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See detailExperimental study and modeling of the quasi-static mechanical behavior of Ti6Al4V at room temperature
Gilles, Gaëtan ULg

Doctoral thesis (2015)

The work aims to characterize the quasi-static mechanical behavior of the Ti6Al4V titanium alloy at room temperature and to describe it by a phenomenological model. The thesis is divided in four parts ... [more ▼]

The work aims to characterize the quasi-static mechanical behavior of the Ti6Al4V titanium alloy at room temperature and to describe it by a phenomenological model. The thesis is divided in four parts. The first one presents a literature review of the basic properties of titanium and its alloys (crystal structure, classification, deformation mechanisms), then it focuses on the specific mechanical features of Ti6Al4V. It also proposes a state of art in the field of the phenomenological constitutive laws used to model the mechanical behaviors of metals. The second part deals with the experimental campaign conducted on a 0.6 mm thick Ti6Al4V sheet. The devices and the tests are first described before giving the test results. The campaign includes experiments with monotonic and complex strain paths (tension, compression, simple shear, plane strain, Bauschinger tests, deep-drawing processes, layer compression tests). The experimental results show that the material displays anisotropy in yield stress, r-ratios and hardening, as well as a strength differential effect between tension and compression. The third part describes the implementation of the yield criteria CPB06exn in the non-linear finite element code LAGAMINE developed in MSM team. These criteria are selected to model the yield locus of Ti6Al4V since they are able to take into account both the anisotropy and the tension-compression asymmetry exhibited by the alloy. Several parameter identifications are performed using the classical simulated annealing algorithm. They determine that CPB06ex2 is required to represent the yield surface. The criterion is next associated to different hardening formulations: (1) Voce isotropic law; (2) mixed Voce isotropic – Armstrong-Frederick kinematic law; (3) model taking into account the evolution of the yield locus shape with the deformation. The identification of the hardening parameters is achieved from the monotonic and Bauschinger tests either by inverse method, or by the simulated annealing method. The last part of the thesis proposed a validation of the different modelings in the case of the layer compression tests and the deep-drawing processes. [less ▲]

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See detailVertical Distribution of Functional Potential and Active Microbial Communities in Meromictic Lake Kivu
İnceoğlu, Özgul; Llirós, Marc; Crowe, Sean A. et al

in Microbial Ecology (2015)

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See detailLes méthodes de prise en charge et de rééducation cognitives
DELRUE, Gaël ULg

Conference (2015, April 25)

Présentation des méthodes de prise en charge neurocognitives de patients traumatisés crâniens légers.

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See detailAge at Retirement: New Proxy of Cognitive Reserve? Results from a French Population-Based Study
Grotz, Catherine ULg; Meillon, Céline; Amieva, Hélène et al

Conference (2015, April 25)

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See detailEffect of nanocrystalline structure on magnetocaloric effect in manganite composites (1/3)La0.7Ca0.3MnO3/(2/3)La0.8Sr0.2MnO3
Pękała, M; Pękała, K; Drozd, V et al

in Journal of Alloys & Compounds (2015), 629

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See detailHenri Pirenne à Liège ou l'ambition (1878-1885). La genèse d’un réseau académique et politique
Genin, Vincent ULg

Conference given outside the academic context (2015)

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See detailWerner Herzog et Alexander Kluge. Regards croisés sur le Nouveau Cinéma Allemand.
Hamers, Jérémy ULg

Conference (2015, April 25)

Alexander Kluge et Werner Herzog sont assurément deux figures antipodiques dans l’histoire du cinéma allemand. L’engagement politique tout d’abord, indissociable de la création audiovisuelle pour le ... [more ▼]

