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See detailIntroduction aux doctrines et aux idées politiques: une approche structurale
Claisse, Frédéric ULg; Counet, Maxime ULg; Verjans, Pierre ULg

Book published by De Boeck Supérieur (2017)

Comment s’articulent les grandes doctrines et idées politiques ? En quoi des auteurs comme Machiavel ou La Boétie peuvent-ils nous aider à comprendre l’exercice du pouvoir et la résistance à la domination ... [more ▼]

Comment s’articulent les grandes doctrines et idées politiques ? En quoi des auteurs comme Machiavel ou La Boétie peuvent-ils nous aider à comprendre l’exercice du pouvoir et la résistance à la domination ? Quels sont les clivages qui constituent la toile de fond de la vie politique ? De Bodin à Maurras et Renan, de Condorcet à Sen, de Montesquieu à Hayek et de Marx à Rawls et Piketty, en passant par Hobbes, Locke et Bossuet, les grands auteurs ont apporté des réponses à quatre questions fondamentales auxquelles toute société se trouve confrontée : Qui sommes-nous ? Pourquoi vivons-nous ensemble ? Comment produisons-nous ? Comment distribuons-nous nos richesses ? Ces réponses continuent d’influencer en profondeur les débats politiques. Plutôt que de présenter les doctrines politiques en familles idéologiques homogènes (libéralisme, socialisme, conservatisme), cet ouvrage met en évidence les unités de base qui sous-tendent les principaux énoncés politiques, quelle que soit l’étiquette sous laquelle ils circulent. Fruit de nombreuses années d’analyse et d’enseignement, ce manuel offre un point de vue original sur les doctrines et idées politiques, à travers une approche structurale qui insiste sur les jeux d’oppositions et de priorités, tout en passant en revue des œuvres fondatrices de notre imaginaire politique. Pour les étudiants, qui trouveront dans cet ouvrage une introduction aux doctrines et idées politiques, ainsi qu’une approche analytique des grands auteurs. Pour les citoyens, à qui il fournira des ressources pour mieux s’orienter parmi les positionnements politiques et en comprendre la logique. [less ▲]

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See detailExperimental and Numerical Study of Mini-UAV Propeller Performance in Oblique Flow
Theys, Bart; Dimitriadis, Grigorios ULg; Hendrick, Patrick et al

in Journal of Aircraft (2017), 54(3), 1076-1084

This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow ... [more ▼]

This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow. Blade Element Momentum Theory (BEMT), Vortex Lattice Method (VLM) and momentum theory for oblique flow are used to predict propeller performance. For validation, the predictions for a commonly used propeller for VTOL MAVs are compared to a set of wind tunnel experiments. Both BEMT and VLM succeed in predicting correct trends of the forces and moments acting upon the propeller shaft, although accuracy decreases significantly in oblique flow. For the dataset analysed here, combining the available data of the propeller in purely axial flow with momentum theory for oblique flow and applying a correction factor for the wake skew angle results in more accurate performance estimates at all elevation angles. [less ▲]

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See detailExperimental passive flutter suppression using a linear tuned vibration absorber
Verstraelen, Edouard ULg; Habib, Giuseppe ULg; Kerschen, Gaëtan ULg et al

in AIAA Journal (2017), 55(5), 1707-1722

The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be ... [more ▼]

The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be increased flexibility, which in turn can lead to un- favourable aeroelastic phenomena involving large amplitude oscillations and non- linear effects such as geometric hardening and stall flutter. Vibration mitigation is one of the approaches currently under study for avoiding these phenomena. In the present work, passive vibration mitigation is applied to a nonlinear experimental aeroelastic system by means of a linear tuned vibration absorber. The aeroelastic apparatus is a pitch and flap wing that features a continuously hardening restoring torque in pitch and a linear restoring torque in flap. Extensive analysis of the sys- tem with and without absorber at pre-critical and post-critical airspeeds showed an improvement in flutter speed of around 36%, a suppression of a jump due to stall flutter, and a reduction in LCO amplitude. Mathematical modelling of the exper- imental system is used to demonstrate that optimal flutter delay is achieved when two of the system modes flutter at the same flight condition. Nevertheless, even this optimal absorber quickly loses effectiveness as it is detuned. The wind tunnel mea- surements showed that the tested absorbers were much slower to lose effectiveness than those of the mathematical predictions. [less ▲]

