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See detailCystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate
Ebert, N; DELANAYE, Pierre ULg; Shlipak, M et al

in Clinica Chimica Acta (2016), 456

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See detailEarly Detection of University Students in Potential Difficulty
Hoffait, Anne-Sophie ULg; Schyns, Michael ULg

E-print/Working paper (2016)

Using data mining methods, this paper presents a new means of identifying freshmen's profiles likely to face major difficulties to complete their first academic year. Academic failure is a relevant issue ... [more ▼]

Using data mining methods, this paper presents a new means of identifying freshmen's profiles likely to face major difficulties to complete their first academic year. Academic failure is a relevant issue at a time when post-secondary education is ever more critical to economic success. We aim at early detection of potential failure using student data available at registration, i.e. school records and environmental factors, with a view to timely and efficient remediation and/or study reorientation. For the sake of accuracy, we adapt three data mining methods, namely random forest, logistic regression and artificial neural network algorithms. Real data pertaining to undergraduates at the University of Liège (Belgium), illustrates our methodology. [less ▲]

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See detailVolumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole Blood
Houbart, Virginie ULg; COBRAIVILLE, Gaël ULg; Nys, Gwenaël ULg et al

in LCGC North America (2016), 34(5),

Whole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were ... [more ▼]

Whole blood analysis is an emerging trend in the field of bioanalysis. We developed a fast and simple protocol to extract and analyze a peptide, hepcidin, from whole blood. Sampling and extraction were carried out using volumetric absorptive microsampling (VAMS), a novel blood collection method that allows the sampling of a known blood volume independently from hematocrit. The composition of the extraction medium was optimized using an experimental design to get the most intense signal of hepcidin, considering different organic solvents and acidic additives. [less ▲]

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See detailLes paysans sans terre et REDD+ en RDC : les logiques locales faces aux interventions internationales
Reyniers, Camille; Karsenty, Alain; Vermeulen, Cédric ULg

in Cahiers africains (2016), 87

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See detailPotentiel des véhicules aériens sans pilote dans la détection des activités humaines illégales dans les aires protégées en République Démocratique du Congo
Semeki Ngabinzeke, Jean; Linchant, Julie ULg; Quevauvillers, Samuel ULg et al

in Journal of Unmanned Vehicle Systems (2016), 4

The recent advent of unmanned aerial vehicles (UAVs) in natural resource management opens new opportunities to help protected area managers fighting against various human pressures. The Falcon UAV was ... [more ▼]

The recent advent of unmanned aerial vehicles (UAVs) in natural resource management opens new opportunities to help protected area managers fighting against various human pressures. The Falcon UAV was used for 15 missions to help detect human activities in Garamba National Park and its surrounding game reserves (Gangala na Bodio, Mondo Missa) in the North-Eastern Democratic Republic of Congo. A Sony Block camera coupled with a Tamarisk thermal camera was used to record videos, whereas photos were acquired with a Sony Nex7 digital camera. Tests showed that it was possible to detect precise objects using the Falcon UAV. Houses, fields, bare ground patches, burned areas, roads and tracks were easily detectable and identified in the videos at a flight altitude of up to 250 m AGL. Artisanal gold mining sites (size ≤ 0.21 ha) are also recognizable on the video and still images. Improvements are needed, notably in photo overlap and georeferencing, but the system shows great potential to ensure detection and continuous surveillance of human activities within protected areas. [less ▲]

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See detailPermutations and negative beta-shifts
Charlier, Emilie ULg; Steiner, Wolfgang

Conference (2016, May)

Elizalde (2011) characterized which permutations can be obtained by ordering consecutive elements in the trajectories of (positive) beta-transformations and beta-shifts. We prove similar results for ... [more ▼]

Elizalde (2011) characterized which permutations can be obtained by ordering consecutive elements in the trajectories of (positive) beta-transformations and beta-shifts. We prove similar results for negative bases beta. [less ▲]

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See detailJustice ou précipitation.L'accélération du temps dans les tribunaux.
Bastard, Benoit; Delvaux, David ULg; Mouhanna, Christian et al

Book published by Presses Universitaires de Rennes (2016)

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See detailManneken-Pis, les chats et la gamelle de la police
Hamers, Jérémy ULg

Article for general public (2016)

En ces temps d’actualité terroriste, politiques, journalistes et citoyens partagent un même constat : « nous avons été attaqués dans nos libertés fondamentales. » À en croire les expressions qu’elles ... [more ▼]

En ces temps d’actualité terroriste, politiques, journalistes et citoyens partagent un même constat : « nous avons été attaqués dans nos libertés fondamentales. » À en croire les expressions qu’elles adoptent sur les réseaux sociaux, ces libertés fondamentales sont surtout des droits. Droit de vivre ses passions, ses désirs, ses amours, droit d’aller en terrasse, droit de boire encore des bières, de manger des frites et des moules. La circulation virale de multiples pieds-de-nez épicuriens après les attentats de ce 22 mars 2016 rappelle une fois de plus que, conformément aux clichés, le belge aime rire, bien manger et se moquer de tout qui s’attaquerait à sa belgitude. Faut-il pour autant y trouver la consolidation de ce que les terroristes risqueraient de nous dérober ? [less ▲]