Alexander Kluge et Werner Herzog sont assurément deux figures antipodiques dans l’histoire du cinéma allemand. L’engagement politique tout d’abord, indissociable de la création audiovisuelle pour le premier, objet de méfiance si pas de rejet pour le second, oppose manifestement ces deux figures de proue du Nouveau Cinéma Allemand, un courant dont l’acte de naissance, le manifeste d’Oberhausen de 1962, coïncide avec les débuts cinématographiques des deux auteurs. Leurs esthétiques respectives ensuite confirment le gouffre irréductible qui semble les séparer. Enfin, auteurs l’un et l’autre d’œuvres théoriques sur le cinéma, ils défendent deux approches réflexives de la création audiovisuelle qui apparaissent a priori comme inconciliables. En première lecture, Kluge et Herzog incarnent donc toute l’hétérogénéité bien connue du Nouveau Cinéma Allemand. À rebours de ce constat largement répandu dans les histoires de ce courant cinématographique, et sans pour autant réconcilier les deux auteurs à tout prix, un regard croisé sur quelques-uns de leurs films (e.a. Gelegenheitsarbeit einer Sklavin et Die Artisten in der Zirkuskuppel : ratlos pour Kluge ; Fata Morgana et Fitzcarraldo pour Herzog) et textes (e.a. les écrits d’Ulm de Kluge et la déclaration du Minnesota de Herzog) permet de dégager plusieurs points de rencontre entre les œuvres des deux cinéastes. Partant plus particulièrement de leurs conceptions de la rencontre entre documentaire et fiction, rencontre essentielle pour l’un comme pour l’autre, il s’agira d’en dégager les similitudes et résonances pour mieux comprendre, grâce à un éclairage réciproque, l’une et l’autre de ces œuvres essentielles du cinéma allemand des années soixante, septante et quatre-vingt. [less ▲]

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See detailLe crime en obsession : "Chien enragé" d'Akira Kurosawa
Tomasovic, Dick ULg

Conference given outside the academic context (2015)

Analyse du film "Chien enragé" d'Akira Kurosawa (1949) et de son contexte de création.

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See detailLes appareils idéologiques du Prince. Une lecture de “Machiavel et nous” (Althusser)
Mancuso, Eva ULg

Scientific conference (2015, April 25)

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See detailTumor suppressive p53 signaling empowers metastatic inhibitor KLF17-dependent transcription to overcome tumorigenesis in non-small cell lung cancer.
Ali, Amjad ULg; Zeeshan Bhatti M; Saboor Shah A et al

in Journal of Biological Chemistry (2015)

Metastasis, which is controlled by concerted action of multiple genes, is a complex process, and is important cause of cancer death. KLF17 is a negative regulator of metastasis and epithelial-mesenchymal ... [more ▼]

Metastasis, which is controlled by concerted action of multiple genes, is a complex process, and is important cause of cancer death. KLF17 is a negative regulator of metastasis and epithelial-mesenchymal-transition (EMT) during cancer progression. However, the underlying molecular mechanism and biological relevance of KLF17 in cancer cells are poorly understood. Here, we show that tumor suppressor protein p53 plays an integral role to induce KLF17 expression in NSCLC. p53 is recruited to KLF17 promoter and results in the formation of p53-DNA complex. p53 enhances binding of p300, and favors histone acetylation on KLF17 promoter. Mechanistically, p53 physically interacts with KLF17 and thereby enhances anti-metastatic function of KLF17. p53 empowers KLF17 mediated EMT genes transcription via enhancing physical association of KLF17 to target gene promoters. Nutlin-3 recruits KLF17 to EMT target gene promoters and results in the formation of KLF17-DNA complex via p53-dependent pathway. p53 depletion abrogates DNA binding affinity of KLF17 to EMT target gene promoters. KLF17 is critical for p53 cellular activities in NSCLC. Importantly, KLF17 enhances p53 transcription to generate a novel positive feedback loop. KLF17 depletion accelerates lungs cancer cells growth in response to chemotherapy. Mechanistically, we found that KLF17 increases tumor suppressor genes p53, p21 and pRB expressions in NSCLC. Functionally, KLF17 required p53 to suppress cancer cell invasion and migration in NSCLC. In sum, our study highlights novel insight into anti-EMT affect of KLF17 via p53-dependent pathway in NSCLC, and KLF17 may be a new therapeutic target in NSCLC with p53 status. [less ▲]

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See detailREGg is critical for skin carcinogenesis by modulating the Wnt/b-catenin pathway
Lei Li; Yongyan Dang; Jishen Zhang et al

in nature communications (2015)

Here we report that mice deficient for the proteasome activator, REGg, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia ... [more ▼]

Here we report that mice deficient for the proteasome activator, REGg, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts. Interestingly, a massive increase of REGg in skin tissues or cells resulting from TPA induces activation of p38 mitogen-activated protein kinase (MAPK/p38). Blocking p38 MAPK activation prevents REGg elevation in HaCaT cells with TPA treatment. AP-1, the downstream effector of MAPK/p38, directly binds to the REGg promoter and activates its transcription in response to TPA stimulation. Furthermore, we find that REGg activates Wnt/b-catenin signalling by degrading GSK-3b in vitro and in cells, increasing levels of CyclinD1 and c-Myc, the downstream targets of b-catenin. Conversely, MAPK/p38 inactivation or REGg deletion prevents the increase of cyclinD1 and c-Myc by TPA. This study demonstrates that REGg acts in skin tumorigenesis mediating MAPK/p38 activation of the Wnt/b-catenin pathway. [less ▲]