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See detailTransparent Electrodes Based on Silver Nanowire Networks: From Physical Considerations towards Device Integration
Bellet, Daniel; Lagrange, Mélanie; Sannicolo, Thomas et al

in Materials (2017), 10

The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells ... [more ▼]

The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells, flexible light-emitting devices, touch screens, electromagnetic devices, and flexible transparent thin film heaters. Currently, the most commonly used TCM for such applications (ITO: Indium Tin oxide) suffers from two major drawbacks: brittleness and indium scarcity. Among emerging transparent electrodes, silver nanowire (AgNW) networks appear to be a promising substitute to ITO since such electrically percolating networks exhibit excellent properties with sheet resistance lower than 10 Ω/sq and optical transparency of 90%, fulfilling the requirements of most applications. In addition, AgNW networks also exhibit very good mechanical flexibility. The fabrication of these electrodes involves low-temperature processing steps and scalable methods, thus making them appropriate for future use as low-cost transparent electrodes in flexible electronic devices. This contribution aims to briefly present the main properties of AgNW based transparent electrodes as well as some considerations relating to their efficient integration in devices. The influence of network density, nanowire sizes, and post treatments on the properties of AgNW networks will also be evaluated. In addition to a general overview of AgNW networks, we focus on two important aspects: (i) network instabilities as well as an efficient Atomic Layer Deposition (ALD) coating which clearly enhances AgNW network stability and (ii) modelling to better understand the physical properties of these networks. [less ▲]

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See detailInvestigation of the glycolytic switch induced by saturated fatty acid in human macrophages
Colonval, Megan ULg; Fettweis, Grégory; L'homme, Laurent et al

Poster (2017, May)

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See detailIntegrated Geological-Geophysical Models of Unstable Slopes in Seismic Areas
Mreyen, Anne-Sophie ULg; Micu, Mihai; Onaca, Alexandru et al

in Mikos, Matjaz (Ed.) Advancing Culture of Living with Landslides (2017, May)

We will present a series of new integrated 3D models of landslide sites that were investigated in distinctive seismotectonic and climatic contexts: (1) along the Hockai Fault Zone in Belgium and (2) in ... [more ▼]

We will present a series of new integrated 3D models of landslide sites that were investigated in distinctive seismotectonic and climatic contexts: (1) along the Hockai Fault Zone in Belgium and (2) in the seismic region of Vrancea, Romania. Both sites are deep-seated failures located in more or less seismically active areas. In such areas, slope stability analyses have to take into account the possible contributions to ground failure. Our investigation methods had to be adapted to capture the deep structure as well as the physico-mechanical characteristics that influence the dynamic behaviour of the landslide body. Field surveys included electrical resistivity tomography profiles, seismic refraction profiles (analysed in terms of both seismic P-wave tomography and surface waves), ambient noise measurements to determine the soil resonance frequencies through H/V analysis, complemented by geological and geomorphic mapping. The H/V method, in particular, is more and more used for landslide investigations or sites marked by topographic relief (in addition to the more classical applications on flat sites). Results of data interpretation were compiled in 3D geological-geophysical models supported by high resolution remote sensing data of the ground surface. Data and results were not only analysed in parallel or successively; to ensure full integration of all inputs-outputs, some data fusion and geostatistical techniques were applied to establish closer links between them. Inside the 3D models, material boundaries were defined in terms of surfaces and volumes. Those were implemented in 2D and 3D numerical dynamic models (presented in a companion paper). [less ▲]

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See detailPrincipes de contentieux administratif
Pâques, Michel ULg

Book published by Larcier - 1re édition (2017)

L’importance du contentieux administratif n’échappe à personne. La qualité de son traitement donne au droit administratif sa consistance. L’obligation faite à l’administration de s’incliner devant la ... [more ▼]

