Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailLe médicament du mois. Le dulaglutide (Trulicity®) : Nouvel agoniste des récepteurs du Glucagon-Like Peptide-1 en injection hebdomadaire pour traiter le diabète de type 2
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : Dulaglutide (Trulicity®) is a new once-weekly agonist of Glucagon-Like Peptide-1 (GLP-1) receptors indicated in the treatment of type 2 diabetes. Phase III clinical trials in AWARD programme ... [more ▼]

Summary : Dulaglutide (Trulicity®) is a new once-weekly agonist of Glucagon-Like Peptide-1 (GLP-1) receptors indicated in the treatment of type 2 diabetes. Phase III clinical trials in AWARD programme demonstrated the efficacy and safety of dulaglutide in patients with type 2 diabetes treated by diet and exercise, metformin, a combination of metformin and a sulfonylurea or metformin and pioglitazone or even by supplements of prandial insulin. In the AWARD programme, dulaglutide (subcutaneous 0.75 or 1.5 mg once weekly) exerted a greater glucose-lowering activity than metformin, sitagliptin, exenatide or insulin glargine, and was non-inferior to liraglutide 1.8 mg once daily. Dulaglutide is currently reimbursed in Belgium after failure of and in combination with a dual oral therapy with metformin and a sulfonylurea or metformin and pioglitazone. [less ▲]

Detailed reference viewed: 56 (3 ULg)
See detail2nd International Conference, Architecture & Philosophy: AT THE TURN OF THE EXPERIENCE, questioning what we build, sharing what we face
YOUNES, Chris; BONNAUD, Xavier; Bodart, Céline ULg et al

Scientific conference (2016, March)

The conference is an initiative of the GERPHAU lab, research group for Philosophy, Architecture, Urban (Architecture School of Paris La Villette, UMR 7218 CNRS-Lavue), in partnership with Cité de l ... [more ▼]

The conference is an initiative of the GERPHAU lab, research group for Philosophy, Architecture, Urban (Architecture School of Paris La Villette, UMR 7218 CNRS-Lavue), in partnership with Cité de l'Architecture et du Patrimoine and philAU (a scientific thematic network : Philosophy, Architecture, Urban). This conference is also supported by ARENA(Architectural Research in Europe Network Association), a shared platform that aims to promote, support, develop and disseminate high-quality research in all fields of architecture in the widest sense. The proposal of the conference AT THE TURN OF THE EXPERIENCE is to start with the hypothesis that the architecture could be conceive as a way of enquiring on this new experience of the world. Because it provides precisely access to the experience modalities of the building world, we argue that it could in return reveal such a processing paradigm shift in the making of human settlements. We invite to re-invest and re-question its representation apparatus that it used to deploy on territories in order to translate in fictions and projects what these ones could become. To discuss about these apparatus just as such these possible translations, the conference is addressed to all researchers and practitioners, architects and creators, the experienced ones and the experiencing ones as well, whose works attempt to question what we build and to share what we face. [less ▲]

Detailed reference viewed: 42 (0 ULg)
Full Text
Peer Reviewed
See detailLa vignette diagnostique de l’étudiant. L’importance du facteur temps et de la chronologie des événements dans l’anamnèse médicale
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails ... [more ▼]

Summary : Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails to use the information on time in an optimal way. The aim of this article is to draw the attention on a few key elements, especially the age of the patient, the duration of symptoms, the time of occurrence of complaints within the 24h period and, finally, how to interpret the simultaneous or sequential occurrence of two (or more) events. [less ▲]

Detailed reference viewed: 26 (5 ULg)
See detailLes Comic strips oubliés par l'histoire
Maresca, Peter; Crucifix, Benoît ULg

Article for general public (2016)

Traduction d'un court essai de Peter Maresca, éditeur de Sunday Press Books

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailÉditorial=Woord vooraf
Decoster, Sara ULg

in Cahiers de la Documentation = Bladen voor Documentatie (2016), 70

Detailed reference viewed: 12 (1 ULg)
See detailCarbon dioxide and vegetable oil for the synthesis of bio-based polymer precursors, theoretical study of the organocatalyzed synthesis of non-isocyanate polyurethanes
Alves, Margot ULg; Jérôme, Christine ULg; Tassaing, Thierry

Conference (2016, March)

Non-isocyanate polyurethanes (NIPUs) represent a green alternative to the classical synthesis route of polyurethanes involving toxic isocyanates. This “greener” approach based upon renewable feedstocks ... [more ▼]

