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See detailStandardization of DiaSorin and Roche automated third generation PTH assays with an international standard: impact on clinical populations
CAVALIER, Etienne ULg; DELANAYE, Pierre ULg; LUKAS, Pierre ULg et al

in Clinical Chemistry & Laboratory Medicine (2014), 52(8), 1137-41

Background: Standardization of parathyroid hormone (PTH) assays is a major issue, especially in hemodialyzed (HD) patients. Two automated third generation PTH assays (Roche Elecsys and DiaSorin Liaison ... [more ▼]

Background: Standardization of parathyroid hormone (PTH) assays is a major issue, especially in hemodialyzed (HD) patients. Two automated third generation PTH assays (Roche Elecsys and DiaSorin Liaison) are now available. These assays are specific for the (1-84) PTH and do not cross-react with the (7-84) fragment, contrary to second generation (intact) assays. We aimed to calibrate the two methods against the WHO International PTH Standard (IS) 95/646 to see if the two assays could provide comparable results in a population of healthy subjects, HD patients and patients suffering from primary hyperparathyroidism (PHP). Methods: We selected 79 healthy subjects and two populations of patients presenting PTH disorders: 56 HD and 27 PHP patients. We reconstituted the IS in a pool of human serum containing undetectable levels of 1-84 PTH and prepared 13 serum standards ranging from 0 to 2000 pg/mL. The standards were run on the two instruments to calibrate the assays on the IS. The different populations were run before and after restandardization. Results: As these kits were differently calibrated, the results obtained after restandarization were significantly different. Restandardization process improved concordance between assays and, taking the analytical variability of the two kits into account, the results could be considered to be similar. Conclusions: Restandardization of automated third generation PTH assays with the WHO 1-84 PTH Standard significantly reduces inter-method variability. Reference ranges and raw values are totally transposable from one method to the other in healthy subjects, but also in diseased patients, e.g., with HD or those suffering from PHP. [less ▲]

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See detailEvaluation of [18F]UCB-H as a novel PET tracer for synaptic vesicle protein 2A in the brain.
Warnock, Geoffrey; Aerts, Joël ULg; Bahri, Mohamed Ali ULg et al

in Journal of Nuclear Medicine (The) (2014), 55(8), 1336-1341

Synaptic vesicle 2 (SV2) proteins are critical to proper nervous system function and are involved in vesicle trafficking. The SV2A isoform has been identified as the binding site of the antiepileptic ... [more ▼]

Synaptic vesicle 2 (SV2) proteins are critical to proper nervous system function and are involved in vesicle trafficking. The SV2A isoform has been identified as the binding site of the antiepileptic levetiracetam (LEV), making it an interesting therapeutic target for epilepsy. [18F]UCB-H is a novel PET imaging agent with a nanomolar affinity for human SV2A. Methods: preclinical PET studies were carried out in isoflurane anesthetized rats. Arterial input function was measured using an arteriovenous shunt and beta microprobe system. [18F]UCB-H was injected IV (140 ± 20 MBq bolus). Results: brain uptake of [18F]UCB-H was high, matching the expected homogeneous distribution of SV2A. The distribution volume (Vt) for [18F]UCB-H was calculated using Logan’s graphical analysis and the effect of LEV pretreatment on Vt measured. In control animals the mean whole-brain Vt was 9.76 ± 0.52 ml/cm3 (mean ± SD, n=4, test-retest), and the mean reproducibility in test-retest studies was 10.4 ± 6.5 %. Uptake of [18F]UCB-H was dose-dependently blocked by pretreatment with LEV (0.1 - 100 mg/kg IV). Conclusion: our results indicate that [18F]UCB-H is a suitable radiotracer for the imaging of SV2A in vivo. This is the first PET tracer for in vivo quantification of SV2A. The necessary steps for implementation of [18F]UCB-H production under GMP conditions and first in human studies are planned. [less ▲]

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See detailRegional, Interregional and Global Arrangements and Multilateral Organizations
Santander, Sébastian ULg

in Telò, Mario (Ed.) European Union and New Regionalism. Regional actors and global governance in a post-hegemonic era (2014)

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See detailImprovement of defect detection in shearography by using Principal Component Analysis
Vandenrijt, Jean-François ULg; Lièvre, Nicolas; Georges, Marc ULg

in Proceedings of Conference on Interferometry XVII: Techniques and Analysis (2014, August)

