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See detailOutils d’étude pour caractériser l’impact de l’ hydrodynamique sur la culture de cellules animales adhérentes cultivées sur microporteurs en bioréacteurs à cuve agitée
Collignon, Marie-Laure ULg

Conference (2014, July 10)

Cette présentation montre l'importance du choix des conditions d'agitation lors de la culture de cellules animales adhérentes sur microporteurs en bioréacteurs à cuve agitée. Elle montre des exemples d ... [more ▼]

Cette présentation montre l'importance du choix des conditions d'agitation lors de la culture de cellules animales adhérentes sur microporteurs en bioréacteurs à cuve agitée. Elle montre des exemples d'outils pour caractériser à l'échelle locale l'hydrodynamique au sein de ces bioréacteurs et une approche Euler-Lagrange qui a terme permettra de faire le lien entre l'hydrodynamique et la réponse cellulaire grâce à l'établissement de l'historique de conditions rencontrées localement par les cellules. [less ▲]

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See detailLiterature through Technology. Depicting the Future of the Book from Verne to Barjavel
Stienon, Valérie ULg

Conference (2014, July 10)

French futuristic novels tend to develop a wide range of representations regarding the book of the future as it is impacted by technical inventions, from the phone to the digital paradigm through ... [more ▼]

French futuristic novels tend to develop a wide range of representations regarding the book of the future as it is impacted by technical inventions, from the phone to the digital paradigm through photography and film: Albert Robida’s “phono-livre” (La Vie électrique, 1890), Octave Uzanne’s “storyographe” powered by electricity from the human body, Henri Allorge’s “bibliophone” (Le grand cataclysme, 1922), Léon Daudet’s “cinébiblat” and “cinélivre” (Le Napus, 1927), Maurice Renard’s telepathic book (Un homme chez les microbes, 1928) or even René Barjavel’s “télélecture” (Ravage, 1943) among others. It is well known that the historical antagonism between Science and the Humanities deeply influenced the disciplinary boundaries and the respective values of the two fields. But it also appears that such a disciplinary discussion does involve the issue of the material and tangible forms of the book considered as an object. Futuristic novels put a specific emphasis on the acoustic, visual and tactile avatars of the book within a sociocultural context characterized by the rise of Applied Sciences and media communication. Do these new media and formats compete with or complement to the former book patterns? Are such representations of the book as an audiovisual item some response to the predicted decline of the Humanities? Or are they rather a means of asserting the faith in a new forthcoming kind of literature? Although science may badly affect literature so as to produce an impoverishing mechanization of literary style (Jules Verne, Paris au XXe siècle, 1863), it also gives a valuable opportunity to create more ergonomic formats for a wider distribution and a more easily handheld book. Since the late 19th century until WWII, many futuristic novels propose to consider the book as it is located at the junction of Science and the Humanities rather than in their dichotomous opposition. Regarded as a specific leitmotiv, such a topic of technological and transmedia conversions of the book leads to reconsider the evolution of the identity paradigm of France as a “literary nation”. It also gives the opportunity to investigate the discrepancies and coincidences between the conjectural scope of these futuristic novels and the factual history of technological advances. [less ▲]

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See detailCommentaire sur l'étude: « Belgique-Maroc, 50 années de migration »
Martiniello, Marco ULg

Scientific conference (2014, July 10)

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See detailSupercritical CO2, impregnation to prepare drug-loaded implants: inpregantion of anti-inflammatory drugs into sutures
Champeau, Mathilde; Tassaing, Thierry; Thomassin, Jean-Michel ULg et al

Conference (2014, July 10)

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See detailSynthesis of degradable polyphosphoester copolymers for templating calcium carbonate drug delivery carriers
Ergül, Zeynep ULg; Debuigne, Antoine ULg; Calvignac, Brice et al

Conference (2014, July 09)

Degradable acid bearing polyphosphoester (PPE) copolymers were prepared by combination of organocatalyzed ring opening polymerization and click chemistry. Their solution behavior and ability to complex ... [more ▼]

Degradable acid bearing polyphosphoester (PPE) copolymers were prepared by combination of organocatalyzed ring opening polymerization and click chemistry. Their solution behavior and ability to complex calcium ions were studied as well as their capacity to template CaCO3 particles dedicated to drug delivery. [less ▲]