Non-isocyanate polyurethanes (NIPUs) represent a green alternative to the classical synthesis route of polyurethanes involving toxic isocyanates. This “greener” approach based upon renewable feedstocks and carbon dioxide consists in a two-step reaction. In a first step, carbonated vegetable oils are obtained using an appropriate catalyst by the chemical fixation of CO2 onto vegetable oils formerly epoxidized. Finally, the ring-opening polymerization (ROP) of the carbonated vegetable oil by a diamine provides hydroxy urethanes. In this las step, some organocatalysts have been recently proposed that allows achieving good conversion rates in particular in the case of aromatic diamines. However, the activation mechanism of these organocatalysts is not fully elucidated. In this context, the aim of the present project relies on the theoretical study of a model reaction using DFT calculations. Bicyclic guanidine based catalysts, 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 7-methyl-TBD (MTBD), were investigated as catalysts for the reaction between propylene carbonate and aliphatic or aromatic amines. The structural ability of TBD to simultaneously give and receive protons was highlighted by the detailed mechanism investigation. The bifunctional activity of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

Detailed reference viewed: 40 (2 ULg)
See detailTheoretical study of the organocatalyzed synthesis of NIPUs
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

Poster (2016, March)

Detailed reference viewed: 6 (3 ULg)
Full Text
Peer Reviewed
See detailFrom Artisanal to CAD-CAM Blocks: State of the Art of Indirect Composites
MAINJOT, Amélie ULg; DUPONT, Nathalie ULg; OUDKERK, Julie ULg et al

in Journal of Dental Research (2016), 95(5), 487-495

Indirect composites have been undergoing an impressive evolution over the last few years. Specifically, recent developments in computer- aided design–computer-aided manufacturing (CAD-CAM) blocks have ... [more ▼]

Indirect composites have been undergoing an impressive evolution over the last few years. Specifically, recent developments in computer- aided design–computer-aided manufacturing (CAD-CAM) blocks have been associated with new polymerization modes, innovative microstructures, and different compositions. All these recent breakthroughs have introduced important gaps among the properties of the different materials. This critical state-of-the-art review analyzes the strengths and weaknesses of the different varieties of CAD- CAM composite materials, especially as compared with direct and artisanal indirect composites. Indeed, new polymerization modes used for CAD-CAM blocks—especially high temperature (HT) and, most of all, high temperature–high pressure (HT-HP)—are shown to significantly increase the degree of conversion in comparison with light-cured composites. Industrial processes also allow for the augmentation of the filler content and for the realization of more homogeneous structures with fewer flaws. In addition, due to their increased degree of conversion and their different monomer composition, some CAD-CAM blocks are more advantageous in terms of toxicity and monomer release. Finally, materials with a polymer-infiltrated ceramic network (PICN) microstructure exhibit higher flexural strength and a more favorable elasticity modulus than materials with a dispersed filler microstructure. Consequently, some high- performance composite CAD-CAM blocks—particularly experimental PICNs—can now rival glass-ceramics, such as lithium-disilicate glass-ceramics, for use as bonded partial restorations and crowns on natural teeth and implants. Being able to be manufactured in very low thicknesses, they offer the possibility of developing innovative minimally invasive treatment strategies, such as “no prep” treatment of worn dentition. Current issues are related to the study of bonding and wear properties of the different varieties of CAD-CAM composites. There is also a crucial need to conduct clinical studies. Last, manufacturers should provide more complete information regarding their product polymerization process, microstructure, and composition, which significantly influence CAD-CAM material properties. [less ▲]

Detailed reference viewed: 73 (6 ULg)
Full Text
Peer Reviewed
See detailUsing platelet-rich plasma to treat jumper’s knees: Exploring the effect of a second closely-timed infiltration
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg et al

in Journal of Science and Medicine in Sport (2016), 19(3), 200-204

Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove ... [more ▼]

Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of proximal patellar tendinopathy. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of two or three successive infiltrations. The aim of this study was to evaluate whether two infiltrations of PRP proves more effective than a single treatment. DESIGN: Prospective, randomized and comparative study of level 2. METHODS: Twenty patients suffering from chronic proximal patellar tendinopathy were enrolled into the study and split into two randomized groups (one or two infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. RESULTS: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. CONCLUSIONS: The comparison between one or two infiltrations of PRP did not reveal any difference between the two groups at short to mid term. A second closely-timed infiltration of PRP to treat proximal patellar tendinopathies is not necessary to improve the efficacy of this treatment in the short term. [less ▲]

Detailed reference viewed: 92 (30 ULg)
Full Text
See detailThe evidentiary effects of authentic acts in the Member States of the European Union, in the context of successions - Report for Belgium
Wautelet, Patrick ULg

Report (2016)

The EU Succession Regulation (Regulation 650/2012) allows for cross-border circulation of authentic instruments in a matter of succession. Authentic instruments are documents created by authorised ... [more ▼]

