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See detailPsychopathologie et monde social : les limites de l'empathie et de la sympathie
Englebert, Jérôme ULiege

in Philosophie (in press)

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See detailIntensity and memory characteristics of near-death experiences
Martial, Charlotte ULiege; Charland-Verville, Vanessa ULiege; Cassol, Helena ULiege et al

in Consciousness & Cognition (in press)

Memories of Near-Death Experiences (NDEs) seem to be very detailed and stable over time. At present, there is still no satisfactory explanation for the NDEs’ rich phenomenology. Here we compared ... [more ▼]

Memories of Near-Death Experiences (NDEs) seem to be very detailed and stable over time. At present, there is still no satisfactory explanation for the NDEs’ rich phenomenology. Here we compared phenomenological characteristics of NDE memories with the reported experience’s intensity. We included 152 individuals with a self-reported “classical” NDE (i.e. occurring in life-threatening conditions). All participants completed a mailed questionnaire that included a measure of phenomenological characteristics of memories (the Memory Characteristics Questionnaire; MCQ) and a measure of NDE’s intensity (the Greyson NDE scale). Greyson NDE scale total score was positively correlated with MCQ total score, suggesting that participants who described more intense NDEs also reported more phenomenological memory characteristics of NDE. Using MCQ items, our study also showed that NDE’s intensity is associated in particular with sensory details, personal importance and reactivation frequency variables. [less ▲]

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See detailInvestigating the impact of river floods on travel demand based on an agent-based modeling approach: The case of Liège, Belgium
Saadi, Ismaïl ULiege; El Saeid Mustafa, Ahmed Mohamed ULiege; Teller, Jacques ULiege et al

in Transport Policy (in press)

In Belgium, river floods are among the most frequent natural disasters and they may have important consequences on travel demand. In order to better understand how the travel patterns vary, we propose to ... [more ▼]

In Belgium, river floods are among the most frequent natural disasters and they may have important consequences on travel demand. In order to better understand how the travel patterns vary, we propose to set up a large scale scenario based on MATSim for guarantying an accurate assessment of the impact of river floods on the transportation system. As inputs, the current agent-based model requires a base year population. A synthetic population with respective set of attributes is generated as a key input. Afterwards, agents are assigned activity chains through an activity-based generation process. Finally, the synthetic population and the transportation network are integrated into MATSim. Regarding data, households travel surveys, OD matrix of Belgium have been used to set up the demand. For simulating river floods effects, a steady-state inundation map has been integrated within MATSim. In the current study, five scenarios have been tested where critical links are associated various levels of service, i.e. 10%, 25%, 50%, 75% and 100% (base case scenario). They are systematically compared to the standard scenario to estimate the deviations in terms of traffic patterns and travel times. The results suggest that compared to the standard scenario, the average trip travel time increased by 16.36%, 44.44%, 126.77% and 144.44% with respect to scenarios 75%, 50%, 25% and 10% respectively. Also, the traffic flows have been re-distributed more uniformly across the transportation network. Roads with important traffic volumes are subjected to a decrease of activity on the contrary of roads with low traffic volumes. A very few studies have focused on how river floods affect transportation systems, this paper provided new insights in term of methodology and traffic patterns analysis under disruptions. [less ▲]

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See detailDifferential contributions of default and dorsal attention networks to remembering thoughts and external stimuli from real-life events
Stawarczyk, David ULiege; Jeunehomme, Olivier ULiege; D'Argembeau, Arnaud ULiege

in Cerebral Cortex (in press)

Episodic memories are typically composed of perceptual information derived from the external environment and representations of internal states (e.g., one’s thoughts during prior episodes). To date ... [more ▼]

Episodic memories are typically composed of perceptual information derived from the external environment and representations of internal states (e.g., one’s thoughts during prior episodes). To date, however, research has mostly focused on the remembrance of external stimuli, such that little is known about how internal mentation is represented within episodic memory. In the present fMRI study, we examined the neural correlates of these two components of episodic memories using a novel method of cuing memories from photographs taken during real-life events. We found that, compared to corresponding semantic memory tasks, memories for internal thoughts and external elements were associated with activity in brain areas supporting episodic recollection. Most importantly, however, the two kinds of memories also showed differential activation in large-scale brain networks: the remembrance of external elements was associated with greater activity in the dorsal attention network, whereas memories of internal thoughts mainly recruited default network areas. These findings shed new light on the representation of internal and external aspects of prior experience within episodic memory. The default network may contribute to the reinstatement of thoughts experienced during past events, whereas the dorsal attention network may support the allocation of attention to visuo-spatial features within episodic memory representations. [less ▲]

