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See detailLe projet EpistolART à la lumière de lettres évoquant Léonard de Vinci
Fagnart, Laure ULiege

in Girotto, Carlo Alberto; Lucas-Fiorato, Corinne (Eds.) L'écriture épistolaire entre Renaissance et Âge baroque. Pratiques, enjeux, pistes de recherche (in press)

Le projet EpistolART explore le matériau épistolaire dans le but de mieux préciser le statut socio-professionnel des artistes de la Renaissance italienne. Dans ce cadre, le "Carteggio inedito d’artisti ... [more ▼]

Le projet EpistolART explore le matériau épistolaire dans le but de mieux préciser le statut socio-professionnel des artistes de la Renaissance italienne. Dans ce cadre, le "Carteggio inedito d’artisti dei secoli XIV, XV, XVI" de Johann Wilhelm Gaye (1839-1840) constitue l’un de nos corpus privilégiés. Méritoire le travail de Gaye n’en demeure pas moins dépassé : les transcriptions, souvent partielles et contestables, requièrent une actualisation, suivant les critères de la philologie, de la codicologie et de la paléographie moderne. Cette contribution s'organise autour de trois lettres évoquant Léonard de Vinci, lettres publiées dans les volumes de Gaye et dont les membres du projet EpistolART proposent une nouvelle édition. Elles constituent des documents extrêmement précieux pour écrire l’histoire des relations entre le maître florentin et la France. Si les historiens qui se sont penchés sur la vie et l’œuvre de Léonard de Vinci connaissent ces correspondances, rares sont ceux qui ont recouru aux documents épistolaires originaux. Or, ce n’est qu’au départ d’un texte sûr, appréhendé tant dans sa matérialité que dans ses contenus, que peuvent se déployer des analyses scientifiquement fondées. [less ▲]

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See detailLa rencontre de juillet-août 1529
Fagnart, Laure ULiege; Le Roux, Nicolas

in La 'paix des Dames', entre politique, mises en scène du pouvoir et célébrations (in press)

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See detailIntroduction
Fagnart, Laure ULiege

in La 'paix des Dames', entre politique, mises en scène du pouvoir et célébrations (in press)

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See detailCarte géologique de Wallonie à l'échelle 1:25 000. Hamoir-Ferrières n°49/1-2
Marion, Jean-Marc ULiege; Barchy, Laurent

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25 000, based on a new field work and using previous scientific data produced since the previous editions of Lohest and Fourmarier (1900)

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See detailSynthetic oligorotaxanes exert high forces when folding under mechanical load
Sluysmans, Damien ULiege; Hubert, Sandrine ULiege; Bruns, Carson et al

in Nature Nanotechnology (in press)

Folding is a ubiquitous process that nature uses to control the conformations of its molecular machines, allowing them to perform chemical and mechanical tasks. Over the years, chemists have synthesized ... [more ▼]

Folding is a ubiquitous process that nature uses to control the conformations of its molecular machines, allowing them to perform chemical and mechanical tasks. Over the years, chemists have synthesized foldamers that adopt well-defined and stable folded architectures, mimicking the control expressed by natural systems. Mechanically interlocked molecules, such as rotaxanes and catenanes, are prototypical molecular machines that enable the controlled movement and positioning of their component parts. Recently, combining the exquisite complexity of these two classes of molecules, donor–acceptor oligorotaxane foldamers have been synthesized, in which interactions between the mechanically interlocked component parts dictate the single-molecule assembly into a folded secondary structure. Here we report on the mechanochemical properties of these molecules. We use atomic force microscopy-based single-molecule force spectroscopy to mechanically unfold oligorotaxanes, made of oligomeric dumbbells incorporating 1,5-dioxynaphthalene units encircled by cyclobis(paraquat-p-phenylene) rings. Real-time capture of fluctuations between unfolded and folded states reveals that the molecules exert forces of up to 50 pN against a mechanical load of up to 150 pN, and displays transition times of less than 10 μs. While the folding is at least as fast as that observed in proteins, it is remarkably more robust, thanks to the mechanically interlocked structure. Our results show that synthetic oligorotaxanes have the potential to exceed the performance of natural folding proteins. [less ▲]

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See detailPerformances of local poultry breed fed black soldier fly larvae reared on horse manure
Moula, Nassim ULiege; Scippo, Marie-Louise ULiege; Douny, Caroline ULiege et al

in Animal Nutrition (in press)

