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See detailGrowth hormone releasing hormone excess and blockade in X-LAG syndrome.
Daly, Adrian Francis ULg; Lysy, Philippe; Defilles, Celine et al

in Endocrine-related cancer (2016)

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and ... [more ▼]

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GH-releasing hormone (GHRH) levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(D-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. [less ▲]

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See detailComparison of Moving Boundary and Finite-Volume Heat Exchanger Models in the Modelica Language
Desideri, Adriano ULg; Dechesne, Bertrand ULg; Wronski, Jorrit et al

in energies (2016)

When modeling low capacity energy systems, such as a small size (5–150kWel) organic Rankine cycle unit, the governing dynamics are mainly concentrated in the heat exchangers. As a consequence, the ... [more ▼]

When modeling low capacity energy systems, such as a small size (5–150kWel) organic Rankine cycle unit, the governing dynamics are mainly concentrated in the heat exchangers. As a consequence, the accuracy and simulation speed of the higher level system model mainly depend on the heat exchanger model formulation. In particular, the modeling of thermo-flow systems characterized by evaporation or condensation requires heat exchanger models capable of handling phase transitions. To this aim, the finite volume (FV) and the moving boundary (MB) approaches are the most widely used. The two models are developed and included in the open-source ThermoCycle Modelica library. In this contribution, a comparison between the two approaches is presented. An integrity and accuracy test is designed to evaluate the performance of the FV and MB models during transient conditions. In order to analyze how the two modeling approaches perform when integrated at a system level, two organic Rankine cycle (ORC) system models are built using the FV and the MB evaporator model, and their responses are compared against experimental data collected on an 11kWel ORC power unit. Additionally, the effect of the void fraction value in the MB evaporator model and of the number of control volumes (CVs) in the FV one is investigated. The results allow drawing general guidelines for the development of heat exchanger dynamic models involving two-phase flows. [less ▲]

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See detailDelayed neuroendocrine sexual maturation in female rats after a very low dose of Bisphenol A through altered GABAergic neurotransmission and opposing effects of a high dose.
Franssen, Delphine ULg; GERARD, Arlette ULg; HENNUY, Benoit ULg et al

in Endocrinology (2016)

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event ... [more ▼]

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event in females after early exposure to a very low dose of Bisphenol A (BPA), a ubiquitous endocrine disrupting chemical. Female rats were exposed to vehicle or BPA 25 ng/kg.day, 25 g/kg.day, or 5 mg/kg.day from postnatal day (PND) 1 to 5 or 15. Exposure to 25 ng/kg.day of BPA for 5 or 15 days was followed by a delay in developmental reduction of GnRH IPI studied ex vivo on PND 20. After 15 days of exposure to that low dose of BPA, vaginal opening tended to be delayed. In contrast, exposure to BPA 5 mg/kg.day for 15 days resulted in a premature reduction inGnRHIPI and a trend toward early vaginal opening. RNAseq analysis on PND20 indicated that exposure to BPA resulted in opposing dose effectsonthemRNAexpression of hypothalamic genes involved inGABAA neurotransmission. The study of GnRH secretion in vitro in the presence of GABAA receptor agonist/antagonist confirmed an increased or a reduced GABAergic tone after in vivo exposure to the very low or the high dose of BPA, respectively. Overall, we show for the first time that neonatal exposure to BPA leads to opposing dose-dependent effects on the neuroendocrine control of puberty in the female rat. A very low and environmentally relevant dose of BPA delays neuroendocrine maturation related to puberty through increased inhibitory GABAergic neurotransmission. [less ▲]

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See detailReal-Time Optimization of Organic Rankine Cycle Systems by Extremum-Seeking Control
Hernandez Naranjo, Jairo Andres ULg; Desideri, Adriano ULg; Ionescu, Clara et al

in Energies (2016), 9

In this paper, the optimal operation of a stationary sub-critical 11kWel organic Rankine cycle (ORC) unit for waste heat recovery (WHR) applications is investigated, both in terms of energy production and ... [more ▼]