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See detailNeuro-functional correlates of the protective effects of exercise against cocaine sensitization and dopamine D2 receptors density: a [18F]Fallypride microPET study.
Becker, Guillaume ULiege; Lespine, Louis-Ferdinand ULiege; Serrano Navacerrada, Maria Elisa ULiege et al

in Molecular Imaging & Biology (in press)

Preclinical studies suggest that free access to a running wheel can attenuate behavioural effects of addictive drugs such as psychomotor sensitization to cocaine in rodents. This phenomenon has an ... [more ▼]

Preclinical studies suggest that free access to a running wheel can attenuate behavioural effects of addictive drugs such as psychomotor sensitization to cocaine in rodents. This phenomenon has an integral role in the process of drug addiction in craving and relapse (Steketee and Kalivas, 2011). Free wheel-running was recently shown to be efficacious at preventing the initiation or the long-term expression of psychomotor sensitization to cocaine in mice or rats (Diaz et al., 2013; Geuzaine and Tirelli, 2014). In the present study, we investigated the neuro-functional correlates of the protection against psychomotor sensitization to cocaine afforded by free wheel-running on dopaminergic neurotransmission, using microPET imaging with [18F]Fallypride, a Dopamine 2 receptor (D2R) antagonist. Sixty-four 28-day-old female C57BL/6J mice were randomly assigned to one of the two housing conditions, defined by the presence or the absence of a running wheel in the cage over a 6-week pre-testing period. Since mice from the two types of housing received either saline (controls) or cocaine (8 mg/kg, i.p.) during testing (9 once-daily sessions to establish sensitization plus 1 single session to test its expression), a basic 2x2 randomized blocks design was generated (2-way ANOVA and planned comparisons; n=10). Experimentation lasted 85 days, with a 42-day period of pre-testing and a 3-week interval preceding the test for long-term expression of sensitization (LTES). All mice underwent a microPET (Focus 120, Siemens) the day after the LTES. The microPET protocol consisted of a 60 min. dynamic acquisition after the injection of 10 MBq of [18F]Fallypride in the tail vein. Wheel-running strongly and significantly attenuated LTES (interaction) to cocaine (Cohen’s d=1.63; t(21)=3.75, p<.001) and cocaine-treated mice exhibited a clear-cut and significant increase (main effect) of the [18F]Fallypride BP (d=0.88, t(31)=2.45, p =.02). Wheel-running induced an overall moderate-sized decrease (main effect) of the [18F]Fallypride BP, but without achieving statistical significance (d=0.64, t(31)=1.79, p =.08). These findings suggest that LTES is associated with an increase of the [18F]Fallypride BP in the mouse striatum, probably reflecting an increase in postsynaptic D2R density in this region. Also, the protecting effect of free running on psychomotor sensitization goes together with a decrease in D2R density in the striatum of exercised mice. We intend to complement the present study with an identical experiment to reach a total number of 80 mice (n=20). This will confer to our study a sufficient power (80%) for the main effect of wheel-running exercise on [18F]Fallypride BP to be detected at an alpha-level of 5%. Finally, autoradiography studies, performed on the same mice with [18F]Fallypride, will strengthen our in vivo results. [less ▲]

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See detailLe rôle du gymnase : espace, rituels et acteurs sociaux dans une perspective comparatiste
Caneva, Stefano ULiege

in Lenzo, Giuseppina; Nihan, Christophe (Eds.) Les cultes aux rois et aux héros dans l’antiquité : continuités et changements à l’époque hellénistique (in press)

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See detailPulse-Based Control Using Koopman Operator Under Parametric Uncertainty
Sootla, Aivar; Ernst, Damien ULiege

in IEEE Transactions on Automatic Control (in press)

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these ... [more ▼]

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these limitations, it may be desirable to derive simple control policies, such as step functions with fixed magnitude and length (or temporal pulses). In this technical note, we further develop a recently proposed pulse-based solution to the convergence problem, i.e., minimizing the convergence time to the target exponentially stable equilibrium, for monotone systems. In particular, we extend this solution to monotone systems with parametric uncertainty. Our solutions also provide worst-case estimates on convergence times. Furthermore, we indicate how our tools can be used for a class of non-monotone systems, and more importantly how these tools can be extended to other control problems. We illustrate our approach on switching under parametric uncertainty and regulation around a saddle point problems in a genetic toggle switch system. [less ▲]

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See detailGlobal structural integrity and effective connectivity in patients with disorders of consciousness
BODART, Olivier ULiege; Amico, Enrico; Gomez, Francisco et al

in Brain Stimulation (in press)

