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See detailAdolescent delinquent behaviours as attempts of group social integration and well-being through social acceptance?
Born, Michel ULg; Cattelino, Elena; Gavray, Claire ULg et al

in Carneiro, Roberto; Carneiro, Maria Ana (Eds.) Youth, Offense and Well-Being . Can Science Enlighten Policy? (2015)

Large surveys in Western countries give pictures of adolescent well-being related to delinquency and group affiliation. The belonging to a particular country, city or neighbourhood with their social ... [more ▼]

Large surveys in Western countries give pictures of adolescent well-being related to delinquency and group affiliation. The belonging to a particular country, city or neighbourhood with their social structure influences the probability to have delinquent activities in group increasing or decreasing the risk of marginalisation, the sensibility to deviant values and the well-being related to peers’ acceptance. A general process would exist by which, firstly adolescents oppose themselves to the parents’ authority and seek for acceptance among their peers. This leads to a spiral when the youth tries to resolve his cognitive dissonance between the immoral acts he is invited to commit with his friends and his personal value system learned in his family, school and other institutions. In adolescence, the influence of peers can be positive or negative; it can be “protective peer-contagion” with positive response to normative talk or “deviant peer-contagion” with positive response to deviant talk or behaviour. At the micro level, well-adjusted peers are able to resist the influence of deviant peers. The participation to non-homogenous mixed groups seems to facilitate more normative talks. This leads to the hypothesis that the progressive extension to differentiated groups when adolescence is going through will strengthen their ties with conventional norms and contribute to their well-being. [less ▲]

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See detailHigh output [18F]FDOPA on AllInOne (Trasis) at commercial scale
Otabashi, Muhammad; Cascione, Christian; Lemaire, Christian ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2015, May), 58

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See detailA spectroscopic investigation of the O-type star population in four Cygnus OB associations. II. Determination of the fundamental parameters
Mahy, Laurent ULg; Rauw, Grégor ULg; De Becker, Michaël ULg et al

in Astronomy and Astrophysics (2015), 577

Aims: Having established the binary status of nineteen O-type stars located in four Cygnus OB associations, we now determine their fundamental parameters to constrain their properties and their ... [more ▼]

Aims: Having established the binary status of nineteen O-type stars located in four Cygnus OB associations, we now determine their fundamental parameters to constrain their properties and their evolutionary status. We also investigate their surface nitrogen abundances, which we compare with other results from the literature obtained for galactic O-type stars. Methods: Using optical spectra collected for each object in our sample and some UV data from the archives, we apply the CMFGEN atmosphere code to determine their main properties. For the binary systems, we have disentangled the components to obtain their individual spectra and investigate them as if they were single stars. Results: We find that the distances of several presumably single O-type stars seem poorly constrained because their luminosities are not in agreement with the "standard" luminosities of stars with similar spectral types. The ages of these O-type stars are all less than 7 Myr. Therefore, the ages of these stars agree with those, quoted in the literature, of the four associations, except for Cyg OB8 for which the stars seem older than the association itself. However, we point out that the distance of certain stars is debatable relative to values found in the literature. The N content of these stars put in perspective with N contents of several other galactic O-type stars seems to draw the same five groups as found in the "Hunter" diagram for the O and B-type stars in the LMC even though their locations are obviously different. We determine mass-loss rates for several objects from the Halpha line and UV spectra. Finally, we confirm the "mass discrepancy" especially for O stars with masses smaller than 30 Msun;. [less ▲]

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See detailAnatomic features underlying wood density, in 110 rainforest tree species from central Congo basin
de Haulleville, Thalès ULg; Rousseau, Mélissa; Morin-Rivat, Julie ULg et al

Poster (2015, May)

Investigate the influence of fiber thickness and vessel diameter on the wood density in 110 rainforest tree species, and the relationships between wood density, wood water content and shrinking ratio.

