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See detailElements of stochastic processes 2016--2017: course material
Arnst, Maarten ULg

Learning material (2017)

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See detailProtean proteases: at the cutting edge of lung diseases.
Taggart, Clifford; Mall, Marcus A.; Lalmanach, Gilles et al

in European Respiratory Journal (2017), 49(2),

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and ... [more ▼]

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and it is now evident that proteases are critical pleiotropic actors orchestrating pathophysiological processes. Recent findings evidenced that the net proteolytic activity also relies upon interconnections between different protease and protease inhibitor families in the protease web.In this review, we provide an overview of these novel concepts with a particular focus on pulmonary pathophysiology. We describe the emerging roles of several protease families including cysteine and serine proteases.The complexity of the protease web is exemplified in the light of multidimensional regulation of serine protease activity by matrix metalloproteases through cognate serine protease inhibitor processing. Finally, we will highlight how deregulated protease activity during pulmonary pathogenesis may be exploited for diagnosis/prognosis purposes, and utilised as a therapeutic tool using nanotechnologies.Considering proteases as part of an integrative biology perspective may pave the way for the development of new therapeutic targets to treat pulmonary diseases related to intrinsic protease deregulation. [less ▲]

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See detailPreterm Infant Growth Velocity Calculations: A Systematic Review
Fenton, Tanis; Chan, Hilton; Madhu, Aiswarya et al

in Pediatrics (2017), 139(3), 1-10

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See detailKey impact of an uncommon plasmid on bacillus amyloliquefaciens subsp. plantarum S499 developmental traits and lipopeptide production
Molinatto, G.; Franzil, L.; Steels, Sébastien ULg et al

in Frontiers in Microbiology (2017), 8(JAN),

The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant ... [more ▼]

The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant disease protection provided by this strain. Sequencing of the S499 genome has highlighted genetic differences and similarities with the closely related rhizobacterium B. amyloliquefaciens subsp. plantarum FZB42 (FZB42). More specifically, a rare 8008 bp plasmid (pS499) harboring a rap-phr cassette constitutes a major distinctive element between S499 and FZB42. By curing this plasmid, we demonstrated that its presence is crucial for preserving the typical physiology of S499 cells. Indeed, the growth rate and extracellular proteolytic activity were significantly affected in the cured strain (S499 P-). Furthermore, pS499 made a significant contribution to the regulation of cyclic lipopeptide production. Surfactins and fengycins were produced in higher quantities by S499 P-, whereas lower amounts of iturins were detected. In line with the increase in surfactin release, bacterial motility improved after curing, whereas the ability to form biofilm was reduced in vitro. The antagonistic effect against phytopathogenic fungi was also limited for S499 P-, most probably due to the reduction of iturin production. With the exception of this last aspect, S499 P- behavior fell between that of S499 and FZB42, suggesting a role for the plasmid in shaping some of the phenotypic differences observed in the two strains. © 2017 Molinatto, Franzil, Steels, Puopolo, Pertot and Ongena. [less ▲]

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See detailA Belgian survey on the diagnosis of asthma-COPD overlap syndrome.
Cataldo, Didier ULg; Corhay, Jean-Louis ULg; Derom, Eric et al

in International Journal of Chronic Obstructive Pulmonary Disease (2017), 12

INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse ... [more ▼]

INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse and inconsistent. This survey aimed to identify consensus on criteria for diagnosing ACOS. METHODS: A Belgian expert panel developed a survey on ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen by >/=70% of survey respondents were considered as useful criteria for ACOS diagnosis. The two most frequently selected answers were considered as major criteria, others as minor criteria. The expert panel proposed a minimal requirement of two major criteria and one minor criterion for ACOS diagnosis. Respondents were also asked which criteria are important for considering inhaled corticosteroids prescription in a COPD patient. RESULTS: To diagnose ACOS in COPD patients, major criteria were "high degree of variability in airway obstruction over time (change in forced expiratory volume in 1 second >/=400 mL)" and "high degree of response to bronchodilators (>200 mL and >/=12% predicted above baseline)". Minor criteria were "personal/family history of atopy and/or IgE sensitivity to >/=1 airborne allergen", "elevated blood/sputum eosinophil levels and/or increased fractional exhaled nitric oxide", "diagnosis of asthma <40 years of age"; "symptom variability", and "age (in favor of asthma)". To diagnose ACOS in asthma patients, major criteria were "persistence of airflow obstruction over time (forced expiratory volume in 1 second/forced vital capacity ratio <0.7)" and "exposure to noxious particles/gases, with >/=10 pack-years for (ex-)smokers"; minor criteria were "lack of response on acute bronchodilator test"; "reduced diffusion capacity"; "limited variability in airway obstruction"; "age >40 years"; "emphysema on chest computed tomography scan". CONCLUSION: Specific criteria were identified that may guide physicians to a more uniform diagnostic approach for ACOS in COPD or asthma patients. These criteria are largely similar to those used to prescribe inhaled corticosteroids in COPD. [less ▲]

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See detailQuadratic reformulations of nonlinear binary optimization problems
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

in Mathematical Programming (2017), 162

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these ... [more ▼]

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these problems when the objective function is a quadratic polynomial. However, no similarly efficient methods are available for the higher degree case. Since high degree objectives are becoming increasingly important in certain application areas, such as computer vision, various techniques have been recently developed to reduce the general case to the quadratic one, at the cost of increasing the number of variables. In this paper we initiate a systematic study of these quadratization approaches. We provide tight lower and upper bounds on the number of auxiliary variables needed in the worst-case for general objective functions, for bounded-degree functions, and for a restricted class of quadratizations. Our upper bounds are constructive, thus yielding new quadratization procedures. Finally, we completely characterize all ``minimal'' quadratizations of negative monomials. [less ▲]

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See detailDurabilité du maraîchage urbain : entre ancrage territorial et trajectoires de mise en œuvre
Plateau, Lou; Maughan, Noémie; Visser, Marjolein et al

Conference (2017)

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See detailConserved Fever Pathways across Vertebrates: A Herpesvirus Expressed Decoy TNF-alpha Receptor Delays Behavioral Fever in Fish.
Rakus, Krzysztof; Ronsmans, Maygane; Forlenza, Maria et al

in Cell Host & Microbe (2017), 21(2), 244-253

Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term "behavioral fever." We studied the ... [more ▼]

Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving to warmer places, hence the term "behavioral fever." We studied the manifestation of behavioral fever in the common carp infected by cyprinid herpesvirus 3, a native carp pathogen. Carp maintained at 24 degrees C died from the infection, whereas those housed in multi-chamber tanks encompassing a 24 degrees C-32 degrees C gradient migrated transiently to the warmest compartment and survived as a consequence. Behavioral fever manifested only at advanced stages of infection. Consistent with this, expression of CyHV-3 ORF12, encoding a soluble decoy receptor for TNF-alpha, delayed the manifestation of behavioral fever and promoted CyHV-3 replication in the context of a temperature gradient. Injection of anti-TNF-alpha neutralizing antibodies suppressed behavioral fever, and decreased fish survival in response to infection. This study provides a unique example of how viruses have evolved to alter host behavior to increase fitness. [less ▲]

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See detailA comparative study on optimum insulation thickness of walls and energy savings in equatorial and tropical climate
Kameni Nematchoua, Modeste; Ricciardi, Paola; Reiter, Sigrid ULg et al

in International Journal of Sustainable Built Environment (2017)

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well ... [more ▼]