In poultry, feed based on maggots, like larvae of Black Soldier fly (Hermetia illucens) is an attractive option to substitute current ingredients which are expensive and often in direct or indirect ... [more ▼]

In poultry, feed based on maggots, like larvae of Black Soldier fly (Hermetia illucens) is an attractive option to substitute current ingredients which are expensive and often in direct or indirect competition with human food. Little information is currently available on the utility of these larvae in poultry feed, so goals of this study were to determine whether larvae could be reared on horse manure under traditional farming conditions and to evaluate the growth performances of a local poultry fed these larvae and the fatty acids profiles of their meat. After freezing and thawing, larvae were introduced in the feed of Ardennaise chickens between 30 and 80 days of age. Birds in the control group received a commercial standard feed while those in the treatment group received the same commercial feed in which 8% was substituted with whole fresh larvae corresponding to 2% on a dry matter basis. Mean ± standard errors of larval length and weight were 20.67 ± 2.21 mm and 0.14 ± 0.02 g, respectively. Mean larval percentages of dry matter and of substances extractable in diethyl ether were 24.6% and 23.1%, respectively. Larval fatty acids profiles were predominantly composed of lauric (28.1%) and palmitic (22.0%) acids. Least squares means of weekly weights of chicken, adjusted for the effects of sex, replication and initial weights, were significantly higher (P < 0.05) by 77.03 ± 53.37 g in larvae-fed than in control chickens. All the other measurements were not statistically different between larvae-fed and control chicken, including fatty acid profiles, protein content and ω6/ω3 ratio. In conclusion, the use of black soldier fly larvae in the diet of local chicken breed may be an alternative to the use of soy. [less ▲]

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See detailDe l’usage des « bons livres » et des autres dans les couvents féminins d’Ancien Régime aux Pays-Bas et en Principauté de Liège
Henneau, Marie-Elisabeth ULiege

in Henryot, Fabienne; Martin, Philippe (Eds.) Les femmes dans le cloître et la lecture (XVIIe-XIXe siècles) (in press)

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See detailHydraulic determination of dam releases to generate warning waves in a mountain stream: performance of an analytical kinematic wave model
Stilmant, Frédéric; Pirotton, Michel ULiege; Archambeau, Pierre ULiege et al

in Journal of Hydraulic Engineering (in press)

In this case study, we study the generation of warning waves with prescribed characteristics in a mountain stream. We determine which dam release will generate the desired warning wave. We solve this ... [more ▼]

In this case study, we study the generation of warning waves with prescribed characteristics in a mountain stream. We determine which dam release will generate the desired warning wave. We solve this inverse problem following a two-model approach. An analytical kinematic model is used for a preliminary design of the dam release and a detailed two-dimensional (2D) fully dynamic model is used to converge to the final solution. Although the presented case study is far from an idealized academic case, the analytical model performs well and, beyond its role for preliminary design, turns out to be of prime interest for both understanding and discussing the results of the detailed 2D model. The complex interactions between the release hydrograph, the geometry of the river and the friction formula are brought to light by the analytical model, which highlights the complementarity of both models and the usefulness of such a two-model approach. [less ▲]

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See detailPsychopathologie et monde social : les limites de l'empathie et de la sympathie
Englebert, Jérôme ULiege

in Philosophie (in press)

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See detailXénophane de Colophon et l’approche critique du religieux
Fortier, Simon ULiege

in Collette, Bernard; Gavray, Marc-Antoine; Narbonne, Jean-Marc (Eds.) Raison et Révélation : l’Héritage Critique de l’Antiquité, Volume I : Le développement de l’esprit critique dans l’Antiquité (in press)

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See detailInvestigating the impact of river floods on travel demand based on an agent-based modeling approach: The case of Liège, Belgium
Saadi, Ismaïl ULiege; El Saeid Mustafa, Ahmed Mohamed ULiege; Teller, Jacques ULiege et al

in Transport Policy (in press)

In Belgium, river floods are among the most frequent natural disasters and they may have important consequences on travel demand. In order to better understand how the travel patterns vary, we propose to ... [more ▼]