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See detailWhich links exist between depression, engagement in activities’ level and several psychological processes?
Wagener, Aurélie ULg; Blairy, Sylvie ULg

Poster (2014, July 09)

In Europe, depression affects 33.4 millions of people every year. According to the World Health Organization, depression will be the leading cause of disabilities in 2030. This highlights the need for ... [more ▼]

In Europe, depression affects 33.4 millions of people every year. According to the World Health Organization, depression will be the leading cause of disabilities in 2030. This highlights the need for available, effective and efficient treatments of this psychopathology. In order to offer such treatments, there is a need for a deep understanding of depression’s mechanisms. Depression is characterized by a decrease of the level of engagement in activities: for instance, depressed patients stay in bed, don’t see friends, don’t go out anymore and can be on sick leave for a long period of time. Reciprocally, this decrease maintains depressive symptoms. This link between depression and level of engagement in activities is well-established in the scientific literature. However, no study has, until yet, determined which psychological processes are mediators of this link. Therefore, this study’s aim is to determine these psychological processes. In order to reach this aim, 500 subjects, suffering from psychopathology or not, will fulfill a set of questionnaires. These questionnaires will assess mood (anxiety and depression), level of engagement in activities and five categories of psychological processes that have been selected from different theoretical models of depression (self-image, environmental satisfaction, negative repetitive thoughts, experiential avoidance and emotional regulation). Statistical analysis will be performed in order to confirm a LISREL model. Data collection is ongoing and results will be presented and discussed during the congress. [less ▲]

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See detailApproximation algorithms for multi-dimensional vector assignment problems
Crama, Yves ULg

Conference (2014, July 09)

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See detailApplication of multiple-point geostatistics on groundwater flow and transport in media with complex geological heterogeneity: lessons learnt and remaining challenges
Huysmans, Marijke; Dassargues, Alain ULg

in Proceedings (2014, July 09)

Multiple-point geostatistics has been increasingly applied on groundwater problems in the last ten years. Several case studies have been published indicating simulating realistic geological heterogeneity ... [more ▼]

Multiple-point geostatistics has been increasingly applied on groundwater problems in the last ten years. Several case studies have been published indicating simulating realistic geological heterogeneity using multiple-point geostatistics can significantly improve groundwater flow and solute transport predictions. There are however several remaining challenges when applying multiple-point geostatistics to groundwater problems often suffering from data scarcity. These challenges might be the reason why multiple-point has been used to a much lesser extent by practitioners than by researchers. This paper gives an overview of the current challenges and discusses new advancements to overcome them. The following questions will be discussed: How to obtain 3D training images? Can the representativity of the used training image be validated ? How sensitive are groundwater calculations to the selection of the training image? Is it worth incorporating fine scale geological heterogeneity in groundwater problems or are other features (boundary conditions, data uncertainty/quality, …) more important for improving predictions? How can multiple-point geostatistics be used without suffering from very long computation times for the numerical models? Is overparametrization of groundwater models an issue ? What are the practical obstacles to apply multiple-point geostatistics by groundwater practitioners? [less ▲]

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See detailLarge-scale stochastic optimization using non-stationary geostatistics for uncertainty assessment of groundwater flow and solute transport, in the framework of a near surface radioactive waste disposal
Rogiers, Bart; Laloy, E.; Gedeon, Matej et al

Poster (2014, July 09)

Uncertainty quantification is very much needed to support decision making related to e.g. environmental impact assessment for waste disposal sites. A probabilistic result provides a much stronger basis ... [more ▼]

