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See detailKIAA1199: a novel regulator of MEK/ERK-induced Schwann cell dedifferentiation
Boerboom, Angelique; Reusch, Céline ULiege; Pieltain, Alexandra ULiege et al

in Glia (2017), 65(10), 1682-1696

The molecular mechanisms that regulate Schwann cell (SC) plasticity and the role of the Nrg1/ErbB-induced MEK1/ERK1/2 signalling pathway in SC dedifferentiation or in myelination remain unclear. It is ... [more ▼]

The molecular mechanisms that regulate Schwann cell (SC) plasticity and the role of the Nrg1/ErbB-induced MEK1/ERK1/2 signalling pathway in SC dedifferentiation or in myelination remain unclear. It is currently believed that different levels of MEK1/ERK1/2 activation define the state of SC differentiation. Thus, the identification of new regulators of MEK1/ERK1/2 signalling could help to decipher the context-specific aspects driving the effects of this pathway on SC plasticity. In this perspective, we have investigated the potential role of KIAA1199, a protein that promotes ErbB and MEK1/ERK1/2 signalling in cancer cells, in SC plasticity. We depleted KIAA1199 in the SC-derived MSC80 cell line with RNA-interference-based strategy and also generated Tamoxifen-inducible and conditional mouse models in which KIAA1199 is inactivated through homologous recombination, using the Cre-lox technology. We show that the invalidation of KIAA1199 in SC decreases the expression of cJun and other negative regulators of myelination and elevates Krox20, driving them towards a pro-myelinating phenotype. We further show that in dedifferentiation conditions, SC invalidated for KIAA1199 exhibit lower myelin clearance as well as increased myelination capacity. Finally, the Nrg1-induced activation of the MEK/ERK/1/2 pathway is severely reduced when KIAA1199 is absent, indicating that KIAA1199 promotes Nrg1-dependent MEK1 and ERK1/2 activation in SCs. In conclusion, this work identifies KIAA1199 as a novel regulator of MEK/ERK-induced SC dedifferentiation and contributes to a better understanding of the molecular control of SC dedifferentiation. [less ▲]

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See detailThe Paleoproterozoic fossil record: Implications for the evolution of the biosphere during Earth's middle-age
Javaux, Emmanuelle ULiege; lepot, kevin

in Earth-Science Reviews (2017)

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See detailOn the phase behaviour of oxetane-CO2 and propargylic alcohols-CO2 binary mixtures by in situ infrared micro-spectrometry
Zaky, Mohamed; Boyaval, Amélie ULiege; Grignard, Bruno ULiege et al

in Journal of Supercritical Fluids (2017), 128

The phase behaviour of carbon dioxide/propargylic alcohols and carbon dioxide/oxetanes mixtures has been investigated using in-situ FTIR microspectrometry that allows us determining the evolution of the ... [more ▼]

The phase behaviour of carbon dioxide/propargylic alcohols and carbon dioxide/oxetanes mixtures has been investigated using in-situ FTIR microspectrometry that allows us determining the evolution of the concentration of each component in the liquid phase as a function of temperature and pressure. It was at the same time possible to look inside the cell and to visualize the expansion of the liquid phase during the increase of the pressure. The measurements were performed at three different temperatures (40, 70 and 100◦C) for pressures ranging between 0.1 and 15 MPa. Propargylic alcohol (PA), 2-methyl-3-butyn-2-ol (MBOL), 3-butyn-1-ol (BOL) and trimethylene oxide (TMO) were selected as these molecules are used in the synthesis of cyclic or polycarbonates by coupling with CO2. Thus, we determined the CO2 sorption and the concentration of the substrate in the liquid phase. Thanks to these measurements, we established the pressure-composition phase diagram for the liquid phase of these substrate/CO2 binary mixtures. [less ▲]

