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See detailAn overview of the plastic‑hinge analysis of 3D steel frames
Hoang, Van Long ULg; Nguyen, Dang-Hung; Jaspart, Jean-Pierre ULg et al

in Asia Pacific Journal on Computational Engineering (2015), 2:4

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See detailEFHC1/Myoclonin-1 modulates the post-translational modification of microtubules
Medard, Laurie ULg; Godin, Juliette; Coumans, Bernard ULg et al

Poster (2015, December)

Rationale: Juvenile myoclonic epilepsies (JME) are one of the most common forms of genetic generalized epilepsy. Genetic studies have shown that heterozygous mutations in EFHC1/Myoclonin1 are responsible ... [more ▼]

Rationale: Juvenile myoclonic epilepsies (JME) are one of the most common forms of genetic generalized epilepsy. Genetic studies have shown that heterozygous mutations in EFHC1/Myoclonin1 are responsible for 3-22% of JME cases worldwide. The Myoclonin1 protein contains three DM10 domains of unknown function and an EF-hand domain. We have previously demonstrated that Myoclonin1 is a microtubule-associated protein involved in cell division and radial migration during neocortex development. In cells, this protein co-localized with specific structures rich in microtubules (MTs) such as the centrosome, the poles of the mitotic spindle or the motile cilia but not with cytoplasmic MTs. This suggests post-translational modifications (PTM) of MTs may be important for the interaction between Myoclonin1 and MTs Methods: We co-expressed the different enzymes catalyzing PTM of MTs with Myoclonin1 in U2OS cell line, and then performed immunocytochemistry and western blot analysis. We next performed pulldown and luciferase complementation assays to test protein interaction Results: With one of these enzymes, we observed a strong increase in PTM in the presence of Myoclonin- 1.Interestingly, the effect is observed even when a DM10 domain alone is co-expressed with the enzyme, suggesting for the first time a role for this domain. This suggests that Myoclonin1 may interact with and modulate the activity of this enzyme. By using luciferase complementation assay and pull down experiments, we could demonstrate that both proteins interact. Conclusions: Our data suggest Myoclonin-1 modulates specific PTM of MTs. This is of prime importance for microtubule dynamic and notably for neuroblast precursor migration during neocortex development. This could be the mechanism that explains why pathological forms of myoclonin-1 may affect brain development. [less ▲]

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See detailSites miniers en République démocratique du Congo: conflits et développement autour d'un espace hybride
Weerts, Audrey ULg

in Bogaert, Jan; Halleux, Jean-Marie (Eds.) Territoires périurbains. Développement, enjeux et perspectives dans les pays du Sud (2015)

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See detailPourquoi Charles de Méan doit-il être considéré comme un grand jurisconsulte ? Méthode et état d'une recherche doctorale
Lagasse, Benoît ULg

Diverse speeche and writing (2015)

Présentation de l'état de ma recherche doctorale après près d'un an

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See detailMesures de la voix en contexte écologique et techniques de biofeedback
Remacle, Angélique ULg; Morsomme, Dominique ULg

in Rééducation Orthophonique (2015), 264

Observer, analyser et améliorer la voix des patients dysphoniques dans leur quotidien relève-t-il encore de l’utopie? La dosimétrie ou accumulation vocale est une technique visant à quantifier la voix en ... [more ▼]

Observer, analyser et améliorer la voix des patients dysphoniques dans leur quotidien relève-t-il encore de l’utopie? La dosimétrie ou accumulation vocale est une technique visant à quantifier la voix en contexte écologique. Elle a d’abord fait l’apanage des laboratoires de recherche. Ensuite, publication après publication, les chercheurs ont mis en avant ses atouts et ses limites. Les dispositifs se sont modernisés, leur commercialisation a vu le jour il y a une dizaine d’années et leur utilisation est de plus en plus conviviale. Le biofeedback a été intégré à certains dosimètres. Cette option permet d’aller au-delà de la simple récolte d’informations sur l’usage vocal des patients. Elle peut, par exemple, avertir le sujet d’un comportement vocal inadéquat en temps réel, le but étant qu’il acquiert le bon geste vocal et l’intègre de manière automatique dans son quotidien. Ces outils participent donc aux quatre étapes de la thérapie, à savoir la conscientisation du dysfonctionnement, l’automatisation du geste vocal adéquat, son transfert, et son maintien dans le temps. [less ▲]

