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See detailSimplified analytical methods for the crashworthiness and the seismic design of lock gates
Buldgen, Loïc ULg

Doctoral thesis (2015)

The PhD dissertation aims to provide simplified tools based on analytical formulations in order to ease the pre-design of lock gates. The first part of the thesis is devoted to ship collisions. The ... [more ▼]

The PhD dissertation aims to provide simplified tools based on analytical formulations in order to ease the pre-design of lock gates. The first part of the thesis is devoted to ship collisions. The resistance of the impacted gate is evaluated by combining global and local deforming modes. In the second part of the dissertation, an analytical solution is proposed to estimate the total hydrodynamic pressure acting on a lock gate during a seism, with due consideration for the fluid-structure coupling. Numerical validations are proposed for both ship collisions and earthquakes. [less ▲]

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See detailÉtude du Typus mélancholicus au sein d’une population de dépressifs unipoalires
ramackers, Amélia; Englebert, Jérôme ULg

Poster (2015, January 21)

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See detailLa personnalité Borderline à travers le test de Rorschach
Rommes, Jennifer; Englebert, Jérôme ULg

Poster (2015, January 21)

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See detailÉtude du récit de vie de l’adulte à haut potentiel
Mormont, Elodie; Gauthier, Jean-Marie ULg; Englebert, Jérôme ULg

Poster (2015, January 21)

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See detailEspace, temps et psychopathologie en prison
Englebert, Jérôme ULg

Scientific conference (2015, January 19)

L’analyse du cas de Nathan, sorte d’épisode princeps de notre analyse de l’univers carcéral, nous permettra d’étudier les notions de temps et d’espace. Ces deux coordonnées sont fondamentales, tant pour ... [more ▼]

L’analyse du cas de Nathan, sorte d’épisode princeps de notre analyse de l’univers carcéral, nous permettra d’étudier les notions de temps et d’espace. Ces deux coordonnées sont fondamentales, tant pour la considération anthropologique de l’homme situation d’enfermement que pour la compréhension psychopathologique. À partir de cette analyse, dans laquelle nous évoquerons notamment un texte peu connu de Sartre sur les Visages ainsi que la philosophie des émotions de Scheler, c’est la problématique fondamentale du corps que nous évoquerons. L’épisode psychopathologique du Gate fever (la « fièvre de la porte ») vécu par Nathan nous permettra également d’évoquer le vécu émotionnel paradoxal de l’expérience psychotique. [less ▲]

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See detailLow molecular weight poly (2-dimethylamino ethylmethacrylate) polymers with controlled positioned fluorescent labeling: Synthesis, characterization and in vitro interaction with human endothelial cells.
Flebus, Luca ULg; Lombart, François ULg; Sevrin, Chantal et al

in International journal of pharmaceutics (2015), 478(1), 278-287

Poly (2-dimethylamino ethylmethacrylate) (PDMAEMA) is an attractive non-degradable polymer studied as nonviral vector for gene delivery but it can be also adopted for delivery of other biopharmaceutical ... [more ▼]

Poly (2-dimethylamino ethylmethacrylate) (PDMAEMA) is an attractive non-degradable polymer studied as nonviral vector for gene delivery but it can be also adopted for delivery of other biopharmaceutical drugs. As a parenteral carrier, the PDMAEMA free form (FF) might interact with tissues and cells. Few data are available on its selective internalization and efflux from cells, while the majority of studies published have followed the distribution of DNA complexed with PDMAEMA. In order to address polycation safety, the first aim was to synthesize by atom transfer radical polymerisation (ATRP) fluorescent labeled PDMAEMA of low molecular weight (Mw) (below 15kDa), controlling the position and density of fluorescein. The second goal was to analyze the possible difference in uptake and subcellular distribution of this labeled FF polycation between human umbilical vein endothelial cells (HUVEC) and hCMEC/D3 cells. These two cell lines have been chosen in order to detect selectivity towards the blood-brain barrier (BBB). In both cases, polycation was detected along the plasma membrane followed by progressive migration to the peri-nuclear region, where it overlapped with lysosomal structures. The analysis by fluorescence-activated cell sorting (FACS) of the PDMAEMA uptake by hCMEC/D3 cells showed a significant (p<0.05) inhibition (40%) in presence of 2-dexoxy-d-glucose inhibitor, a result supporting an energy-dependence mechanism(s). Cytotoxicity study showed that low Mw PDMAEMA (10kDa) lead to a minor cytotoxicity compared to the higher ones. As main conclusion this study highlights the similitude in cell trafficking of FF PDMAEMA and data previously reported for PDMAEMA/DNA complexes. [less ▲]

