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See detailComment élaborer des tarifs en assurance non vie
Esch, Louis ULg

Scientific conference (2016, October)

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See detailClassification Criteria for Neurogenic Claudication Caused by Lumbar Spinal Stenosis
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in EuroSpine 2016 (2016, October)

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis ... [more ▼]

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis (LSS) or lumbar disc herniations (LDH) may not be associated with symptoms, clinical classification criteria based upon patient symptoms and physical examination findings are required. This study sought to develop a set of criteria identifying patients with neurogenic claudication (NC) caused by LSS and patient with radicular pain (RP) caused by LDH. This abstract reports the results concerning NC caused by LSS. METHODS Phase 1: Nineteen spine specialists (clinicians and researchers) from 8 countries participated in a Delphi process, using an internet program, to rank symptoms and signs which suggest LSS as the cause of NC or DH as the cause of RP. Phase 2: Nineteen different spine specialists (surgeons and non-surgeons) from 5 countries recruited patients during office visits and classify them with a high degree of confidence as having with either: 1) NC caused by LSS 2) RP caused by LDH or 3) non-specific low back pain (NSLBP) with non-specific leg pain radiation. Patients completed survey items and specialists documented examination signs. Signs and symptoms present in ≥ 10 patients were analyzed by using Generalized Estimating Equations (GEE). Patients with NC caused by LSS or NSLBP served as controls. Items with p<0.1 in univariate analysis were entered in the multivariate analysis. A score to predict NC caused by LSS was developed based on the coefficient of the GEE, and used to obtain a ROC curve and the associated area under the curve (AUC). RESULTS A list of 46 clinical signs and 28 patient-reported symptoms were selected by the group of spine specialists during the 1st phase. For the 2nd phase, 209 patients with high confidence in the diagnosis were included 63 NC caused by LSS, 89 RP caused by DH, and 57 NSLBP with non-specific leg pain radiation. Items which predicted NC with a p-value <0.1 included age >60, bilateral leg pain, leg pain relieved by sitting, leg pain decreased by leaning or flexing, positive30 seconds extension test, negative straight leg raise test. The score had an AUC of 0.91, and the cutoff to obtain a specificity of 92.1% resulted in a sensitivity of 80.0%. CONCLUSION An international collaboration of surgeon and non-surgeon spine specialists produced a set of diagnostic criteria with high specificity and sensitivity for identifying patients with NC caused by LSS. Using this set could improve the quality of basic science and clinical research in this field by improving homogeneity within groups of patients. [less ▲]

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See detailClassification criteria for neurogenic claudication caused by lumbar spinal stenosis
Genevay, Stéphane; Courvoisier, Delphine; Konstantinou, Kika et al

in 9th Interdisciplinary World Congress on Low Back And Pelvic Girdle Pain (2016, October)

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis ... [more ▼]