The EU Succession Regulation (Regulation 650/2012) allows for cross-border circulation of authentic instruments in a matter of succession. Authentic instruments are documents created by authorised authorities which benefit from certain evidential advantages. As this Regulation does not harmonise Member State substantive laws or procedures concerning succession the laws relating to the domestic evidentiary effects of succession authentic instruments remain diverse. Article 59 of the Succession Regulation requires the Member States party to the Regulation to give succession authentic instruments the evidentiary effects they would enjoy in their Member State of origin. The only limits on this obligation being public policy or the irreconcilability of the authentic instrument with a court decision, court settlement or another authentic instrument. This report, which was commissioned by the University of Aberdeen in the framework of a request of the Committee on Legal Affairs, provides an information resource for legal practitioners concerning the evidentiary effects of succession authentic instruments in Belgium. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailL'échocardiographie en médecine équine: principe et interprétation des images.
Amory, Hélène ULg

in Nouveau Praticien Vétérinaire Equine (2016), 11(39), 55-60

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailTraumatologie du joueur de tennis
Kaux, Jean-François ULg; Schaus, Jean; Delvaux, François ULg et al

in Journal de Traumatologie du Sport (2016), 33(1), 43-47

Tennis is a racquet sport with approximately 10 million licensees and 26 million unaffiliated players in Europe. Tennis injuries represent 21%of those generated by rackets sports. Tennis players are ... [more ▼]

Tennis is a racquet sport with approximately 10 million licensees and 26 million unaffiliated players in Europe. Tennis injuries represent 21%of those generated by rackets sports. Tennis players are subject to traumatic and microtraumatic pathologies. This epidemiological review oftennis-related injuries addresses their type and locations, the cause and time of absence, the demographic and gender differences, as well as theinfluence of technique of play and type of field on their impact. [less ▲]

Detailed reference viewed: 57 (12 ULg)
See detailGCxGC-TOFMS for the Investigation of Archeological Mysteries
Perrault, Katelynn ULg; Dubois, Lena ULg; Stefanuto, Pierre-Hugues ULg et al

Scientific conference (2016, March)

Detailed reference viewed: 15 (4 ULg)
Full Text
Peer Reviewed
See detailQuelle est la stratégie idéale pour traiter l’hyperglycémie du diabète de type 2 ?
SCHEEN, André ULg

in Médecine des Maladies Métaboliques (2016), 10(2), 91-93

Detailed reference viewed: 36 (1 ULg)
Full Text
Peer Reviewed
See detailComment on: Hemidystonia caused by frontal cortical infarction.
Garraux, Gaëtan ULg

in Acta Neurologica Belgica (2016), 116

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailIntroduction of sociology-inspired parameters in the energy performance certification calculation method
Monfils, Stéphane ULg; Hauglustaine, Jean-Marie ULg

Scientific conference (2016, March)

EPCs in their actual form, calculated with a standardized approach which purposefully (and understandably), gets human factor out of the equations, do not allow appropriation of the results by potential ... [more ▼]

EPCs in their actual form, calculated with a standardized approach which purposefully (and understandably), gets human factor out of the equations, do not allow appropriation of the results by potential buyers or tenants. Often distant from reality, overestimating consumption, they usually result in a general misunderstanding and misuse of the document. This study aims at verifying that the actual calculation method used in certification could approach the objectives it has been designed for, by using additional data on occupants’ behaviour and household characteristics. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
See detailLa glande pinéale, la mélatonine, et la régulation des rythmes hormonaux
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2016, February 29)

The pineal gland, melatonin, and the regulation of hormonal rhythms Dr. H Valdés-Socin. Head of clinic. Department of Endocrinology. CHU de Liège The pineal gland is known by Anatomists since the middle ... [more ▼]