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See detailIntroduction to item response theory (IRT) and computerized adaptive testing (CAT) with the R software
Magis, David ULg

Scientific conference (2015, January 13)

Item response theory (IRT) has become an important field of research for psychology and educational assessment. Recently, with the increase of computational power, several IRT-related topics have emerged ... [more ▼]

Item response theory (IRT) has become an important field of research for psychology and educational assessment. Recently, with the increase of computational power, several IRT-related topics have emerged, among others, computerized adaptive testing (CAT). The main aim of CAT is to provide a framework for individualized assessment by means of optimal item selection and administration to the test takers. CAT has several assets to linear (non-adaptive) testing: individualized assessment, limited risk of cheating or fraud, shorter tests providing the same amount of information as longer linear tests, automatic scoring and reporting at the end of the test. Practical use of CAT, however, remains limited so far due to several factors (lack of available large item banks, content validity and security, lack of suitable software for practical CAT assessment, ethical issues in administering different tests to estimate the same ability, etc.). The purpose of this workshop is threefold: (a) to provide a general overview of IRT and CAT, (b) to introduce the R software in a user-oriented way, as well as several IRT tools (including the package catR for CAT simulations), (c) to perform practical training sessions with the participants. The workshop will be a mix of oral presentations, demonstrations related to the R software, and practical sessions where participants will be invited to train with R and catR. The R software is an open-source platform for statistical inference and testing, graphical display and data visualization. It also holds several add-on packages for specific IRT purposes (item calibration, ability estimation, multidimensional scaling, equating, differential item functioning etc.). The R community is worldwide and proposes free exchanges of shared R packages through the CRAN (comprehensive R archive network). In this workshop, the R package catR will be examined and used in the practical sessions. [less ▲]

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See detailEffect of stress path on the miniaturizatio size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Duchene, Laurent ULg et al

Conference (2015, January 04)

The mechanical behavior of mettalic materials deeply depends on the size of samples. For specimen dimensions de creasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of mettalic materials deeply depends on the size of samples. For specimen dimensions de creasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. This effect is triggered by the derease of the number of grains across the thickness ( also called thickness"t" over grain size "d" ratio). The objective of this work is to provide new experimental results in order to analyse the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensil tests, large tensile tests and shear tests have been performed on Ni sheets ( 0.5mm) with various grain sizes ensuring different t/d ratios. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanicval softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. Attempts of numerical simulations using strain gradient crystal plasticity model are also performed to confirm the role played by surface effects. [less ▲]

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See detailBasin-scale partitioning of Greenland ice sheet mass balance components (2007–2011)
Andersen, M.L.; Stenseng, L.; Skourup, H. et al

in Earth and Planetary Science Letters (2015), 409

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be ... [more ▼]

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be well captured by observationally-constrained climate modeling, insight into D is relatively limited. We use InSAR-derived velocities, in combination with ice thickness observations, to quantify the mass flux (F ) across a flux perimeter around the ice sheet at ∼1700 m elevation. To quantify D , we correct F for SMB , as well as changes in volume due to ice dynamics, in the area downstream of the gate. Using a 1961–1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007–2011 mean D of View the MathML source. We find a 2007–2011 mean total mass balance of View the MathML source, which is equal to a 0.73 mm yr−1 global sea level rise contribution. This mass loss is dominated by SMB, which accounts for 61% of mass loss in the basins where partitioning is possible. [less ▲]

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See detailFood provioning influences ranging patterns in northern pigtailed macaques (Macaca leonina)
Huynen, Marie-Claude ULg; Savini, Tommaso ULg; Asensio, Norberto et al

in International Journal of Primatology (2015, January)

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See detailMetabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study.
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Herve et al

in Journal of proteomics (2015), 113

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for ... [more ▼]