In Belgium, river floods are among the most frequent natural disasters and they may have important consequences on travel demand. In order to better understand how the travel patterns vary, we propose to set up a large scale scenario based on MATSim for guarantying an accurate assessment of the impact of river floods on the transportation system. As inputs, the current agent-based model requires a base year population. A synthetic population with respective set of attributes is generated as a key input. Afterwards, agents are assigned activity chains through an activity-based generation process. Finally, the synthetic population and the transportation network are integrated into MATSim. Regarding data, households travel surveys, OD matrix of Belgium have been used to set up the demand. For simulating river floods effects, a steady-state inundation map has been integrated within MATSim. In the current study, five scenarios have been tested where critical links are associated various levels of service, i.e. 10%, 25%, 50%, 75% and 100% (base case scenario). They are systematically compared to the standard scenario to estimate the deviations in terms of traffic patterns and travel times. The results suggest that compared to the standard scenario, the average trip travel time increased by 16.36%, 44.44%, 126.77% and 144.44% with respect to scenarios 75%, 50%, 25% and 10% respectively. Also, the traffic flows have been re-distributed more uniformly across the transportation network. Roads with important traffic volumes are subjected to a decrease of activity on the contrary of roads with low traffic volumes. A very few studies have focused on how river floods affect transportation systems, this paper provided new insights in term of methodology and traffic patterns analysis under disruptions. [less ▲]

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See detailDifferential contributions of default and dorsal attention networks to remembering thoughts and external stimuli from real-life events
Stawarczyk, David ULiege; Jeunehomme, Olivier ULiege; D'Argembeau, Arnaud ULiege

in Cerebral Cortex (in press)

Episodic memories are typically composed of perceptual information derived from the external environment and representations of internal states (e.g., one’s thoughts during prior episodes). To date ... [more ▼]

Episodic memories are typically composed of perceptual information derived from the external environment and representations of internal states (e.g., one’s thoughts during prior episodes). To date, however, research has mostly focused on the remembrance of external stimuli, such that little is known about how internal mentation is represented within episodic memory. In the present fMRI study, we examined the neural correlates of these two components of episodic memories using a novel method of cuing memories from photographs taken during real-life events. We found that, compared to corresponding semantic memory tasks, memories for internal thoughts and external elements were associated with activity in brain areas supporting episodic recollection. Most importantly, however, the two kinds of memories also showed differential activation in large-scale brain networks: the remembrance of external elements was associated with greater activity in the dorsal attention network, whereas memories of internal thoughts mainly recruited default network areas. These findings shed new light on the representation of internal and external aspects of prior experience within episodic memory. The default network may contribute to the reinstatement of thoughts experienced during past events, whereas the dorsal attention network may support the allocation of attention to visuo-spatial features within episodic memory representations. [less ▲]

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See detailPartenariats transrégionaux, technologies numériques et culture : de la convergence numérique aux divergences normatives
Vlassis, Antonios ULiege

in Deblock, Chrstian; Levesque, Céline; Paquin, Stephane (Eds.) et al Les partenariats commerciaux à l'ére de l'interconnexion (in press)

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See detailNeuro-functional correlates of the protective effects of exercise against cocaine sensitization and dopamine D2 receptors density: a [18F]Fallypride microPET study.
Becker, Guillaume ULiege; Lespine, Louis-Ferdinand ULiege; Serrano Navacerrada, Maria Elisa ULiege et al

in Molecular Imaging & Biology (in press)

Preclinical studies suggest that free access to a running wheel can attenuate behavioural effects of addictive drugs such as psychomotor sensitization to cocaine in rodents. This phenomenon has an ... [more ▼]

