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See detailOpening Speech
Martiniello, Marco ULg

Scientific conference (2015, December 08)

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See detailE-Mental Health - La psychiatrie et la psychotherapie à l'ère de l'électronique
Desseilles, Martin ULg

Scientific conference (2015, December 08)

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Peer Reviewed
See detailBrûlures domestiques enfants et adultes : les gestes qui sauvent.
ROUSSEAU, Anne-Françoise ULg

Conference (2015, December 08)

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See detailDe "la faute à l'Europe" à la crise de la représentation
Grandjean, Geoffrey ULg

Conference given outside the academic context (2015)

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See detailVers une fiscalité européenne?
Richelle, Isabelle ULg

Speech/Talk (2015)

Evolution de l'Europe, Union européenne, fiscalités nationales et fiscalité européenne.

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See detailOn the LZ distance for dereplicating redundant prokaryotic genomes
Léonard, Raphaël ULg; Baurain, Denis ULg; Kerff, Frédéric ULg et al

Poster (2015, December 07)

The fast-growing number of available prokaryotic genomes, along with their uneven taxonomic distribution, is a prob- lem when trying to assemble broadly sampled genome sets for phylogenomics and ... [more ▼]

The fast-growing number of available prokaryotic genomes, along with their uneven taxonomic distribution, is a prob- lem when trying to assemble broadly sampled genome sets for phylogenomics and comparative genomics. Indeed, most of the new genomes belong to the same subset of hyper-sampled phyla, such as Proteobacteria and Firmicutes, or even to single species, such as Escherichia coli (almost 2000 genomes as of Sept 2015), while the continuous flow of newly discovered phyla prompts for regular updates. This situation makes it difficult to maintain sets of representative genomes combining lesser known phyla, for which only few species are available, and sound subsets of highly abundant phyla. An automated straightforward method is required but none are publicly available. The LZ distance, in conjunction with the quality of the annotations, can be used to create an automated approach for selecting a subset of represen- tative genomes without redundancy. We are planning to release this tool on a website that will be made publicly available. [less ▲]

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See detailPathologies neuromusculaires
WANG, François-Charles ULg

Learning material (2015)

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See detailLes carrières des cadres : le genre à l'épreuve des catégories d'âge
Grodent, Françoise ULg

Doctoral thesis (2015)

Le but de notre thèse est de savoir, si en termes de carrières et de conciliation avec la vie privée et/ou familiale des cadres, il existe un effet d'âge qui se superpose à celui du sexe. En effet, il ... [more ▼]

Le but de notre thèse est de savoir, si en termes de carrières et de conciliation avec la vie privée et/ou familiale des cadres, il existe un effet d'âge qui se superpose à celui du sexe. En effet, il existe peu de travaux sur les carrières des cadres qui ont intégré la thématique de l'équilibre entre les sphères privée et professionnelle ainsi qu'une approche intersectionnelle qui conjugue les rapports sociaux de sexe et d’âge. Pour analyser les carrières subjectives des cadres et la conciliation avec leur vie privée et/ou familiale, nous avons opté pour les lunettes d'analyse du genre permettant de dépasser la comparaison hommes-femmes et de tenir compte de l'évolution de la socialisation ainsi que des opportunités historiques des hommes et des femmes dans le travail et dans la famille. En effet, nous ne pouvons pas étudier la carrière des hommes et des femmes sans tenir compte de leur âge et du fait qu'ils ne disposent pas, notamment, des mêmes ressources et des mêmes attributions. Etant donné notre objet d'étude, nous avons opté pour une approche qualitative, exploratoire et inductive. Nos données empiriques ont été récoltées via des entretiens semi-directifs menés auprès de 104 cadres dans une optique de "storytelling". Elles ont été traitées par l'intermédiaire d'une analyse de contenu qualitative thématique et d'une analyse structurale du discours des cadres. Les préoccupations liées à l'évolution historique de la place des hommes et des femmes au travail et dans la famille transforment les relations entre les sexes tant aux niveaux professionnel que familial. L'intersectionnalité des rapports sociaux de sexe et d'âge génère donc des portraits de carrière et de conciliation avec la vie privée et/ou familiale différents pour chacun de nos six sous-groupes de cadres. Les orientations professionnelles et de conciliation ne sont pas uniquement le fruit de décisions ou de contraintes individuelles. En effet, d'autres niveaux d'influence (relationnel, groupal, organisationnel, institutionnel, etc.) interviennent que ce soit au point de vue du travail ou de la famille. [less ▲]

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See detailSerum calcitriol concentrations measured with a new direct automated assay in a large population of adult healthy subjects and in various clinical situations
Souberbielle, JC; CAVALIER, Etienne ULg; DELANAYE, Pierre ULg et al

in Clinica Chimica Acta (2015), 451 (Pt B)