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See detailFrom Metabolomics Study of Age-Related Macular Degeneration (AMD) to the Development of New Pyruvate Dehydrogenase Kinase Inhibitors (PDK)
Arslan, Deniz ULg; Schoumacher, Matthieu ULg; Pirotte, Bernard ULg et al

Poster (2016, May)

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population of industrialized countries. This blindness results from the deterioration of the macula, a small part of ... [more ▼]

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population of industrialized countries. This blindness results from the deterioration of the macula, a small part of the retina specialized for the high-acuity vision. Exudative AMD, called “wet”, is characterized by the formation of new blood vessels growing under the retina according to a process named choroidal neovascularization (CNV). Currently, the aetiology and pathogenesis of AMD remain unclear. Nevertheless, a recent metabolomics study performed on the serum of “wet” AMD patients and on a CNV murine model, that mimics the effect of “wet” AMD, have demonstrated that lactate level is clearly involved in the severity of the pathology as well as the relationship between lactate, CNV and AMD. According to this result, we suggest a new therapeutic approach of AMD based on the normalization of blood lactate level. The modulation of the lactate plasma concentration by treatment of the animals with synthetic compounds and more specifically Pyruvate Dehydrogenase Kinase (PDK) inhibitors significantly decrease the CNV. PDK and its four isoforms (PDK1-4) regulate the activity of the pyruvate dehydrogenase complex (PDH), a mitochondrial enzyme that plays a major role in the metabolic pathway of glucose, by reversible phosphorylation. Starting from these results, development of new PDK inhibitors could open the way to innovative treatment opportunities in AMD disease. Different analogues of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide (fig.1) have been already synthetized and pharmacological evaluation is currently in progress. According to the results obtained, various pharmacomodulations will be investigated [less ▲]

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See detailAddressing the risk of maladaptation to climate change
Magnan, Alexandre; Schipper, E.L.F.; Burkett, Maxine et al

in WIREs Clim Change (2016)

This paper reviews the current theoretical scholarship on maladaptation and provides some speci!c case studies—in the Maldives, Ethiopia, South Africa, and Bangladesh—to advance the !eld by offering an ... [more ▼]

This paper reviews the current theoretical scholarship on maladaptation and provides some speci!c case studies—in the Maldives, Ethiopia, South Africa, and Bangladesh—to advance the !eld by offering an improved conceptual understanding and more practice-oriented insights. It notably highlights four main dimensions to assess the risk of maladaptation, that is, process, multiple drivers, temporal scales, and spatial scales. It also describes three examples of frameworks— the Pathways, the Precautionary, and the Assessment frameworks—that can help capture the risk of maladaptation on the ground. Both these conceptual and practical developments support the need for putting the risk of maladaptation at the top of the planning agenda. The paper argues that starting with the intention to avoid mistakes and not lock-in detrimental effects of adaptation-labeled initiatives is a !rst, key step to the wider process of adapting to climate variability and change. It thus advocates for the anticipation of the risk of maladaptation to become a priority for decision makers and stakeholders at large, from the international to the local levels. Such an ex ante approach, however, supposes to get a clearer understanding of what maladaptation is. Ultimately, the paper af!rms that a challenge for future research consists in developing context-speci!c guidelines that will allow funding bodies to make the best decisions to support adaptation (i.e., by better capturing the risk of maladaptation) and practitioners to design adaptation initiatives with a low risk of maladaptation. [less ▲]

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See detailFrom Metabolomics to Identification of a new therapeutic approach for Age-Related Macular Degeneration (AMD)
Schoumacher, Matthieu ULg; De Tullio, Pascal ULg; LAMBERT, Vincent ULg et al

Poster (2016, May)

Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world among people aged 50 or older. 90% of all vision loss due to AMD result from the exudative form, which is ... [more ▼]

Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world among people aged 50 or older. 90% of all vision loss due to AMD result from the exudative form, which is characterized by choroidal neovascularization (CNV). Age-related changes that induce pathologic CNV are incompletely understood and critical issues remain to be addressed. Metabolomics is defined as the comprehensive study of endogenous metabolites changes in various biological systems. This newly emerging “omic” science provides a unique opportunity to correlate variation of the metabolome with pathological occurrence or progression and/or to identify metabolites that are implicated in the disease. We apply a 1H NMR metabolomics approach on sera collected from AMD patient and healthy volunteers and form a mice model of laser-induced CNV which mimics the effect of exudative AMD. After post-processing treatments, the different spectra were analyzed by statistical discriminant methodologies (PCA, ICA, PLS-DA, O-PLS-DA). These approaches allow the differentiation between control and AMD patients and between laser-induced mice and the control mice group. Moreover, the same discriminating spectral zones have been identified in human and mice model, leading to the emergence of different putative biomarkers. Among these markers, lactate emerges as a key metabolite in both settings. Mechanistically, lactate produced locally and by inflammatory cells, plays a critical role in the onset of the inflammatory and angiogenic phases. In mice model of laser-induced CNV, normalization of circulating lactate by dichloroacetate a pyruvate dehydrogenase kinase (PDK) inhibitor, decreases CNV development. Our data support the innovative concept of lactate as a parainflammation- and angio-metabolite associated to AMD and CNV progression. Moreover, control of blood lactate level via inhibition of PDK provides new options for the treatment of exudative AMD. This study demonstrates the ability of metabolomics for drug target discovery and opens new perspectives for AMD treatment and patient follow-up. [less ▲]