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See detailDeveloping situational judgment tests to assess organizational citizenship behaviours
Lothe, Benoit ULg; Hansez, Isabelle ULg

Conference (2014, August)

a) Purpose As Organizational Citizenship Behaviours (OCBs) positively influence a number of important outcomes (e.g. job performance, unit productivity, organizational efficiency, etc.) and are valued by ... [more ▼]

a) Purpose As Organizational Citizenship Behaviours (OCBs) positively influence a number of important outcomes (e.g. job performance, unit productivity, organizational efficiency, etc.) and are valued by managers as well, Organ, Podsakoff and Podsakoff (2010) assert the need “to try to identify and select those job candidates who have a propensity to exhibit these behaviours” (p.314). This study provides some empirical evidence about using Situational Judgment Tests (SJTs) for this specific target and allows us to discuss the main methodological issues in the development of such SJTs. b) Method Based on relevant best practices and recommendations from the literature (e.g. Weekley, Ployhart & Holtz, 2006), two distinct SJTs were especially developed to comply with OCBs assessment. The two SJTs differ on their job specificity degree (project manager in the industrial sector vs transversal function in the services sector), both propose ten different work related situations and, for each stem, five action proposals are available. Data were collected through online survey on two different samples (220 white collars professionals and 291 university students). Professionals were allowed to choose which SJT they wanted to participate, students were randomized within the two SJTS. An experimental manipulation of the response instructions (ipsative vs normative) was added within the student sample. OCBs were concurrently collected using self-reported measurement scales. c) Results In both samples (respectively professionals and students), the internal consistency was higher for the “job specific” SJT (α = .79 & .81) than for the “transversal job” SJT (α = .49 & 64). Notwithstanding, significant relations were found between the SJT scores and overall OCB ratings for both of the SJT forms in each of the two samples (r ranged from .30 to .57). Other specifics findings also provided substantial evidence for the concurrent validity of the SJTs to measure sub-dimensions of OCBs (altruism, courtesy, civic virtue, sportsmanship, loyalty and voice). d) Conclusions This study is, to our knowledge, the first to address the development and validation of a SJT for the assessment of OCBs. Review of the literature indicates that researches on techniques to predict OCBs are scarce and the present findings appear to surpass the average personality traits validity coefficients (r= .20) according to Organ & al. (2010)’s meta-analysis. There are two main practical implications. The first is the opportunity to use OCBs-SJTs as an alternative to assess applicants OCBs for job-specific or generic personnel selection issue. The second is to provide methodological development advices (e.g. the choice of response instruction) to ensure the SJT match the OCBs assessment requirement. Principal current limitations call for further research development that will be discussed: using different sources of OCBs rating, testing the incremental validity on personality tests, determining whether OCBs-SJTs are correlated with cognitive ability and establishing criterion validity with job performance. [less ▲]

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See detailNatural intrauterine infection with Schmallenberg virus in malformed newborn calves: pathology and distribution of viral RNA
Bayrou, Calixte ULg; Garigliany, Mutien-Marie ULg; Sarlet, Michaël ULg et al

in Emerging Infectious Diseases (2014), 20(8),

We comprehensively surveyed morphologic alterations in calves naturally infected in utero by Schmallenberg virus (SBV) and born deformed. SBV-specific RNA was distributed unevenly in different tissues ... [more ▼]

We comprehensively surveyed morphologic alterations in calves naturally infected in utero by Schmallenberg virus (SBV) and born deformed. SBV-specific RNA was distributed unevenly in different tissues. Implications for diagnosic procedures are highlighted. [less ▲]

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See detailPhénologie et intensité de la migration postnuptiale diurne en Ardenne du nord-est par le suivi migratoire (Ramecroix, 2006 à 2010)
Beckers, Arnaud ULg; Baron, André

in Aves (2014), 51(2), 87-106

Nous présentons les résultats de 5 années de suivi migratoire postnuptial en Ardenne du nord-est (site de Ramecroix) de 2006 à 2010. La phénologie et l’intensité du flux migratoire ont été calculées pour ... [more ▼]