In this paper, the optimal operation of a stationary sub-critical 11kWel organic Rankine cycle (ORC) unit for waste heat recovery (WHR) applications is investigated, both in terms of energy production and safety conditions. Simulation results of a validated dynamic model of the ORC power unit are used to derive a correlation for the evaporating temperature, which maximizes the power generation for a range of operating conditions. This idea is further extended using a perturbation-based extremum seeking (ES) algorithm to identify online the optimal evaporating temperature. Regarding safety conditions, we propose the use of the extended prediction self-adaptive control (EPSAC) approach to constrained model predictive control (MPC). Since it uses input/output models for prediction, it avoids the need for state estimators, making it a suitable tool for industrial applications. The performance of the proposed control strategy is compared to PID-like schemes. Results show that EPSAC-MPC is a more effective control strategy, as it allows a safer and more efficient operation of the ORC unit, as it can handle constraints in a natural way, operating close to the boundary conditions where power generation is maximized. [less ▲]

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See detailInteractions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes
Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg; Lins, Laurence ULg et al

in Biochimie (2016), In Press

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became ... [more ▼]

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems. [less ▲]

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See detailLa cognitivo-linguistique : pour une tentative de rapprochement de la clinique et de l'actuariel
Courtain, Audrey ULg; Glowacz, Fabienne ULg

in Revue Internationale de Criminologie et de Police Technique et Scientifique [= RICPTS] (2016), 1

Anchored in the actuarial field, risk assessment is a tool clinicians are more and more likely to use (because they can or have to) among delinquents. But, due to epistemological differences, an important ... [more ▼]

Anchored in the actuarial field, risk assessment is a tool clinicians are more and more likely to use (because they can or have to) among delinquents. But, due to epistemological differences, an important debate has been occurring between the clinical evaluation and the actuarial one since the fifties. This paper suggests a media between those perspectives through cognitive linguistics: it allows a complementary articulation, while insisting on what is at stake for both clinical and actuarial developments. Linking language and cognitions, the paper introduces a reflexion that may be useful to actuarial assessment and clinical support, and may facilitate rapprochement between the latter. In this case, our linguistic approach focusses on different matters targeted by actuarial tools and whose clinical understanding may be deepened by studying the link between language and cognition; this clinical understanding bringing singularity to risk assessment. [less ▲]

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See detailPlan de formation-insertion et garantie d'emploi : l'employeur qui s'engage
Cordier, Quentin ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), 14

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See detailExpression of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH cells.
Rotondi, Sandra; Modarelli, Alessio; Oliva, Maria-Antonietta et al

in Molecular and cellular endocrinology (2016)

PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas ... [more ▼]

PURPOSE: To search for a possible role of Peroxisome Proliferator-Activated Receptor alpha (PPARalpha), a molecular partner of the Aryl hydrocarbon receptor Interacting Protein (AIP), in somatotropinomas. METHODS: Tumours from 51 acromegalic patients were characterized for PPARalpha and AIP expression by immunohistochemistry (IHC) and/or Real Time RT-PCR. Data were analysed according to tumour characteristics and pre-operative treatment with somatostatin analogues (SSA). The effects of fenofibrate were studied in GH3 cells in vitro. RESULTS: PPARalpha was expressed in most somatotropinomas. A modest relationship was found between PPARalpha and AIP expression, both being significantly higher in the presence of pre-operative SSA. However, only AIP expression was influenced by the response to treatment. Dual effects of fenofibrate were observed in GH3 cells, consisting of cell growth inhibition and an increase in GH secretion inhibited by octreotide. CONCLUSIONS: PPARalpha is a new player in somatotropinomas. Potential interactions between PPARalpha agonists and SSA may deserve further investigation. [less ▲]

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See detailL'élevage du hotu en Wallonie
Gennotte, Vincent ULg; Prignon, Christian ULg

Book published by Les Presses Agronomiques de Gembloux (2016)

Ce document décrit les techniques d’élevage du hotu, parcourant la reproduction, l’élevage larvaire et le grossissement des juvéniles, dans différentes conditions de production. Il constitue la synthèse ... [more ▼]

Ce document décrit les techniques d’élevage du hotu, parcourant la reproduction, l’élevage larvaire et le grossissement des juvéniles, dans différentes conditions de production. Il constitue la synthèse des résultats d’un programme de recherche mené par le Centre de Formation et de Recherche en Aquaculture (CEFRA, Université de Liège), et financé par le Service Public de Wallonie et le Fonds Européen pour la Pêche, visant à développer les techniques d’élevage de cette espèce dans le cadre d’un programme plus vaste de restauration des populations piscicoles patrimoniales de Wallonie. Ces résultats ont été complétés par les connaissances issues de recherches antérieures pour constituer un guide technique le plus complet possible, destiné au pisciculteur intéressé par la production de nouvelles espèces. [less ▲]

