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See detailQuand la voix s'enraye. Application de l'EBP à la rééducation vocale.
Morsomme, Dominique ULg

Scientific conference (2017, February 10)

La rééducation orthophonique des troubles de la voix est un vaste sujet. Mon intention n’est pas de vous exposer des séries d’exercices consacrées à la coordination pneumo-phonique, à la qualité de ... [more ▼]

La rééducation orthophonique des troubles de la voix est un vaste sujet. Mon intention n’est pas de vous exposer des séries d’exercices consacrées à la coordination pneumo-phonique, à la qualité de l’accolement cordal, au placement de la voix dans les résonateurs ou encore à la posture. De nombreux ouvrages orthophoniques expliquent ces pratiques et peuvent aisément enrichir vos connaissances sur le sujet. Après une brève introduction, j’ai choisi de vous présenter une démarche thérapeutique concrète qui repose sur une pratique basée sur les preuves (Evidence Based Practice, EBP). Autrement dit, comment un thérapeute de la voix peut-il implémenter dans sa pratique les bases de l’EBP afin d’assurer le meilleur traitement à son patient. Aussi, pour illustrer mon propos, j’ai opté pour une technique très discutée : la thérapie manuelle. Nous débattrons donc de l’efficacité thérapeutique sachant que les études de niveau 1A ou 1B sur le classement des niveaux de preuves sont rares dans le domaine de la vocologie. Ensuite, je ferai entendre une série de voix pré et post traitements. Cette étape, je l’espère, vous réconciliera avec le concept d’efficacité parfois si compliqué à démontrer. Je clôturerai la séance par une capsule vidéo illustrant des morceaux choisis de la thérapie vocale de trois patientes. Ces patientes et leur thérapeute, Catherine Jansen, ont aimablement accepté de livrer leur voix face caméra. [less ▲]

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See detailProteomic differential distribution of 53BP1 in serrated and conventional adenomas validated by histological characterisation
QUESADA-CALVO, Florence ULg; Merli, Angela-Maria ULg; MASSOT, Charlotte ULg et al

Poster (2017, February 10)

INTRODUCTION: Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, mostly located in the right side of the colon (cecum, ascending and transverse colon). The difficulty is to visualize this ... [more ▼]

INTRODUCTION: Sessile serrated adenoma/polyp (SSA/p) is a precancerous lesion, mostly located in the right side of the colon (cecum, ascending and transverse colon). The difficulty is to visualize this lesion during colonoscopy because of its subtle appearance. MATERIAL AND METHOD: We compared proteomes of serrated polyps (SSA/p) and conventional adenomas using residual human formalin fixed paraffin embedded (FFPE) samples. FFPE-FASP method was applied on samples before label free proteomic analysis. Immunohistochemistry (IHC) characterisation of one candidate marker was performed for tissue validation on an independent set of samples including: conventional adenomas (low and high-grade dysplasia), serrated polyps (hyperplastic polyps, SSA/p and traditional serrated adenoma) and finally normal colon (taken at the margin of colorectal cancer (CRC) or of diverticular disease). RESULTS: Proteomics provided 765 proteins (out of 5992 proteins identified) significantly discriminating conventional adenomas from serrated lesions. We selected 53BP1 (Tumor suppressor p53-binding protein 1) among these for IHC validation, because of its tumor suppressor gene function and role as a mediator of DNA damage checkpoint. 53BP1 appeared significantly up-regulated in proteomes of low and high grade adenomas compared to these of normal tissue and SSA/p. 53BP1 IHC signal was located in the nucleus and the percentage of positive nucleus decreased in serrated polyps, especially in crypts and in the border epithelium, confirming part of the proteomic results. CONCLUSION: This study highlights potential marker proteins, including 53BP1 from which IHC signal was strongly decreased in some serrated polyps. The loss of 53BP1 has been associated with tumour progression and poor prognosis, while little is currently known about its involvement in precancerous CRC lesions. 53BP1 decrease of expression in the nucleus and therefore possible loss of function in some epithelial cells could reflect important changes occurring during dysplasia to neoplasia progression in serrated lesions. [less ▲]

