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See detailDevelopment of Mass Spectrometry based Analytical Tools for Animal Venoms Characterization
Echterbille, Julien ULg

Doctoral thesis (2017)

Animal venoms and toxins are now recognized as major sources of bioactive molecules that may be tomorrow’s new drug leads. Their complexity and their potential as drug sources have been demonstrated by ... [more ▼]

Animal venoms and toxins are now recognized as major sources of bioactive molecules that may be tomorrow’s new drug leads. Their complexity and their potential as drug sources have been demonstrated by application of modern analytical technologies, which have revealed venoms to be vast peptide combinatorial libraries. Structural as well as pharmacological diversity is immense, and mass spectrometry is now one of the major investigative tools for the structural investigation of venom components. The present work is dedicated to the development of new mass spectrometry-based methodologies for the study of animal venoms. The first methodology depicts an original approach to sequence snake toxins in a higher throughput way after an orthogonal separation of the crude venom. The second analytical development is devoted to decipher disulfide connectivity in cone snails’ toxins through a combination of partial reduction/oxidation followed by ion mobility separation of the semi-reduced/oxidized species and CID fragmentation. The last part of this work is focused on the capture of ligands of nAChRs in complex mixtures of peptides, especially in cone snail venoms. A new ligand has been discovered and fully characterized. [less ▲]

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See detailL'interdiction du port du voile au travail
Kéfer, Fabienne ULg

Scientific conference (2017, March 28)

Séminaire faisant suite aux arrêts de la CJUE du 17 mars 2017 (C.J.U.E., 14 mars 2017, G4S Secure Solutions, C-157/15 ; C.J.U.E., 14 mars 2017, Micropole Univers, C-188/15)

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See detailResearch in Prison from the inside. An uncomfortable position for the "Official-Researcher"?
Sevenants, Yves ULg

Conference (2017, March 28)

Presentation about the experience of a native researcher in prison.

Detailed reference viewed: 16 (1 ULg)
See detailCorps et virtualité : Psychopathologie du sujet borderline
Englebert, Jérôme ULg

Scientific conference (2017, March 24)

Detailed reference viewed: 37 (3 ULg)
See detailThe implicit transformation of national administrative authorities in the service of supranational ‘fair trial’ rights
Van Cleynenbreugel, Pieter ULg

Scientific conference (2017, March 24)

This presentation analyses to what extent the fundamental right to a fair trial has been instrumental in shaping or modifying the structure of national competition and financial market authorities in five ... [more ▼]

This presentation analyses to what extent the fundamental right to a fair trial has been instrumental in shaping or modifying the structure of national competition and financial market authorities in five States (the United Kingdom, France, Germany, the Netherlands and Belgium). Submitting that the ECtHR and the CJEU have succeeded in imposing a limited number of administrative organisation templates on administrative authorities and uncovering the limits of that approach, it will call for a more fundamental reflection on the risks and opportunities associated with inter- and supranational courts establishing, in a bottom-up fashion, administrative organisation templates subsequently imposed on States. [less ▲]

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See detailAnosognosia for behavioral disorder is related to confidence for false self-related memories in Alzheimer’s disease
Mélon, Marlène; Collette, Fabienne ULg; Salmon, Eric ULg et al

Poster (2017, March 24)

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and ... [more ▼]

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and memory cognitive systems in AD, reducing cognitive advantages of self-related memories (i.e. decreasing self reference effect, SRE) in these patients. However, how anosognosia relates to impaired metacognitive monitoring in AD, particularly for self-related memories, is still an open question. To investigate this question, an ecological memory task based on face-name associations was administrated to 20 healthy older controls (HC) and 20 mild AD patients. The influence of self-reference at encoding was assessed on subsequent name recall and recollective experience, as well as on predictive (feeling-of-knowing, FOK) and postretrieval (judgments-of-confidence, JOC) metacognitive judgments on name recognition in all participants. Furthermore relationships between metacognitive outcomes and awareness of daily cognitive and behavioral impairment was examined in AD. Altered SRE was evidenced in name recall and recollective experience in AD. Patients also showed impaired FOK and JOC, as well as lower awareness of their daily functioning impairment (anosognosia). Nevertheless, differential effect of self on metacognitive judgment in AD and HC was only observed on JOC for false memories. Importantly, anosognosia for behavioral disorders was related to post-retrieval confidence for false recognition of self-related items in AD patients. Thus, anosognosia concerning behavioral disorder and altered post-retrieval monitoring of self-related memories appear to be related in AD. We hypothesized that impaired monitoring of personal false memories may lead AD patients to rely on distorted recent reality when providing judgment about their everyday behavioral functioning. [less ▲]