Preclinical studies suggest that free access to a running wheel can attenuate behavioural effects of addictive drugs such as psychomotor sensitization to cocaine in rodents. This phenomenon has an integral role in the process of drug addiction in craving and relapse (Steketee and Kalivas, 2011). Free wheel-running was recently shown to be efficacious at preventing the initiation or the long-term expression of psychomotor sensitization to cocaine in mice or rats (Diaz et al., 2013; Geuzaine and Tirelli, 2014). In the present study, we investigated the neuro-functional correlates of the protection against psychomotor sensitization to cocaine afforded by free wheel-running on dopaminergic neurotransmission, using microPET imaging with [18F]Fallypride, a Dopamine 2 receptor (D2R) antagonist. Sixty-four 28-day-old female C57BL/6J mice were randomly assigned to one of the two housing conditions, defined by the presence or the absence of a running wheel in the cage over a 6-week pre-testing period. Since mice from the two types of housing received either saline (controls) or cocaine (8 mg/kg, i.p.) during testing (9 once-daily sessions to establish sensitization plus 1 single session to test its expression), a basic 2x2 randomized blocks design was generated (2-way ANOVA and planned comparisons; n=10). Experimentation lasted 85 days, with a 42-day period of pre-testing and a 3-week interval preceding the test for long-term expression of sensitization (LTES). All mice underwent a microPET (Focus 120, Siemens) the day after the LTES. The microPET protocol consisted of a 60 min. dynamic acquisition after the injection of 10 MBq of [18F]Fallypride in the tail vein. Wheel-running strongly and significantly attenuated LTES (interaction) to cocaine (Cohen’s d=1.63; t(21)=3.75, p<.001) and cocaine-treated mice exhibited a clear-cut and significant increase (main effect) of the [18F]Fallypride BP (d=0.88, t(31)=2.45, p =.02). Wheel-running induced an overall moderate-sized decrease (main effect) of the [18F]Fallypride BP, but without achieving statistical significance (d=0.64, t(31)=1.79, p =.08). These findings suggest that LTES is associated with an increase of the [18F]Fallypride BP in the mouse striatum, probably reflecting an increase in postsynaptic D2R density in this region. Also, the protecting effect of free running on psychomotor sensitization goes together with a decrease in D2R density in the striatum of exercised mice. We intend to complement the present study with an identical experiment to reach a total number of 80 mice (n=20). This will confer to our study a sufficient power (80%) for the main effect of wheel-running exercise on [18F]Fallypride BP to be detected at an alpha-level of 5%. Finally, autoradiography studies, performed on the same mice with [18F]Fallypride, will strengthen our in vivo results. [less ▲]

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See detailTraité 31 [V, 8]
Fortier, Simon ULiege

in Narbonne, Jean-Marc (Ed.) Plotin, Œuvres complètes, tome II, vol. II (in press)

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See detailLe rôle du gymnase : espace, rituels et acteurs sociaux dans une perspective comparatiste
Caneva, Stefano ULiege

in Lenzo, Giuseppina; Nihan, Christophe (Eds.) Les cultes aux rois et aux héros dans l’antiquité : continuités et changements à l’époque hellénistique (in press)

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See detailThe X-ray footprint of the CircumNuclear Disk
Mossoux, Enmanuelle ULiege; Eckart, Andreas

in Monthly Notices of the Royal Astronomical Society (in press)

We studied the central regions of the Galactic Centre to determine if the CircumNuclear Disk (CND) acts as an absorber or a barrier for the central X-rays diffuse emission. After reprocessing 4.6Ms of ... [more ▼]

We studied the central regions of the Galactic Centre to determine if the CircumNuclear Disk (CND) acts as an absorber or a barrier for the central X-rays diffuse emission. After reprocessing 4.6Ms of Chandra observations, we were able to detect, for the first time, a depression in the X-ray luminosity of the diffuse emission whose size and location correspond to those of the CND. We extracted the X-ray spectra for various regions inside the CND footprint as well as for the region where the footprint is observed and for a region located outside the footprint. We simultaneously fitted these spectra as an optically thin plasma whose absorption by the interstellar medium and by the local plasma were fitted independently using the MCMC method. The hydrogen column density of the ISM is 7.5x10^22 cm^-2. The X-ray diffuse emission inside the CND footprint is formed by a 2T plasma of 1 and 4keV with slightly super-solar abundances except for the iron and carbon which are sub-solar. The plasma from the CND, in turn, is better described by a 1T model with abundances and local hydrogen column density which are very different to those of the innermost regions. The large iron abundance in this region confirms that the CND is dominated by the shock-heated ejecta of the Sgr A East supernova remnant. We deduced that the CND rather acts as a barrier for the Galactic Centre plasma and that the plasma located outside the CND may correspond to the collimated outflow possibly created by Sgr A* or the interaction between the wind of massive stars and the mini-spiral material. [less ▲]

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See detailPulse-Based Control Using Koopman Operator Under Parametric Uncertainty
Sootla, Aivar; Ernst, Damien ULiege

in IEEE Transactions on Automatic Control (in press)

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these ... [more ▼]

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these limitations, it may be desirable to derive simple control policies, such as step functions with fixed magnitude and length (or temporal pulses). In this technical note, we further develop a recently proposed pulse-based solution to the convergence problem, i.e., minimizing the convergence time to the target exponentially stable equilibrium, for monotone systems. In particular, we extend this solution to monotone systems with parametric uncertainty. Our solutions also provide worst-case estimates on convergence times. Furthermore, we indicate how our tools can be used for a class of non-monotone systems, and more importantly how these tools can be extended to other control problems. We illustrate our approach on switching under parametric uncertainty and regulation around a saddle point problems in a genetic toggle switch system. [less ▲]

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