L’importance du contentieux administratif n’échappe à personne. La qualité de son traitement donne au droit administratif sa consistance. L’obligation faite à l’administration de s’incliner devant la décision du juge permet l’État de droit. Du projet à la pratique, le trajet n’est bien entendu pas toujours rectiligne. La tension entre efficacité, sécurité juridique et légalité est constante, tout comme est ininterrompue la quête d’un meilleur système. En cette matière, les tendances sont longues, mais la réforme est permanente. L’ouvrage a été conçu pour les étudiants de la troisième année du baccalauréat en droit à qui il s’agit de présenter les principes du contentieux, mais aussi les éléments forts du droit positif. Le plan est celui d’un cours, en vue de l’acquisition progressive des connaissances nécessaires à ce qui vient ensuite. La pratique, pour sa part, doit bien entendu tout mettre en œuvre en même temps. L’utilisation de deux types de caractères et de notes permet de viser l’objectif d’une présentation structurante tout en présentant déjà les nuances, les exemples et parfois les conseils immédiatement utiles à la pratique contemporaine. Quelques développements sont consacrés à la manière concrète d’exercer certains recours, comme la formulation d’un moyen dans une requête en annulation. Questions clés : recours administratif, droit au juge et limitations, compétence fédérale, régionale et communautaire en matière de juridiction, droits subjectifs de l’administré, responsabilité de l’administration, faute et illégalité, censure de l’acte illégal, séparation des pouvoirs, pouvoir d’injonction contre l’administration, contentieux objectif et subjectif, Conseil d’État, autorité administrative, recours en annulation, compétence et incompétence du Conseil d’État en raison de l’objet véritable du litige, recevabilité, délais, intérêt au recours et au moyen, référé administratif, annuler ou ne pas annuler l’acte illégal ou limiter les effets de l’annulation, indemnité réparatrice. [less ▲]

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See detailIdentifying novel biomarkers for the rapid diagnosis of invasive aspergillosis using GC×GC-TOFMS
Stefanuto, Pierre-Hugues ULg; Rees, Christiaan A.; Beattie, Sarah R. et al

Conference (2017, May)

Aspergillus fumigatus is a filamentous fungus responsible for the life-threatening infection, invasive aspergillosis (IA), in immunocompromised individuals. Currently, IA diagnostic methods take days to ... [more ▼]

Aspergillus fumigatus is a filamentous fungus responsible for the life-threatening infection, invasive aspergillosis (IA), in immunocompromised individuals. Currently, IA diagnostic methods take days to produce a result and methods to obtain samples are invasive. One approach to improve the time-to-diagnosis is based on utilizing our knowledge of fungal metabolism during pathogenesis. Recent studies have demonstrated the importance of oxygen availability during IA, which presents a potential diagnostic opportunity. In this study, we analyzed the early (1 hr) and late (8 hr) volatile profile of A. fumigatus strain CEA1o under oxygen replete (~20% O2) and deplete (0.2% O2) conditions. In order to comprehensively screen the headspace of these cultures, we applied headspace solid phase microextraction (HS-SPME) associated with comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry (GC×GC-TOFMS). Comparing the headspace of the four culture conditions, we were able to identify specific volatile biomarkers of low oxygen fungal growth: ethanol, acetaldehyde, 2-propanol, 2,3-butanedione, and 3-hydroxy-2-butanone. Based on the putative identifications of these compounds, we identified potential metabolic pathways that are responsible for their production. The two first compounds are known to be produced during hypoxia metabolism of glucose, however, the three others suggest that previously uncharacterized metabolic pathways may be utilized by A. fumigatus in low oxygen conditions. Validation of these biomarker identities and translation into patients may generate metabolic insight into these organisms during IA pathogenesis. [less ▲]

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See detailIdentifying infectious agents from lung transplant patients using GC×GC-TOFMS
Stefanuto, Pierre-Hugues ULg; Rees, Christiaan A.; Romamno, Rosalba et al

Poster (2017, May)

During the first year post-surgery, bacterial and fungal infections are the main causes of death in lung transplant recipients. Contributing substantially to the high mortality rate (35%) is the lengthy ... [more ▼]

During the first year post-surgery, bacterial and fungal infections are the main causes of death in lung transplant recipients. Contributing substantially to the high mortality rate (35%) is the lengthy time-to-diagnosis, which includes both pathogen identification and antibiotic resistance profiling. A novel diagnostic strategy based on the detection of volatile compounds in breath seems a promising option to improve these patients’ outcomes. In order to demonstrate the feasibility of this approach, we characterized the volatile fraction of different clinical matrices (i.e., bronchoalveolar lavage (BAL) and blind bronchial aspirate (BBA)). Due to the complexity of the mixture and high dynamic range of the concentrations, we applied headspace solid phase microextraction (HS-SPME) combined with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS) to obtain a comprehensive overview of the sample headspace composition. Following the analytical step, we applied various univariate and multivariate statistical methods (e.g. random forest, principal component analysis, and hierarchical cluster analysis) in order to extract required information from the data. Based on the composition of the volatile fraction, we were able to differentiate between BAL and BBA with a classification accuracy of 88.4 %. Furthermore, we could correctly distinguish between individuals with active respiratory infections and those without infection with a 72.2 % classification accuracy. In some cases, it was also possible to differentiate between pathogens at the species level. These results are preliminary evidence to suggest the possibility of detecting infections in these patient without the use of time-consuming culture techniques. [less ▲]