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See detailInactivation of DNA damage repair provides additional efficacy to the treatment of thyroid cancer
Neelature Sriramareddy, Sathyanarayana ULg

Doctoral thesis (2017)

Incidence of thyroid cancer has increased steadily over the last several decades. This type of neoplasm accounts for the majority of deaths due to endocrine cancers. The most frequent form, well ... [more ▼]

Incidence of thyroid cancer has increased steadily over the last several decades. This type of neoplasm accounts for the majority of deaths due to endocrine cancers. The most frequent form, well-differentiated thyroid cancer, is characterized by disease persistence, recurrence and a lack of response to radioiodine-131. With survival rates of 9 weeks to 5 months, anaplastic thyroid cancer has very poor prognosis. To provide additional efficacy to the treatment of thyroid cancer, we investigated the mechanisms of DNA damage and repair. We found that thyroid cancer cells undergo mitosis in presence of unrepaired DNA damage. To proliferate and survive, these cells repair DNA lesions very efficiently using homologous recombination (HR) and non-homologous end joining (NHEJ). Pharmacological inhibition of these pathways significantly increases apoptosis of thyroid cancer cells. This thesis thus demonstrates that targeting DNA damage repair pathways might have therapeutic value in relapsing and advanced thyroid cancers. [less ▲]

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See detailMonitoring Lions (Panthera leo) using Digital 3D Models of their Tracks
Marchal, Antoine ULg

Doctoral thesis (2017)

As the Earth may be entering a new human-influenced geological time, the Anthropocene, the pressure on biodiversity due to increasing human populations and activities is unprecedented. Monitoring animal ... [more ▼]

As the Earth may be entering a new human-influenced geological time, the Anthropocene, the pressure on biodiversity due to increasing human populations and activities is unprecedented. Monitoring animal populations is essential to gain demographic data and assess their viability. Because of the difficulties linked to invasive methods that involve direct observation or handling, many researchers have explored alternative approaches such as using tracks. Tracks are the material by-product of the interaction between terrestrial animals and their physical environment due to gravity. The interpretation of tracks exists since the dawn of mankind and is a crucial factor for human evolution. As an integral part of hunting, the art of tracking involves cognitive thinking that may well be part of the origin of science. However, monitoring species through their tracks is controversial due to several reasons: unreliable recording techniques limited to two-dimensions, manipulator bias, substrate variation, misidentification of the foot from which each track originates, and subjective identification of the age, sex and/or individual. The aim of this thesis was to evaluate the possibility of monitoring lions Panthera leo through digital three-dimensional (3D) models of their tracks. The first step was to assess close-range digital photogrammetry as a low-cost, rapid, practical and reliable field technique for the digital 3D modelling of lion paws, tracks and trails. A trail, that is a continuous sequence of tracks made by the same individual, reflects the morphology and kinematics of that individual. The use of traditional morphometrics enabled the extraction of variables such as distances, angles and areas from the digital 3D trails originating from individuals of known age, sex and/or identity. When comparing adult lions walking at the same gait (i.e. same kinematics), the trail variables provided sufficient information to identify the sex and individual. The digital solution permitted the extraction of more variables than the usual pace, stride and straddle. These additional variables enabled a better discrimination between the sexes and individuals. As for the paw and track morphology, traditional morphometrics conveys limited information about the geometric structure, and fails to quantify the shape variations along curves and surfaces. To overcome these drawbacks, geometric morphometrics allowed the extraction of the form (i.e. size and shape) by means of superimposed fixed landmarks, and curve- and surface-slider semi-landmarks. Using fixed landmarks, the paws and tracks presented enough shape variation to identify their position along the anteroposterior (front or hind) and mediolateral (right or left) axes. We used fixed landmarks, with and without curve- and surface-sliders, on paws and tracks from lions of known age, sex and/or identity. The identification of the age and sex from the paws, and the age, sex and individual from the tracks achieved higher accuracies when using size and shape variables together rather than independently. The information from curves and surfaces offered an advantage for the identification from the tracks but not from the paws. Due to the variation in anatomy, paw morphology and individuality in walking, tracks and trails contain information about the individual lion that created them. Recent advances in digital close-range photogrammetry and geometric morphometrics allow the recording and extraction of that information, which can then provide data to help monitor lion populations using a non-invasive approach. [less ▲]