Nous présentons les résultats de 5 années de suivi migratoire postnuptial en Ardenne du nord-est (site de Ramecroix) de 2006 à 2010. La phénologie et l’intensité du flux migratoire ont été calculées pour les 19 espèces les plus fréquentes. De manière générale, la phénologie montre une forte variabilité interannuelle par espèce. Le caractère extrêmement concentré dans le temps du passage a été mis en évidence chez deux espèces (Vanneau huppé et Grive musicienne). La phénologie est ensuite comparée à celle des Pays-Bas et celle des Awirs (Liège) et suggère des variations géographiques. L’ensemble du jeu de données constitue une référence utile pour de futures études traitant de la variabilité spatiale des flux migratoires. [less ▲]

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See detailOlympiades mathématiques belges - Recueil de questions - Tome 8 (2011-2014)
Dupont, Pascal ULg; Sebille, Michel

Book published by SBPMef (2014)

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See detailThe quest for rurality in Wallonia in 2013 (Belgium)
Schmitz, Serge ULg

in Bokwa, Anita (Ed.) Changes, Challenges Responsability. IGU 2014 Book of Abstarcts. (2014, August)

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See detailDiplomacia pública, ¿de la teoría a la práctica?: El caso de la Unión Europea en Brasil
Azpíroz Manero, María Luisa ULg

Conference (2014, August)

El entusiasmo académico por la diplomacia pública no se refleja en una atención específica a la misma en las estrategias de política exterior de la Unión Europea (UE). Sin embargo, su presencia se revela ... [more ▼]

El entusiasmo académico por la diplomacia pública no se refleja en una atención específica a la misma en las estrategias de política exterior de la Unión Europea (UE). Sin embargo, su presencia se revela en múltiples iniciativas en las que los agentes no gubernamentales tienen un papel clave como receptores o actores: actividades de cooperación, de intercambio, informativas. La diplomacia pública es una actividad diplomática y de comunicación política internacional que busca influenciar a públicos extranjeros con el fin de contribuir al logro de objetivos de política exterior y/o generar una imagen positiva. Funciona como una herramienta efectiva para movilizar recursos de poder blando, un poder basado en la atracción y la persuasión que se produce de modo indirecto cuando los actores políticos movilizan recursos como la cultura, los valores, las instituciones y las estrategias de política exterior. Pese a la crisis económica, la UE conserva un gran potencial de poder blando. Por eso, y dada la relevancia de Brasil como socio prioritario en la región latinoamericana, este artículo investiga qué diplomacia pública ha desarrollado la UE en este país los últimos tres años, así como su correspondencia con el cuerpo teórico sobre esta actividad. [less ▲]

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See detailThe cerato-mandibular ligament: a key functional trait for grazing in damselfishes (Pomacentridae)
Olivier, Damien ULg; Frederich, Bruno ULg; Spanopoulos-Zarco, Milton et al

in Frontiers in Zoology (2014), 11(63), 1-14

Introduction: The success of a taxonomic group can be promoted by a key character that allows the group to interact with its environment in a different way and to potentially occupy new niches. The ... [more ▼]

Introduction: The success of a taxonomic group can be promoted by a key character that allows the group to interact with its environment in a different way and to potentially occupy new niches. The Pomacentridae possess a synapomorphic trait, the cerato-mandibular (c-md) ligament, which joins the hyoid bar to the inner part of the lower jaw. It has previously been shown that this ligament is a key trait in communication in damselfishes because it enables them to slam the oral jaws shut causing teeth collision and sound production. This specific behavior of mouth closing could, however, also be used for other tasks, such as feeding. Many territorial damselfishes are referred to as farmers, due to their ability to manage algal crops on which they feed. This study hypothesizes that the c-md ligament provides an advantage for grazing filamentous algae, and should thus be considered a key trait for farming behavior. Results: The kinematic patterns associated with sound production and biting filamentous algae or attached animal prey are all based on the same mechanism and are associated with a slam of the oral jaws. We observed that transection of the c-md ligaments makes the fish unable to perform such actions. We also counted biting rates on filamentous algae in fish with and without the c-md ligament and observed a drop of more than 80% in the latter. Conclusion: This study shows that the c-md ligament is a key trait both for sound production and for grazing activities in damselfishes. The buccal jaw slam enables the fish to perform accurate strikes on small filamentous algae. This kind of bite probably plays a major role in farming activity and allows grazing damselfishes to occupy distinct niches, possibly increasing their competitive evolutionary success. [less ▲]

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See detailAn AC OPF-based Heuristic Algorithm for Optimal Transmission Switching
Capitanescu, Florin; Wehenkel, Louis ULg

in Proceedings of the 18th Power Systems Computation Conference (2014, August)