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for nucleotide, protein and lipid synthesis necessary for macromolecule assembly and tumor growth. We applied a 2D-DIGE (Two-Dimensional Differential in-Gel Electrophoresis) quantitative proteomic analysis to characterize the proteomes of mouse astrocytes that underwent in vitro cancerous transformation, and of their normal counterparts. Metabolic reprogramming effects on enzymatic and structural protein expression as well as associated metabolites abundance were quantified. Using enzymatic activity measurements and zymography, we documented and confirmed several changes in abundance and activity of various isoenzymes likely to participate in metabolic reprogramming. We found that after transformation, the cells increase their expression of glycolytic enzymes, thus augmenting their ability to use aerobic glycolysis (Warburg effect). An increased capacity to dispose of reducing equivalents through lactate production was also documented. Major effects on carbohydrates, amino acids and nucleotides metabolic enzymes were also observed. Conversely, the transformed cells reduced their enzymatic capacity for reactions of tricarboxylic acid oxidation, for neurotransmitter (glutamate) metabolism, for oxidative stress defense and their expression of astroglial markers. BIOLOGICAL SIGNIFICANCE: The use of a global approach based on a 2D DIGE analysis allows obtaining a comprehensive view of the metabolic reprogramming undergone by astrocytes upon cancerous transformation. Indeed, except for a few enzymes such as pyruvate carboxylase and glutaminase that were not detected in our initial analysis, pertinent information on the abundance of most enzymes belonging to pathways relevant to metabolic reprogramming was directly obtained. In this in vitro model, transformation causes major losses of astrocyte-specific proteins and functions and the acquisition of metabolic adaptations that favor intermediate metabolites production for increased macromolecule biosynthesis. Thus our approach appears to be readily applicable for the investigation of changes in protein abundance that determine various transformed cell phenotypes. It could similarly be applied to the evaluation of the effects of treatments aimed at correcting the consequences of cell transformation. [less ▲]

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See detailEffect of stress path on the miniaturization size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Habraken, Anne ULg et al

in International Journal of Plasticity (2015), 64

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. The objective of this work is to provide new experimental results in order to analyze the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensile tests, large tensile tests and shear tests have been performed on Ni sheets with various grain sizes. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanical softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. From an industrial point of view, it is hence possible to improve the forming of microparts using suitable stress paths. [less ▲]

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See detailDépasser la situation : de la situation-limite à la personnalité borderline. Généalogie, critique et clinique d’un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

Conference (2015, January)

Nous souhaitons interroger ici le concept sartrien de situation à partir d’une double approche historique et psychopathologique qui semble en diagnostiquer la disparition tout aussi bien conceptuelle ... [more ▼]

Nous souhaitons interroger ici le concept sartrien de situation à partir d’une double approche historique et psychopathologique qui semble en diagnostiquer la disparition tout aussi bien conceptuelle qu’existentielle : la notion de situation, organisatrice de l’ontologie phénoménologique de Sartre et pivot de son engagement, semble s’être aujourd’hui désintégrée en tant que concept (voir ses usages pseudo-conceptuels dans les domaines de la pédagogie et du management), alors que ce qu’on appelle la « condition postmoderne », telle qu’elle s’exprime dans de nouvelles symptomatologies psychopathologiques, rend apparemment caduque, face à la fragmentation des repères de l’existence, l’exigence de penser en/la situation. Nous procèderons en trois temps. Nous ferons d’abord la généalogie du concept, dont l’application à la psyché humaine et à la représentation théâtrale de celle-ci remonte, selon Leo Spitzer, à la fin du 17ème siècle. Dans cette première section, nous insisterons en particulier sur le rapport que l’élaboration du concept de situation entretient, au début du 20ème siècle, avec l’émergence de la psychopathologie notamment chez Jaspers (« situation-limite ») et chez Minkowski (nous rappellerons à cet égard le rôle de Gabriel Marcel dans le champ philosophique français de l’entre-deux-guerres). Nous serons également attentifs à la critique méthodologique que le concept de situation permet d’adresser à la métapsychologie freudienne. Sur cette base, nous reprendrons ensuite les principales étapes chez Sartre de la prise en considération de l’homme en situation et des possibilités de dépassement de cette situation. Nous envisagerons successivement l’Esquisse d’une théorie des émotions, « Questions de méthode » et L’Idiot de la famille. Il conviendra certes de rappeler comment l’existentialisme, comme le situationnisme à sa façon, a cherché, dans le sillage du marxisme, à réaliser la philosophie et du coup à transformer le concept en vécu. Mais nous montrerons aussi, à rebours, comment l’œuvre sartrienne, confrontée aux exigences conjointes du marxisme et de la psychanalyse (cf. l’analyse des pressions familiales dans le Flaubert), a dû dépasser le cadre de la magie émotionnelle au sein duquel la notion de situation s’était d’abord élaborée. Au-delà de la « situation sartrienne » – et peut-être en la prolongeant –, la critique de Deleuze des dispositifs nous servira enfin, dans un troisième temps, de point de bascule vers la condition postmoderne et la fragmentation de la situation en tant que repère d’existence. Le sujet borderline – véritable éclat de la postmodernité – nous permettra ainsi de conclure en reprenant le propos psychopathologique maturé par l’évolution conceptuelle de la situation. Nous caractériserons l’existence borderline par une fragmentation du soi corrélée à une explosion, voire à un morcellement, des espaces de vie qui répondent à la nécessité ontologique d’une « ubiquité instantanée » dénuée de présence corporelle (comme le permettent les espaces virtuels « connectés »). [less ▲]