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See detailLe tradipraticien est un acteur incontournable dans l’offre des soins de santé en territoire péri-urbain : équilibre entre légitimité et illégalité ?
Manzambi Kuwekita, Joseph ULg; Mbadu Kivuidi, Véronique; Bruyère, Olivier ULg et al

in Halleux, Jean-Marie; Bogaert, Jan (Eds.) Territoires Périurbains (2015)

Summary This study examines people’s and public actors’s perception of traditional healers in Kisenso, and their potential integration into the health system. The findings of this study are based on focus ... [more ▼]

Summary This study examines people’s and public actors’s perception of traditional healers in Kisenso, and their potential integration into the health system. The findings of this study are based on focus groups conducted in 2013. According to the key results of this study, 100% of participants acknowledge the existence of traditional practitioners and all have used them. 80% found the care provided by these healers to be effective. However, the study participants found them to be lacking in hygiene in their handling of products. The use of traditional healers is justified in particular by the effectiveness of care, the type of illness suffered, the possibility of credit payment and their proximity. Public actors recognize both the existence of traditional healers and their effectiveness. They deplore their clandestine operation. Traditional healers claiming to be GPs (60%) and specialists (40%) say they work illegally because of the cost of administrative acts and their mistrust of intellectuals and biomedical practitioners. They complain about the insolvency of their patients who do not honor their commitments. For an effective integration of traditional healers in the health system, it would be useful to remove administrative barriers imposed on them for a balance between ancestral legitimacy and illegality in which they work, give them access to training, accept them as full participants in the health system, and explore the possibilities of contracting. [less ▲]

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See detailMultivariate coefficients of variation: Comparison and influence functions
Aerts, Stéphanie ULg; Haesbroeck, Gentiane ULg; Ruwet, Christel ULg

in Journal of Multivariate Analysis (2015), 142

In the univariate setting, coefficients of variation are well-known and used to compare the variability of populations characterized by variables expressed in different units or having really different means ... [more ▼]

In the univariate setting, coefficients of variation are well-known and used to compare the variability of populations characterized by variables expressed in different units or having really different means. When dealing with more than one variable, the use of such a relative dispersion measure is much less common even though several generalizations of the coefficient of variation to the multivariate setting have been introduced in the literature. In this paper, the lack of robustness of the sample versions of the multivariate coefficients of variation (MCV) is illustrated by means of influence functions and some robust counterparts based either on the Minimum Covariance Determinant (MCD) estimator or on the S estimator are advocated. Then, focusing on two of the considered MCV’s, a diagnostic tool is derived and its efficiency in detecting observations having an unduly large effect on variability is illustrated on a real-life data set. The influence functions are also used to compute asymptotic variances under elliptical distributions, yielding approximate confidence intervals. Finally, simulations are conducted in order to compare, in a finite sample setting, the performance of the classical and robust MCV’s in terms of variability and in terms of coverage probability of the corresponding asymptotic confidence intervals. [less ▲]

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See detailFestivals Acadiens et Creoles
Sacré, Robert ULg

E-print/Working paper (2015)

Comptes-rendus avec photos et liens Internet : 1) Houston et Galveston ( TX) 2) Festivals Acadiens et Créoles à Lafayette ( LA) jours 1 , 2 et 3 3) Lafayette by night

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See detailA metagenomic approach from aphid’s hemolymph sheds light on the potential roles of co-existing endosymbionts
De Clerck, Caroline ULg; Fujiwara, Akiko; Joncour, Pauline et al

in Microbiome (2015), 3(63),

Background: Aphids are known to live in symbiosis with specific bacteria, called endosymbionts which can be classified as obligate or accessory. Buchnera aphidicola is generally the only obligatory ... [more ▼]