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See detailTableaux, livres, tapisseries. Les chefs d’œuvre nordiques
Fagnart, Laure ULiege

in François Ier et l'art des Pays-Bas. Musée du Louvre (2017)

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See detailDu trou de ver au trou de serrure...
Gernay, Delphine; Moukhaiber, Sophie; Maenhout, Marine et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2017), 19

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See detailSans titre (postface)
Dejasse, Erwin ULiege

in Muñoz, José; Sampayo, Carlos (Eds.) Le Bar à Joe (édition intégrale) (2017)

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See detailPraxis et anti-praxis des revues intellectuelles de l’immédiat après-guerre
Franck, Thomas ULiege

in Argumentation et Analyse du Discours (2017), 19

The sociodiscursive analysis of post-war intellectual reviews’ editorials, especially Socialisme ou Barbarie, gives rise to rhetorical and argumentative interpretations determined by the socio-historical ... [more ▼]

The sociodiscursive analysis of post-war intellectual reviews’ editorials, especially Socialisme ou Barbarie, gives rise to rhetorical and argumentative interpretations determined by the socio-historical context, by reviews’ editorial features and by the Marxist discursive formation. On the one hand the polemic dimension of these discourses (structured by a logic of ideological dispute), the reproduction of the fixed formula “marxisme véritable” and the use of ironical “îlots textuels” (parts of discourse that quote words of the opponent to discredit him) are all rhetorical examples of the influence of an intellectual discourse’s instituted state. On the other hand the militant ethos developed by Socialisme ou Barbarie and the presupposition of the link between Stalinism and State capitalism are parts of a discursive innovation. This dialectical logic between a discursive determination and a power of innovation has to be studied from a materialist point of view. Thus the dialectical movement between a discursive creation – for example the militant activism of Socialisme ou Barbarie – and a discourse’s instituted state – for example the Marxist dogmatism – must be understood on the basis of different materialist notions. Also the notion of “group praxis” allows to overpass this movement between determination and innovation. Consequently the possibility arises to think the rhetorical particularities and the critical process of intellectual reviews. [less ▲]

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See detailClinical classification criteria for radicular pain caused by lumbar disc herniation: the radicular pain caused by disc herniation (RAPIDH) criteria
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in Spine Journal (2017), 17(10), 1464-1471

BACKGROUND CONTEXT: Classification criteria are recommended for diseases that lack specific biomarkers to improve homogeneity in clinical research studies. Because imaging evidence of lumbar disc ... [more ▼]

BACKGROUND CONTEXT: Classification criteria are recommended for diseases that lack specific biomarkers to improve homogeneity in clinical research studies. Because imaging evidence of lumbar disc herniations (LDHs) may not be associated with symptoms, clinical classification criteria based on patient symptoms and physical examination findings are required. PURPOSE: This study aimed to produce clinical classification criteria to identify patients with radicular pain caused by LDH. STUDY DESIGN: The study design was a two-stage process. Phase 1 included a Delphi process and Phase 2 included a cohort study. PATIENT SAMPLE: The patient sample included outpatients recruited from spine clinics in five countries. OUTCOME MEASURES: The outcome measures were items from history and physical examination. MATERIALS AND METHODS: In Phase 1, 17 spine experts participated in a Delphi process to select symptoms and signs suggesting radicular pain caused by LDH. In Phase 2, 19 different clinical experts identified patients they confidently classified as presenting with (1) radicular pain caused by LDH, (2) neurogenic claudication (NC) caused by lumbar spinal stenosis, or (3) non-specific low back pain (NSLBP) with referred leg pain. Patients completed survey items and specialists documented examination signs. A score to predict radicular pain caused by LDH was developed based on the coefficients of the multivariate model. An unrestricted grant of less than US$15,000 was received from MSD: It was used to support the conception of the Delphi, data management, and statistical analysis. No fees were allocated to participating spine specialists. RESULTS: Phase 1 generated a final list of 74 potential symptoms and signs. In Phase 2, 209 patients with pain caused by LDH (89), NC (63), or NSLBP (57) were included. Items predicting radicular pain caused by LDH (p<.05) were monoradicular leg pain distribution, patient-reported unilateral leg pain, positive straight leg raise test <60° (or femoral stretch test), unilateral motor weakness, and asymmetric ankle reflex. The score had an AUC of 0.91. An easy-to-use weighted set of criteria with similar psychometric characteristics is proposed (specificity 90.4%, sensitivity 70.6%). CONCLUSIONS: Classification criteria for identifying patients with radicular pain caused by LDH are proposed. Their use could improve the homogeneity of patients enrolled in clinical research studies. [less ▲]

