Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailUse of a multivariate moving window PCA for the untargeted detection of contaminants in agro-food products, as exemplified by the detection of melamine levels in milk using vibrational spectroscopy.
Fernandez Pierna, Juan A; Vincke, Damien; Baeten, Vincent et al

in Chemometrics and Intelligent Laboratory Systems (2016)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailStrain-Engineered Multiferroicity in Pnma NaMnF3 Fluoroperovskite
Garcia Castro, Andrés Camilo ULg; Bousquet, Eric ULg; Romero, Aldo H.

in Physical Review Letters (2016)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailFully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging
Henrottin, Jean ULg; Lemaire, Christian ULg; Egrise, Dominique et al

in Nuclear Medicine & Biology (2016)

Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor ... [more ▼]

Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-DL-tryptophan (1-[19F]FE-DL-Trp) was reported as a good and specific substrate of this enzyme. Herein, the radiosynthesis of its radioactive isotopomer (1-[18F]FE-DL-Trp, DL-[18F]5) is presented along with in vitro enzymatic and cellular uptake studies. Methods: The one-pot n.c.a. radiosynthesis of this novel potential PET imaging tracer, including HPLC purification and formulation, has been fully automated on a FASTlabTM synthesizer. Chiral separation of both isomers and their formulation were implemented on a second cassette. In vitro enzymatic and cellular uptake studies were then conducted with the D-, L- and DL-radiotracers. Results: The radiolabeling of the tosylate precursor was performed in DMF (in 5 min; RCY: 57% (d.c.), n=3). After hydrolysis, HPLC purification and formulation, DL-[18F]5 was obtained with a global radiochemical yield of 18±3% (not decay corrected, n=7, in 80 min) and a specific activity of 600±180 GBq/µmol (n=5). The subsequent separation of L- and D-enantiomers was performed by chiral HPLC and both were obtained after formulation with a RCY (d.c.) of 6.1% and 5.8%, respectively. In vitro enzymatic assays reveal that L-[18F]5 is a better substrate than D-[18F]5 for human IDO. In vitro cellular assays show an IDO-specific uptake of the racemate varying from 30% to 50% of that of L-[18F]5, and a negligible uptake of D-[18F]5. Conclusion: In vitro studies show that L-[18F]5 is a good and specific substrate of hIDO, while presenting a very low efflux. These results confirm that L-[18F]5 could be a very useful PET radiotracer for IDO expressing cells in cancer imaging. [less ▲]

Detailed reference viewed: 33 (8 ULg)
Full Text
Peer Reviewed
See detailGender effect on the scapular 3D posture and kinematic in healthy subjects
Schwartz, Cédric ULg; Croisier, Jean-Louis ULg; Rigaux, Elise et al

in Clinical Physiology and Functional Imaging (2016)

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However ... [more ▼]

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapula-thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno-humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation were significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero-thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behavior of men and women should not be expected to be similar. [less ▲]

Detailed reference viewed: 108 (34 ULg)
Full Text
Peer Reviewed
See detailThe Calern Asteroid Polarimetric Survey using the Torino Polarimeter: assessment of instrument performances and first scientific results
Devogele, Maxime ULg; Cellino, Alberto; Bagnulo, Stefano et al

in Monthly Notices of the Royal Astronomical Society (2016)

A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the ``Observatoire de la C ... [more ▼]

A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the ``Observatoire de la C{\^o}te d'Azur''. Its main purpose is to carry out a polarimetric survey of Solar System objects. This survey is called CAPS (Calern Asteroid Polarimetric Survey). In this paper, the new Torino polarimeter (ToPo) and its preliminary validation campaign is described. The first results of the CAPS survey are also presented. A number of standard stars with known polarization states, as well as a number of asteroids for which the polarimetric properties are known, have been observed in order to assess the instrument accuracy. The instrument response over the field of view and also its stability over single nights and longer periods have also been tested. It has been found that the instrument polarization is stable within a few $10^{-4}$ units. The first polarimetric observations of a still limited number of asteroids show an excellent agreement with previously available data and make already some significant contributions by adding new data to a number of objects that had been poorly observed so far. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailFarmers’ Perception and Willingness to Pay for Climate Information in Burkina Faso
Zongo, Bétéo ULg; Diarra, Abdoulaye; Barbier, Bruno et al

in Journal of Agricultural Science (2016), 8

This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access ... [more ▼]