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well that energy supply does not always satisfy demand. Thermal insulation technology can be one of the leading methods for reducing energy consumption in these new buildings. However, choosing the thickness of the insulation material often causes high insulation costs. In the present study, the optimum insulation thickness, energy saving and payback period were calculated for buildings in Yaounde´ and Garoua cities, located in two climatic regions in Cameroon. The economic model including the cost of insulation material and the present value of energy consumption and the cost over a life time of 22 years of the building, were used to find the optimum insulation thickness, energy saving, and payback period. Materials that extruded polystyrene were chosen and used for two typical wall structures (concrete block (HCB) and compressed stabilized earth block wall (CSEB)). The early cooling transmission loads, according to wall orientations and percentage of radiation blocked were calculated using the explicit finite-difference method under steady periodic conditions. As a result, it was found that the west- and east-facing walls are the least favourite in the cooling season, whereas the south and north orientations are the most economical. Although wall orientation had a significant effect on the optimum insulation thickness, it had a more significant effect on energy savings. In equatorial region (Yaounde´), for south orientation, the optimum insulation thickness was 0.08 m for an energy savings of 51.69 $/m2. Meanwhile, in tropical region (Garoua), for north orientation, the optimum insulation thickness was 0.11 m for an energy savings of 97.82 $/m2. [less ▲]

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See detailEvaluation of the long-term effect of biochar on properties of temperate agricultural soil at pre-industrial charcoal kiln sites in Wallonia, Belgium
Hardy, Brieuc; Cornelis, Jean-Thomas ULg; Houben, David et al

in European Journal of Soil Science (2017), 68

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See detailLa « discrimination à rebours » au sein du marché intérieur : une illégalité qu’il ne faut pas voir au niveau européen ?
Van Cleynenbreugel, Pieter ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017)

Cet article dresse un panorama de la jurisprudence sur les situations purement internes au droit du marché intérieur et du phénomène juridique de la discrimination à rebours. Il est conclu qu'une telle ... [more ▼]

Cet article dresse un panorama de la jurisprudence sur les situations purement internes au droit du marché intérieur et du phénomène juridique de la discrimination à rebours. Il est conclu qu'une telle discrimination est inhérente au régime juridique de l'Union européenne caractérisé par le principe d'attribution des compétences. Il convient aux Etats membres d'y apporter des solutions fondées sur leurs droits constitutionnels respectifs. [less ▲]

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See detailComparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species
Kapepula, Paulin Mutwale; Kabamba Ngombe, Nadege; Tshisekedi Tshibangu, Pascal et al

in Natural Product Research (2017), 6419(March), 1--8

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See detailLa « personnalité antisociale », antithèse de la psychopathologie
Englebert, Jérôme ULg; Adam, Christophe

in Déviance et Société (2017), 41(1), 3-28

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au ... [more ▼]

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au sein du système de justice pénale. Notre réflexion débutera par une généalogie du vocable dans différentes versions de la classification psychiatrique, depuis les années cinquante jusqu’aujourd’hui, et plus particulièrement celle faisant autorité du Manuel statistique et diagnostique des troubles mentaux (DSM). L’absence de raisonnement sociologique dans l’usage d’une notion impliquant pourtant la référence au « social » sera discutée ainsi que ses évolutions historiques. Ensuite, la démonstration de l’antithèse que cette notion constitue pour une perspective psychopathologique digne de ce nom – dynamique, compréhensive et phénoménologique – sera développée en six arguments majeurs et plurivoques, tantôt empiriques et cliniques, tantôt théoriques. [less ▲]

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See detailCrise de la démocratie et nouveau management public : Discours, pratiques, instruments
Fallon, Catherine ULg; Ficet, Joël ULg

Book published by Academia (2017)

Les discours de légitimation du corps de doctrines et de dispositifs généralement associés sous le terme de « nouveau management public » (NMP) s’appuient non seulement sur un idéal de performance mais ... [more ▼]