Background Previous studies have separately reported impaired functional, structural, and effective connectivity in patients with disorders of consciousness (DOC). The perturbational complexity index (PCI ... [more ▼]

Background Previous studies have separately reported impaired functional, structural, and effective connectivity in patients with disorders of consciousness (DOC). The perturbational complexity index (PCI) is a transcranial magnetic stimulation (TMS) derived marker of effective connectivity. The global fractional anisotropy (FA) is a marker of structural integrity. Little is known about how these parameters are related to each other. Objective We aimed at testing the relationship between structural integrity and effective connectivity. Methods We assessed 23 patients with severe brain injury more than 4 weeks post-onset, leading to DOC or locked-in syndrome, and 14 healthy subjects. We calculated PCI using repeated single pulse TMS coupled with high-density electroencephalography, and used it as a surrogate of effective connectivity. Structural integrity was measured using the global FA, derived from diffusion weighted imaging. We used linear regression modelling to test our hypothesis, and computed the correlation between PCI and FA in different groups. Results Global FA could predict 74% of PCI variance in the whole sample and 56% in the patients' group. No other predictors (age, gender, time since onset, behavioural score) improved the models. FA and PCI were correlated in the whole population (r = 0.86, p < 0.0001), the patients, and the healthy subjects subgroups. Conclusion We here demonstrated that effective connectivity correlates with structural integrity in brain-injured patients. Increased structural damage level decreases effective connectivity, which could prevent the emergence of consciousness. [less ▲]

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See detailBelgian and Swiss service providers faced with the challenge of jobseeker guidance. Predominance of stakeholder games or of the collaborative framework?
Remy, Céline ULiege

in International Review of Administrative Sciences (in press)

The public employment services have contracted out their jobseeker guidance role to service providers. The paper focuses on how the collaboration between the public services and private employment ... [more ▼]

The public employment services have contracted out their jobseeker guidance role to service providers. The paper focuses on how the collaboration between the public services and private employment operators is organised in Belgium and Switzerland. These partnerships have to contend with two challenges, which are the recruitment of candidates for training projects and the measurement of the results of the service. Our initial hypothesis supports the idea that stakeholder games are more effective in solving critical situations than the collaborative framework. The international comparison allows us to vary the partnership creation methods and to show a particular articulation between the stakeholder games and collaborative framework. [less ▲]

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See detailApproaches to handling future use of the single-family housing stock
Berndgen-Kaiser, Andrea; Kohler, Tine; Marique, Anne-Françoise ULiege et al

in Open House International (in press)

Single-family houses are a common form of housing in Europe. Most were built in the context of the suburbanization after World War II and are now facing challenges arising from generational changes as ... [more ▼]

Single-family houses are a common form of housing in Europe. Most were built in the context of the suburbanization after World War II and are now facing challenges arising from generational changes as well as increasing living and energy standards (Fina, Planinsek and Zakrzewski, 2009). According to the hypothesis of this paper, in several EU regions, single-family houses may face future challenges arising from oversupply and lack of adaptation to current demand. To examine this, the paper analyses the present situation and discusses the prognosis for the challenges described above regarding the three neighbouring north-western European countries Belgium, Germany, and the Netherlands, based on available data and a review of country-specific characteristics of housing markets as well as national policies. Despite an impending mismatch between demand and supply, planning policies still support the emergence of new single-family houses. The comparison of Belgium, Germany, and the Netherlands shows the growing polarization between shrinking and growing regions and central and peripheral sites apparent at different stages in the three countries. While a high rate of vacancies is already registered for some regions in Germany (Effenberger, 2015), in the Netherlands this phenomenon can only be seen near the borders and in villages within the Randstadt conurbation (Hospers et al., 2015). In Belgium also, this phenomenon is not yet widespread, but in some suburban neighbourhoods dating from the 1950’s and 1960’s more and more single-family houses are becoming more difficult to sell, indicating an emerging mismatch between supply and demand (Chambre des Notaires de la Province de Liège, 2015). This article proposes some instruments which enable municipalities to intervene in single family housing neighbourhoods which are largely dominated by private ownership. These instruments are not yet widely established in single-family housing neighbourhoods but that may become important in the future [less ▲]

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See detailLiving and Printing in Antwerp in the Late Fifteenth and Early Sixteenth Centuries: a Social Enquiry
Adam, Renaud ULiege

in Van Bruaene, Anne-Laure; Kavaler, Ethan Matt (Eds.) Urban Perspectives on Sixteenth-Century Netherlandish Art & Culture (in press)

