Last 7 days
Bookmark and Share    
Full Text
See detailOn the GMP production of [18]FUCB-H : Imaging neurotransmission
Warnier, Corentin ULg

Doctoral thesis (2016)

We herein describe the straightforward synthesis of a stable pyridyl(aryl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radi-osynthesis of [18F]UCB-H, a ... [more ▼]

We herein describe the straightforward synthesis of a stable pyridyl(aryl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radi-osynthesis of [18F]UCB-H, a PET tracer for the imaging of Synaptic Vesicle glycoprotein 2A (SV2A). Over the course of one year, 40 automated productions provided 34±2% of injectable [18F]UCB-H from up to 7.7 Ci of [18F]fluoride in 50 minutes (uncorrected radiochemical yield. Specific Activity = 22±5 Ci/µmol). The successful implementation of our synthetic strategy within routine, high-activity and cGMP productions attests to its practicality and reliability for the production of large doses of [18F]UCB-H. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts in the cGMP 18F-PET tracer manufacturing industry and their ability to fulfill practical and regulatory requirements in that field. [less ▲]

Detailed reference viewed: 11 (1 ULg)
See detailRelectures de La Misère du monde: Bourdieu, Sartre, Enzensberger
Cormann, Grégory ULg

Conference (2016, September 26)

Detailed reference viewed: 16 (0 ULg)
See detailHydrodynamics and bed stability at smooth-to-rough transitions. Experiments based on acoustic flow measurements
Duma, Diana ULg

Doctoral thesis (2016)

As reflected in the scale of large contemporary hydropower schemes, flowing water may carry huge amounts of energy. If not mastered properly, this energy may cause impressive channel erosion and local ... [more ▼]

As reflected in the scale of large contemporary hydropower schemes, flowing water may carry huge amounts of energy. If not mastered properly, this energy may cause impressive channel erosion and local scour. Therefore, one lasting concern in hydraulic engineering has been the stability of structures, riverbeds and riverbanks against flow erosion. Two main limitations of current understanding of riverbed and riverbank stability are highlighted: the first one is directly linked to the evaluation of the flow action, while the second one relates to the conceptual framework in which stone stability is evaluated. Since the standard approaches use the mean bed shear stress to quantify the flow forces, they may only apply under uniform flow conditions, for which the ratio of turbulence intensity to the bed shear stress remains almost constant and the influence of turbulence is therefore implicitly incorporated. For non-uniform flow, correction factors have been conventionally applied to account for the turbulence fluctuations; but this approach does not reproduce the physical influence of turbulence higher in the water column and can only be used as a rule of thumb. A new approach was initiated recently in literature. Instead of using the standard Shields parameter, it quantifies the flow forces by means of a new set of parameters which combine explicitly the velocity and turbulence distributions over a certain water depth above the riverbed, while remaining reasonably accessible for engineering applications. Next, this quantity is related to a mobility parameter, which describes the bed damage. This new approach requires additional high quality experimental data to confirm its validity for a wider range of non-uniform flow. In this research, the focus was set on a single canonical configuration, namely a smooth-to-rough transition. We take a preventive perspective by focusing on the flow and bed stability conditions before a scour hole starts to develop and we are interested in characterising the flow conditions to ensure bed stability, i.e. prevent the dislodging of bed material downstream of the structure. As a second specific objective of the thesis, we aimed at evaluating the feasibility of using acoustic techniques to properly estimate the new bed stability parameters proposed in literature in the last decade and draw conclusions on stone mobility at smooth-to-rough transitions. The experimental tests were conducted in two laboratory flumes, a horizontal bottom flume (6 m long and 15 cm wide) and a tilting flume (up to 4% slope, 20 m long and 50 cm wide), in which we measured the flow velocity at a 100 Hz frequency, using two different acoustic instruments: an Ultrasound Velocity Profiler (UVP) and a 3D Acoustic Doppler Velocity Profiler (ADVP). The measurements were done immediately downstream of the transition from smooth-to-rough. Two types of tests were undertaken. In the first type, the stones were glued with silicone on the flume bottom and velocity measurements were performed without stone motion. This enables measurements of the flow characteristics both below and above the threshold for inception of sediment motion, without perturbations induced by stone displacements. In the second type, the stones in the measurement area were laid on the bottom of the flume (i.e. not glued) and the number of entrained stones was recorded. The tests were conducted by varying (i) the grain size of the bed material (8 mm, 15 mm and 30 mm), (ii) the flow velocity (between 0.74 m/s and 1.16 m/s), (iii) the sediments density (1410 kg/m³, 1690 kg/m³ and 2650 kg/m³) and (iv) the configuration (quasi-uniform vs. smooth-to-rough transition). Indeed, for the purpose of comparison, a uniform rough bed (quasi-uniform configuration) was considered also, by replacing the smooth part of the bed with similar sediments as in the measurement area. After a specific signal processing, flow variables were derived from the measurements and were next exploited to evaluate several bed stability parameters, with the aim of correlating them with bed damage data obtained from dedicated experiments. The results showed no correlation between the bed damage and the bed shear stress or between the bed damage and flow turbulent kinetic energy. In contrast, when the flow action is described by both mean velocity and turbulence characteristics, a relative good correlation with the bed damage was observed. Nonetheless, these correlations appear only per subset of points corresponding to the same grain size and/or same material density or flume geometry. With a total of 45 hydraulic configurations for which the flow characteristics were measured and 66 (times four repetitions) tests in which the bed damage was observed, the present research ends up with a unique dataset, which may prove useful in various research such as for the validation of 2D-vertical and 3D turbulent flow and morphodynamic simulations. Another key outcome of the present doctoral research is a systematic comparison between measurements conducted with the UVP and the ADVP. The ADVP is deemed generally more accurate and reliable. Nonetheless, both instruments remain somehow complementary. We showed that, under certain conditions, the considered instruments have the potential to contribute to the assessment of bed stability in the considered configurations. [less ▲]