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See detailElectromagnetic Investigation of the Pb-Zn deposit of Lontzen, Belgium
Evrard, Maxime ULg; Pirard, Eric ULg; Nguyen, Frédéric ULg

in First International Conference: MINING IN EUROPE, ABTSRACT volume (2016, May)

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See detailPRODUCTION OF BIOFUELS AND BIOBASED COMPOUNDS IN URBAN BIOREFINERIES: A STRATEGY TO MANAGE WASTE IN WALLONIA?
Richel, Aurore ULg; Haubruge, Eric ULg; Jacquet, Nicolas ULg

Conference (2016, May)

“Urban biorefining” is an original concept aiming at using urban wastes (household wastes, municipal wastes, industrial liquid and/or solid residues and side-products, etc.), mainly of vegetal origin, for ... [more ▼]

“Urban biorefining” is an original concept aiming at using urban wastes (household wastes, municipal wastes, industrial liquid and/or solid residues and side-products, etc.), mainly of vegetal origin, for the production of an array of biofuels and bioproducts. This “urban biorefining” concept fits particularly with the economic, geographic and politic contexts and constraints of the Walloon Region (south part of Belgium). Indeed, Walloon Region is a very small territory (area of about 6,504 sq mi) with a temperate climate. Supply feedstock, mainly arising form forestry and agriculture, are thus rather restricted, submitted to importation, and subjected to non-standardized quality. Several examples of our regional strategy, still available on an industrial scale, are herein proposed and detailed. [less ▲]

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See detailGarric (Henri), dir., L’Engendrement des images en bande dessinée
Crucifix, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2016), (48), 172-174

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See detailAtypical myopathy: an update
Votion, Dominique ULg

in In Practice (2016), 38(5), 241-246

This article gives an overview of atypical myopathy, discussing the mechanism involved, its aetiology and the clinical signs and management (therapeutic and prevention).

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See detailRapport d'activité semestriel n°3
Legrand, Catherine ULg; Henrotin, Yves ULg

Report (2016)

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See detailDélinquance et désistance : quelle méthodologie de recherche ?
Puglia, Rosa ULg; Glowacz, Fabienne ULg

Conference (2016, May)

Dans la littérature concernant la délinquance, les auteurs se sont, au départ, principalement intéressés aux raisons qui poussent les individus à commettre des délits mais peu ont tenté de comprendre ... [more ▼]

Dans la littérature concernant la délinquance, les auteurs se sont, au départ, principalement intéressés aux raisons qui poussent les individus à commettre des délits mais peu ont tenté de comprendre pourquoi et comment certains individus, qui ont commis des actes délictueux, sortent de la délinquance. En effet, la désistance, c’est-à-dire le processus de sortie de la délinquance, a longtemps été négligée par les chercheurs. À partir des années '50, un intérêt croissant pour ce domaine de recherche apparaît. La désistance devient alors un sujet d’étude indépendant et non plus un appendice de la recherche sur les carrières délinquantes (Mohammed, 2012). Malgré l’intérêt croissant pour ce champ de recherche, de nombreuses zones d’ombre persistent. Sur base d’une recherche longitudinale réalisée sur une population d’adultes en émergence délinquants (17-25ans), nous tentons d’avoir une approche holistique de la désistance. Celle-ci est définie ici comme un processus impliquant des changements individuels et sociaux, qui s’inscrit dans le temps et qui peut être marqué par des réitérations d’actes délinquants. Dans notre étude, la désistance sera étudiée à travers une approche mixte combinant un récit de vie et des questionnaires. L’approche narrative est essentielle dans notre recherche, elle permettra d’appréhender les transformations identitaires, les schémas de changement et de stabilité dans le parcours de vie et dans la trajectoire délinquante. Elle permettra également de mettre en avant les facteurs internes et externes identifiés comme des facteurs de désistance. Par ailleurs, comme Maruna (2001), nous posons l’hypothèse que les persistants et les désistants sont des individus similaires qui se trouvent à des stades différents du processus de changement. C’est pourquoi, en toile de fond, la désistance sera envisagée à travers le modèle transthéorique de Proshaska et DiClemente (1982) où différentes étapes se succèdent avant l’arrêt du comportement problématique. [less ▲]

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See detailRecrutement et réseaux des représentants diplomatiques belges auprès du royaume d'Italie (1861-1911)
Genin, Vincent ULg

in Michel Dumoulin, Catherine Lanneau (Ed.) La biographie individuelle et collective dans le champ des relations internationales (2016)

Detailed reference viewed: 20 (2 ULg)