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol ... [more ▼]

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol with a new automated direct assay on the Liaison XL platform in 888 healthy French Caucasian subjects aged 18–89 years, 32 patients with a surgically-proven PHPT, 32 pregnant women at the end of the first and at the end of the third trimester, and 24 dialysis patients before and after one year of supplementationwith vitamin D3 or placebo. The mean calcitriol concentration (±SD) in the healthy population was 52.9 ± 14.5 ng/L with a 95% CI interval of 29–83.6 ng/L. In PHPT patients, calcitriol concentration was 81.6±29.0 ng/L, 15 of them (46.9%) having a concentration N83.6 ng/L. In pregnant women, calcitriol was 80.4 ± 26.4 ng/L at the end of the first trimester, and 113.1±33.0 ng/L at the end of the third trimester, 12 (37.5%) and 26 (81.3%) of them having a calcitriol concentration N83.6 ng/L at the first and third trimesters respectively. In 14 dialysis patients, calcitriol was 9.5±7.7 ng/L and rose to 19.3 ng/L after one year of supplementation with 50,000 IU vitamin D3/month. In 10 other dialysis patients, calcitriol was 9.9±2.9 ng/L and remained stable (12.4±3.7 ng/L) after one year of placebo. In conclusion, this new automated calcitriol assay, in addition to presenting excellent analytical performances, gives the expected variations in patients compared to “normal” values obtained in an extensive reference population [less ▲]

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See detailHeavy-chain antibody fragments as model proteins to investigate the molecular mechanism of formation of amyloid fibrils
Chavignon, Chloé ULg

Doctoral thesis (2015)

Amyloidoses are rather common and widespread debilitating and/or life-threatening diseases. They display structurally identical amyloid fibrils, and consequently appears to share a common, but still ... [more ▼]

Amyloidoses are rather common and widespread debilitating and/or life-threatening diseases. They display structurally identical amyloid fibrils, and consequently appears to share a common, but still poorly understood, mechanism of fibrillogenesis. Variable domains of camelid heavy-chain antibodies, referred to as VHHs or nanobodies, were chosen to investigate the factors that favour amyloid fibrillogenesis and to get a better understanding of the mechanism of Ig fibrillogenesis. Our study focused on the contribution of protein regions, i.e. the framework (FR) and the complementary determining regions (CDRs) of VHHs, to the formation of amyloid fibrils. Three VHHs were selected: cAb HuL6, cAb BcII10 and cAb BcII10 H H H, a chimera bearing the FR of cAb BcII10 and the CDRs of cAb HuL6. We first established experimental conditions suitable for fibrillogenesis: even the especially stable and soluble VHHs can form amyloid fibrils in denaturing conditions. This comforts the proposal that amyloid conformation is a generic structural form that all proteins can adopt in the appropriate conditions. Amyloid fibrils were characterised by transmission electron microscopy (TEM), circular dichroism (CD), thioflavin T (ThT) fluorescence and X-ray fibre diffraction. The kinetics of fibril formation were monitored by turbidity measurements. We then determined conditions suitable for characterising self-seeding and cross-seeding kinetics, and ascertained that the three VHHs convert into amyloid fibrils according to a nucleation-dependent process. Fibril elongation rates in self-seeding and cross-seeding experiments suggest that amyloid fibril elongation occurs through sequential addition of protein monomers to preformed fibrils. The kinetics of aggregation and self-seeding of cAb-HuL6 and cAb-BcII10 differ significantly, and a remarkable specificity for cross-seeding was observed, with cAb-BcII10 being unable to cross-seed the formation of fibrils by the two other VHHs, while cAb-HuL6 and cAb BcII10 H-H-H mutually cross-seed each other’s fibril formation. With the help of three prediction algorithms (AGGRESCAN, Zyggregator and 3D-profile), we showed that various peptides of the VHHs had the ability to form fibrils by themselves. Our results strongly suggest that the sequences of the regions forming the core of the fibrils essentially correspond to the CDRs. Concurrently, we set up experimental conditions for interrupting the fibril formation process and we characterised the multimer and fibril species formed in the early stages of fibrillogenesis by analytical ultracentrifugation (AUC) and small angle neutron scattering (SANS) ex situ. [less ▲]

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See detailCombining tree-based and dynamical systems for the inference of gene regulatory networks
Huynh-Thu, Vân Anh ULg; Sanguinetti, Guido

Conference (2015, December 07)

Detailed reference viewed: 4 (1 ULg)
See detailG-CSF as a non-invasive predictive marker for embryo implantation
Munaut, Carine ULg; NOEL, Laure ULg; Lédée, N et al

Scientific conference (2015, December 07)

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailRecent technical developments of non-invasive cultural heritage analysis at the University of Liège
Strivay, David ULg; Chene, Grégoire ULg; Calvo Del Castillo, Helena ULg et al