This paper focuses on reducing generators dispatch cost by means of transmission line switching. The problem is formulated as a mixed-integer nonlinear program (MINLP) optimal power flow (OPF). A scalable ... [more ▼]

This paper focuses on reducing generators dispatch cost by means of transmission line switching. The problem is formulated as a mixed-integer nonlinear program (MINLP) optimal power flow (OPF). A scalable heuristic algorithm is proposed to break-down the complexity of the problem due to the huge combinatorial space. The algorithm aims at providing the sequence of lines to be removed from service, one at the time, until no further decrease in the dispatch cost can be obtained. It identifies the line candidate for removal at each step by exploiting the (continuously relaxed values of) lines breaker statuses at the solution of a relaxed OPF problem. The algorithm thus relies on solving a sequence of OPF problems formulated as nonlinear programs (NLPs). The effectiveness of the approach is demonstrated on the IEEE118-bus system. Results show that the approach can provide good quality sub-optimal solutions with relatively small computational effort and by removing only few lines from service. [less ▲]

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See detailAdvanced optimization methods for power systems
Panciatici, Patrick; Campi, M.C.; Garatti, S. et al

in Proceedings of the 18th Power Systems Computation Conference (2014, August)

Power system planning and operation offers multitudinous opportunities for optimization methods. In practice, these problems are generally large-scale, non-linear, subject to uncertainties, and combine ... [more ▼]

Power system planning and operation offers multitudinous opportunities for optimization methods. In practice, these problems are generally large-scale, non-linear, subject to uncertainties, and combine both continuous and discrete variables. In the recent years, a number of complementary theoretical advances in addressing such problems have been obtained in the field of applied mathematics. The paper introduces a selection of these advances in the fields of non-convex optimization, in mixedinteger programming, and in optimization under uncertainty. The practical relevance of these developments for power systems planning and operation are discussed, and the opportunities for combining them, together with high-performance computing and big data infrastructures, as well as novel machine learning and randomized algorithms, are highlighted. [less ▲]

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See detailAphid - symbiont interactions : multitrophic "omic" approaches to investigate multitrophic interactions
Bosquée, Emilie ULg; Bauwens, Julien ULg; Mazzucchelli, Gabriel ULg et al

Poster (2014, August)

« Omics » found recent developments due to significant improvement and availability of both separation and identification methods. For proteomics, functional information’s linked to the studied proteins ... [more ▼]

« Omics » found recent developments due to significant improvement and availability of both separation and identification methods. For proteomics, functional information’s linked to the studied proteins was brought when compared to genomic approach. For these reasons, a panel of tools is available to determine the proteome patterns related to differential adaptation of insects to cope with plant defence mechanisms or to transmit virus. The adaptation and metabolic changes of aphids in relation to host plants focusing on the role of the bacterial endosymbionts was investigated. Use of artificial diet including diverse antibiotics but also the comparison of proteomes related to whole aphid and respective purified bacterial symbionts were studied to identify the respective origin and function of proteins constituting the studied proteomes. Diverse methods including 2D-DIGE, liquid chromatography coupled with mass spectrometry and data bank investigations were developed. From the proteome investigation, characterisation of good and bad virus vectors was also performed in different aphid - plant - virus models. Particular proteins of interest were selected. This broad proteomic approach will be discussed as an interesting and reliable tool to study the biologically involved proteins from aphids in response to several environmental changes [less ▲]

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See detailRevision of the tabulated methods of EN1992-1-2 for concrete columns in fire - Part 1
Gernay, Thomas ULg; Franssen, Jean-Marc ULg

Report (2014)

This report presents the results of numerical simulations conducted on reinforced concrete columns in fire for comparison of the computed fire resistance with the fire resistance obtained by the tabulated ... [more ▼]

This report presents the results of numerical simulations conducted on reinforced concrete columns in fire for comparison of the computed fire resistance with the fire resistance obtained by the tabulated methods of EN1992-1-2. The data for the studied RC columns have been provided by the CERIB in the document “CENTC250-SC2-WG1-TG5_N0037_Annex_C_studies_Jesper_Jensen”. This study is part of the research project CEN-TC250-SC2-WG1-TG5. The objective is to assess the validity of and possibly to revise the tabulated methods of EN1992-1-2. The numerical software that is used for the simulations is the non-linear finite element software SAFIR, version 2013a0. [less ▲]

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