Les discours de légitimation du corps de doctrines et de dispositifs généralement associés sous le terme de « nouveau management public » (NMP) s’appuient non seulement sur un idéal de performance mais aussi sur une aspiration à remédier à une « crise de la démocratie » qui se manifesterait par l’insatisfaction des populations des pays occidentaux vis-à-vis de leurs gouvernants, et ce de deux façons : en aidant les Etats à mieux répondre aux attentes de leurs populations d’une part, en créant au bénéfice des citoyens de nouvelles voies d’accès à la décision et de nouveaux droits d’autre part (DeLeon, 2005 ; Behn, 1998). Le livre rassemble des études interrogeant à partir de perspectives théoriques diverses (analyse des politiques publiques, sociologie des organisations, sciences de gestion, théorie politique…) la capacité des instruments du NPM à apporter une plus-value démocratique à la gestion publique et, inversement, analysant ce que le NPM nous révèle sur les transformations de la notion de démocratie dans un espace politique de plus en plus complexe et technocratique (Rose, 1991 ; Salais,2010; Ogien, 2013). Le NMP ne s’est pas construit en lui-même autour d’un impératif démocratique : dans sa version la plus pure, il consiste essentiellement, soit à confier au marché la réalisation d’un certain nombre de tâches relevant classiquement de l’administration (solution « anglo-saxonne »), soit à séparer la sphère politique de l’administration en responsabilisant les fonctionnaires en fonction d’objectifs de performance (solution « continentale »). Toutefois, certains de ses outils ont été conçus (à titre principal ou secondaire) comme moyens de promotion d’une logique démocratique, à même de contrer certains effets perçus comme pervers de la gestion publique : des instruments visant à faciliter le contrôle des administrations par les instances parlementaires ou juridictionnelles (Cour des comptes…) ; des instruments visant à accroître l’implication citoyenne dans la décision publique ; des instruments visant à améliorer la relation directe entre administration et citoyens (ombudsmen, sondages, cercles de qualité, chartes…) ; des instruments visant à accroître la transparence des processus administratifs et de leurs résultats (évaluation des politiques publiques, normes comptables) ; etc. Le pluralisme de ces dispositifs reflète à la fois l’hétérogénéité du NMP et l’ambiguïté du thème de la démocratie dès lors qu’appliqué à la responsabilité des acteurs politiques, ouvrant ainsi une opportunité d’analyse critique. Ainsi, les tenants des démarches d’évaluation défendent le rôle qu’elles peuvent jouer pour un approfondissement démocratique, par une meilleure lisibilité de l'action publique, une circulation des savoirs, un renforcement de la logique de responsabilité de l'administration et de son devoir de rendre des comptes. Certains auteurs, à l’inverse, dénoncent cette « idéologie de la gestion » (de Gaulejac, 2005) comme une colonisation du raisonnement politique par les catégories de l’économie et du management (Ogien, 2013), les chiffres structurant le processus décisionnel au lieu d’en être les simples auxiliaires, mathématisation du social (Salais, 2010) qui contribue à neutraliser les questions politiques et la délibération publique (Rose, 1991). Ces contributions permettent d’alimenter les réflexions sur la crise des formes contemporaines du politique à partir des analyses concrètes de l’action publique et des instruments mobilisés pour sa mise en œuvre. Cette posture permet d’interroger les processus de construction de ces instruments et les conditions concrètes de leur émergence, en dépassant la rationalité apparente des outils et l’image de « métrologues démiurges capables de maîtriser toutes les conséquences de l’introduction des instruments qu’ils ont retenus » (Mouhanna, 2011). [less ▲]

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See detailLocal planning in Belgium: a myriad of policy styles?
Wayenberg, Ellen; Reuchamp, Min; Kravagna, Marine et al

in Brans, Marleen; Aubin, David (Eds.) Policy Analysis in Belgium (2017)

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See detailBelgium - La collégiale Sainte-Croix à Liège
Houbart, Claudine ULg; Piavaux, Mathieu

in Machat, Christoph; Ziesemer, John (Eds.) Heritage at Risk. World Report 2014-2015 on Monuments and Sites in Danger (2017)

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See detailMurray Bail's Eucalyptus: An Australian Fairy-Tale?
Herbillon, Marie ULg

in Collier, Gordon; Davis, Geoffrey V.; Delrez, Marc (Eds.) et al The Cross-Cultural Legacy: Critical and Creative Writings in Memory of Hena Maes-Jelinek (2017)

Detailed reference viewed: 30 (15 ULg)