BACKGROUND Classification criteria are recommended for diseases that lack highly specific biomarkers in order to improve homogeneity in clinical research. Since imaging evidence of lumbar spinal stenosis (LSS) or lumbar disc herniations (LDH) may not be associated with symptoms, clinical classification criteria based upon patient symptoms and physical examination findings are required. This study sought to develop a set of criteria identifying patients with neurogenic claudication (NC) caused by LSS and patient with radicular pain (RP) caused by LDH. This abstract reports the results concerning NC caused by LSS. METHODS Phase 1: Nineteen spine specialists (clinicians and researchers) from 8 countries participated in a Delphi process, using an internet program, to rank symptoms and signs which suggest LSS as the cause of NC or DH as the cause of RP. Phase 2: Nineteen different spine specialists (surgeons and non-surgeons) from 5 countries recruited patients during office visits and classify them with a high degree of confidence as having with either: 1) NC caused by LSS 2) RP caused by LDH or 3) non-specific low back pain (NSLBP) with non-specific leg pain radiation. Patients completed survey items and specialists documented examination signs. Signs and symptoms present in ≥ 10 patients were analyzed by using Generalized Estimating Equations (GEE). Patients with NC caused by LSS or NSLBP served as controls. Items with p<0.1 in univariate analysis were entered in the multivariate analysis. A score to predict NC caused by LSS was developed based on the coefficient of the GEE, and used to obtain a ROC curve and the associated area under the curve (AUC). RESULTS A list of 46 clinical signs and 28 patient-reported symptoms were selected by the group of spine specialists during the 1st phase. For the 2nd phase, 209 patients with high confidence in the diagnosis were included 63 NC caused by LSS, 89 RP caused by DH, and 57 NSLBP with non-specific leg pain radiation. Items which predicted NC with a p-value <0.1 included age >60, bilateral leg pain, leg pain relieved by sitting, leg pain decreased by leaning or flexing, positive30 seconds extension test, negative straight leg raise test. The score had an AUC of 0.91, and the cutoff to obtain a specificity of 92.1% resulted in a sensitivity of 80.0%. CONCLUSION An international collaboration of surgeon and non-surgeon spine specialists produced a set of diagnostic criteria with high specificity and sensitivity for identifying patients with NC caused by LSS. Using this set could improve the quality of basic science and clinical research in this field by improving homogeneity within groups of patients. [less ▲]

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See detailLes dernières évolutions en droit européen en matière d'assurance protection juridique
Wildemeersch, Jonathan ULg

in Wildemeersch, Jonathan (Ed.) L'assurance protection juridique : quid pour demain? (2016, October)

L'assurance protection juridique est régie par une directive européenne. Comment la Cour de justice interprète-t-elle le principe du libre choix de l'avocat imposé par la directive ? Tel est l'objet de ... [more ▼]

L'assurance protection juridique est régie par une directive européenne. Comment la Cour de justice interprète-t-elle le principe du libre choix de l'avocat imposé par la directive ? Tel est l'objet de cette contribution. [less ▲]

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See detailThe fabrication of Otherness. Leeds Kirkgate Market
Dobbels, Rachel ULg

Scientific conference (2016, October)

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See detailELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer
Delaunay, Sylvain ULg; Rapino, Francesca ULg; Tharun, Lars et al

in The Journal of Experimental Medicine (2016), 213

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Post-transcriptional nucleoside modifications of transfer RNAs (tRNAs) at the ... [more ▼]

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Post-transcriptional nucleoside modifications of transfer RNAs (tRNAs) at the wobble U34 base are highly conserved and contribute to translation fidelity. Here, we show that ELP3 and CTU1/2, partner enzymes in U34 mcm5s2-tRNA modification, are upregulated in human breast cancers and sustain metastasis. Elp3 genetic ablation strongly impaired invasion and metastasis formation in the PyMT model of invasive breast cancer. Mechanistically, ELP3 and CTU1/2 support cellular invasion through the translation of the oncoprotein DEK. As a result, DEK promotes the IRES-dependent translation of the pro-invasive transcription factor LEF1. Consistently, a DEK mutant, whose codon composition is independent of U34 mcm5s2-tRNA modification, escapes the ELP3- and CTU1-dependent regulation and restores the IRES-dependent LEF1 expression. Our results demonstrate the key role of U34 tRNA modification to support specific translation during breast cancer progression and highlight a functional link between tRNA modification- and IRES-dependent translation during tumor cell invasion and metastasis. [less ▲]

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See detailThe road from the adenoma valley through the forest of genetic testing in pituitary adenoma
Beckers, Albert ULg

Scientific conference (2016, October)

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See detailSarcopenia in daily practice: assessment and management
Beaudart, Charlotte ULg; McCloskey, Eugène; Bruyère, Olivier ULg et al

in BMC Geriatrics (2016), 16(170),

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools ... [more ▼]