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See detailPancreatitis in familial hypocalciuric hypercalcaemia
Potorac, Iulia ULg; MALAISE, Olivier ULg; Daly, Adrian ULg et al

in Endocrine Abstracts (2015, May)

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See detailFiches techniques de mesure de la biomasse
Bauwens, Sébastien ULg; Fayolle, Adeline ULg; Dubiez, Emilien et al

Report (2015)

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See detailIn silico screening to predict chondrocyte hypertrophy using a semiquantitative gene network model
Kerkhofs, Johan ULg; Leijten, Jeroen; Luyten, Frank et al

Poster (2015, April 30)

PURPOSE: In development, chondrocyte hypertrophy is a crucial and well-studied step in endochondral ossification. Hypertrophy may also play a role in pathophysiological processes, including osteoarthritis ... [more ▼]

PURPOSE: In development, chondrocyte hypertrophy is a crucial and well-studied step in endochondral ossification. Hypertrophy may also play a role in pathophysiological processes, including osteoarthritis. We employ a computational approach to estimate the effect of individual factors in this complex process. METHODS: We have combined information gleaned from a high number of publications on chondrocyte differentiation into a gene regulatory network of 46 factors and over 150 interactions. This network can estimate the stability of proliferative chondrocytes/permanent cartilage (stable state with SOX9 activity) and hypertrophic chondrocytes (stable state with RUNX2 activity) by employing 2 measures. A first measure is a Monte Carlo analysis that assesses stability in the face of random initial conditions, the second modifies stable states to estimate the sensitivity to perturbation. RESULTS: For each factor, these qualitative measures are calculated in silico under knockout and overexpression conditions and compared to the wild type situation. This enables screening of the effects of all incorporated factors on cartilage homeostasis, differentiation and pathogenesis via the initiation of hypertrophy. Indeed, our gene network analysis indicated multiple candidate genes for the development of osteoarthritis. Factors that amplify the SOX9 attractor basin include TGFβ, PPR, IGF-I, and PKA. The presence of RAS, IHH, GLI2 and FGF is required for the Runx2 stable state. Using a literature study, we corroborated several of the proposed factors. CONCLUSIONS: In silico screening of overexpression and knockout presents a novel strategy to improve bone and cartilage tissue engineering approaches, and can be used to propose a list of putative therapeutic targets for e.g. osteoarthritis. [less ▲]

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See detailLes réseaux scientifiques du Roi en Belgique
Pirot, Pascal ULg

Conference (2015, April 30)

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See detailRepresenting a Minority Group in Multinational Federal Systems: Career Patterns in Catalonia, Scotland and Wallonia
Dodeigne, Jérémy ULg

Doctoral thesis (2015)

Dans nos démocraties représentatives, comprendre « qui » gouverne et plus précisément « comment » et « pourquoi » certains accèdent aux positions de pouvoir a toujours été un enjeu démocratique majeur ... [more ▼]

Dans nos démocraties représentatives, comprendre « qui » gouverne et plus précisément « comment » et « pourquoi » certains accèdent aux positions de pouvoir a toujours été un enjeu démocratique majeur. Avec les processus de régionalisation et de fédéralisation observés à travers le monde, cette question s’est complexifiée en raison de la multiplication des lieux de décision politique. Dans de nombreux pays, les représentants politiques évoluent désormais dans des systèmes multi-niveaux. L’une des conséquences directes de ces réformes institutionnelles est la transformation des carrières parlementaires, particulièrement dans les régions minoritaires des états plurinationaux comme la Belgique, l’Espagne et le Royaume-Uni. L’objectif de cette recherche doctorale est double. D’une part, elle cherche à définir l’orientation régionale et/ou nationale qui caractérise la carrière des élus depuis l’instauration des assemblées régionales. D’autre part, elle vise à identifier les facteurs qui expliquent l’émergence de ces différents types de carrières. À cette fin, la thèse développe une étude comparée de la Catalogne, de l’Écosse et de la Wallonie qui combine analyses quantitatives et qualitatives. Une des conclusions majeures de cette recherche est que le niveau de pouvoir régional est devenu une arène politique de plus en plus attractive – voire prédominante pour certains acteurs. Toutefois, contrairement à ce qui fut suggéré par des études antérieures, les parlements nationaux espagnol, britannique et belge continuent d’être des arènes politiques attractives pour les élus catalans, écossais et wallons. [less ▲]

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See detailCompétitivité, valorisation des ressources et objectifs de sécurité alimentaire pour la filière sucrière au Maroc
Redani, Latifa ULg

Doctoral thesis (2015)

The general objective of this work is to examine the coherence between food security policies and economic efficiency and valuation of resources policies for the sugar sub-sector in Morocco. A food ... [more ▼]