Background: Aphids are known to live in symbiosis with specific bacteria, called endosymbionts which can be classified as obligate or accessory. Buchnera aphidicola is generally the only obligatory symbiont present in aphids, supplying essential nutrients that are missing in the plants phloem to its host. Pentalonia nigronervosa is the main vector of the banana bunchy top virus, one of the most damageable viruses in banana. This aphid is carrying two symbionts: B. aphidicola (BPn) and Wolbachia sp. (wPn). The high occurrence of Wolbachia in the banana aphid raises questions about the role it plays in this insect. The goal of this study was to go further in the understanding of the role played by the two symbionts in P. nigronervosa. To do so, microinjection tests were made to see the effect of wPn elimination on the host, and then, high-throughput sequencing of the haemolymph was used to analyze the gene content of the symbionts. Results: We observed that the elimination of wPn systematically led to the death of aphids, suggesting that the bacterium could play a mutualistic role. In addition, we identify and annotate 587 and 250 genes for wPn and BPn, respectively, through high-throughput sequencing. Analysis of these genes suggests that the two bacteria are working together for the production of several essential nutrients. The most striking cases are for lysin and riboflavin which are usually provided by B. aphidicola alone to the host. In the banana aphid, the genes involved in the production pathways of these metabolites are shared between the two bacteria making them both essential for the survival of the aphid host. Conclusions: Our results suggest that a co-obligatory symbiosis between B. aphidicola and Wolbachia occurs in the banana aphid, the two bacteria acting together to supply essential nutrients to the host. This is, to our knowledge, the first time Wolbachia is reported to play an essential role in aphids. [less ▲]

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See detailEulerian Formulation of Spatially Constrained Elastic Rods
Huynen, Alexandre ULg

Doctoral thesis (2015)

Slender elastic rods are ubiquitous in nature and technology. For a vast majority of applications, the rod deflection is restricted by an external constraint and a significant part of the elastic body is ... [more ▼]

Slender elastic rods are ubiquitous in nature and technology. For a vast majority of applications, the rod deflection is restricted by an external constraint and a significant part of the elastic body is in contact with a stiff constraining surface. The research work presented in this doctoral dissertation formulates a computational model for the solution of elastic rods constrained inside or around frictionless tube-like surfaces. The segmentation strategy adopted to cope with this complex class of problems consists in sequencing the global problem into, comparatively simpler, elementary problems either in continuous contact with the constraint or contact-free between their extremities. Within the conventional Lagrangian formulation of elastic rods, this approach is however associated with two major drawbacks. First, the boundary conditions specifying the locations of the rod centerline at both extremities of each elementary problem lead to the establishment of isoperimetric constraints, i.e., integral constraints on the unknown length of the rod. Second, the assessment of the unilateral contact condition requires, in principle, the comparison of two curves parametrized by distinct curvilinear coordinates, viz. the rod centerline and the constraint axis. Both conspire to burden the computations associated with the method. To streamline the solution along the elementary problems and rationalize the assessment of the unilateral contact condition, the rod governing equations are reformulated within the Eulerian framework of the constraint. The methodical exploration of both types of elementary problems leads to specific formulations of the rod governing equations that stress the profound connection between the mechanics of the rod and the geometry of the constraint surface. The proposed Eulerian reformulation, which restates the rod local equilibrium in terms of the curvilinear coordinate associated with the constraint axis, describes the rod deformed configuration by means of either its relative position with respect to the constraint axis (contact-free segments) or its angular position on the constraint surface (continuous contacts.) This formulation circumvents both drawbacks that afflict the conventional Lagrangian approach associated with the segmentation strategy. As the a priori unknown domain, viz. the rod length, is substituted for the known constraint axis, the free boundary problem and the associated isoperimetric constraints are converted into a classical two-point boundary value problem. Additionally, the description of the rod deflection by means of its eccentricity with respect to the constraint axis trivializes the assessment of the unilateral contact condition. Along continuous contacts, this formulation expresses the strain variables, measuring the rod change of shape, in terms of the geometric invariants of the constraint surface, and emphasizes the influence of the constraint local geometry on the reaction pressure. Formalizing the segmentation strategy, a computational model that exploits the Eulerian formulation of the rod governing equations is devised. To solve the quasi-static deflection of elastic rods constrained inside or around a tube-like surface, this computational model identifies the number of contacts, their nature (either discrete or continuous), and the rod configuration at the connections that satisfies the unilateral contact condition and preserves the rod integrity along the sequence of elementary problems. [less ▲]