The pineal gland, melatonin, and the regulation of hormonal rhythms Dr. H Valdés-Socin. Head of clinic. Department of Endocrinology. CHU de Liège The pineal gland is known by Anatomists since the middle ages. Andrea Vesalius described it in the chap VII of his monumental book "De humani corporis fabrica (1555)". René Descartes had the intuition that the pineal gland is a "third eye" and that is how his illustrator Florent Schuyl represented it in figure 34 of Descartes book "De Homine" (1662). As for the artists, some of them illustrated from their paintings some craniotomies in which the surgeon performs the extraction of the stone of madness. Thus, "the extraction of the stone of madness" from Pieter Huys, is exposed in the Museum of the Périgord (1561). Jan Sanders showed the same subject in his painting "The surgeon" (1550) exhibited in the Museo Nacional del Prado, Madrid. During the 20th century the anatomy and the physiology of the pineal gland will be revisited: it appears so that the pinealocytes are in close relationship to the photoreceptors. In certain animal species (birds, reptiles) the pinealocytes are also photosensitive: their pineal gland is directly sensitive to light. In addition, in humans, the pinealoblastomes may occur related to the "trilateral retinoblastoma syndrome" caused by mutations in the RB1 gene (13q14.2) (Plowman & al Clin Oncol 2004). These patients present with retinoblastoma in both eyes but also in the pineal. This only strengthens the intuition of Descartes as the pineal as a "third eye". As for the genetic and hereditary aspect, we had the opportunity as well as other authors, to describe the family presentation of pineal lesions with hypersecretion of melatonin (Allouch & al 2002). With the greater availability of Radiology and brain scans, it was discovered with interest that the pineal gland is often calcified. This calcification can be observed since the second decade of life. It is not yet established if the pineal gland should be considered a"stone of madness " however it is a sort of “cerebral lithiasis”. Indeed, during this oral presentation, we will show some data linking the pineal gland and the light to seasonal depression. "Folly" induced by the long winter nights can be prevented from light therapy treatment. Severe head trauma is associated to Hypopituitarism up to 10-35% of cases, depending on the dynamic tests used to diagnose hypopituitarism (Valdés-Socin & al 2009, Valdés-Socin & al 2015). A current research topic is the study of disturbance of circadian hormonal cycles and secretion of melatonin. The secretion of melatonin occurs at night, and its synthesis is made in the pineal gland and then discharged to the general circulation. However, there is a quantitatively most important melatonin production at the level of the digestive tract. This melatonin would have essentially a paracrine effect. The administration of melatonin in humans results in variable pharmacokinetics due to its hepatic metabolism and its urinary excretion. Membrane melatonin MT1 and MT2 receptors use G proteins transduction. They are distributed mainly in the CNS at the level of the retina, hypothalamic nuclei and the pineal gland. They are also found in the periphery and in endocrine glands. A third melatonin receptor or MT3 is intracellular: this is the quinone reductase enzyme that has an important role in protection against oxidative stress (Lucchetti & al FASEB 2010). A current research topic is the role of a variant MT2 receptor (Variant rs 10830963) in diabetology. Patients harbouring this variant has been shown to have a a decrease in the early phase of insulin secretion(Langenberg & al Diabetologia 2009), and have a higher fasting morning glycemia, and consequently, an increased risk of developing a type 2 diabetes. These findings were demonstrated in a meta-analysis involving 170 000 patients (Mao & al PLOS one 2012). The same variant has been identified in patients at risk of developing glucose intolerance and gestational diabetes (al Diabetologia 2012, Liao, Walford & al PLO one 2012) Melatonin is synthesized in the pineal gland from the conversion of tryptophan to serotonin. Enzymes such as alkylamine N-acetyltransferase (NAT) and of acetylserotonin O-methyltransferase (ASMT) ensure the synthesis of melatonin from serotonin. Apart from melatonin which can be prescribed as such in Belgium, there are synthetic analogs of melatonin such as CIRCADIN. AGOMELATONINE is available in France (lab SERVIER). VALDOXAN is a structural analogue of melatonin developed as a sedative antidepressant daily, which must be taken at sunset. It is a MT1 and MT2 melatonin receptor agonist and antagonist of the serotonin 5HT2C receptors. We can also mention RAMELTEON (TAKEDA lab), which is registered as an hypnotic. Références B Claustrat. Médecine du Sommeil 2009 Allouch A , Valdes Socin H, Hendrick JC, Beckers A et Legros JJ. Pinéalomes familiaux: études biologiques et génétiques préliminaires. Annales Endocrinol 2002 (abstract). H Valdes-Socin, L Vroonen, P Robe, D Martin, A Beckers. Hypopituitarisme consécutive aux dommages cérébraux: le trauma crânien et l’hémorragie sous-arachnoïdienne mis en cause. Rev Med Liège 2009 ;64(9),457-464. Valdes-Socin, Potorac , Matagne, Bonneville & Beckers. Etude et prévalence des troubles neuroendocriniens dans une série de 65 patients avec dommages cérébraux post traumatiques (TBI) recrutés à partir de la médecine d'expertise. Annales d'Endocrinologie (abstract) 2015 Goyal &l. Diabetol Metab Syndr. Melatonin supplementation to treat the metabolic syndrome: a randomized controlled trial.2014 Nov 18;6:124. doi: 10.1186/1758-5996-6-124. eCollection 2014. Romo-Nava & al. Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, double-blind, parallel-group, placebo-controlled clinical trial. Bipolar Disord. 2014 Jun;16(4):410-21. doi: 10.1111/bdi.12196. Epub 2014 Mar 17. [less ▲]

Detailed reference viewed: 61 (8 ULg)
See detail1949/1979 : Les Temps Modernes et l'Allemagne
Cormann, Grégory ULg

Scientific conference (2016, February 29)

Detailed reference viewed: 22 (1 ULg)
Full Text
See detailMultiscale approach of spray retention on superhydrophobic plant surfaces
Massinon, Mathieu ULg

Doctoral thesis (2016)

Detailed reference viewed: 106 (40 ULg)