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools have been recommended to assess muscle mass, muscle strength and physical performance in clinical trials. Whilst these tools have proven to be accurate and reliable in investigational settings, many are not easily applied to daily practice. Methods: This paper is based on literature reviews performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group on frailty and sarcopenia. Face-to-face meetings were afterwards organized for the whole group to make amendments and discuss further recommendations. Results: This paper proposes some user-friendly and inexpensive methods that can be used to assess sarcopenia in real-life settings. Healthcare providers, particularly in primary care, should consider an assessment of sarcopenia in individuals at increased risk; suggested tools for assessing risk include the Red Flag Method, the SARC-F questionnaire, the SMI method or different prediction equations. Management of sarcopenia should primarily be patient centered and involve the combination of both resistance and endurance based activity programmes with or without dietary interventions. Development of a number of pharmacological interventions is also in progress. Conclusions: Assessment of sarcopenia in individuals with risk factors, symptoms and/or conditions exposing them to the risk of disability will become particularly important in the near future. [less ▲]

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See detailInvestigating the potential of Cymodocea nodosa (Ucria) Ascherson as a coastal carbon sink coupling marine habitat cartographies and in situ nondestructive sampling
Abadie, Arnaud ULg; Richir, Jonathan ULg; Pieraccini, Riccardo ULg et al

Poster (2016, October)

Seagrass meadows are major carbon sinks, trapping about 10% of the total CO2 sequestrated in the oceans. In the Mediterranean, a major focus has been made on the climax species Posidonia oceanica (L ... [more ▼]

Seagrass meadows are major carbon sinks, trapping about 10% of the total CO2 sequestrated in the oceans. In the Mediterranean, a major focus has been made on the climax species Posidonia oceanica (L.) Delile, while other species remained little studied. In the framework of the STARECAPMED project, we thus chose to study Cymodocea nodosa (Ucria) Ascherson, a pioneer species with a rapid turnover and an expected high stocking capacity. Furthermore, the area covered by that species has been largely underestimated. In order to fill these two knowledge gaps, we first mapped all seagrass habitats within a Mediterranean bay (Calvi, Corsica, France) using side scan images, aerial photographs and ground truths. This cartography was followed by seasonal in situ density measurements and non-destructive shoot sampling (leaf cutting). Samplings were performed at different depths (5 to 23 m depth) in 6 contrasted stations (small patchy meadows to continuous beds) in order to cover all the existing facies of the bay. Elementary contents (carbon, nitrogen and stable isotope ratios) were measured in laboratory. This first work shows that C. nodosa meadows in Calvi Bay cover an area of 0.498 km2. Carbon stocks of the leaves reached 0.25 tons in winter and 2.72 tons in summer. Their nitrogen contents showed a marked seasonality with a maximum value of 0.020 mgN.m-2 in July and a minimum value of 0.005 mgN.m-2 in March. Some modifications in the trophic conditions of the water column at several stations were put in an obvious through the N stable isotopes values, mostly during the summer period. The actual underestimation of the area covered by that species in Calvi Bay has been properly mapped thanks to side scan sonar techniques revealing, together with elementary content analysis, its importance in the carbon balance of coastal areas. [less ▲]

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See detailQuality Control Laboratories involved in the WHO Prequalification
Marini Djang'Eing'A, Roland ULg

Conference (2016, October)

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See detailLes ressources du sous-sol du bassin du Hoyoux jusqu’aux portes de la ville d’Andenne. Un riche passé industriel qui se conjugue au présent
Goemaere, Eric; Marion, Jean-Marc ULg; Mottequin, Bernard

in Michel, Georges; Thys, Georges (Eds.) Atlas du karst wallon. Bassins versants du Hoyoux et de la Solières (2016)

The outcrops made by the incision of the Hoyoux and its tributaries have largely favored the opening of numerous quarries and some mines, in parallel with the installation of various transforming ... [more ▼]

