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See detailKDIGO a guidelines for bone turnover management in dialysis patients
CAVALIER, Etienne ULg

Conference (2015, November 20)

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See detailL'ambiguïté de la médiation
Dethier, Baptiste ULg; Dubois, Christophe ULg

Conference (2015, November 20)

Qu’elle soit appréhendée comme un symptôme ou un remède, la médiation apparaît dans un contexte où les liens sociaux se recomposent, où les institutions traditionnelles (état, église, école, justice, etc ... [more ▼]

Qu’elle soit appréhendée comme un symptôme ou un remède, la médiation apparaît dans un contexte où les liens sociaux se recomposent, où les institutions traditionnelles (état, église, école, justice, etc.) sont questionnées et où la prise en compte des singularités devient la norme. Depuis près de quarante ans, de multiples fonctions et dispositifs dits « de médiation » prolifèrent dans le but affirmé de créer ou renouer des liens entre les individus. Pour ce faire, les processus communicationnels sont privilégiés, alternativement ou parallèlement à une approche autoritaire. « La » médiation, pratiquée dans différents champs (notre entrée empirique étant celle de la médiation scolaire), fait l’objet de nombreux discours (politiques, managériaux, professionnels, scientifiques, etc.) mais sa définition et sa mise en œuvre entraînent plusieurs difficultés. Son caractère indéfini ou multidéfini, flexible et malléable ouvre certes à une utilisation contextualisée, adaptée aux situations et aux individus. Mais ceci ouvre également à des interprétations et à des usages hétérogènes, parfois paradoxaux, et à des « débordements » pouvant menacer la légitimité des médiateurs et des dispositifs de médiation. Notre contribution vise par conséquent à rendre compte de l’ambiguïté constitutive des discours, des dispositifs et des pratiques de médiation scolaire, ceci afin d’en éclairer les ressources et les limites. [less ▲]

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See detailgammaMAXT: a fast multiple-testing correction algorithm
Van Lishout, François ULg; Gadaleta, Francesco; Moore, Jason H. et al

in BioData Mining (2015), 8(36),

Background: The purpose of the maxT algorithm is to provide a significance test algorithm that controls the family-wise error rate (FWER) during simultaneous hypothesis testing. However, the requirements ... [more ▼]

Background: The purpose of the maxT algorithm is to provide a significance test algorithm that controls the family-wise error rate (FWER) during simultaneous hypothesis testing. However, the requirements in terms of computing time and memory of this procedure are proportional to the number of investigated hypotheses. The memory issue has been solved in 2013 by Van Lishout’s implementation of MaxT, which makes the memory usage independent from the size of the dataset. This algorithm is implemented in MBMDR-3.0.3, a software that is able to identify genetic interactions, for a variety of SNP-SNP based epistasis models effectively. On the other hand, that implementation turned out to be less suitable for genome-wide interaction analysis studies, due to the prohibitive computational burden. Results: In this work we introduce gammaMAXT, a novel implementation of the maxT algorithm for multiple testing correction. The algorithm was implemented in software MBMDR-4.2.2, as part of the MB-MDR framework to screen for SNP-SNP, SNP-environment or SNP-SNP-environment interactions at a genome-wide level. We show that, in the absence of interaction effects, test-statistics produced by the MB-MDR methodology follow a mixture distribution with a point mass at zero and a shifted gamma distribution for the top 10 % of the strictly positive values. We show that the gammaMAXT algorithm has a power comparable to MaxT and maintains FWER, but requires less computational resources and time. We analyze a dataset composed of 106 SNPs and 1000 individuals within one day on a 256-core computer cluster. The same analysis would take about 104 times longer with MBMDR-3.0.3. Conclusions: These results are promising for future GWAIs.However, the proposed gammaMAXT algorithm offers a general significance assessment and multiple testing approach, applicable to any context that requires performing hundreds of thousands of tests. It offers new perspectives for fast and efficient permutation-based significance assessment in large-scale (integrated) omics studies. [less ▲]