Uncertainty quantification is very much needed to support decision making related to e.g. environmental impact assessment for waste disposal sites. A probabilistic result provides a much stronger basis for decision making compared to a single deterministic outcome. Accurate posterior exploration of high-dimensional and CPU-intensive models, which are often used for environmental impact assessment, is however a challenging task. To quantify the uncertainty associated with solute transport in the framework of a near surface radioactive waste disposal in Mol/Dessel, Belgium, we investigate combining the adaptive Metropolis (AM) McMC algorithm for updating the global model parameters, and adaptive spatial resampling (ASR) for updating of the spatially distributed model parameters, by block sampling. The forward model used is a groundwater flow model conditioned on borehole and direct push data, that accounts for non-stationary heterogeneity in hydraulic conductivity. The obtained flow solutions are used for solute transport simulations, and the results are compared with a different groundwater flow model parameterization, that makes use of homogeneous hydrogeological layers. Moreover, a number of simulations is performed to assess the effect of realistic dispersivity, which is derived from outcrop investigations. The obtained results indicate that the combination of AM and ASR using block sampling seems not to be very efficient for McMC sampling with the forward model used in this study. However, using the algorithm in optimization mode seems to work fine, and provides an alternate way for exploring the parameter space and the prediction uncertainty. [less ▲]

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See detailEuropean Renal Best Practice Guideline on kidney donor and recipient evaluation and perioperative care
Abramowicz, Daniel; Cochat, Pierre; Claas, Frans H.J et al

in Nephrology Dialysis Transplantation (2014)

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See detailA longitudinal perspective of alcohol use among adolescents: the predictive role of peers and internalizing factors.
Schmits, Emilie ULg; Glowacz, Fabienne ULg; Quertemont, Etienne ULg

Poster (2014, July 09)

Alcohol is the most commonly used psychoactive substance among teenagers. Consumption is influenced by environmental factors and personal characteristics, events or experiences. High use can lead to ... [more ▼]

Alcohol is the most commonly used psychoactive substance among teenagers. Consumption is influenced by environmental factors and personal characteristics, events or experiences. High use can lead to substantial problems, especially after an early consumption. Detecting and preventing an increase of alcohol use among teenagers, through the identification of risk and protective factors, seems essential in terms of public health. This study aimed to examine the progression of use in young teenagers, to identify protective and risk factors of alcohol use (including peers and internalizing factors) and to specifically focus on the influence of social anxiety. A questionnaire was administered twice to 877 teenagers (49.94% female, M=15.61) with one year interval (T1 and T2). Sex, age, alcohol use, number of friends, social comparison, trait-anxiety, social anxiety and depression were assessed through validated scales. T-test for paired sample and hierarchical regressions were performed. During the follow-up year, the average alcohol use significantly increased. A positive social comparison at T1 significantly predicted alcohol use at T2. The more teenagers positively compared themselves to their friends and felt popular, the more they consume alcohol. A similar significant effect was demonstrated for depression. The more young people manifested depressive affects at T1, the more they used alcohol at T2. However, social anxiety significantly protected from this substance use. More social anxiety at T1 was associated with less alcohol consumption at T2. The number of friends and trait-anxiety at T1 did not significantly influence alcohol use at T2. A positive social comparison and depressive affects could be considered as risk factors, whereas social anxiety could be defined as protective factor. At this developmental period, young people suffering from social anxiety symptoms subsequently use less alcohol, maybe due to the lack of contact with this substance usually socially consumed, whereas more popular and integrated teenagers are more at risk. The present results challenge the tension-reduction model according to which alcohol is consumed to reduce anxious affects and to facilitate social relationships. However, results suggest that alcohol might be used to reduce unpleasant depressive affects. [less ▲]

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See detailThe consumption of pornography and sexuality during adolescence : between exploratory behaviour and risks of deviant behaviour
Glowacz, Fabienne ULg; Puglia, Rosa ULg

Conference (2014, July 09)

Pornographic consumption or exposure to sexually explicit media (SEM) during adolescence raises many questions, in particular concerning its incidence on the level of a teenager's psychosexual development ... [more ▼]

Pornographic consumption or exposure to sexually explicit media (SEM) during adolescence raises many questions, in particular concerning its incidence on the level of a teenager's psychosexual development and sexual behaviour. Adolescence is a stage of identity formation, characterized by the adoption of risk taking and exploratory behaviours, of which the consumption of pornography is part. Whereas some studies noticed an impact of the exposure to sexually explicit media on the level of the subject's psychosexual development, attitudes towards sexuality and sexual behaviour, other studies do not highlight any significant links between the voluntary or involuntary exposure to pornography and risk taking sexual behaviours. Two researches will be presented to deal with this question. The first study, relating to a sample of 319 teenagers aged between 15 to 18 (52% boys), shows that 85% of the subjects have already seen pornographic material, the average age a child first views pornography being between 10 and 14. Our results indicate that the forms of exposure to SEM as well as the representations of pornography and the impact of pornographic material on their sexuality are different depending on the subject's gender. Our second study, relating to a sample of 47 juvenile sexual offenders, will make it possible to consider the forms of consumption of these young people and the possible links between their sexual offence and the consumption of pornography. [less ▲]