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See detailDisrupting the wall accumulation of human sperm cells by artificial corrugation
Guidobaldi, H.A.; Jeyaram, Y.; Condat, C.A. et al

in Biomicrofluidics (2015), 9

Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very di erent from that observed in the bulk. Swimming along walls is bene cial for ... [more ▼]

Many self-propelled microorganisms are attracted to surfaces. This makes their dynamics in restricted geometries very di erent from that observed in the bulk. Swimming along walls is bene cial for directing and sorting cells, but may be detrimental if homogeneous populations are desired, such as in counting microchambers. In this work, we characterize the motion of human sperm cells 60 um long, strongly confi ned to 25u m shallow chambers. We investigate the nature of the cell trajectories between the con fining surfaces and their accumulation near the borders. Observed cell trajectories are composed of a succession of quasi-circular and quasi-linear segments. This suggests that the cells follow a path of intermittent trappings near the top and bottom surfaces separated by stretches of quasi-free motion in between the two surfaces, as confi rmed by depth resolved confocal microscopy studies. We show that the introduction of arti cial petal-shaped corrugation in the lateral boundaries removes the tendency of cells to accumulate near the borders, an e ffect which we hypothesize may be valuable for micro fluidic applications in biomedicine. [less ▲]

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See detailLe futur du vieillissement de la population en Wallonie
Delvenne, Pierre ULg

Conference given outside the academic context (2015)

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See detailEffects of enzymatic hydrolysis on conformational and functional properties of chickpea protein isolate
Ghribi, Abir Mokni; Maklouf Gafsi, Ines; Sila, Assaâd et al

in Food Chemistry (2015), 187

The impact of enzymatic hydrolysis by Alcalase on the conformational and functional properties of chickpea protein isolate (CPI) was investigated. The physicochemical, interfacial tension and surface ... [more ▼]

The impact of enzymatic hydrolysis by Alcalase on the conformational and functional properties of chickpea protein isolate (CPI) was investigated. The physicochemical, interfacial tension and surface characteristics of CPI and their hydrolysates (CPH) according to the degree of hydrolysis (DH) were also determined. These parameters were then related to the changes in the emulsification activity (EAI) and stability (ESI). The enzymatic hydrolysis was found to improve protein recovery and solubility, leading to a reduction in the molecular weight bands with a concomitant increase in the intensity and appearance of protein bands having apparent molecular mass below 20 kDa. The interfacial tension decreased from _66.5 mN m_1 for CPI to _59.1 mN m_1 for CPH. A similar trend was observed for the surface charge which declined from _27.55 mV to _16.4 mV for the CPI and CPH, respectively. These changes were found to have a detrimental effect on the EAI and ESI values. [less ▲]

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See detailRetour au travail après un cancer du sein
Mairiaux, Philippe ULg; Schippers, Nathalie ULg; DESREUX, Joëlle ULg et al

Conference (2015, April 23)

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See detailEfficient one-pot synthesis of trans- Pt(II)(salicylaldimine)(4-picoline)Cl complexes: Effective agents for enhanced expression of p53 tumor suppressor genes
Faiz-Ur-Rahman; Ali, Amjad ULg; Rong Guo et al

in Dalton Transactions (2015)

A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were ... [more ▼]

A series of trans-Pt(II)(salicylaldimine)(4-picoline)Cl complexes were synthesized in 78‒87% yield using one-pot procedure from commercially available precursors. The structures of these complexes were characterized by 1H, 19F and 13C NMR spectroscopy, HRMS (ESI) as well as single crystal X-ray analysis. Bioactivity investigations including bio-assay, time- and dosedependent, cell cycle progression study, caspase 3 and 9 apoptosis marker assay and DNA interaction using pBR322 plasmid DNA by gel electrophoresis were performed. The results indicated that the complexes showed promising in vitro cytotoxicity in MCF-7 and A549 cancer cell lines. Moreover these complexes enhanced the expression of p53 tumor suppressor gene family members such as p63 and p73. [less ▲]

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