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See detailMitigating the Nuclear ‘Dual-Use Dilemma’: Suggestions for the Enhancement of the Culture of Responsibility
Colussi, Ilaria Anna ULg

Conference (2015, November 19)

The speech aims at delineating a proper ethical and legal response to the ‘dual-use dilemma’ of nuclear science and technologies. After assessing the different models of governance proposed so far in ... [more ▼]

The speech aims at delineating a proper ethical and legal response to the ‘dual-use dilemma’ of nuclear science and technologies. After assessing the different models of governance proposed so far in nuclear field for addressing the ‘dual-use’ feature of nuclear technologies, and based on precautionary, proactionary or cost/benefit approaches, it suggests the adoption of a framework based on the notion of ‘responsible stewardship’. This model entails: (a) a constant analysis of nuclear technology, both on the side of risks and of benefits, through the involvement and cooperation of all the stakeholders in the field (the involvement of both ‘top down’ and ‘bottom up’ actors, i.e. governments and scientific community); (b) the adoption of policies through ‘hard law’ and ‘soft law’ sources, which should be periodically revised, and based on the proportionality principle and the reasonableness one (with a balance among rights and freedom, from a constitutional viewpoint); (c) an ongoing communication, dialogue and interaction between actors in the nuclear area. A specific attention is devoted to the balance between the freedom to research and the security needs. Then, the concrete ways for applying such model are explained, in particular with regards to the issue of control of materials, education of people, and control of information. Finally, the historical steps in the governance of nuclear technologies and the positions of different religions addressing the issue have been explored, in order to provide some examples of the suggested approach. [less ▲]

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See detailAnomalies de l’expérience de soi exprimées par le sujet schizophrène et par ses proches
Lo Presti, Fanny; Englebert, Jérôme ULg

Scientific conference (2015, November 19)

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See detailL'Azacytidine comme traitement de la maladie du greffon contre l'hôte de type chronique sclérodermique expérimentale.
Fransolet, Gilles ULg; Ehx, Grégory ULg; SOMJA, Joan ULg et al

Conference (2015, November 19)

Introduction: Graft-versus-host disease (GVHD) has remained a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) for the last decades. Following unmanipulated peripheral-blood ... [more ▼]

Introduction: Graft-versus-host disease (GVHD) has remained a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) for the last decades. Following unmanipulated peripheral-blood stem cell transplantation, 60% of the patients experience chronic GVHD while approximately 15% of them develop a sclerodermic form of chronic GVHD characterized by multiple organ fibrosis and loss of skin elasticity. Regulatory T cells (Tregs) play a pivotal protective role in the pathogenesis of chronic GVHD by inhibiting alloreactive conventional T cells (Tconvs). Several studies have shown that hypomethylating agents such as azacytidine (Aza) can demethylate the master transcription factor of Treg (Forkhead box protein 3 factor, FoxP3), thus promoting Treg differentiation from Tconvs. This work investigates the impact of Aza in a classical murine model of sclerodermic chronic GVHD (B10.D2  BALB/cJ). Methods: In vitro analyses have been performed to determine the impact of Aza on collagen production. NIH-3T3 fibroblastic cells were plated and stimulated with 50 ng of PDGF or 10 ng of TGF-beta. Cells were then cultured with various concentrations of Aza for 48 hours. After culture, cells were stained with Sirius Red before quantification of collagen amount by absorbance at 490 nm. For in vivo experiments, lethally irradiated (7 Gy) BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107splenocytes from B10.D2 donor mice to induce scl-cGVHD. Recipients were injected with either 0,5 or 2 mg/kg of Aza every 48 hours from day 10 to 30 following transplantation. GVHD was scored using a five criteria scale (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 (or > 20% weight loss) or at day 52 after transplantation (end of experiment). Results: Concerning in vitro analyses, results suggest a decreased production of collagen at higher concentration of Aza with both stimulations (seen by a gradual diminution of absorbance). For in vivo experiments, mice treated with Aza 0.5 mg/kg (n = 14) or 2 mg/kg (n = 25) had significant lower clinical scores of GVHD compared to control ones (n = 23) after treatment. FACS analysis showed a higher proportion of Treg among CD4+ T cells in the blood of Aza 2 mg/kg mice than in control mice at day 35 following transplantation (P = 0.047), as well as a higher percentage of Tregs expressing the KI67 proliferative marker on the same time point (P = 0.0005). Finally, analyses of the cellular blood components with Cell-dyn demonstrated that Aza 2 mg/kg treated mice were significantly lymphopenic as compared to control mice at day 35 after transplantation (P = 0.05). Conclusion : Aza prevented sclerodermic GVHD in this classical murine model of chronic GVHD. [less ▲]