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See detailDu processus aux soins intégrés : expérience de gestion de projet bottom-up
ERPICUM, Marie ULg; BASSLEER, Bernard ULg; Defraigne, Jean-Olivier ULg et al

Conference (2014, July 08)

Implementation of blood conservation strategies is a current issue in a public health view, especially in cardiac surgery. A service project has been initiated in the cardiovascular department of the CHU ... [more ▼]

Implementation of blood conservation strategies is a current issue in a public health view, especially in cardiac surgery. A service project has been initiated in the cardiovascular department of the CHU of Liege aiming to develop a blood conservation program. This project has evolved into the creation of a clinical pathway of the cardiac surgery patient and then into an institutional model for the development of other clinical pathways. This evolution leads to meet with the missions and strategic objectives of the Institution and some national projects. The process of this approach weaves a horizontal and vertical grid. The multidisciplinary membership, supported by medical and nursing leadership and the institutional support, will determine the sustainability of this project. [less ▲]

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See detailBiomarker for osteoarthritis and/or other ageing-related diseases, and use thereof
Henrotin, Yves ULg; Gharbi, Myriam; DEBERG, Michelle ULg et al

Patent (2014)

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See detailModélisation numérique de la localisation des déformations dans le béton avec un modèle de second gradient
Jouan, Gwendal ULg

Doctoral thesis (2014)

Cette thèse porte sur l’utilisation d’un modèle de second gradient pour les problèmes de localisation dans le béton. La localisation des déformations est un phénomène courant dans les solides qui ont subi ... [more ▼]

Cette thèse porte sur l’utilisation d’un modèle de second gradient pour les problèmes de localisation dans le béton. La localisation des déformations est un phénomène courant dans les solides qui ont subi des chargements importants et qui mène progressivement à la fissuration du milieu. D’un point de vue pratique, il importe de prévoir la possible occurrence de tels phénomènes et de simuler le comportement de la structure après son apparition (on parlera alors de comportement post-localisation). Pour modéliser de façon objective ce phénomène, le modèle dit de second gradient «local», cas particulier des milieux à microstructure, est ici appliqué à des structures en béton. Le comportement du modèle est étudié pour des essais représentatifs de telles structures (poutre en flexion, propagation de fissures en mode I). Certaines limitations du modèle dans le cas de localisations importantes des déformations sont mises en évidence et on propose la transition vers un modèle cohésif afin de décrire l’ensemble du processus de fissuration. Ce modèle cohésif et la transition depuis la description continue sont formulés et implémentés dans un code de calcul éléments finis. [less ▲]

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See detailAnalyse des facteurs de perception du risque de mauvaise localisation de la tumeur par les travailleurs dans un service de radiothérapie
Kamto Kenmogne, Marius ULg

Conference (2014, July 08)

A la suite des scandales médicaux de Toulouse et d’Epinal, la sécurité des soins en radiothérapie a connu un intérêt croissant. En même temps qu’une réglementation plus exigeante est émise, des méthodes ... [more ▼]

A la suite des scandales médicaux de Toulouse et d’Epinal, la sécurité des soins en radiothérapie a connu un intérêt croissant. En même temps qu’une réglementation plus exigeante est émise, des méthodes de gestion de risques issues de l’industrie sont expérimentées et les résultats des expériences publiés. Toutefois, ces méthodes sont souvent basées sur des hypothèses à priori sur le comportement humain et aucune n’analyse spécifiquement comment les risques sont évalués par les divers acteurs et groupes d’acteurs intervenant dans le processus de prise en charge du patient. Le présent article fournit les résultats d’une étude empirique analysant les facteurs psychologiques expliquant les différences de perception du risque de mauvaise localisation par les travailleurs d’un service de radiothérapie. Il démontre que les médecins qualifiés d’experts minimisent ce risque en s’appuyant d’une part sur leur connaissance de la fréquence de réalisation du risque et des conséquences pour le patient et d’autre part sur leur expérience et leurs compétences pour le prévenir et le réduire. Le personnel d’administration qualifié de profane ne s’estime pas concerné par ce risque. Bien que beaucoup le considèrent comme élevé, ils n’ont pas d’avis sur les différents facteurs de perception proposés dans le cadre d’analyse de Slovic. [less ▲]