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See detailSniffing Out the Hypoxia Volatile Metabolic Signature of Aspergillus fumigatus
Stefanuto, Pierre-Hugues ULg; Rees, Christiaan A.; Beattie, Sarah R. et al

Poster (2017, May)

Background: Aspergillus fumigatus is responsible for the life-threatening infection invasive aspergillosis (IA) that is associated with high mortality in immunocompromised individuals. Current diagnostics ... [more ▼]

Background: Aspergillus fumigatus is responsible for the life-threatening infection invasive aspergillosis (IA) that is associated with high mortality in immunocompromised individuals. Current diagnostics for IA are either highly invasive or suffer from inadequate sensitivity and/or specificity. Improvement of IA diagnostic assays requires a better understanding of fungal metabolism inside the host. The infection microenvironment becomes progressively depleted of oxygen during IA. Thus, metabolites associated with hypoxia metabolism may yield to novel diagnostic biomarkers. Here, we report on the volatile metabolites emitted from A. fumigatus batch cultures under normoxia and hypoxia conditions. Methods: A. fumigatus strain CEA10 was incubated in glucose minimal medium at 37 °C under either normoxia (21% O2, 0.04% CO2) or hypoxia (0.2% O2, 5% CO2) growth conditions. Volatile molecules from the supernatants of early (1 h) and late (8 h) cultures were collected using headspace solid-phase microextraction (HS-SPME) and analyzed using two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS). Results: We identified 10 volatile compounds that are significantly more abundant in late hypoxia cultures compared with all other experimental conditions. Among these compounds, we identified ethanol and acetaldehyde, which are known to result from hypoxia metabolism of glucose by A. fumigatus. In addition, we detected 2-propanol, which can be generated by the reduction of acetone via alcohol dehydrogenase, as well as 2,3-butanedione (diacetyl) and 3-hydroxy-2-butanone (acetoin), which results from the catabolism of acetolactate. Transcriptomic data collected from normoxia and hypoxia cultures validates our volatilomic findings through the identification of putative catabolic pathways that are upregulated during hypoxia growth. Diacetyl is known to be produced by bacteria as a pH-neutral fermentative byproduct to prevent lethal acidification, and we speculate that A. fumigatus may use the same pathway. Conclusion: The composition of A. fumigatus’ volatile metabolome changes according to the oxygen tension in the environment. We measured hypoxia-associated compounds, ethanol and acetaldehyde which have been previously identified as byproducts of hypoxia metabolism in this organism. 2-propanol, 2, 3-butanedione and 3-hydroxy-2-butanone represent novel metabolites that suggests the existence of other catabolic pathways activated in A. fumigatus under hypoxia growth conditions. [less ▲]

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See detailTargeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides
Delierneux, Céline ULg; Donis, Nathalie ULg; servais, laurence et al

in Journal of Thrombosis and Haemostasis (2017), 15(5), 983-997

Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment ... [more ▼]

Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicates that CpG ODNs activate human platelets via the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor glycoprotein VI. Objective: To further analyze the mechanisms of CpG ODN-induced platelet activation and identify potential inhibitory strategies. Methods: In vitro analyses were performed on human and mouse platelets, and on cell lines expressing platelet ITAM receptors. CpG ODN platelet activating effects were evaluated in a mouse model of thrombosis. Results: We demonstrated platelet uptake of CpG ODNs, resulting in platelet activation and aggregation. The C-type lectin-like receptor 2 (CLEC-2) expressed in DT40 cells bound CpG ODNs. CpG ODN uptake did not occur in CLEC-2-deficient mouse platelets. Inhibition of human CLEC-2 with a blocking antibody inhibited CpG ODN-induced platelet aggregation. CpG ODNs caused CLEC-2 dimerization, and provoked its internalization. They induced dense granule release before the onset of aggregation. Accordingly, pretreating platelets with apyrase, or inhibiting P2Y12 with cangrelor or clopidogrel prevented CpG ODN platelet activating effect. In vivo, intravenously injected CpG ODN interacted with platelets adhered to mouse injured endothelium, and promoted thrombus growth, which was inhibited by CLEC-2 deficiency or by clopidogrel. Conclusions: CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis and might be targeted to prevent adverse events in patients at risk. [less ▲]