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See detailA KNOWLEDGE-BASED APPROACH FOR MAPPING LAND DEGRADATION IN THE ARID RANGELANDS OF NORTH AFRICA
Mahyou, Hamid; Tychon, Bernard ULg; Balaghi, Riad et al

in Land Degradation & Development (2015)

Rangelands cover about 82% of the arid area of Morocco. It is generally acknowledged that these areas are threatened by desertification. Monitoring desertification requires accurate knowledge about the ... [more ▼]

Rangelands cover about 82% of the arid area of Morocco. It is generally acknowledged that these areas are threatened by desertification. Monitoring desertification requires accurate knowledge about the current status of rangeland degradation. Remote sensing is widely used to assess changes in land cover, but its use in arid rangelands has limitations because of spectral confusion among various types of land cover. The objective of this study was to assess the severity and spatial extent of rangeland degradation in the high plateaus of eastern Morocco, using a knowledge-based approach combining remote sensing and ancillary data. This approach relies on analyzing datasets derived from Landsat TM satellite imagery, lithology, bioclimatic data and field measurements. The level of rangeland degradation was assessed using indicators such as vegetation parameters, grazing levels and cultivation intensity, which provided a high level of accuracy for mapping and monitoring the degradation of the arid rangelands. The results showed that the total area of degraded rangeland in the high plateaus of eastern Morocco is about 17,417 km², accounting for 48% in the studied area. [less ▲]

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See detailÉtude comparative de nouveaux indices de détection de la réponse qui s’apparentent au hasard et à l’inattention
Béland, Sébastien; Raîche, Gilles; Magis, David ULg et al

Conference (2015, November 19)

Certains étudiants peuvent répondre au hasard ou être inattentifs dans une situation de testing. Plusieurs approches ont déjà été développées pour détecter ce type de réponse (Zickar et Drasgow, 1996 ... [more ▼]

Certains étudiants peuvent répondre au hasard ou être inattentifs dans une situation de testing. Plusieurs approches ont déjà été développées pour détecter ce type de réponse (Zickar et Drasgow, 1996). Parmi celles-ci, l’utilisation d’indices de détection de patrons de réponses inappropriés (person-fit indices) est l’approche qui est la plus étudiée et qui semble la plus prometteuse (Karabatsos, 2003; Meijer et Sijtsma, 2001). Dans le cadre de cette étude, nous nous concentrerons sur trois indices de détection populaires qui présentent des caractéristiques permettant d’en faciliter l’interprétation : lz (Drasgow, Levine et Williams, 1985), ZU (Wright et Masters, 1982) et ZW (Wright et Masters, 1982). Toutefois, il s’est avéré qu’ils sont tous fortement affectés par le fait que l’habileté d’un étudiant est estimée plutôt que réelle (Li et Olejnik, 1997; Molenaar et Hoijtink, 1990). Voilà pourquoi Snijders (2001) a proposé une version corrigée de l’indice lz (nommée lz*) qui prend en considération ce problème important. Nous avons déjà appliqué la correction de Snijders aux indices U et W en créant les indices ZU* et ZW* (Magis, Béland et Raîche, 2014). L’objectif de cette étude sera d’examiner le comportement des indices corrigés lz*, ZU* et ZW* et de leur version standardisée. Pour ce faire, nous effectuerons trois études différentes : une analyse descriptive des scores des indices, une analyse des erreurs de type I et une analyse de leur puissance de détection. Les analyses ont démontré que ce sont les indices corrigés lz* et ZW* qui sont les plus intéressants à utiliser puisque leurs scores suivent approximativement la loi N(0,1) et puisqu’ils permettent de bien détecter les réponses qui s’apparentent au hasard et à l’inattention. [less ▲]