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See detailThe impact of transport policies on railroad intermodal freight competitiveness – The case of Belgium
Santos, Bruno F.; Limbourg, Sabine ULg; Carreira, Joana Silva

in Transportation Research. Part D : Transport and Environment (2015), 34

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist ... [more ▼]

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist in subsidizing intermodal transport operations (such as in Belgium, to stimulate rail transport), internalizing external costs (as recommended by the European Union in order to foster cleaner modes), and adopting a system perspective when optimizing the location of inland intermodal terminals. The study proposes an innovative mixed integer intermodal freight location-allocation model based on hub-location theory and deals with non-linear transport costs in order to replicate economies of distance. Our analysis suggests that subsidizing has a significant impact on the volumes transported by intermodal transport, and, to a lesser extent, that optimizing terminal location increases the competitiveness of intermodal transport. On the other hand, according to our assumptions, internalizing external costs can negatively impact the promotion of intermodality. This finding indicates that innovative last-mile transports are needed in order to reduce the external impacts of drayage operations. [less ▲]

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See detailBiochemical characterisation of the seed oils of four safflower (Carthamus tinctorius) varieties grown in north-eastern of Morocco
Ben Moumen, Abdessamad; Mansouri, Farid; Richard, Gaetan ULg et al

in International Journal of Food Science & Technology (2015)

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi ... [more ▼]

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi-arid region of eastern Morocco) was evaluated through analysis of their phenolic and carotenoid contents. The composition of the phenolic compounds of safflower oil has not yet been documented. Therefore, in this preliminary study, Thirty different phenolic compounds were identified, and significant differences between the oil varieties were observed (P < 0.05). In the seed oil from the Rancho and Sharda safflower varieties, the main phenolic compound was trans-chalcone, representing 13.45% and 11.8%, respectively, of the total phenolics, whereas in Cartamar and Cartafri oils, naringin accounted for 26.82% and 16.5%, respectively, of the total phenolics. The total carotenoid contents ranged from 1.13 mg/kg (Rancho) to 1.34 mg/kg (Cartamar and Cartafri).We observed that b-cryptoxanthin (0.31–0.37 mg/kg) and b-carotene (0.3–0.35 mg/kg) were the predominant carotenoids in all of the safflower oils that were studied. [less ▲]

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See detailA review of gliptins for 2014.
Scheen, André ULg

in Expert opinion on pharmacotherapy (2015), 16(1), 43-62

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a personalized medicine in patients with Type 2 diabetes. Areas covered: An updated review providing an analysis of available recent data with commercialized DPP-4 inhibitors, with a special focus on: differences between the various molecules, novelties regarding their mechanism of action, clinical efficacy in mono- and various combined therapies, comparison with other new therapies, efficacy-safety profile in at risk patients, concern about pancreatic safety, perspectives in cardiovascular prevention and, finally, a selection of remaining unanswered important questions for the clinician. Expert opinion: DPP-4 inhibitors offer various advantages when compared to other glucose-lowering agents. Despite they have been commercialized since a few years only, available data obtained in randomised controlled trials are of better quality compared to those available with ancient classical glucose-lowering agents, especially in more fragile populations such as elderly people, individuals with renal impairment or at high cardiovascular risk and patients at higher risk of hypoglycaemia. However, there remain uncertainties and controversies that should be resolved by further ongoing large prospective controlled trials and increasing clinical experience combined with a careful post-marketing surveillance. [less ▲]

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