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See detailAn overview of potamodromous fish upstream movements in medium-sized rivers, by means of fish passes monitoring
Benitez, Jean-Philippe ULg; Nzau Matondo, Billy ULg; Dierckx, Arnaud ULg et al

in Aquatic Ecology (2015), 49(4), 481-497

This study aims to investigate the upstream movement patterns of potamodromous fish species using multi-annual monitoring of modern multi-species fish passes in two medium-sized Belgian rivers: the ... [more ▼]

This study aims to investigate the upstream movement patterns of potamodromous fish species using multi-annual monitoring of modern multi-species fish passes in two medium-sized Belgian rivers: the Berwinne and the Amble`ve. During a 6-year monitoring period including a frequency of 1–5 times per week, the captured individuals were identified, measured and weighed to determine species abundance, and the periodicity of their seasonal movement patterns was investigated in relation to environmental factors. In the Amble`ve, 22 different fish species were monitored (n = 1513 individuals; biomass of 154 kg) and 14 species in the Berwinne (n = 3720; 408 kg). In both fish passes, inter-annual differences were observed, but the first year of monitoring was the best in terms of biomass, indicating the existence of an opening effect just after the fish passes opening, which allowed new migration routes. Salmonids and rheophilic cyprinids were predominant in terms of biomass, while minnow and spirlin were predominant in terms of number of fishes. The diversity in sizeranged from 46 to 760 mm demonstrating the importance of movements in various life stages. The capture periodicity showed different mobility patterns between the adult and juvenile stages in most species. Movements occurred frequently during the circus reproduction period for some species, but many species moved also apart from spawning period. This study highlights the omnipresence of patrimonial holobiotic potamodromous fish at different life stages that reflect their biological needs to move throughout the annual cycle. They must be considered as target species in river continuity restoration programmes and fish-pass design. [less ▲]

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See detailA probabilistic model for predicting the uncertainties of the humid stiction phenomenon on hard materials
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Journal of Computational & Applied Mathematics (2015), 289

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the ... [more ▼]

Stiction is a major failure in microelectromechanical system (MEMS) devices in which two contacting surfaces can remain stuck together because of the adhesive forces. Due to the difference between the surfaces roughness and the adhesive force range, the real contact areas are usually smaller than the apparent one, resulting in a scatter in the adhesive forces. Consequently, the stiction is an uncertain phenomenon. In this work, we develop a probabilistic model to predict the uncertainties of stiction due to the capillary forces acting on stiff materials. This model contains two levels: at the deterministic level, the model can predict the pull-out adhesive contact forces for a given surface topology; at the probabilistic level, the model generates independent identically distributed surfaces on which the deterministic solution can be applied to evaluate the uncertainties related to the stiction phenomenon. [less ▲]

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See detailMAVEN/IUVS Apoapse Observations of the Martian FUV Dayglow
Correira; IUVS team; Stiepen, Arnaud ULg

Poster (2015, December)

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See detailThe Two Types of Aurora on Mars as Observed by MAVEN's Imaging UltraViolet Spectrograph
Schneider; IUVS team; Stiepen, Arnaud ULg

Poster (2015, December)

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See detailH Escape in 3D: MAVEN IUVS observations of the Mars corona
Chaffin; IUVS team; Stiepen, Arnaud ULg

Conference (2015, December)

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See detailMars Ozone Mapping with MAVEN IUVS
Lefèvre; IUVS team; Stiepen, Arnaud ULg

Poster (2015, December)

Detailed reference viewed: 9 (0 ULg)
See detailTides in the Martian Atmosphere as Observed by MAVEN IUVS
Lo; IUVS team; Stiepen, Arnaud ULg

Poster (2015, December)

Detailed reference viewed: 9 (0 ULg)
See detailThe Hot Oxygen Corona of Mars: Observations by MAVEN IUVS
Deighan; IUVS team; Stiepen, Arnaud ULg

Poster (2015, December)

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See detailStudy of the Martian cold oxygen corona from the O I 130.4 nm by IUVS/MAVEN
Chaufray; IUVS team; Stiepen, Arnaud ULg

Poster (2015, December)

Detailed reference viewed: 13 (0 ULg)