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See detailPassé et présent de la prise en charge de l'acromégalie et ses complications
NECHIFOR, Iulia ULiege; Beckers, Albert ULiege

in Médecine Clinique Endocrinologie & Diabète (2017), 90

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See detailDisseminated histoplasmosis: case report and review of the literature
Evrard, Séverine; CAPRASSE, Philippe ULiege; Gavage, Pierre et al

in Acta Clinica Belgica (2017)

Case report: We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest ... [more ▼]

Case report: We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a ‘miliary pattern’. Bone marrow aspiration pointed out yeast inclusions within macrophages. Given the morphological aspect, the clinical presentation and immunosuppression, histoplasmosis was retained as a working hypothesis. Antiretroviral and amphotericin B treatments were promptly initiated. Review: Given the immigration wave that Europe is currently experiencing, we think it is important to share experience and knowledge, especially in non-endemic areas such as Europe, where clinicians are not used to face this disease. Histoplasmosis is due to Histoplasma capsulatum var. capsulatum, a dimorphic fungus. Infection occurs by inhaling spores contained in soils contaminated by bat or bird droppings. The clinical presentation depends on the immune status of the host and the importance of inoculum, varying from asymptomatic to disseminated forms. AIDS patients are particularly susceptible to develop a severe disease. Antigen detection, molecular biology techniques, and microscopic examination are used to make a rapid diagnosis. However, antigen detection is not available in Europe and diagnosis needs a strong clinical suspicion in non-endemic areas. Because of suggestive imagery, clinicians might focus on tuberculosis. Our case illustrates the need for clinicians to take histoplasmosis [less ▲]

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See detailImprovement of battery life of iPhones Inertial Measurement Unit by using edge computing Application to cattle behavior
Debauche, Olivier ULiege; Mahmoudi, Saïd; Manneback, Pierre et al

Conference (2017, October)

Smartphones, particularly iPhones, can be relevant instruments for researchers widely used around the world in multiple domains of applications such as animal behavior. iPhones are readily available on ... [more ▼]

Smartphones, particularly iPhones, can be relevant instruments for researchers widely used around the world in multiple domains of applications such as animal behavior. iPhones are readily available on the planet, contain many sensors and require no hardware development. They are equipped with high performance inertial measurement units (IMU) and absolute positioning systems analyzing users movements, but they can easily be diverted to analyze likewise the behaviors of domestic animals such as cattle. Using smartphones to study animal behavior requires the improvement of the autonomy to allow the acquisition of many variables at a high frequency over long periods of time on a large number of individuals for their further processing through various models and decision-making tools. Storing, treating data at the iPhone level with an optimal consumption of energy to maximize battery life was achieved by using edge computing on the iPhone. It reduced the size of the raw data by 42% on average by eliminating redundancies. The decrease in sampling frequency, the selection of the most important variables and postponing calculations to the cloud allowed also an increase in battery life by reducing of amount of data to transmit. [less ▲]

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See detailThe Psychometric Properties of the French Version of the Trait Emotional Intelligence Questionnaire-Child Short Form
Stassart, Céline ULiege; Etienne, Anne-Marie ULiege; Luminet, Olivier et al

in Journal of Psychoeducational Assessment (2017)

