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See detailAbout Quaternary prevention in Public health ; comment on Dr Jong-Myon Bae paper
Jamoulle, Marc ULg

in Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi (2016), 49(2), 139-140

The recent paper of Dr Jong-Myon Bae about Quaternary Prevention and Public Health in your journal has attracted my interest. The spread of this concept is beyond all expectation and I am quite happy it ... [more ▼]

The recent paper of Dr Jong-Myon Bae about Quaternary Prevention and Public Health in your journal has attracted my interest. The spread of this concept is beyond all expectation and I am quite happy it contributes to the analytic thinking of complexity of health care. The particular application of the quaternary prevention (P4) concept is absolutely brilliant. Nevertheless I would propose some slight modifications to the table 1 edited by the author which I have taken the liberty to reproduce here with the due authorization of Dr Bae and after several mail exchanges with him. [less ▲]

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See detailGembloux veut sauver les oliviers
Jijakli, Haissam ULg

Article for general public (2016)

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See detailUne solution belge pour sauver les oliviers du sud de l'Italie?
Jijakli, Haissam ULg

Article for general public (2016)

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See detailImpacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment
Leroi, Natacha ULg; LALLEMAND, François ULg; COUCKE, Philippe ULg et al

in Frontiers in Pharmacology (2016), 7

During the last decade, the initial cancer cell-centered view of tumors has greatly evolved to an integrated vision of tumor biology taking into account the key contribution of the TME. Obviously, the ... [more ▼]

During the last decade, the initial cancer cell-centered view of tumors has greatly evolved to an integrated vision of tumor biology taking into account the key contribution of the TME. Obviously, the different compartments of TME are closely related and contribute not only to tumor progression, but also to its response to treatments. Importantly, the TME evolves over time during the different steps of cancer development and is also affected by different therapeutic modalities. Although, improvements have been achieved regarding RT delivery to the primary tumor, ionizing radiation also target nontumor cells that influence tumor growth and metastatic dissemination. Different approaches have been proposed to overcome the radioresistance of cancer cells. The TME-mediated radioresistance is now the object of researches, which has been elegantly reviewed recently by Barker et al. (2015) and severalarticles pointed out the importance of treatments that modify the TME and likely radiosensitize tumor (Ansiaux et al., 2005; Crokart et al., 2005b; Frérart et al., 2008). However, the impact of anti-cancer treatments on the TME and consequently on the tumor phenotype, response to treatment and metastases, is often neglected. Here we pointed out the impact of RT on the TME. Recent findings emphasize the interest to optimize RT (i.e., dose per fraction) and timing of surgery (Leroi et al., 2015; Surace et al., 2015) in order to prevent metastatic spreading. The future challenge in RT will be to define the most appropriate combinations between RT, and other therapeutic modalities with the optimal sequence and timing of treatments. In this context, investigation of the TME-related acquired resistance will be essential and will provide important innovative data. [less ▲]

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See detailValeurs de l'information et performances algorithmiques pour des problèmes multi-périodes et stochastiques
Pironet, Thierry ULg

Scientific conference (2016, March 30)

voir document

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See detailRevealing the role of network rigidity on the fragility evolution of glass-forming liquids
Yildirim, Can ULg; Raty, Jean-Yves ULg; Micoulaut, Mathieu

E-print/Working paper (2016)

If quenched fast enough, a liquid is able to avoid crystallization and will remain in a metastable supercooled state down to the glass transition, with an important increase in viscosity and relaxation ... [more ▼]

If quenched fast enough, a liquid is able to avoid crystallization and will remain in a metastable supercooled state down to the glass transition, with an important increase in viscosity and relaxation time towards equilibrium upon further cooling [1,2]. There are important differences in the way liquids relax as they approach the glass transition, rapid or slow variation in dynamic quantities under moderate temperature changes, and a simple means to quantify such variations is provided by the concept of "fragility". Here, we report molecular dynamics simulations of a typical network-forming glass, and find that the relaxation behaviour of the supercooled liquid is strongly correlated to the variation of rigidity with temperature and the spatial distribution of the corresponding topological constraints which, ultimately connect to fragility minima . This permits extending the fragility concept to aspects of topology/rigidity, and to the degree of homogeneity of the atomic-sale interactions for a variety of structural glasses. [less ▲]

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See detailhCG: false positives and persistent hCG levels
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2016, March 29)