The outcrops made by the incision of the Hoyoux and its tributaries have largely favored the opening of numerous quarries and some mines, in parallel with the installation of various transforming industries. The list of materials exploited is impressive: limestones, dolomites, sandstones and quartzites, conglomerates, clays, sands, iron ores, etc. Their exploitation required an abundant labor force. The quarries were predominantly located in the bottom of the valley, which allowed the establishment of vast and high operating fronts and the extraction of healthy stones, in particular ornamental stones which were declined in different chromatic varieties. Walking today through this popular wooded and bucolic valley, one hardly imagines the industrious activity where resonated the noise of the tools and the labor of the workers. [less ▲]

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See detailAperçu géologique du bassin du Hoyoux
Marion, Jean-Marc ULg; Goemaere, Eric; Mottequin, Bernard

in Michel, Georges; Thys, Georges (Eds.) Atlas du karst wallon. Bassins versants du Hoyoux et de la Solières (2016)

The Hoyoux hydrographic basin comprises two regions characterized by karstic phenomena and a rich hydrologic potential. On the one hand, the Condroz, where the Dinantian limestones are in synclinal ... [more ▼]

The Hoyoux hydrographic basin comprises two regions characterized by karstic phenomena and a rich hydrologic potential. On the one hand, the Condroz, where the Dinantian limestones are in synclinal position in the bottom of depressions, separated from one another by anticlinal crests which are occupied by the Upper Famennian sandstones. On the other hand, the narrow strip of Devonian limestones (of Givetian and Frasnian ages), positioned immediately at the NW of the previous region, separates the Condroz, which is constituted by an alternation of deposits of Famennian and Dinantian (sandstones and limestones) and, the Ardennes Condroz, which consists of lower devonian and eifelian deposits (conglomerates, quartzites, sandstones and schists). Since 2015, the Walloon Public Service's site "WalOnMap", using the ultra-precise digital terrain model "MNT 2013-2014 Hillshade" obtained after a LIDAR scan of the soil surface, offers a remarkable mapping tool essential to geological mapping, in general, and to the cartography and prospection of Karstic phenomena in particular. [less ▲]

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See detailLa viande des uns, la faune des autres. Analyse anthropologique de la conservation de la faune dans trois villages Badjoué de la zone forestière de l'Est-Cameroun
Dieudonné, Mélodie ULg

Doctoral thesis (2016)

The Cameroonian forestry and environmental policies adopted in 1994 come within the scope of a will to manage forests sustainably and to involve local populations in the management of their environment ... [more ▼]

The Cameroonian forestry and environmental policies adopted in 1994 come within the scope of a will to manage forests sustainably and to involve local populations in the management of their environment. The aim of this doctoral thesis is to take an anthropological look at the wildlife conservation at the “microsociological” level of three Badjoué villages from the East region while putting these observations in the larger context of Cameroonian forest governance. In what way are wildlife community management measures appropriated, transformed and distorted by the actors? How do interactions between local populations and conservation organizations help transform local contexts and relations to wildlife? By applying an approach at the crossroads of the anthropology of conservation, the anthropology of development and an anthropology of nature which considers human-animal relations in an interactive and dynamic perspective, this thesis aims at paying a particular attention to the relations that the Badjoué of the Dja entertain with their environment, the intertwining of these relations in the local social, economic and political dynamics as well as to the evolution of these problems in the context of the community management of forest resources in Cameroon. The thesis so allows a reflection on the place of participation and local community autonomy in the management of natural resources and a questioning of the impact of coercive models on the environmental practices and conceptions. It finally raises the question of the intertwining between global environmental issues and the necessary consideration of peoples’ right to self-determination. [less ▲]

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See detailL'apprentissage des conversations de conception. Analyse exploratoire des pratiques discursives et graphiques médiées par ordinateur.
Joachim, Guillaume ULg

Doctoral thesis (2016)

A large proportion of architects’ educational and professional activities take place in the form of informal and formal discussions revolving around design artefacts, such as blueprints, sketches and ... [more ▼]