The psychometric properties of the French version of the Child Short Form of the Trait Emotional Intelligence Questionnaire (TEIQue-CSF) were investigated in a sample of 556 from 9 to 13 years old. The ... [more ▼]

The psychometric properties of the French version of the Child Short Form of the Trait Emotional Intelligence Questionnaire (TEIQue-CSF) were investigated in a sample of 556 from 9 to 13 years old. The internal consistency and temporal stability were satisfactory. A significant difference for gender, but not for age, was observed. With regard to the factor structure, the best fit was found for a two-factor solution, emotion control and socioemotionality. Regarding convergent validity, positive correlations were found with the total and all except one-factor scores of the Emotion Awareness Questionnaire score (EAQ30). Evidences of concurrent validity were demonstrated, with negative correlations with State-Trait Anxiety Inventory for Children (STAIC) and Childhood Anxiety Sensitivity Index (CASI). Results also showed a positive correlation with Children’s Social Desirability Scale (CSD). In conclusion, these findings provide additional support for the use of the TEIQue-CSF for researchers and practitioners who want to assess emotion-related constructs in children. [less ▲]

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See detailObjectif #No Hep
DELWAIDE, Jean ULiege

in Tempo Médical (2017), 402

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See detailCeci n'est pas de l'abolitionnisme. Le régime juridique de la prostitution : un surréalisme à la belge?
André, Sophie ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2017)

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See detailBarthes entre sémiologie et sémiotique : le cas de la photographie
Dondero, Maria Giulia ULiege

in Bertrand, Jean-Pierre (Ed.) Roland Barthes : continuités. Cerisy 2016 (2017)

Dans cet article, je vise à reparcourir les textes que Barthes a écrits sur la photographie, sans aucune ambition philologique ni chronologique. Le but est plutôt de revenir sur les questions que le ... [more ▼]

Dans cet article, je vise à reparcourir les textes que Barthes a écrits sur la photographie, sans aucune ambition philologique ni chronologique. Le but est plutôt de revenir sur les questions que le médium photographique a posées à la sémiologie et continue, en partie, de poser à la sémiotique. La théorie barthésienne sera mise en contraste avec la sémiotique de l'image initiée par A.J. Greimas, et développée par l'Ecole de Paris (J.M. Floch, J. Fontanille...). [less ▲]

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See detailNonlinear asteroseismology: insight from amplitude and frequency modulations of oscillation modes in compact pulsators from Kepler photometry
Zong, Weikai; Charpinet, Stéphane; Vauclair, Gérard et al

in EPJ Web of Conferences (2017, October), 160

Nonlinear mode interactions are difficult to observe from ground-based telescopes as the typical periods of the modulations induced by those nonlinear phenomena are on timescales of weeks, months, even ... [more ▼]

Nonlinear mode interactions are difficult to observe from ground-based telescopes as the typical periods of the modulations induced by those nonlinear phenomena are on timescales of weeks, months, even years. The launch of space telescopes, e.g., Kepler, has tremendously changed the situation and shredded new light on this research field. We present results from Kepler photometry showing evidence that nonlinear interactions between modes occur in the two compact pulsators KIC 8626021, a DB white dwarf, and KIC 10139564, a short period hot B subdwarf. KIC 8626021 and KIC 10139564 had been monitored by Kepler in short-cadence for nearly two years and more than three years without interruption, respectively. By analyzing these high-quality photometric data, we found that the modes within the triplets induced by rotation clearly reveal different behaviors: their frequencies and amplitudes may exhibit either periodic or irregular modulations, or remain constant. These various behaviors of the amplitude and of the frequency modulations of the oscillation modes observed in these two stars are in good agreement with those predicted within the amplitude equation formalism in the case of the nonlinear resonant mode coupling mechanism. [less ▲]

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See detailA clinician's Guide to familial pituitary tumors
Beckers, Albert ULiege

Scientific conference (2017, October)

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