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See detailChemical Ecology of Aphids (Hemiptera: Aphididae)
Boullis, Antoine ULg; Verheggen, François ULg

in VILCINSKAS, Andreas (Ed.) Biology and Ecology of Aphids (2016)

Aphids are widespread insects considered as crop pest throughout the world. In order to control them, different techniques are known. The study of aphid-related semiochemicals is one topic recently ... [more ▼]

Aphids are widespread insects considered as crop pest throughout the world. In order to control them, different techniques are known. The study of aphid-related semiochemicals is one topic recently studied in integrated pest management, used to control aphid outbreaks. These semiochemicals include those involved in intraspecific communication, in communication among different trophic levels, those which attract or repel aphids, or those which enhance the efficiency of aphid natural enemies. This book chapter summarises the recent findings on aphid chemical ecology, from the discovery of molecules of interest, to their use in IPM methods. [less ▲]

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See detailÉthologie et criminologie clinique : Debuyst avec Demaret pour une éthique de l’adaptation
Adam, Christophe; Englebert, Jérôme ULg

in Cahiers de Psychologie Clinique (2016), 47

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See detailCopper-Cobalt Flora of Upper Katanga and Copperbelt : Field Guide
Malaisse, François ULg; Schaijes, Michel; D’Outreligne, Claire

Book published by Presses agronomiques de Gembloux (2016)

The copper-cobalt outcrops of Upper Katanga and north-western Zambia host a particular flora which comprises an estimated 750 species of which more than 400 are treated in this copper-cobalt field guide ... [more ▼]

The copper-cobalt outcrops of Upper Katanga and north-western Zambia host a particular flora which comprises an estimated 750 species of which more than 400 are treated in this copper-cobalt field guide. The aim of this book, resulting from several years of intensive field work and study, is to bring together the basic knowledges permitting an easy approach to the identification of a great number of the species to be encountered. More than 400 species are illustrated with color photographs and/or drawings together with comments concerning synonyms, habit, description, ecology and distribution. Plant species are listed and colour-coded according to classification: Cyanoprocaryota, lichenized Fungi, Anthocerophyta, Marchantiophyta and Bryophyta (red edge), Lycophyta and Monilophyta (green edge), Magnoliopsida (blue edge) and Liliopsida (yellow edge). An index allows easy location either according to genus and species. An account of the research on copper-cobalt ecosystems carried out during the last ten years in southeastern D.R. Congo is also presented. The editors have spent more than twenty years in the area concerned and have collected more than 8,500 voucher specimens, including eleven species new to science (holotypes). [less ▲]

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See detailNoWaste: waste heat re-use for greener truck
Bettoja, Federica; Perosino, Andrea; Lemort, Vincent ULg et al

in Proceedings of 6th Transport Research Arena (2016)

The present paper summarizes the key points of the European NoWaste Project, which aims at developing Rankine cycle systems for integration into long-haul trucks with the aim to convert the waste heat of ... [more ▼]

The present paper summarizes the key points of the European NoWaste Project, which aims at developing Rankine cycle systems for integration into long-haul trucks with the aim to convert the waste heat of the exhaust gases into useful energy usable in mechanical or electrical form. The first part of the paper describes the ORC system architectures defined for two different truck engines: one with EGR and the other one without EGR. For both engines, different cycle configurations and working fluids are compared in terms of energy performance and technical constraints. For both ORC systems, the paper shows the final technical choices made in terms of main components: boiler, condenser, expander and pump. The second part of the paper presents preliminary experimental results carried out on demonstrators of the two ORC systems. The objectives of these tests were to check the performance announced by the components’ manufacturers. Finally, the last part of the paper compares the cost of both systems. [less ▲]

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See detailThe Law of Nationality - Comparative and International Perspectives
Wautelet, Patrick ULg

Learning material (2016)

This presentation was used as support for a course taught in English (in 2016) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition ... [more ▼]

This presentation was used as support for a course taught in English (in 2016) which provides an overview of the major questions arising in the field of nationality law. The course focuses on acquisition and loss of nationality and touches upon other issues such as multiple nationalities and the influence of the European construction on nationality law. All these questions are studied using comparative materials (mainly from Western Europe) as basis. [less ▲]

