC) and Shigatoxigenic (STEC) Escherichia coli from healthy cattle at slaughterhouses in Wallonia.
Takaki, Shino; Duprez, Jean-Noël ULg; Fakih, Ibrahim et al

Poster (2016, September)

Escherichia coli producing the attachment-effacement (AE) lesion (EPEC) and/or Shiga toxins (STEC) cause enteritis and (bloody) diarrhoea in young calves and in humans, and are also present in the ... [more ▼]

Escherichia coli producing the attachment-effacement (AE) lesion (EPEC) and/or Shiga toxins (STEC) cause enteritis and (bloody) diarrhoea in young calves and in humans, and are also present in the intestines of healthy cattle. Besides the O157:H7 serotype, which is the main serotype causing STEC outbreaks in the world EPEC and STEC can belong to dozens of O serogroups. Of them, 9 have been frequently identified worldwide: O5, O26, O103, O104, O111, O118, O121, O145 and O165. The aim of this study is to identify the virulotypes and the O serotypes of EPEC and STEC isolated from healthy cattle at slaughterhouses in Wallonia. A total of 245 faeces (216 <1year-old bulls, 25 cows and 4 heifers) were sampled between April and June 2014 in 2 slaughterhouses in Wallonia and grown overnight at 37°C in Lauryl sulfate Enterobacteriaceae selective broth. The enrichment broths were assayed with an stx1, stx2 (Shiga toxin) and eae (AE lesion) triplex PCR and positive broths were inoculated onto 4 agar media: McConkey’s, Chromagar ES, Chromagar ES with tellurite and Chromagar STEC. Up to ten colonies per plate were picked up, sub-cultured and tested by the colony hybridization assay with gene probes targeting the stx1, stx2 and eae genes. The triplex PCR was again performed on all probe-positive isolates. The PCR-positive E. coli were subsequently assayed with two pentaplex PCR targeting the specific genes coding for the ten O serogroups listed above. Of the 2563 sub-cultured isolates, 744 isolates (29%) from 62 animals (25%) tested positive with the colony hybridization assay. Of them, 687 isolates (92%) from 59 animals were positive with the triplex PCR and the results of both tests were in agreement for 617 isolates (83%). One to 29 isolates per animal were probe- and PCR-positive. The positive isolates grew on Chromagar STEC (379; 55%), on Chromagar ES with tellurite (189; 28%), on Chromagar ES (62; 9%) or on McConkey’s agar (57; 8%). The most frequent virulotypes were eae+ (EPEC: 372 isolates; 54%), eae+stx1+ (AE_STEC: 119 isolates; 17%) and stx2+ (STEC: 118 isolates; 17%). In some animals different virulotypes were identified. The serogrouping with the two pentaplex PCR is in progress. AE-STEC, EPEC and STEC are excreted by 25% of the healthy cattle at slaughterhouses in Wallonia and different virulotypes can be excreted by the same animal. Conversely the methodology followed gives no precise idea of the actual level of excretion since the hybridization and PCR were performed after enrichment in selective broth. Therefore multiple isolates belonging to the same virulotype might represent the same clone. Identification of the serogroups and comparison by Pulsed Field Gel Electrophoresis should help to clarify that point. Quantitative (q)PCR is today the best method to quantify bacterial excretion, but is more expensive. The results of the hybridization and PCR correspond to between 80 and 90%. Though the colony hybridization is still useful for large-scale surveillance it needs radioactive probes for highest sensitivity and is more time-consuming than PCR. Therefore the PCR should be the first routine choice if it can be automatized at large scale. Further steps are the confirmation of the PCR results of the 70 isolates with different hybridization and PCR results and the identification of the serogroups with the two pentaplex PCR and later with PCR for the other serogroups, to compare them with isolates from young diarrhoeic calves and from humans. [less ▲]

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