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See detailEmergence du sujet-entrepreneur au Cameroun. L'engagement entrepreneurial saisi par la réappropriation subjective d'expériences socio-biographiques
Amougou, Gérard ULg

Doctoral thesis (2017)

Cette recherche traite de la dynamique de subjectivation portée par la figure du sujet-entrepreneur, évoluant en dehors du sérail étatique au Cameroun. Son expérience biographique laisse percevoir un ... [more ▼]

Cette recherche traite de la dynamique de subjectivation portée par la figure du sujet-entrepreneur, évoluant en dehors du sérail étatique au Cameroun. Son expérience biographique laisse percevoir un modèle d’engagement dit entrepreneurial qui l’inscrit au cœur de l’histoire sociale et politique en cours. Le récit de vie laisse percevoir un souci pressant de réalisation de soi qui le pousse à relativiser les supports institutionnels classiques, et non moins contraignantes, de socialisation. Durant son parcours, la démarcation de ces dernières conduit à la répugnance d’une carrière administrative « tranquille » et est assortie d’un discours critique sur la politique du ventre. Cette démarcation serait en outre au cœur d’une rupture biographique qui l’astreint à s’engager, de manière individualisée, à la promotion d’une société utopique à partir de son champ professionnel. Son engagement présente une variété de typologies d’action liées à la sensibilité et aux convictions personnelles, à l’expérience acquise au cours de la trajectoire biographique, et à l’orientation donnée à l’activité. Cette variété d’actions trouve un lieu commun dans le besoin de subvertir l’ordre sociopolitique dominant en vue de promouvoir l’avènement d’une cité alternative. En cela, les logiques d’action du sujet-entrepreneur s’inscrivent dans une dynamique historique de subjectivation qui informe les processus d’individualisation. [less ▲]

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See detailImportance of using Geographic Information System for extensive Middle Palaeolithic open air sites in northern France. The example of Caours (Somme, France) and Beauvais (Oise, France).
Moreau, Gwénaëlle ULg; Locht, Jean-Luc; Patou-Mathis, Marylène et al

Poster (2017, February 09)

During the middle Palaeolithic, the northern France was only occupied by Neanderthals groups. However, successions of glacial and interglacial cycles explain a complex and discontinuous settlement ... [more ▼]

During the middle Palaeolithic, the northern France was only occupied by Neanderthals groups. However, successions of glacial and interglacial cycles explain a complex and discontinuous settlement, raising complication in the study of its dynamics at a regional scale. Therefore, some aspects of Neanderthals behaviour are still mischaracterize: in most cases, the function of the site and its territorial management over the northern France have to be specified. The spatial analysis of open air sites from northern France will help us to answer those questions. However, for Middle Palaeolithic sites, we can't see systematically on the field the spatial organisation directly, we sometimes need modelization. Therefore, we started to build a spatial analysis protocol adapted to this site and applied to such sites. The sites of Caours (Somme, France) and Beauvais (Oise, France) are two open air sites that are exceptionally well preserved and displaying a large amount of faunal and lithic rests. Both are perfect candidate to apply and test the new protocol. First results proved that for each site the existence of a spatial organisation as remains concentration zones. Then, we characterize this areas – number, distribution. Finally, we were able to associate them to human activity areas like hearths, butchery or knapping areas. [less ▲]

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See detailCharles de Méan et sa portée mémorielle
Lagasse, Benoît ULg

Conference (2017, February 09)

La présente présentation contient, d'une part, une courte biographie de Charles de Méan, juriste liégeois du 17e siècle et, d'autre part, trois exemples de sa portée mémorielle.