This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access to climate information, while 93% of them need climate information to guide through their decision in planning agricultural activities. Option value shows the interest granted by farmers using climate information. About 64% of the farmers are willing to pay an average of Francs CFA 546.34 to obtain climate information. The willingness to pay is determined by the the farmers’ ability to predict the climate, to use radio as a means of information, farmers’ awareness of previous forecasts and early onset of rainy season. While farmers considered benefits from the use of climate information, it is clear that its contribution to farm income remains a field of research to explore. Thus it is necessary to experiment with individual farms and to evaluate the contribution of climate information to the value added in different crops and farmers’ income. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Peer Reviewed
See detailHow climate extremes are affecting the movement of populations in the Asia Pacific region
Gemenne, François ULg; Blocher, Julia ULg; De Longueville, Florence ULg et al

in Price, Susanna; Singer, Jane (Eds.) Global Implications of Development, Disasters and Climate Change: Responses to Displacement from Asia Pacific (2016)

Detailed reference viewed: 60 (16 ULg)
Full Text
Peer Reviewed
See detailL'impôt sur les revenus des salariés et l'extranéité (2e partie)
Docclo, Caroline ULg

in Journal des Tribunaux du Travail (2016)

Detailed reference viewed: 15 (1 ULg)
Full Text
See detailPathologie du muscle - Anamnèse - Clinique - Imagerie
Kaux, Jean-François ULg

Learning material (2016)

Detailed reference viewed: 154 (69 ULg)
Full Text
Peer Reviewed
See detailPersistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease.
Gonzalez Aguilera, B.; Syrios, P.; Gadisseur, R et al

in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2016)

Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old ... [more ▼]

Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old woman with persistent low levels of serum hCG detected one month after miscarriage. As choriocarcinoma was suspected, a chemotherapy trial of methotrexate was prescribed, without any hCG reduction. Subsequently, laparoscopy ruled out a trophoblastic residue and the patient was referred to the Endocrine Unit for further investigations. While low levels of hCG were still detected in serum, no hCG was detected in the urine. In addition, when serum was processed in a HBT tube for revealing heterophilic antibodies, hCG was no longer detected. Such finding indicated the presence of phantom hCG due to heterophilic mouse antibodies interaction. This case raises the need of clinico-biological discussion to avoid inappropriate therapeutic decisions. Based on this case experience and after review of the literature, we suggest that current gynecological protocols for the diagnosis and treatment of trophoblastic disease should consider the inclusion of urinary hCG and/or a test for serum heterophilic antibodies when appropriate. [less ▲]

Detailed reference viewed: 26 (9 ULg)
Full Text
Peer Reviewed
See detailInvestigation on possible transmission of monkeys' Plasmodium to human in a populations living in the equatorial rainforest of the Democratic republic of Congo
MVUMBI, Dieudonné; BOBANGA, Thierry; UMESUMBU, Solange et al

in International Journal for Parasitology: parasites and wild life (2016), 5

Plasmodiums are protozoa that may infect various hosts. Only five species are now recognized as naturally parasitizing humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ... [more ▼]