The general objective of this work is to examine the coherence between food security policies and economic efficiency and valuation of resources policies for the sugar sub-sector in Morocco. A food security policy implies state intervention and thus leads implicitly to market distortions, while a resource valuation policy would imply a free market. To address this issue, I will firstly adopt an approach that involves a sugar market analysis (measuring determinants of demand and changes in international prices against their impact on food security). Then, an economic analysis which attempts at assessing the competitiveness of the various segments of the sugar sub-sector will be undertaken. Finally, an analysis of the relative valuation of resources (capital, labor and irrigation water) by sugar crops compared to different irrigated crops will be led, in order to determine their private and social returns on. The analysis of demand during the period between 2000 and 2010 shows that the trend of domestic consumption witnessed major increases, which lead to the enhancement of food insecurity for sugar in the future. The analysis of volatility of world sugar prices from 1960 to 2010, through the decomposition method of time series, allows the isolation of an accidental effect, which reflects variability due neither to seasonal effects nor to trend. This accidental effect is mainly marked during three periods: 1973-1975, 1980-1981 and 2009-2010. In terms of food security, these fluctuations in world sugar prices have no impact on household access to sugar, yet they have a significant impact on state budget. Any variation in prices in the international market is absorbed by the compensation system since prices are regulated by this system. The food safety policy conducted during the sixties and seventies have mitigated the country's dependence on imports and thus reduce the impact of world sugar price fluctuations. However, this policy has often been criticized in terms of market efficiency and valuation of resources. The economic analysis of the sugar sub-sector in Morocco shows that the different segments of the value chain don’t enjoy the same level of protection. If the production segment of sugar beet doesn’t receive any protection, the processing segment of raw sugar will remain protected. However, the level of this protection has generally declined during the post structural adjustment period. In terms of competitiveness, while the sugar beet crop becomes competitive, the effective competitiveness of the industrial segment, and given the significant distortions in the world market, is difficult to assess. The analysis of the valuation of resources (capital, labor and water) shows that sugar crops, especially sugar beets, value relatively better capital resources and labor than most horticultural crops. They occupy an important position in terms of employment and value added created per hectare. However, the valuation of irrigation water remains low for sugar beet (excluding the region of Doukkala). But the technology trend shows substantial opportunities for improvement. Food security policy for sugar has been efficient since it helped establish a competitive national production which is generally able to value resources better. The distortions introduced by state intervention gave the time to farmers to improve their technical skills and to become competitive in the framework of international market, marked as it was by significant distortions. Finally, a food security policy is in no way inconsistent with a policy of valuation of resources on the condition that when the sub-sector becomes competitive, a way to market mechanisms must be given. [less ▲]

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See detailCes années incroyables : Programme d’aide aux parents 
Boulard, Aurore ULg; Mathys, Cécile ULg

Conference given outside the academic context (2015)

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See detailPoint de vue scientifique : l'impression 3D des aliments
Goffin, Dorothée ULg

Conference given outside the academic context (2015)

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See detailL'opposition et le délai de prescription de la peine
Michiels, Olivier ULg

in Revue de Droit Pénal et de Criminologie (2015)

L'opposition formée après le délai de prescription de la peine prononcée par défaut est, sauf cas de force majeure, irrecevable.

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See detailEffondrement culturel à l'île de Pâques ? Ce qu'en dit l'archéologie.
Flas, Damien ULg; Cauwe, Nicolas ULg

Conference given outside the academic context (2015)

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See detailCochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling
Defourny, Jean; Mateo Sanchez, Susana ULg; Schoonaert, Lies et al

in Nature Communications (2015)

In mammals, cochlear sensory hair cells that are responsible for hearing are postmitotic and are not replaced after loss. One of the most promising strategies to regenerate hair cells is to identify and ... [more ▼]

In mammals, cochlear sensory hair cells that are responsible for hearing are postmitotic and are not replaced after loss. One of the most promising strategies to regenerate hair cells is to identify and inhibit the factors preventing the conversion of adjacent non-sensory supporting cells into hair cells. Here we demonstrate that mammalian hair cells can be directly generated from supporting cells by inhibition of ephrin-B2 signalling. Using either ephrin-B2 conditional knockout mice, shRNA-mediated gene silencing or soluble inhibitors, we found that downregulation of ephrin-B2 signalling at embryonic stages results in supporting cell translocation into hair cell layers and subsequent switch in cell identity from supporting cell to hair cell fate. As transdifferentiation is here a result of displacement across boundary, this original finding presents the interest that newly generated hair cells directly integrate either hair cell layer, then would be likely more rapidly able to fit into functional circuitry. [less ▲]

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