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See detailLab Pay(S)age: a Laboratory of Observation as an activator for Landscape Awareness Process
Baldin, Elisa ULg; Occhiuto, Rita ULg

Poster (2017, February 09)

The notion of Landscape Observatory (ELC 2000), in the work of LabVTP at the Faculty of Architecture in the University of Liège (Wallonia-BE), has been linked with the concept of Landscape Laboratory (R ... [more ▼]

The notion of Landscape Observatory (ELC 2000), in the work of LabVTP at the Faculty of Architecture in the University of Liège (Wallonia-BE), has been linked with the concept of Landscape Laboratory (R. Gustavsson) in order to enhance and underline perceptive, experiential and active dimensions of sites, responding to the Universities’ missions required by the ELC: education and sensitization. Lab Pay(s)age, as a new typology of landscape laboratory, has developed methodological tools for landscape research, based on a multi-scale and diachronic reading of the territory, where natural and artificial traces are the complementary elements to be reinterpreted and relaunched in new participative scenarios. The Meuse valley, reshaped by deep transformations, is the main topic for researches, concerning specific morphological, typological and social characters. All along the river, the scars of industries mark the territory as a land in search of new cycle of life1. The regeneration of abandoned industrial sites, as a practice of territorial recycle, is part of sustainability policies in urban planning, based on the enhancement of local resources. The Observatory Lab Pay(s)age, is intended as a structure for site-specific study and continuous fieldwork, concerning both the evolutionary processes of natural structures and the involution of built environment. Starting from these materials, many different regeneration methodologies and temporalities have been imagined. Following the logic promoted by the ELC, the work has started by monitoring some specific areas and by contacting different local representatives with the aim of collecting data and experiences to construct a shared knowledge of the places. Then the project has become an on-going tool including all phases in the regeneration process: observation, analysis, interpretation and re-launch of new hypothesis are fundamental elements to increase the public knowledge about the cultural factors characterizing the landscape discipline. Thus, the notion of « observatory » is a strategic device, monitoring the evolution of places in time through actions of dialogue and awareness raising, in order to get citizens re-acquire a consciousness of their territory. The collected qualitative data, describe the peculiar features of the sites, based on the local actors experience and knowledge. These elements are the basis for new scenarios, used as progressive steps leading the recovery process. For this reason, the « observatory » is also a « laboratory », as the experimental projects accompany the transformation of the places through intermediate phases. Understanding and accepting mutability as a character of landscape is a preliminary step towards a co-action, where the project accords with natural dynamics. Lab Pay(s)age, according to the ELC principles, is using the earliest local answers as re-launch factors for consecutive projects, taking into account the territorial temporalities as priority in transformation process. The presentation concerns the ongoing projects and obtained reactions, such as the earliest re-naturalization programs, some selected sites for monitoring activities and Phd researches on new regeneration methods using vegetation as an active element in reclamation of industrial sites. 1 Occhiuto, R. 2016. Healing the scars of industry in Liège, in Scape n.15, 2016 [less ▲]

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See detailSegmentation of the LBO market based on projects' risk and return characteristics
Bonesire, Thomas ULg

Scientific conference (2017, February 09)

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See detailIdentification of proteins discriminating inflammation induced dysplasia from simple inflammation in ulcerative colitis by laser capture microdissection and label free proteomics – a pilot study
Merli, Angela-Maria ULg; QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg et al

Conference (2017, February 09)

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when ... [more ▼]