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See detailThe Distribution of Spanish Books in Brussels during the 16th century
Adam, Renaud ULiege

in Quaerendo: A Journal Devoted to Manuscripts and Printed Books (in press)

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See detailConsidérations sur la construction et l’affirmation de l’identité patrimoniale de la Bibliothèque royale de Belgique
Adam, Renaud ULiege

in Henryot, Fabienne (Ed.) La fabrique du patrimoine écrit : objets, acteurs, usages sociaux (in press)

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See detailIndustrial Integration of Biotechnological Processes from Raw Material to Energy Integration: Study by Modeling Approach
Léonard, Grégoire ULiege; Pfennig, Andreas ULiege; Celebi, Ayse Dilan et al

in Darvishi, Farshad; Hiligsmann, Serge (Eds.) Microbial Fuels: Technologies and Applications (in press)

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See detailSteady-State, Nonlinear Analysis of Large Arrays of Electrically Actuated Micromembranes Vibrating in a Fluid
Halbach, Alexandre ULiege; Geuzaine, Christophe ULiege

in Engineering with Computers (in press)

This paper describes a robust and efficient method to obtain the steady-state, nonlinear behaviour of large arrays of electrically actuated micromembranes vibrating in a fluid. The nonlinear ... [more ▼]

This paper describes a robust and efficient method to obtain the steady-state, nonlinear behaviour of large arrays of electrically actuated micromembranes vibrating in a fluid. The nonlinear electromechanical behavior and the multiple vibration harmonics it creates are fully taken into account thanks to a multiharmonic finite element formulation, generated automatically using symbolic calculation. A domain decomposition method allows to consider large arrays of micromembranes by efficiently distributing the computational cost on parallel computers. Two- and three- dimensional examples highlight the main properties of the proposed method. [less ▲]

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See detailComprehensive Ion Mobility Calibration: Poly(ethylene oxide) Polymer Calibrants and General Strategies
Haler, Jean ULiege; Kune, Christopher ULiege; Massonnet, Philippe ULiege et al

in Analytical Chemistry (in press)

Ion Mobility (IM) is now a well-established and fast analytical technique. The IM hardware is constantly being improved, especially in terms of the resolving power. The Drift Tube (DTIMS), the Traveling ... [more ▼]

Ion Mobility (IM) is now a well-established and fast analytical technique. The IM hardware is constantly being improved, especially in terms of the resolving power. The Drift Tube (DTIMS), the Traveling Wave (TWIMS), and the Trapped Ion Mobility Spectrometry (TIMS) coupled to mass spectrometry are used to determine the Collision Cross-Sections (CCS) of ions. In analytical chemistry, the CCS is approached as a descriptor for ion identification and it is also used in physical chemistry for 3D structure elucidation with computational chemistry support. The CCS is a physical descriptor extracted from the reduced mobility (K0) measurements obtainable only from the DTIMS. TWIMS and TIMS routinely require a calibration procedure to convert measured physical quantities (drift time for TWIMS and elution voltage for TIMS) into CCS values. This calibration is a critical step to allow inter-instrument comparisons. The previous calibrating substances lead to large prediction bands and introduced rather large uncertainties during the CCS determination. In this paper, we introduce a new IM calibrant (CCS and K0) using singly charged sodium adducts of poly(ethylene oxide) monomethyl ether (CH3O-PEO-H) for positive ionization in both helium and nitrogen as drift gas. These singly charged calibrating ions make it possible to determine the CCS/K0 of ions having higher charge states. The fitted calibration plots exhibit larger coverage with less data scattering and significantly improved prediction bands and uncertainties. The reasons for the improved CCS/K0 accuracy, advantages and limitations of the calibration procedures are also discussed. A generalized IM calibration strategy is suggested. [less ▲]

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See detailA Nineteenth-Century National Prussian Macroseismic Questionnaire
Knuts, Elisabeth ULiege; Hinzen, K-H; Reamer, S.K. et al

in Seismological Research Letters (in press)

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See detailLouise de Savoie. The King's Mother
Fagnart, Laure ULiege; Winn, Mary Beth

in Broomhall, Susan (Ed.) Women and Power at the French Renaissance Court (in press)

Louise de Savoie occupies a singular place at the French royal court : neither queen nor queen-mother, but mother of the King, she nonetheless played a prominent role in the political and cultural affairs ... [more ▼]