Human Chorionic gonadotropin (hCG) is a complex glycoprotein with several bioactive forms. These five variants comprise placental forms (hyperglycosilated hCG is the first form, then after 10 weeks of ... [more ▼]

Human Chorionic gonadotropin (hCG) is a complex glycoprotein with several bioactive forms. These five variants comprise placental forms (hyperglycosilated hCG is the first form, then after 10 weeks of pregnancy total hCG takes over), cancer promoter forms (hCGb, hyperglycosilated hCGb), and a pituitary form (sulfated hCG). Current routine laboratory tests do not discriminate between these multiple variants of hCG. Low persistent detectable levels of hCG may be associated with various benign and malignant conditions, such as quiescent gestational trophoblastic disease, raised pituitary hCG, or false positive elevation caused by circulating heterophilic antibodies. Clinico-biological discussion are mandatory to avoid erroneous diagnosis and treatment.In this review we summarize and discuss the different causes of false positive hCG assay. We suggest that current gynecological protocols for the diagnosis and treatment of trophoblastic disease should consider the inclusion of hCG test in urine and/or a test for heterophilic antibodies, when appropriate to avoid unnecessary studies and treatment. References. Valdes Socin H, Syrios P, Gadisseur R, et al. Persistent low levels of hCG: please do not miss phantom hCG! (pseudohypergonadotropinemia syndrome). Acta Clinica Belgica (abstract) 2013;68:465. Cole LA. hCG, the wonder of today’s science. Reprod Biol Endocrinol 2012;10:24–42. B. González Aguilera, P. Syrios, R. Gadisseur, F. Luyckx, E. Cavalier, A. Beckers & H. Valdes-Socin. Persistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease . Gynecological Endocrinology 2016. DOI:10.3109/09513590.2015.1132303 [less ▲]

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See detailEspace, temps et angoisse psychotique : à propos d'un cas magistral
Englebert, Jérôme ULg

Scientific conference (2016, March 26)

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See detailInfluence of extraction conditions on characteristics of microbial polysaccharide kefiran isolated from kefir grains biomass
Pop Rodica, Carmen; Salanţă, Liana; M. Rotar, Ancuţa et al

in Journal of Food and Nutrition Research (2016)

Kefiran is a water-soluble polysaccharide, which can be isolated from kefir grains biomass. Rheological behaviour and physico-chemical characteristics of kefiran solutions were influenced by the ... [more ▼]

Kefiran is a water-soluble polysaccharide, which can be isolated from kefir grains biomass. Rheological behaviour and physico-chemical characteristics of kefiran solutions were influenced by the extraction parameters. Degradation of the polymer chain occurred at the highest temperature tested (100 °C). The intrinsic viscosity of kefiran solutions (0.1 g·ml-1) varied between 8.24 mPa at 100 °C to 19.32 mPa at 80 °C. Regarding rheological properties, kefiran solutions had characteristics of a Newtonian behaviour in diluted solutions and pseudoplastic at higher concentrations. High-performance liquid chromatography analysis of monosaccharides revealed that kefiran is composed of glucose and galactose in a relative molar ratio of 0.94–1.1. Infrared spectra of kefiran suggested the structure of α- and β-configurations in pyranose-form carbohydrates, which indicated a purified structure of kefiran. The molecular weight of kefiran polymer was between 2.4 × 106 Da and 1.5 × 107 Da, the values of molecular weight depending on extraction conditions. This polysaccharide was found to have higher intrinsic viscosity and higher apparent viscosity in aqueous solutions, which brings a perspective for its use as thickening or gelling agent in food, or as a matrix in film-forming solutions. [less ▲]

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See detailZinc and Iron interplay in Arabidopsis relatives
Hanikenne, Marc ULg

Scientific conference (2016, March 25)

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See detailDurée excessive d'une procédure pénale et mise en cause de la responsabilité civile de l'Etat
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (2016/12), 569-574

Le jugement commenté présente la principale particularité d'aborder la mise en cause de la responsabilité civile de l'Etat en cas de dépassement du délai raisonnable d'une procédure pénale. Le commentaire ... [more ▼]