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See detailGlobal Grid(s) versus Microgrids
Ernst, Damien ULg

Speech/Talk (2015)

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See detailProfessionnel-le-s de l’enfance : Les compétences au cœur du métier
Pirard, Florence ULg

Conference given outside the academic context (2015)

A partir des résultats de deux recherches participatives sur les formations initiales dans le champ de l’enfance, financées par l’Office de la Naissance et de l’Enfance (ONE) en Fédération Wallonie ... [more ▼]

A partir des résultats de deux recherches participatives sur les formations initiales dans le champ de l’enfance, financées par l’Office de la Naissance et de l’Enfance (ONE) en Fédération Wallonie Bruxelles (César et al., 2012 ; Pirard et al., 2015), la communication présente une série de principes directeurs pour les politiques de formation et le développement professionnel des acteurs concernés. Elle propose une redéfinition des compétences d’accueil articulées autour des dimensions organisationnelles, réflexives et relationnelles qui permet de dépasser la vision technique et hygiénico-médicale du passé et de reconnaitre la dimension psychoéducative qui s’est affirmée de manière plus récente. [less ▲]

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See detailVoyage dans le Système Solaire
Stiepen, Arnaud ULg

Conference given outside the academic context (2015)

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See detail5-Azacytidine and Rapamycin: different and synergistic effect on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Conference (2015, November 19)

BACKGROUND: Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin ... [more ▼]

BACKGROUND: Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells OBJECTIVE: We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. METHODS: CD4+CD25+ and CD4+CD25- T cells were isolated from PBMC of normal controls using Miltenyi beads and FACS ARIA sorting. These cells subsets were cultured in the presence of anti-CD3/CD28 antibodies and 200 IU/ml of IL2 for 2 weeks. RAPA (100nM) and 5-azaC (1µM) were added to half of the cultures. We monitored cell expansion and after harvest, the cell phenotype, gene expression, T suppression activity and Annexin V binding were determined and compared to values obtained with control cell culture and with freshly-separated CD4+CD25+ and CD4+CD25- T cells. Also we tested the absolute number of Treg in the several culture conditions during the time of expansion. RESULTS: We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. The addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. CONCLUSION: 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

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See detailNew technologies in Mycology: PCR for diagnosis
Hayette, Marie-Pierre ULg

Conference (2015, November 19)

Molecular biology techniques are widely used in mycology. First of all they are used for confirmation of difficult or uncertain identifications. In this case PCR followed by ITS sequencing is generally ... [more ▼]

Molecular biology techniques are widely used in mycology. First of all they are used for confirmation of difficult or uncertain identifications. In this case PCR followed by ITS sequencing is generally used. For diagnostic purposes, PCR is mostly applied for the detection of invasive infections such as pneumocystosis, candidosis or aspergillosis. However these techniques (Candida and Aspergillus detection) are still not included in the recommandations given by EORTC by lack of standardisation. However, the development of new commercially available techniques, will probably change the diagnostic algorithm. New commercial PCR kits applied to the detection of dermatophytes are also recently available to the laboratories and they will be a good complement to culture-based diagnostic methods. [less ▲]

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See detailLes portails occidentaux de la cathédrale d'Amiens
Lekane, Marie ULg

Doctoral thesis (2015)

Detailed reference viewed: 57 (14 ULg)
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See detailParler pour soi-même dans un espace médiatique : les postures énonciatives dans le blog d'Ivan Rioufol
Servais, Christine ULg

Conference (2015, November 19)

A partir de l'analyse de l'énonciation dans le Blog d'Ivan Rioufol, je tente de mettre en évidence les caractéristiques politiques de ce discours, c'est-à-dire la manière dont il structure l'espace public ... [more ▼]