Louise de Savoie occupies a singular place at the French royal court : neither queen nor queen-mother, but mother of the King, she nonetheless played a prominent role in the political and cultural affairs of France. Daughter of Philippe de Bresse, duc de Savoie, she was raised at the court of her aunt, Anne de France, and married in 1488 at age 11 to Charles d’Angoulême, head of a cadet branch of the royal house of Valois. At Cognac where the couple resided, she gave birth to her illustrious children, Marguerite in 1492, and François in 1494. After the sudden death of her husband in 1496, she was herself still too young to be appointed their official guardian. Obliged to share that responsibility with Louis d’Orléans who became king in 1498, the young widow nonetheless asserted her authority in their education. How she succeeded in establishing her place at court, while her son, at first a distant heir to the throne, rose to be king in 1515, can be viewed through her astute patronage of arts and letters. Keenly aware of the power of books and images, Louise multiplied commissions that would reinforce her own position and that of her family and entourage, striving to align herself with illustrious women, past and present. Identified with “Dame Prudence” as she overcame obstacles and rivals, Louise de Savoie’s tenacious devotion to her children culminated in power that was fully recognized in the appointment of « Madame » as Regent of France. [less ▲]

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See detailAn Optimal Control Formulation of Pulse-Based Control Using Koopman Operator
Sootla, Aivar; Mauroy, Alexandre; Ernst, Damien ULiege

in Automatica (in press)

In many applications, and in systems/synthetic biology in particular, it is desirable to compute control policies that force the trajectory of a bistable system from one equilibrium (the initial point) to ... [more ▼]

In many applications, and in systems/synthetic biology in particular, it is desirable to compute control policies that force the trajectory of a bistable system from one equilibrium (the initial point) to another equilibrium (the target point), or in other words to solve the switching problem. It was recently shown that, for monotone bistable systems, this problem admits easyto-implement open-loop solutions in terms of temporal pulses (i.e., step functions of fixed length and fixed magnitude). In this paper, we develop this idea further and formulate a problem of convergence to an equilibrium from an arbitrary initial point. We show that this problem can be solved using a static optimization problem in the case of monotone systems. Changing the initial point to an arbitrary state allows to build closed-loop, event-based or open-loop policies for the switching/convergence problems. In our derivations we exploit the Koopman operator, which offers a linear infinite-dimensional representation of an autonomous nonlinear system. One of the main advantages of using the Koopman operator is the powerful computational tools developed for this framework. Besides the presence of numerical solutions, the switching/convergence problem can also serve as a building block for solving more complicated control problems and can potentially be applied to non-monotone systems. We illustrate this argument on the problem of synchronizing cardiac cells by defibrillation. Potentially, our approach can be extended to problems with different parametrizations of control signals since the only fundamental limitation is the finite time application of the control signal. [less ▲]

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See detailExploring the effect of a second closely-timed PRP infiltration for tendinopathy
Kaux, Jean-François ULiege; Croisier, Jean-Louis ULiege; Forthomme, Bénédicte ULiege et al

in British Journal of Sports Medicine (in press)

Introduction: Some clinical series have previously evaluated the effect of PRP in the treatment of proximal patellar tendinopathies. Although it is possible that a single infiltrative administration may ... [more ▼]

Introduction: Some clinical series have previously evaluated the effect of PRP in the treatment of proximal patellar tendinopathies. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of successive infiltrations which is arguably likely to increase the risks of complications. Methods: Our study is a single blinded, randomized controlled clinical trial on 20 leisure sportsmen (2 groups, respectively 1 or 2 infiltrations of pure PRP) with chronic proximal patellar tendinopathies, rebel to classical management. PRP was obtained using an aphaeresis machine. The one-year follow-up evaluation consisted of VAS, IKDC and VISA-P scores, while algometer, isokinetic and ultrasounds evaluations were carried out up to 3 months. Results: The concentration of the PRP used was similar in both groups. The VAS significantly decreased with time over the 3-month follow-up period (p=0.002), with no difference observed between the two groups (p=0.2). Values obtained with the pressure algometer increased with time across both groups over the 3-month follow-up period (p<0.0001), and values were significantly higher for Group 1 (p=0.001). The IKDC score increased with time in both groups over the follow-up period (p=0.034), with values again significantly higher for Group 1 (p=0.0026). The VISA-P score increased with time in both groups over the follow-up period (p=0.0023), with no difference observed between the groups (p=0.41). No improvements in isokinetic physical performance were observed in either group. However, pain during E30 significantly decreased over the 3-month follow-up period (p=0.027) for patients in both groups. No improvement in either jumping performances or in pain was observed in either group during opto-jump evaluation. No improvements in US findings were observed. After one year, 90% patients of group 1 did not report anymore pain during daily activities, in comparison with only 20% in group 2. Conclusions: A second closely-timed infiltration of PRP to treat proximal patellar tendinopathies is not necessary to improve the efficacy of this treatment. [less ▲]

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