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See detailNew geochronological history of the Mbuji-Mayi Supergroup (Proterozoic, DRC) through U-Pb and Sm-Nd dating
François, Camille ULg; Kabamba Baludikay, Blaise ULg; Storme, Jean-Yves et al

in European Geosciences Union General Assembly 2016 Vienna, Austria, 2016 (2016)

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See detailTranscriptome of the freshwater amphipod Gammarus pulex hepatopancreas
Gismondi, Eric ULg; Thomé, Jean-Pierre ULg

in Genomics Data (2016), 8

So far, ecotoxicological studies used biomarkers of exposure or of effects in order to investigate the impacts of contaminated areas on biota (Peakall, 1994 [6]). However, although these results are ... [more ▼]

So far, ecotoxicological studies used biomarkers of exposure or of effects in order to investigate the impacts of contaminated areas on biota (Peakall, 1994 [6]). However, although these results are important in the ecotoxicological risk assessment, biomarkers are very specific and only provide information on the biological processes or physiological pathways targeted by the biomarkers experimenters choose to test (Monsinjon and Knigge, 2007 [5]). In recent years, proteomics have become a major tool in ecotoxicology, as they provide a global insight into the mechanism of action of pollutants without the need of hypothesis testing or any preconception on the biological processes likely impacted (Gismondi et al., 2015; Trapp et al., 2015 [7]; Truebano, 2016 [8]). However, the analysis of proteomic results is often limited due to the lack of database, especially for non-model organisms, such as Gammarus sp, commonly used as biological model in ecotoxicology (Sornom et al., 2012 [11]; Vellinger et al., 2013 [9]; Gismondi and Thomé, 2014 [1]; Lebrun et al., 2014 [3]). Here, we performed Illumina HiSeq sequencing to total RNA isolated from the hepatopancreas (i.e. detoxification tissue) of Gammarus pulex males and females coming from uncontaminated river and contaminated river (e.g. PCB, benzo(a)pyrene). Approximately 290Mpaired-end readswere assembled, filtered and sorted into 39,801 contigswhose 10.878 were similar of proteins available in databases. The assembled contigs could represent a reference hepatopancreas transcriptome for G. pulex, and constitute an important resource for future investigations on the impacts of pollutants on invertebrate biota, since itwould improve the understanding of the mechanisms of action involved in toxicity. In addition, the hepatopancreas transcriptome will also allow the identification of new potential biomarkers for the ecotoxicological risk assessments. Assembled contigswere deposited in the European Nucleotide Archive under the BioProject number PRJEB13055, with accession numbers FJVI01000001-FJVI01039801. [less ▲]

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See detailMicroanalyzes of remarkable microfossils of the Late Mesoproterozoic–Early Neoproterozoic
Cornet, Yohan ULg; Beghin, Jérémie ULg; Kabamba Baludikay, Blaise ULg et al

in European Geosciences Union General Assembly 2016 Vienna, Austria, 2016 (2016)

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See detailThermal maturity of carbonaceous material from Mbuji-Mayi Supergroup (Kasai, Democratic Republic of Congo)
Kabamba Baludikay, Blaise ULg; Storme, Jean-Yves; Baudet, Daniel et al

in European Geosciences Union General Assembly 2016 Vienna, Austria, 2016 (2016)

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See detailRisk factors and effect of selective removal on retroviral infections prevalence in Belgian stray cats.
Garigliany, Mutien-Marie ULg; Jolly, Sandra ULg; Dive, M. et al

in The Veterinary record (2016), 178(2), 45

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in ... [more ▼]

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in 302 stray cats captured during a trap-neuter-release programme in a mixed urban-rural area from Belgium, from 2010 to 2012. The impact of selective removal of FIV-positive cats on the apparent prevalence in the remaining population over this three-year period was also assessed. The seroprevalences over three years were 18.8 per cent for FIV and 0.7 per cent for FeLV. For FIV, the seroprevalence decreased significantly from the first year of the programme (2010; 30.5 per cent) to the last (2012; 13.1 per cent). Sex (male) and age (adult and old cats) were risk factors, while the year of sampling (years 2011 and 2012) was a protective factor. Age, sex and location were the most relevant predictors of FIV status. The data presented in this study revealed a very high FIV seroprevalence in Belgian stray cats, while FeLV was almost absent. The selective removal of positive cats had a drastic effect on the FIV seroprevalence in the remaining cat population. [less ▲]

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