Conference (2015, December 07)

The University of Liège has more than twenty years of experience in the use of ion beam analysis techniques for cultural heritage research. We will present here some of the recent developments. First, we ... [more ▼]

The University of Liège has more than twenty years of experience in the use of ion beam analysis techniques for cultural heritage research. We will present here some of the recent developments. First, we have developed a high energy extracted beamline up to 20 MeV on our cyclotron with a good energy resolution of a few keV. These last years Ion Beam Analysis users show an interest in High Energy Alpha beam. These beams can be used for on-site analysis by means of radioactive sources e.g. for space application but they also offer a powerful combination of properties for the analysis of thick layers (about 10 to 20 µm). This kind of layers are often met in cultural heritage applications but can be also present on new materials. Contrary to this kind of materials where the principal information needed is the in-depth profiles as the sample are of known composition, for cultural heritage materials the combination of elemental analysis and their in-depth distribution is essential as the nature of the material is a-priori not known. We will also present the development around our first extracted beamline. We have indeed improved the automatic scanning system for macro-PIXE. Some examples will be shown. Finally we will show other non-invasive analysis developments related to cultural heritage. [less ▲]

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See detailLaparoscopic management of a traumatic lumbar hernia: about a case
Vandermeulen, morgan; DETRY, Olivier ULg

Conference (2015, December 07)

Traumatic Lumbar hernia (TLH) is a very rare clinical entity with about 100 cases reported worldwide. It is a difficult challenge when encountered and there is no consensus on the best management: early ... [more ▼]

Traumatic Lumbar hernia (TLH) is a very rare clinical entity with about 100 cases reported worldwide. It is a difficult challenge when encountered and there is no consensus on the best management: early or delayed, open or laparoscopic. We report the clinical case of a 28-year-old man who suffered from a TLH after a 6- meter-high fall. The diagnosis was based on CT imaging showing a defect in the postero-lateral abdominal wall by disinsertion of the lumbar origin of transverse, internal and external oblique muscles. A few months after the trauma, it became gradualy more painful, the hernia was clinically increased with a large swelling on the right flank majored by valsalva. CT imaging showed herniation of the right colic flexure through the defect. Eight months after the trauma, we performed an intra-abdominal laparoscopic approach. Herniated structures were reduced and we opened the peritoneum. The defect was repaired by placing a pre-peritoneal polypropylene mesh fixed by laparoscopic staples before closing the peritoneum. The patient had an uneventful recovery. Ten weeks after the surgery the result was clinically very good. The CT scanner showed a good recovery of parietal continuity. [less ▲]

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See detailLes relations entre universités et entreprises comme vecteurs d'innovation
Artige, Lionel ULg

Conference given outside the academic context (2015)

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See detailIdentification of the concepts at stake during a consultation. Clinical exercises
Jamoulle, Marc ULg

E-print/Working paper (2015)

During a consultation between a patient and a doctor, symptoms, process and health problems are at stake and could be identified and retrieved through the use of ICPC.(refer to www.ph3c.org) Specific ... [more ▼]

During a consultation between a patient and a doctor, symptoms, process and health problems are at stake and could be identified and retrieved through the use of ICPC.(refer to www.ph3c.org) Specific training and managerial competences of the doctor could be identified and explained through the Q-Codes Together ICPC and Q-Codes form 3CGP ; Core Content Classification in General Practice/ Family Medicine The concepts identified in ICPC and Q-Codes could be useful to understand and teach the content of consultation in family medicine. [less ▲]

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See detailFraming the Concept of Citizenship in a Contested Nation-State: Reflections on Kosovo
Mazur Kumric, Nives ULg

in Pécs Journal of International and European Law (2015), (II), 70-88

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty ... [more ▼]

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty, perplexed inter-ethnic relations, profound international interference and parallel jurisdictions with the Republic of Serbia. The efforts put forth to conceptualise the meaning and scope of Kosovo citizenship in such a sensitive socio-political environment have proved particularly challenging. This paper aims to provide an analytical framework for determining essential elements of Kosovo citizenship, with particular emphasis on its practical and ideological implications for the multicultural, yet ethnically divided society. This is done through an assessment of the key nation-constituting legal norms as well as the deep-rooted ethnic tensions sparked by conflicting perceptions of Kosovo's statehood by the majority (Kosovo Albanian) and minority (Kosovo Serbian) population. By formal definition, Kosovo is an indivisible state of all citizens, however, polarised majority-minority interests have impinged the constitutionally guaranteed civic spirit of the entity, thereby threatening not only national, but also wider international security and integrity. With the purpose of determining and delineating labyrinthine intersections of a contested nation-state, citizenship, 'communities' and security, the paper offers a comprehensive theoretical analysis of the respective quadrilateral nexus. [less ▲]

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