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See detailDephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients.
DELANAYE, Pierre ULg; KRZESINSKI, Jean-Marie ULg; Warling, X et al

in BMC Nephrology (2014), 15

Background: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last ... [more ▼]

Background: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being dependent on vitamin K. The present study focused on the inactive form of MGP (dephosphorylated and uncarboxylated: dp-ucMGP) in a population of hemodialyzed (HD) patients. Results found in subjects being treated or not with vitamin K antagonist (VKA) were compared and the relationship between dp-ucMGP levels and the vascular calcification score were assessed. Methods: One hundred sixty prevalent HD patients were enrolled into this observational cohort study, including 23 who were receiving VKA treatment. The calcification score was determined (using the Kauppila method) and dp-ucMGP levels were measured using the automated iSYS method. Results: dp-ucMGP levels were much higher in patients being treated with VKA and little overlap was found with those not being treated (5604 [3758; 7836] vs. 1939 [1419; 2841] pmol/L, p <0.0001). In multivariate analysis, treatment with VKA was the most important variable explaining variation in dp-ucMGP levels even when adjusting for all other significant variables. In the 137 untreated patients, dp-ucMGP levels were significantly (p < 0.05) associated both in the uni- and multivariate analysis with age, body mass index, plasma levels of albumin, C-reactive protein, and FGF-23, and the vascular calcification score. Conclusion: We confirmed that the concentration of dp-ucMGP was higher in HD patients being treated with VKA. We observed a significant correlation between dp-ucMGP concentration and the calcification score. Our data support the theoretical role of MGP in the development of vascular calcifications. We confirmed the potential role of the inactive form of MGP in assessing the vitamin K status of the HD patients. [less ▲]

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See detailInter-method variability in bone alkaline phosphatase measurement : clinical impact on the management of dialysis patients
CAVALIER, Etienne ULg; Souberbielle, Jean-Claude; GADISSEUR, Romy ULg et al

in Clinical Biochemistry (2014), 47(13-14), 1227-30

BACKGROUND: Bone-specific alkaline phosphatase (BAP) is now recommended to assess bone turnover in hemodialysis (HD) patients. However, little is known about potential variability between methods ... [more ▼]

BACKGROUND: Bone-specific alkaline phosphatase (BAP) is now recommended to assess bone turnover in hemodialysis (HD) patients. However, little is known about potential variability between methods available to measure BAP. METHODS: We measured BAP in 76 HD patients with six different assays (Beckman-Coulter Ostase IRMA, Beckman-Coulter Ostase Access, IDS iSYS Ostase, IDS Ostase enzyme immunoassay, DiaSorin Liaison Ostase and Quidel MicroVue BAP). RESULTS: We observed a high correlation between all the assays ranging from 0.9948 (IDS iSYS vs. IDS EIA) to 0.9215 (DiaSorin Liaison vs. Quidel MicroVue). However, using the regression equations, the equivalent concentration of a Beckman-Coulter Access value of 10μg/L can range from 7.7 to 14.4μg/L and of 20μg/L can range from 16.9 to 27.9μg/L with other assays. According to Beckman-Coulter Access, 13%, 50% and 37% of the patients presented BAP values ≤10, between 10 and 20 and ≥20μg/L, respectively. Discrepancies are observed when other assays are used (concordance from 10 to 100%). CONCLUSIONS: Analytical problems leading to inter-method variation should be overcome to improve the usefulness of this marker in clinical practice. According to correlation results, recalibration of BAP assays is necessary but should not be a major issue. [less ▲]

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See detailBatch enzymatic interesterification of fat blends using microwave
Danthine, Sabine ULg; Simon, C.; Richel, Aurore ULg et al

Poster (2014, September)

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See detailEffect of AMF enrichment with 13C-­‐triacylglycerol tracers on its thermal and structural behavior
Danthine, Sabine ULg; Vors, C.; Michalski, M-C

Poster (2014, September)

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See detailEvaluation of Temocillin for treatment of nosocomial infections
LAYIOS, Nathalie ULg; CIUTEA, Mirela ULg; LONGUEVILLE, Manon et al

Poster (2014, September)

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See detailLes "PAPS "   Un projet visant à augmenter l’activité physique scolaire des enfants dans l’enseignement primaire
Cloes, Stéphanie; Cloes, Marc ULg

in Science & Sports (2014), 29(Hors-série 1), 53

Starting from Brain Breaks (HopSports) and during a teaching internship activity, the first author implemented one project of movement breaks (PAPS) in a class of 1st grade (6-7 year-old), a class of 5th ... [more ▼]

Starting from Brain Breaks (HopSports) and during a teaching internship activity, the first author implemented one project of movement breaks (PAPS) in a class of 1st grade (6-7 year-old), a class of 5th grade (10-11 year-old) and one of special education (11-15 year-old). PAPS have been proposed one to two times per day pendant periods of 2 to 4 weeks. Pupils' involvement, positive effects informally observed on academic learning and the wish of the pupils to continue the experience would support the interest of the movement breaks. [less ▲]