A partir de l'analyse de l'énonciation dans le Blog d'Ivan Rioufol, je tente de mettre en évidence les caractéristiques politiques de ce discours, c'est-à-dire la manière dont il structure l'espace public et la place qu'il y donne à son lecteur. Ce sont donc les effets politiques et policiers, au sens de Rancière, que j'y mets en évidence. [less ▲]

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See detail“Shakespeare was wrong”: counter-discursive intertextuality in Gail Jones’s Sorry
Belleflamme, Valérie-Anne ULg

in Journal of Postcolonial Writing (2015), 51(6), 661671

In what is presented as a moment of truth in Gail Jones’s novel Sorry, the narrator’s brief statement that “Shakespeare was wrong” appears to call into question the English dramatist’s literary and ... [more ▼]

In what is presented as a moment of truth in Gail Jones’s novel Sorry, the narrator’s brief statement that “Shakespeare was wrong” appears to call into question the English dramatist’s literary and epistemological supremacy. Starting from this unsettling premise, this article seeks to define Jones’s counter-discursive use of Shakespearean intertextuality. While it has, for decades, proved a risky task for both historians and novelists to write about the delicate issue of silence in Australia without risking the appropriation of an Aboriginal voice, the article examines how Jones exploits defamiliarizing techniques in order to undermine the dominant European discourse (as encoded in the Shakespearean text) without assuming an Aboriginal perspective. Her aim is to facilitate the emergence of an incipient, tentatively-defined counter-discourse sufficiently attuned to the specific realities of Australia. The article argues that by adopting an Australian cultural perspective designed to decentre Shakespeare Jones hopes to reconcile history and writing, but also the divided aspects of White Australia’s twofold identity at a time of profound national changes. [less ▲]

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See detailDialectiques du commun chez Sartre
Oulc'hen, Hervé ULg

Scientific conference (2015, November 19)

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See detailEmotional distress in Pediatric Cystic Fibrosis: using the Common-Sense Model of Self-Regulation to understand the role of illness perception and coping strategies
Toucheque, Malorie ULg; Stassart, Céline ULg; Duncan, Christina et al

Conference (2015, November 19)

Background: The common sense model of self-regulation (CSM) provides a framework for understanding the connection between emotions, thoughts and behaviors in people experiencing illness. However, most of ... [more ▼]

Background: The common sense model of self-regulation (CSM) provides a framework for understanding the connection between emotions, thoughts and behaviors in people experiencing illness. However, most of model in health psychology, including the CSM, were initially addressed to adult patients. Objective: This study examines the traditional conceptualization of the CSM where coping act as a mediator of the relation between illness perception and emotional distress in a pediatric population with chronic disease, namely Cystic Fibrosis (CF). Method: Using a cross-sectional design, 38 children with CF aged between 8 and 12 years participated in the study. All children were asked to complete: the State-Trait Anxiety Inventory for Children (STAIC), the Children’s Depression Inventory (CDI), the Kidcope and the Children’s Illness Perception Questionnaire (CIPQ). A composite score labelled “emotional distress” including scores of anxiety and depressive symptoms were created. Results: Illness perception predicted emotional distress (Timeline: β = .43; t = 2.835; p = .007; Consequences: β = .50; t = 3.429; p = .002; Control: β = .18; t = 1.088; p = .284). As regard with coping strategies, only emotional outburst and distraction predicted emotional distress (emotional outburst: β = .48; t = 3.241; p = .003; distraction: β = .32; t = 2.038; p = .049). However, there were no relation of illness perception subscales with emotional outburst and distraction. Therefore, the mediational role of coping strategies between illness perception and emotional distress could not be tested. Conclusion: Findings did not confirm the original conceptualization of coping as a mediator suggesting that the CSM needs to be adapted when applied with a pediatric population. Even though young children are able to think before acting (i.e. Piaget’s work), future research should explore the possibility that cognitions and actions exist at the same level and can independently impact adjustment outcomes. [less ▲]

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See detailLiquidity patterns in the US corporate bond market
Heck, Stéphanie ULg; Margaritis, Dimitri; Muller, Aline ULg

Conference (2015, November 19)

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