Plasmodiums are protozoa that may infect various hosts. Only five species are now recognized as naturally parasitizing humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. This fifth species, P. knowlesi, previously identified as naturally parasitizing the monkey Macaca fascicularis, has been microscopically confused for a long time with P. malariae or P. falciparum and it was not possible to correctly differentiate them until the advent of molecular biology. To date, natural human infections with P. knowlesi only occur in Southeast Asia and a similar phenomenon of natural transmission of simian plasmodium to humans has not been reported elsewhere. This study was conducted to investigate a possible transmission of African small monkey's plasmodium to humans in populations living near the rainforest of the Democratic Republic of Congo (DRC) where several species of non-human primates are living. Two successive real-time PCRs were identified in the literature and used in combination for purpose. Only P. falciparum was found in this study. However, studies with larger samples and with more advanced techniques should be conducted. [less ▲]

Detailed reference viewed: 31 (5 ULg)
Full Text
Peer Reviewed
See detailL’adaptation du pervers et du psychopathe : compréhension phénoménologique et éthologique
Englebert, Jérôme ULg

in PSN. Psychiatrie, Sciences Humaines, Neurosciences (2016), 16

Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have ... [more ▼]

Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have to note that there are moments of mismatch and maladjustment. These ‘‘perverse moments’’ are very important to be observed and regarded as a pathognomonic symptomatology. The specificity of the perverse functioning should be viewed as a continuum of adaptation along which an individual may pass from ‘‘hyperadaptation’’ on the one hand, to moments of failures and mis-adapting on the other hand. Then, we propose a comparison between the binswangerian conception of mania and the psychopathic functioning. The maniac has a fundamental crisis of the ‘‘ego’’, which the psychopath does not have. A second finding of our investigations concerns emotions and the dimension of the adaptive psychopathic disorder. The last point we discuss is about the concepts of empathy and sympathy. Finally, a significant part of this paper is to propose a differentiation concerning adaptive behaviour: one is more social (the pervert); the other is more solitary (the psychopath). [less ▲]

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailBispecial factors in the Brun S-adic system
Labbé, Sébastien ULg; Leroy, Julien ULg

E-print/Working paper (2016)

Detailed reference viewed: 1 (0 ULg)
Full Text
Peer Reviewed
See detailFurther insights into the metamorphosis process in a carapid fish
Parmentier, Eric ULg

in Journal of Zoology (2015)

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailLe couplage « Micro-crédit, Micro-assurance santé et Offre des soins » peut améliorer l’accessibilité aux soins de santé de qualité en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Médecine et Santé Tropicales (2015), 25

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in ... [more ▼]

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in Kinshasa. The bivariate analysis shows a significant association between the increase in purchasing power and realization of benefit (p = 0, 001), achievement of benefit and savings (p = 0, 000) savings and insurance health and improved access to health care: according to the main results, 68.8 %t of borrowers reported an increase in their purchasing power which 81.8% making benefit. Those with savings were 24.7 times more likely to contribute to a health insurance scheme than those without; 71.9% of those who have regularly contributed to health insurance have improved their access to care. Coupling microcredit, health microinsurance and health care can improve access to quality health care at lower cost. This suggests the integration of health insurance in the primary health care system. [less ▲]

Detailed reference viewed: 152 (42 ULg)
Full Text
See detailLe droit constitutionnel de la Principauté de Liège au 18e siècle
Behrendt, Christian ULg; Vandenbosch, Sofia ULg

in Revue Belge de Droit Constitutionnel [= RBDC] (2015), 2015

Detailed reference viewed: 557 (171 ULg)
Full Text
Peer Reviewed
See detailUn moment machiavélien dans la théorie. Sur Althusser
Oulc'hen, Hervé ULg

in Cahiers du GRM (2015), 8

Detailed reference viewed: 19 (1 ULg)
Peer Reviewed
See detailCirculating microRNA-based screening tool for breast cancer
Freres, Pierre ULg; Wenric, Stéphane ULg; Boukerroucha, Meriem et al

in Oncotarget (2015)

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative ... [more ▼]

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis. A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors. A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. The accuracy of the diagnostic tool remained unchanged considering age and tumor stage. The miRNA signature correctly identified patients with metastatic breast cancer. The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group. Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. [less ▲]

Detailed reference viewed: 51 (15 ULg)