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when tissue inflammation is present. The aim of this retrospective pilot study was to highlight proteins specifically associated with inflammation induced dysplasia in UC. We performed a pilot experiment on 15 Formalin-Fixed, Paraffin-Embedded (FFPE) samples isolated from 5 cases of UC patients with a Polypoïd Pedunculated dysplasia (UC-PP). We compared the proteomes of the UC-PP, the inflammatory (UC-I) and the normal (UC-NL) tissues of each patient. We performed Laser Capture Microdissection (LCM) in order to collect only epithelial cells, avoiding inflammatory infiltrating ones. Label free proteomic analysis using a 2D-nanoUPLC coupled with a hybrid Quadrupole-Orbitrap was applied, as well as differential analysis on the paired samples. Immunohistochemistry (IHC) characterisation of one of the selected proteins of interest was used for validation. Out of 985 quantified proteins, 7 were found significantly more abundant in UC-PP compared to UC-I tissues, with 6 being only detected in UC-PP using proteomics. One of these is Solute Carrier Family 12 member 2 (SLC12A2), also known as Na-K-2Cl co-transporter 1 (NKCC1), a protein involved in ionic balance, in T-cell migration promotion and in some features involved in cancer development like proliferation, migration or invasion. IHC results obtained were in correlation with proteomic results and showed that SLC12A2 was more abundant in UC-PP tissue than in UC-I and UC-NL tissues, with a signal clearly delimiting the dysplastic region from the surrounding inflammatory tissue. This pilot experiment shows a different proteomic profile in inflammation-associated dysplasia and simple inflammation. This should be replicated using other types of dysplasia in IBD. SLC12A2 could be a potential biomarker of inflammation-associated dysplasia. [less ▲]

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See detailStress indicator gene expression profiles, colony dynamics and tissue development of honey bees exposed to sub-lethal doses of imidacloprid in laboratory and field experiments
De Smet, Lina; Hatjina; Ioannidis, Pavlos et al

in PLOS One (2017), 10(137),

In this study, different context-dependent effects of imidacloprid exposure on the honey bee response were studied. Honey bees were exposed to different concentrations of imidacloprid during a time period ... [more ▼]

In this study, different context-dependent effects of imidacloprid exposure on the honey bee response were studied. Honey bees were exposed to different concentrations of imidacloprid during a time period of 40 days. Next to these variables, a laboratory-field comparison was conducted. The influence of the chronic exposure on gene expression levels was determined using an in-house developed microarray targeting different immunity-related and detoxification genes to determine stress-related gene expression changes. Increased levels of the detoxification genes encoding, CYP9Q3 and CYT P450, were detected in imidacloprid- exposed honey bees. The different context-dependent effects of imidacloprid exposure on honey bees were confirmed physiologically by decreased hypopharyngeal gland sizes. Honey bees exposed to imidacloprid in laboratory cages showed a general immunosuppression and no detoxification mechanisms were triggered significantly, while honey bees infield showed a resilient response with an immune stimulation at later time points. However, the treated colonies had a brood and population decline tendency after the first brood cycle in the field. In conclusion, this study highlighted the different context-dependent effects of imidacloprid exposure on the honey bee response. These findings warn for possible pitfalls concerning the generalization of results based on specific experiments with short exposure times. The increased levels of CYT P450 and CYP9Q3 combined with an immune response reaction can be used as markers for bees which are exposed to pesticides in the field. [less ▲]

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See detailMusées d'ethnographie et art contemporain
Bawin, Julie ULg

Conference (2017, February 09)

Depuis le milieu des années 2000, nombreux sont les musées d’ethnographie à avoir développé une politique d’ouverture à l’art contemporain, consacrant même dans leur programmation des espaces réservés à ... [more ▼]