Le jugement commenté présente la principale particularité d'aborder la mise en cause de la responsabilité civile de l'Etat en cas de dépassement du délai raisonnable d'une procédure pénale. Le commentaire de cette décision s'attache encore à mettre en perspective cette décision avec l'arrêt Panju c. Belgique prononcé le 28 octobre 2014 par la Cour européenne des droits de l'homme. [less ▲]

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See detailDéveloppement de procédés sol-gel de fabrication de matériaux de batterie
Eskenazi, David ULg

Doctoral thesis (2016)

Différents procédés, installations et moyens d'analyse ont été développés pour la fabrication de matériaux de batterie Li-ion par procédé sol-gel. Leur objectif est de faciliter l'utilisation industrielle ... [more ▼]

Différents procédés, installations et moyens d'analyse ont été développés pour la fabrication de matériaux de batterie Li-ion par procédé sol-gel. Leur objectif est de faciliter l'utilisation industrielle de ces matériaux. Il s'agit d'un réacteur continu de fabrication de xérogels de carbone sous forme de billes, d'un réacteur de nitruration de phosphates, et d'une technique d'analyse thermique couplée à de la spectrométrie de masse. [less ▲]

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See detailMesure, réalité et grandeurs intensives dans la Critique de la raison pure
Pieron, Julien ULg

Scientific conference (2016, March 25)

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See detailLes troubles spécifiques du langage : la piste de la mémoire procédurale
Maillart, Christelle ULg

Scientific conference (2016, March 25)

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See detailVoyage d'étude curriculum et évaluation de la qualité
Pirard, Florence ULg; Goossens, Xavier

Conference (2016, March 25)

Quand ils sont inscrits dans des dispositifs d’accompagnement organisé en réseau et ancré dans les pratiques professionnelles, on peut faire l’hypothèse que les voyages d’étude contribuent à une ... [more ▼]

Quand ils sont inscrits dans des dispositifs d’accompagnement organisé en réseau et ancré dans les pratiques professionnelles, on peut faire l’hypothèse que les voyages d’étude contribuent à une transformation à la fois des acteurs qui découvrent d’autres manières de penser et d’agir et des actions qu’ils sont susceptibles d’améliorer. Ils s’inscrivent dans des dispositifs qui relèvent d’une culture de la professionnalisation. Nous analyserons un dispositif d’accompagnement centré sur le travail avec les familles qui intègre des voyages d’étude pour des professionnel-le-s de l’accueil en collectivité (fonction d’accueil, direction et coordination). Elle questionne la place du voyage d’étude dans le dispositif, les conditions de sa mise en œuvre et les effets observés sur les pratiques professionnelles. [less ▲]

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See detailA new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials.
GRENADE, Charlotte ULg; Moniotte, Nicolas; Rompen, Eric ULg et al

in Cytotechnology (2016)

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of ... [more ▼]

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to study cell behavior on rigid and flexible/permeable biomaterials elaborating two specific insert-based systems (IBS-R and IBS-F respectively). IBS-R was designed as a specific cylindrical polytetrafluoroethylene (PTFE) system to evaluate attachment, proliferation and morphology of human gingival fibroblasts (HGFs) on grade V titanium and lithium disilicate glass-ceramic discs characteristics of dental prostheses. The number of cells, their covering on discs and their morphology were determined from MTS assays and microscopic fluorescent images after 24, 48 and 72 h. IBS-F was developed as a two components system to study HGFs behavior on guided bone regeneration polyester membranes. The viability and the membrane barrier effect were evaluated by metabolic MTS assays and by scanning electron microscopy. IBS-R and IBS-F were shown to promote (1) easy and rapid handling; (2) cell retention on biomaterial surface; (3) accurate evaluation of the cellular proliferation, spreading and viability; (4) use of non-toxic material. Moreover IBS-F allowed the study of the cell migration through degradable membranes, with an access to both faces of the biomaterial and to the bottom of culture wells for medium changing. [less ▲]

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See detailUne généralisation du triangle de Pascal et la suite A007306
Stipulanti, Manon ULg

Conference (2016, March 25)

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpinski gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1]×[0, 1] associated with this extended Pascal triangle modulo a prime p. We consider a sequence (S(n))n≥0 counting the number of positive entries on each row of the generalized Pascal triangle. By introducing a convenient tree structure, we provide a recurrence relation for (S(n))n≥0, we prove that the sequence is 2-regular, give a linear representation and make the connection with the sequence of denominators occurring in the Farey tree. [less ▲]

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