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See detailL'hôpital, une entreprise comme les autres ? Oui, mais ...
Van Caillie, Didier ULg

Conference (2014, July 07)

A l’instar d’une entreprise industrielle, l’hôpital actuel présente les caractéristiques suivantes, quel que soit son statut ou sa localisation : Il est constitué d’un ensemble de ressources rares et ... [more ▼]

A l’instar d’une entreprise industrielle, l’hôpital actuel présente les caractéristiques suivantes, quel que soit son statut ou sa localisation : Il est constitué d’un ensemble de ressources rares et limitées, de nature humaines, techniques, financières et immatérielles (savoirs et connaissances), dont il doit justifier d’une utilisation efficiente (en clair, maximiser le rapport output/coût) en regard des attentes diverses et parfois contradictoires de ses différentes parties prenantes (patients, collaborateurs, autorités de financement, autorités de contrôle) s’il veut remplir le rôle de création de valeur sociétale naturellement dévolu à toute organisation. En terme managérial, son défi quotidien est de : Gérer de manière coordonnée des flux multiples (flux des patients physiques, objets des soins ; flux des médicaments et des traitements, nécessaires à la fluidité du flux des patients ; flux d’information, traduction virtuelle des patients physiques nécessaire lui aussi à la fluidité du flux des patients) dans un souci permanent d’efficience multiple : garantir le bon soin au bon patient au bon moment avec l’information suffisante, les médicaments et l’infrastructure adéquate, le tout, au moindre coût. Simultanément, coordonner en permanence l’ensemble des ressources humaines, matérielles et financières de l’organisation, et surtout motiver la principale ressource critique, l’ensemble des collaborateurs (corps médical, corps infirmier, corps technicien de support, corps de support à la gestion), en résolvant de manière continue les défis quotidiens d’une bonne communication interpersonnelle (dans et entre les services), d’une motivation individuelle alignée sur les besoins et les attentes de l’organisation et d’une parfaite coordination avec les attentes du patient. [less ▲]

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See detailThe paleoearthquake record of the Cinarcık Segment of the North Anatolian Fault in the Marmara Sea (Turkey) and its implication regarding past historical rupture scenario across the Marmara Sea
Hubert, Aurelia ULg; Drab, Laureen; Albini, P et al

Poster (2014, July 07)

Istanbul and its 12 million inhabitants borders the Marmara Sea, a submarine pull-apart basin related to the North Anatolian Fault (NAF), a major strike slip fault that ruptures in M>7 earthquakes ... [more ▼]

Istanbul and its 12 million inhabitants borders the Marmara Sea, a submarine pull-apart basin related to the North Anatolian Fault (NAF), a major strike slip fault that ruptures in M>7 earthquakes. Constraining the recurrence rate of M>7 earthquakes that threaten the megacity is problematic because the active faults are submarine. For assessing past submarine earthquake ruptures of the Cinarcik Fault Segment located just south of Istanbul, we studied two sedimentary cores and identified seismoturbidites related to historical ruptures. Earthquake related turbidites are identified in both cores, based on their distinctive sedimentological and geochemical signatures. The seismoturbidites recorded in one of the core named Klg04 are inferred to record only mass wasting events related to the rupture on the Cinarcik Segment because of its specific geomorphological location. To constrain the seismoturbidites chronology, we combine short-lived radionuclide, radiocarbon and paleoinclination data. The first four seismoturbidites recorded match the 1894, 1509, 14th century and 989 historical earthquakes. The obtained age model allows us to discuss past historical rupture scenario across the Marmara Sea. The fact that the 1766 earthquakes are not recorded is further discussed based on new macroseismic intensity data and sedimentary records East of the Cinarcik Basin. [less ▲]

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