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See detailDroit électoral et principe d'égalité. L'élection des assemblées législatives nationales en droits allemand, belge et britannique
Bouhon, Frédéric ULg

Book published by Bruylant (2014)

The book concerns the election law and the equality principle in three European legal systems, i.e. the Federal Republic of Germany, the Kingdom of Belgium and the United Kingdom. In this framework, the ... [more ▼]

The book concerns the election law and the equality principle in three European legal systems, i.e. the Federal Republic of Germany, the Kingdom of Belgium and the United Kingdom. In this framework, the research is structured into two principal questions. I firstly wonder whether the election law guarantees equality among the governed people. Should the answer to that question be negative, I secondly check if the inequality can be legally justified in democratic systems. My thesis is a nuanced answer to these questions. The work shows that election law, considered under the scope of the equality principle, includes two categories of legislations which effect is opposed: some legal rules tend to distribute equally the faculty to influence the composition of the elected assemblies, while others tend to distribute unequally that faculty. Among the rules of the second category, I argue that the tendency to inequality can be partly legally justified by the purposes of these rules, but is also a mean – hardly justifiable in a democratic system – that helps persons and parties in government to remain in power. [less ▲]

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See detailTemperature management, statistical local results
KOCH, Jean-Noël ULg

Conference (2014, September)

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See detailConservation et biodiversité animale en Afrique centrale
Vermeulen, Cédric ULg; Linchant, Julie ULg

in Delvingt, Willy; Vermeulen, Cédric; Lebrun, Philippe (Eds.) et al La recherche dans les aires protégées d'Afrique centrale. Parcs et Réserves 69 (3). (2014)

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See detailβ 5 tubulin and 15-protofilament microtubules appeared in supporting cells of the Corti’s organ during development in rodents
Renauld, Justine ULg; Thelen, Nicolas ULg; Johnen, Nicolas et al

Conference (2014, August 31)

A feature of the organ of Corti’s supporting cells is the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor ... [more ▼]

A feature of the organ of Corti’s supporting cells is the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor mammalian tubulin, the β5-tubulin [1], recently related as a biomarker for cancer outcome [2] and cell proliferation [3]. It was shown that a β-tubulin isoform can specified the microtubule architecture, such as the expression of the Moth β2 in the Drosophila testes imposed the 16 protofilaments (16pf) structure on the corresponding subset of Drosophila microtubules, which normally contain 13pf [4]. Moreover, supporting cell microtubules are formed by 15pf instead of the canonical 13, a unique fact among vertebrates [5]. Such a protofilament configuration has been observed in C. elegans’ neurons which are responsible for the mechanosensory sense of touch [6]. It was also shown that these 15pf microtubules were essential to the proper functioning of these mechanosensory neurons [6]. To determine the role of this particular tubulin in the auditory organ and its possible involvement in the formation of the unusual 15pf microtubules of supporting cells, we studied the spatiotemporal localization of β5-tubulin during development in rats from embryonic day 18 until P25 (25th postnatal day). We also analyzed the localization of β5-tubulin mRNA expression in the Corti’s organ. Then we examined the fine structure of microtubules at the electron microscope level. For these experiments, we used an early postnatal stage and a late postnatal stage. Our results showed that β5-tubulin, contrary to other β-tubulins, had a unique distribution in the cochlea. This β-tubulin appeared at a postnatal stage, before the opening of the Corti’s tunnel and being restricted to supporting cells, especially in pillar and Deiters cells,. The same localization of β5-tubulin mRNA was observed by in Situ Hybridization. Electron microscopy indicated further that Pillar and Deiters cells were composed by 15-protofilament microtubules at the late postnatal stage (P25). In conclusion, all these data strongly suggest that there is a relationship between the presence of β5-tubulin and 15-protofilament microtubules in the supporting cells of the auditory organ. Further studies are now needed to elucidate their role. [less ▲]

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See detailAmélioration des moyens d'existence durables. Une voie pour la durabilité des exploitations agricoles familiales de coton au Bénin
Assogba, Claude Gervais; Tossou, C. R.; Lebailly, Philippe ULg et al

Conference (2014, August 30)

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See detailThe effects of a Global Agricultural Policy on the smallholder farmers in ending hunger
Paveliuc-Olariu, Codrin; Burny, Philippe ULg

Conference (2014, August 30)

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See detailL'agriculture de subsistance et de semi-subsistance en Roumanie
Dona, Ion; Burny, Philippe ULg

Conference (2014, August 30)

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See detailAspects économiques de la filière du vermicelle de tolomane au Vietnam
Le Thi Long, Vy; Vu Dinh, Ton; Lebailly, Philippe ULg et al

Conference (2014, August 30)

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See detailProblématique foncière chez les exploitants agricoles de la Province de Kirundo au nord du Burundi
Minani, Bonaventure; Rurema, Déo-Guide; Burny, Philippe ULg et al