A large proportion of architects’ educational and professional activities take place in the form of informal and formal discussions revolving around design artefacts, such as blueprints, sketches and models. However, there has been little investigation into the multimodal resources mobilized by designers in order to collectively simulate experiments on their projects. In this thesis, we focus on remote mediated-by-computer design conversations in which architects jointly mobilise speech, inscription practices and artefacts handling for the purpose of examining how these function in the negotiation and joint development of architectural design knowledge. On the basis of a cross-cutting theoretical appraisal to the design conversation and on-field observations of remote synchronous meetings between professional designers, this exploratory study aims to describe and define the interactional processes implemented by architects in order to develop a shared reasoning on their project. The cross-disciplinary approach developed in the course of this research results in the formulation of a theoretical and analytical framework for studying the interactional organization behind jointly constructing the meaning of an architectural design. It also offers a better understanding of the fundamental links between graphical and discursive activities in communication between architects, while examining their digital mediations. [less ▲]

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See detailDetection and characterization of transiting hot Jupiters
Delrez, Laetitia ULg

Doctoral thesis (2016)

Detailed reference viewed: 52 (19 ULg)
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See detailDesign of an experimental set-up to analyse compliant mechanisms used for the deployment of a panel
Dewalque, Florence ULg; Bruls, Olivier ULg

in Proceedings of the 14th European Conference on Spacecraft Structures, Materials and Environmental Testing (ECSSMET) (2016, September 30)

Due to their high complexity, compliant mechanisms require high-fidelity mechanical models to reach a detailed understanding of their characteristics and predict their actual behaviour in various ... [more ▼]

Due to their high complexity, compliant mechanisms require high-fidelity mechanical models to reach a detailed understanding of their characteristics and predict their actual behaviour in various situations. This work focuses on tape springs which are used as an alternative to common mechanisms composed of kinematic joints. They present several assets such as, among others, passive deployment and self-locking, but they are characterised by a highly nonlinear behaviour including buckling, the formation of folds and hysteresis. An experimental set-up is then designed to gather information on these phenomena, while in parallel an equivalent finite element model is developed. Quasi-static and dynamic tests are performed, as well as small amplitude vibration tests and large amplitude deployments in order to collect data in a broad variety of cases. The post-processing of the numerous raw data shows, with the help of statistical considerations, the good quality of the acquisitions. Finally, the finite element model proves to be fairly well correlated to the experimental results. [less ▲]

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See detailPrésentation de l'Atlas national de Belgique - versions 1 à 3 et version numérique
Van Hecke, Etienne; Binard, Marc ULg; Donnay, Jean-Paul ULg

Conference (2016, September 30)

This presentation is divided into 3 parts: The "paper" version of the National Atlas, from the first to the third edition. The digital version of the National Atlas. A presentation of Geomatics Unit of ... [more ▼]

This presentation is divided into 3 parts: The "paper" version of the National Atlas, from the first to the third edition. The digital version of the National Atlas. A presentation of Geomatics Unit of the University of Liege, and its role in the realization of the 3rd edition of the National Atlas and its digital version. [less ▲]

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See detailRésultats d'une enquête sur la diffusion des thèses en droit
Bouhon, Frédéric ULg

Conference (2016, September 30)

Cette interviention, destinée aux doctorants et aux jeunes docteurs en droit, visait à présenter les résultats d'une enquête menée par l'auteur sur la diffusion des thèses en droit. Il s'agissait de ... [more ▼]

Cette interviention, destinée aux doctorants et aux jeunes docteurs en droit, visait à présenter les résultats d'une enquête menée par l'auteur sur la diffusion des thèses en droit. Il s'agissait de présenter les tendances suivies par les docteurs récemment diplômés dans les facultés de droit de Belgique francophone. L'intervention a été suivie d'un débat avec le public ainsi qu'avec des éditeurs présents. [less ▲]

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