Depuis le milieu des années 2000, nombreux sont les musées d’ethnographie à avoir développé une politique d’ouverture à l’art contemporain, consacrant même dans leur programmation des espaces réservés à des résidences d’artistes ou à des expositions carte blanche. C’est le cas notamment du Weltkulturen Museum de Francfort, du Musée national des cultures du monde de Göteborg en Suède, du Pitt Rivers Museum d’Oxford, du Musée de la Civilisation à Québec, du Tropenmuseum à Amsterdam ou, plus récemment encore, du Musée de Tervuren et du Musée du quai Branly à Paris. Pour comprendre ce qui s’apparente à un véritable phénomène de mode – cette ouverture à la création vivante concernant par ailleurs l’ensemble du monde muséal –, il convient de s’intéresser aux premières interventions d’artistes dans les musées d’ethnographie, lesquelles remontent au milieu des années 1980, un moment charnière dans l’histoire de ces insitutions. Sous l’impulsion des Postcolonial Studies, les musées d’ethnographie extra-occidentale entrent progressivement dans une phase de redéfinition de leur mission et dans un processus d’auto-évaluation aux conséquences plus ou moins grandes sur les dispositifs d’exposition et de réception des objets ethnographiques. En axant notre attention sur trois expositions pionnières – celles d’Eduardo Paolozzi au Museum of Mankind à Londres (1985), de Fred Wilson au Maryland Historical Society à Baltimore (1992) et de Toma Muteba Luntumbue au Musée royal de l’Afrique centrale à Tervuren (2000) –, nous voudrions non seulement comprendre le rôle joué par l’art contemporain dans le procesus de refondation et les stratégies d’exposition des musées d’ethnographie extra-occidentale, mais saisir aussi la nature à la fois féconde et ambiguë des liens tissés entre le monde des anthropologues et celui des artistes. Le célèbre article d’Hal Foster, L’artiste comme ethnographe, servira de base à nos réflexions. [less ▲]

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See detailThermoelectric properties of layered calcium cobaltite Ca3Co4O9 from hybrid functional first-principles calculations
Lemal, Sébastien ULg; Varignon, Julien ULg; Bilc, Daniel ULg et al

in Physical Review B (2017), 95

Using a combination of first-principles calculations based on density functional theory and Boltzmann semiclassical transport theory, we compute and study the properties of pristine layered calcium ... [more ▼]

Using a combination of first-principles calculations based on density functional theory and Boltzmann semiclassical transport theory, we compute and study the properties of pristine layered calcium cobaltite Ca3Co4O9. We model the system with the B1WC hybrid functional. Two supercells of increasing size which approximate the incommensurate crystallographic structure of the compound are studied and we determine their structural, magnetic, and electronic properties. It is found that the B1WC hybrid functional is appropriate to reproduce the structural, electronic, and magnetic properties, which are then extensively discussed. From the electronic band structure, the Seebeck (S) and electrical resistivity (ρ) tensors are computed using Boltzmann transport theory within the constant relaxation-time approximation. The differences between the diagonal components are detailed and reveal a strong in-plane anisotropy of the properties. The qualitative behavior of the averaged in-plane properties, S // and ρ//, is consistent with the measurements reported in the literature. Our calculation clarifies and provides a broad picture of the evolution of the thermoelectric properties with both carrier density and temperature, and suggests that the change in S// and ρ// around 100 K is not necessarily related to the magnetic transitions occurring around 100 K. [less ▲]

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See detailA modified graded response model to account for guessing in multiple-choice items
Magis, David ULg

Conference (2017, February 09)

This presentation focuses on multiple-choice items without any correction or control for guessing. Most often, item responses are recoded as binary outcomes so that dichotomous logistic item response ... [more ▼]

This presentation focuses on multiple-choice items without any correction or control for guessing. Most often, item responses are recoded as binary outcomes so that dichotomous logistic item response models (such as the 2PL or 3PL models) can be used to estimate ability levels. This is however at the cost of loosing information from collapsing all distractors into a single FALSE category. Polytomous IRT models could be considered to overcome that drawback but none of the classical models are suitable to incorporate guessing into account. The purpose of this talk is to introduce a modification to the graded response model (Samejima, 1969) that can take guessing into account. The modification consists in introducing lower and upper asymptotes to the cumulative probability curves. After a brief theoretical and technical description, practical implementation using the R package mirt (Chalmers, 2012) is discussed. Primary results from a simulation study are eventually presented and compared to traditional IRT scoring methods for scoring multiple-choice items. [less ▲]

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