Conference (2014, August 30)

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See detailAccelerating Random Forests in Scikit-Learn
Louppe, Gilles ULg

Conference (2014, August 29)

Random Forests are without contest one of the most robust, accurate and versatile tools for solving machine learning tasks. Implementing this algorithm properly and efficiently remains however a ... [more ▼]

Random Forests are without contest one of the most robust, accurate and versatile tools for solving machine learning tasks. Implementing this algorithm properly and efficiently remains however a challenging task involving issues that are easily overlooked if not considered with care. In this talk, we present the Random Forests implementation developed within the Scikit-Learn machine learning library. In particular, we describe the iterative team efforts that led us to gradually improve our codebase and eventually make Scikit-Learn's Random Forests one of the most efficient implementations in the scientific ecosystem, across all libraries and programming languages. Algorithmic and technical optimizations that have made this possible include: - An efficient formulation of the decision tree algorithm, tailored for Random Forests; - Cythonization of the tree induction algorithm; - CPU cache optimizations, through low-level organization of data into contiguous memory blocks; - Efficient multi-threading through GIL-free routines; - A dedicated sorting procedure, taking into account the properties of data; - Shared pre-computations whenever critical. Overall, we believe that lessons learned from this case study extend to a broad range of scientific applications and may be of interest to anybody doing data analysis in Python. [less ▲]

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See detailComputational homogenization of cellular materials with propagation of instabilities through the scales
Nguyen, Van Dung ULg; Noels, Ludovic ULg

Conference (2014, August 29)

The aim of this work is to develop an efficient multi–scale finite element framework to capture the buckling instabilities in cellular materials. As a classical multi–scale computational homogenization ... [more ▼]

The aim of this work is to develop an efficient multi–scale finite element framework to capture the buckling instabilities in cellular materials. As a classical multi–scale computational homogenization scheme looses accuracy with the apparition of the macroscopic localizations resulting from the micro–buckling, the second–order multi–scale computational homogenization scheme1 is considered. This second–order computational framework is herein enhanced with the following novelties so that it can be used for cellular materials. First, at the microscopic scale, the periodic boundary condition is used because of its efficiency. As the meshes generated from cellular materials exhibit a large void part on the boundaries and are not conforming in general, the classical enforcement based on the matching nodes cannot be applied. A new method based on the polynomial interpolation2 without the requirement of the matching mesh condition on opposite boundaries of the representative volume element (RVE) is developed. Next, in order to solve the underlying macroscopic Mindlin strain gradient continuum of this second–order scheme by the displacement–based finite element framework, the treatment of high order terms is based on the discontinuous Galerkin (DG) method to weakly impose the C1-continuity3. Finally, as the instability phenomena are considered at both scales of the cellular materials, the path following technique is adopted to solve both the macroscopic and microscopic problems4. The micro–buckling leading to the macroscopic localization and the size effect phenomena can be captured within the proposed framework. In particular it is shown that results are not dependent on the mesh size at the macroscopic scale during the softening response, and that they agree well with the direct numerical simulations. [less ▲]

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See detailLa place de la communication dans la gestion du risque sous l'angle de la responsabilité sociale: le cas des entreprises seveso
Robert, Jocelyne ULg; Frau, Maité; al

in Boudrandi, Stéphane; Delaye, Richard; Peretti, Jean-Marie (Eds.) L'audit social au service du progrès du management et de la bonne gouvernance-Proceedings (2014, August 29)

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See detailLower critical field and SNS-Andreev spectroscopy of 122-arsenides: Evidence of nodeless superconducting gap
Abdel-Hafiez, M.; Pereira, P.J.; Kuzmichev, S.A. et al

in Physical Review. B : Condensed Matter (2014), 90

Using two experimental techniques, we studied single crystals of the 122-FeAs family with almost the same critical temperature, Tc. We investigated the temperature dependence of the lower critical field ... [more ▼]

Using two experimental techniques, we studied single crystals of the 122-FeAs family with almost the same critical temperature, Tc. We investigated the temperature dependence of the lower critical field Hc1(T) of a Ca0.32Na0.68Fe2As2 (Tc ≈ 34 K) single crystal under static magnetic fields H parallel to the c axis. The temperature dependence of the London penetration depth can be described equally well either by a single anisotropic s-wave-like gap or by a two-gap model, while a d-wave approach cannot be used to fit the London penetration depth data. Intrinsic multiple Andreev reflection effect spectroscopy was used to detect bulk gap values in single crystals of the intimate compound Ba0.65K0.35Fe2As2, with the same Tc. We estimated the range of the large gap value L = 6–8 meV (depending on small variation of Tc) and its a k space anisotropy of about 30%, and the small gap Delta ≈ 1.7 ± 0.3 meV. This clearly indicates that the gap structure of our investigated systems more likely corresponds to a nodeless s-wave two gaps. [less ▲]

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