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See detailA Highly Durable RNAi Therapeutic Inhibitor of PCSK9
LANCELLOTTI, Patrizio ULg; Oury, Cécile ULg

in New England Journal of Medicine (2017), 376

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See detailContinental Climate Gradients in North America and Western Eurasia before and after the Closure of the Central American Seaway
Utescher, Torsten; Dreist, Andreas; Henrot, Alexandra-Jane ULg et al

in Earth and Planetary Science Letters (2017), 472

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See detailChallenges of CO2 capture as an application of fluid separation techniques
Léonard, Grégoire ULg

Conference (2017, May)

The presentation offers a review of CO2 capture technologies presented as an application of fluid separation. CO2 capture processes (Post-combustion, pre-combustion, oxyfuel combustion and industrial ... [more ▼]

The presentation offers a review of CO2 capture technologies presented as an application of fluid separation. CO2 capture processes (Post-combustion, pre-combustion, oxyfuel combustion and industrial processes) and CO2 capture methods (absorption, adsorption, membranes...) are described, and illustrated by industrial examples of these technologies. Techno-economic challenges faced by these technologies are also mentionned, and perspectives for future developments are discussed. [less ▲]

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See detailLe boom des maladies auto-immunes.
Luong, Julie; GEENEN, Vincent ULg

Article for general public (2017)

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See detailHandicap et aménagements raisonnables: importation et usages d'une catégorie juridique en France et en Belgique
Lejeune, Aude ULg; Hubin, Joël; Ringelheim, Julie et al

Report (2017)

La notion d’aménagement raisonnable désigne toute tentative, dans une société, de s’accommoder ou de s’ajuster aux besoins d’un individu qui découlent de son appartenance à une minorité, dans le respect ... [more ▼]

La notion d’aménagement raisonnable désigne toute tentative, dans une société, de s’accommoder ou de s’ajuster aux besoins d’un individu qui découlent de son appartenance à une minorité, dans le respect de l’égalité de traitement entre tous les êtres humains et des libertés fondamentales. A travers cette recherche, centrée sur les aménagements à destination des travailleurs en situation de handicap, nous proposons d’interroger l’émergence de cette catégorie en droit, ainsi que les usages qui en sont faits par les acteurs sociaux dans le domaine du travail. Deux dimensions sont centrales dans ce projet. D’une part, l’examen des législations en vigueur, de la jurisprudence et de la doctrine donnent à voir les conditions d’importation de cette catégorie juridique en Belgique et en France et son articulation avec d’autres législations qui encadrent les relations de travail (obligation de reclassement, bien-être au travail, etc.). D’autre part, l’analyse des pratiques et des représentations des acteurs du monde du travail met en lumière la façon dont cette catégorie juridique est mobilisée, contournée ou évitée. Notre enquête porte sur trois groupes de professionnels qui interviennent auprès des travailleurs, les syndicats, avocats et agents des organismes publics de lutte contre les discriminations, ainsi que sur les parties prenantes, à savoir les employeurs et les travailleurs. La comparaison de la France et de la Belgique met en évidence l’influence des différentes configurations de relations professionnelles, que nous définissons comme un ensemble de règles et de pratiques qui structurent les rapports entre les salariés, les employeurs et l’Etat et qui sont spécifiques à chaque contexte national. Plus généralement, cette recherche montre les effets produits par l’introduction de cette obligation d’aménagement raisonnable. Les acteurs du monde du travail se réfèrent peu aux législations en matière d’aménagement raisonnable et ne perçoivent pas ces normes comme des contraintes fortes. Néanmoins, notre étude montre que le droit produit des effets diffus, parfois inattendus : les employeurs, les travailleurs et les professionnels qui défendent leurs droits se saisissent des cadres juridiques existants, les intègrent dans leurs discours et parfois dans leurs pratiques, lui donnent sens, et contribuent ainsi à remodeler les contours des normes juridiques. [less ▲]

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See detailLa Cour de cassation face à sa propre faute (obs. sous C.C. 2017/22)
Bouhon, Frédéric ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), 2017/22

Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les ... [more ▼]

Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les dommages engendrés par la faute du juge. Il est question du cas particulier où un justiciable demande au juge du fond de condamner l’État belge à réparer un dommage causé par une faute qu’aurait commise la Cour de cassation. Plus précisément, il apporte une réponse – positive – à la question de savoir si cette haute juridiction peut, dans l’hypothèse où un pourvoi est formé contre la décision du juge du fond, intervenir dans une affaire qui concerne une faute qu’elle a prétendument commise, en influençant, le cas échéant, l’interprétation de la notion de faute appliquée à son propre acte. [less ▲]

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See detailPerceived management commitment to safety and safety behaviors: the moderating role of trust and support
Laurent, Julie ULg; Chmiel, Nik; Hansez, Isabelle ULg

Conference (2017, May)

Instrumental processes, based on the idea that individual perceptions of safety climate inform behavior outcomes expectancies (Zohar, 2008), and reciprocation processes, based on social exchange theory ... [more ▼]

Instrumental processes, based on the idea that individual perceptions of safety climate inform behavior outcomes expectancies (Zohar, 2008), and reciprocation processes, based on social exchange theory (Blau, 1964), have been identified as important processes to take into account in order to understand safety behaviors (Chmiel & Hansez, 2016). The main aim of this study is to go further in the explanation of the processes linking perceived management commitment to safety (PMCS) to safety behaviors, by testing the moderating role of two variables reflecting the way workers perceive their supervisor: safety specific trust in the supervisor, illustrating instrumental processes and perceived supervisor support (PSS), illustrating reciprocation processes. In two samples, a survey methodology and Latent Moderated Structural (LMS) equation modelling were used to test our hypotheses. Overall, and although results were mixed and discussed, high PMCS, when combined with high trust or high PSS, resulted in safer behaviors. We did not find such significant effects as explaining routine violations. The patterns of results were similar in the two samples. The main limitations are the use of single-source and self-reported data may lead to common-method variance bias and the cross-sectional nature of the study. Future longitudinal research is needed to test causality. An important implication for companies is to be aware of the powerful role played by management: building trusting relationship (by behaving consistently regarding safety) and encouraging managers to show support to their employees in a context where safety is considered as important are keys to potentially achieve safe behaviors. [less ▲]

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See detailBasic Helix loop Helix transcription factor twist1a and twist1b and their involvement in the skeletal development of zebrafish.
Zappia, Jérémie ULg; Windhausen, Thomas ULg; Renn, Jörg ULg et al

Poster (2017, May)

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to ... [more ▼]

1. Objective The twist1a and twist1b genes code for transcription factors involved during embryogenesis in the craniofacial development. The human ortholog of twist1a and twist1b, TWIST1 has been shown to be mutated in cases of the Saethre–Chotzen syndrome (SCS). However, the roles of these genes in skeletal development in zebrafish remain to be clarified. The aim of our research is to characterize the effects of the knock-down of twist1a and twist1b in the zebrafish. 2. Methods Antisens morpholino are used for the knock-down of twist1a and twist1b (respectively MoTwist1a and MoTwist1b). The sox9a expression is investigated using whole amount in situ hybridization. 3. Results We show the spatio-temporal expression pattern of twist1a and twist1b during the first 6 days of zebrafish development and present the effects observed on cartilage and bone formation upon knock-down of these genes in zebrafish larvae. The results reveal a decrease of the cranial cartilage and bone formation in both MoTwist1a and MoTwist1b. Interestingly, when MoTwist1a and MoTwist1b are co-injected, the cranial cartilage formation is strongly reduced, while ectopic cartilage formation appeared in the front of the head. We also show an increase in expression of sox9a, a master regulator of chondrogenesis, in morphants. 4. Summary and Conclusions Even though it was shown that twist1a and twist1b maintain a pool of osteoprogenitor-like cells, we show that a knock-down of these genes induces a decrease of skeletal formation. Our hypothesis is that the morphants run out of progenitor cells to assure correct bone and cartilage formation. In the future, we plan to generate twist1a mutants in order to further characterize the effect of this mutation. The twist1a mutant will eventually serve for a rescue study using human TWIST1 mRNA, wild-type or mutant in order to have a better understanding of the human disorder SCS. [less ▲]

Detailed reference viewed: 19 (3 ULg)