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See detailAmok. De quelques perdants radicaux chez Hans Magnus Enzensberger.
Hamers, Jérémy ULg; Cormann, Grégory ULg

Conference (2017, March 23)

En 2006, l’écrivain et essayiste allemand Hans Magnus Enzensberger publie Le perdant radical, un « essai sur les hommes de la terreur », conformément au sous-titre de cet ouvrage d’une soixantaine de ... [more ▼]

En 2006, l’écrivain et essayiste allemand Hans Magnus Enzensberger publie Le perdant radical, un « essai sur les hommes de la terreur », conformément au sous-titre de cet ouvrage d’une soixantaine de pages dans lequel l’auteur décrit les multiples facettes d’un ensemble de figures meurtrières. Du tireur fou dans un lycée américain au combattant islamiste ceinturé d’explosifs, isolé ou organisé en groupe, tout perdant radical répond au même mécanisme : c’est « lorsqu’il aura repris à son compte le jugement des autres, ceux qu’il tient pour les gagnants (…) qu’il pète les plombs. » L’indistinction est frappante : pour Enzensberger, le perdant radical peut sévir seul ou en groupe ; son moteur profond, irréductible à un engagement politique ou religieux, reste le même dans les deux cas. Car pour l’essayiste, rien, pas même une théorie critique de la société, ne permet de rendre compte de la nature du perdant radical, si ce n’est la suppression de l’instinct de conservation. Dans plusieurs textes littéraires – on songe notamment à son poème Zur Frage der Bedürfnisse (1991) et à son entretien autobiographique fictif avec lui-même Erinnerungen an einen Tumult (2014) –, Hans Magnus Enzensberger crée ou recrée des figures de terroristes qui réalisent parfaitement le profil type du perdant radical. Andreas Baader, les jeunes bourgeois d’une secte marxiste en Suède, un terroriste islamiste en fuite, un guérillero sud-américain qui a perdu tout sens de la réalité, autant de figures fictionnelles ou refictionnalisées qui, partant d’une même position d’échec apparemment imposée de l’extérieur et assumée en tant que telle, superposent destruction et autodestruction. L’hypothèse générale à laquelle nous voudrions soumettre ces personnages de terroristes est qu’ils sont les héritiers d’une figure essentielle pour la littérature allemande et anglo-saxonne : l’amok. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULg; Blanpain, Manon ULg; Van Egroo, Maxime ULg et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailConstruction, restauration et ornement: pour une histoire de quelques chantiers "décapants"
Houbart, Claudine ULg; Detry, Nicolas

Conference (2017, March 23)

Detailed reference viewed: 22 (2 ULg)
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See detailRelating pessimistic memory predictions to Alzheimer’s disease brain structure
Genon, Sarah ULg; Simon, Jessica ULg; Bahri, Mohamed Ali ULg et al

Poster (2017, March 23)

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory ... [more ▼]

Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients. [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

Detailed reference viewed: 13 (1 ULg)
See detailLe droit de vote en Belgique, 1830-2017
Lanneau, Catherine ULg

Conference given outside the academic context (2017)

Detailed reference viewed: 21 (0 ULg)