Detailed reference viewed: 8 (3 ULg)
See detailSupprimer la Communauté française ? Quelles perspectives pour le paysage institutionnel francophone ?
Behrendt, Christian ULg

Conference given outside the academic context (2016)

Conférence donnée à l'invitation de l'Union des entreprises à profit social (UNIPSO), à Bruxelles, Centre "Le Botanique", le 23 septembre 2016

Detailed reference viewed: 17 (1 ULg)
Full Text
See detailDevelopment of alternative methods to control aphids (Hemiptera: Aphididae): from wheat-pea intercropping to the use of semiochemical dispensers
Chevalier Mendes Lopes, Thomas ULg

Doctoral thesis (2016)

Increasing the sustainability of food production is a major challenge in today’s agriculture. Several practices can be implemented to reduce the use of external inputs such as agrochemicals. In terms of ... [more ▼]

Increasing the sustainability of food production is a major challenge in today’s agriculture. Several practices can be implemented to reduce the use of external inputs such as agrochemicals. In terms of insect pest control, the concept of integrated pest management (IPM) has been exploited to minimize the application of chemical insecticides. The idea is to limit pest infestations while promoting their control by natural enemies. One possibility is to increase within crops plant diversity namely by intercropping. Semiochemical dispensers may also be used to attracted natural enemies into crops. Focusing on wheat (Triticum aestivum Linnaeus), several types of intercropping can be practiced with variable effects on pests and natural enemies. This PhD thesis focuses on the potential of wheat-pea (Pisum sativum Linnaeus) intercropping as a way to reduce aphid (Hemiptera: Aphididae) infestations. We firstly assessed the diversity of aphid and their parasitoid species in wheat and pea fields using yellow pan traps and in situ observations on plants. Whether several aphid species were trapped, only Sitobion avenae (Fabricius), Metopolophium dirhodum (Walker), Rhopalosiphum padi (Linnaeus) and Acyrthosiphon pisum (Harris) were found on wheat tillers and pea plants respectively. Regarding parasitoids, some species can use wheat and/or pea aphids as hosts. The first Belgian parasitoid species checklist was established, with the inclusion of four Aphidiinae (Hymenoptera: Braconidae) and three Aphelinus (Hymenoptera: Aphelinidae) species as new records. In terms of abundance, we firstly compared the effect of two types of wheat-pea intercropping (mixed and alternate strip cropping) on aphids and their natural enemies with pure stands of both crops. The mixture was particularly efficient to reduce pea aphid populations, while alternate strips were more suitable for the control of wheat aphids. However, natural enemies were more abundant in the pure stands, showing that additional methods may be needed to attract them more efficiently. One possibility is the use of semiochemicals dispensers. In another field study, we combined a wheat-pea mixture with methyl salicylate (MeSA) dispensers. This substance was selected due to its known attractive effect towards some aphid beneficials. Even though adult hoverflies (Diptera: Syrphidae) were not particularly attracted by the mixture combined with MeSA dispensers, they may have stimulated their oviposition behaviour. Also, mummified aphids were significantly more abundant in the pure stand of pea compared with the mixture (with and without MeSA). However, parasitism rates did not differ significantly between treatments. Beneficial effects of wheat-pea intercropping were clearly demonstrated for aphid control. Other agronomic aspects make this practice particularly interesting in low-input farming systems. These are discussed, along the limitations related to the use semiochemicals in field conditions. Perspectives for further research works are also proposed. [less ▲]

Detailed reference viewed: 20 (7 ULg)
Full Text
See detailInfluence d'un programme de revalidation multidisciplinaire post-cancer du sein sur la fonction physique
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; BURY, Thierry ULg et al

in 9ème Congrès commun SFMES - SFTS : Abstract book (2016, September 22)

Objectif : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables, notamment sur la fonction physique. Cette étude a pour objectif de déterminer les ... [more ▼]

Objectif : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables, notamment sur la fonction physique. Cette étude a pour objectif de déterminer les bénéfices éventuels d’un programme de revalidation multidisciplinaire sur la santé physique des femmes ayant été traitées pour un cancer du sein et d'évaluer l'influence de certaines caractéristiques individuelles initiales sur la réponse du groupe expérimental au programme de revalidation. Matériel et méthodes : L'étude constitue un essai clinique contrôlé non-randomisé évaluant une population totale de 209 patientes, recrutées sur base du volontariat et réparties en deux groupes, soit un groupe contrôle (n = 106) et un groupe expérimental (n = 103). Ce dernier a bénéficié d’une revalidation de trois mois comprenant un entraînement physique supervisé à raison de trois séances par semaine et diverses sessions psycho-éducatives. Pour l'ensemble des participantes, des évaluations constituées d'une part de mesures physiques et fonctionnelles et d'autre part de mesures de composition corporelle ont été programmées à 0 et 3 mois. Celles-ci ont inclus un test de souplesse ("Sit and Reach"), un test d'effort maximal sur bicyclette ergométrique avec suivi cardio-respiratoire, un test de marche de six minutes et la mesure de l'indice de masse corporelle et du pourcentage de graisse corporelle. Afin d'affiner l'analyse, trois groupes ont également été constitués au sein du groupe expérimental à partir des caractéristiques individuelles de thérapie adjuvante (présence de chimiothérapie ou non), de chirurgie (mastectomie ou tumorectomie) et de délai de fin de traitement (délai ≤ 4 mois ou ≥ 8 mois). Résultats : Initialement, toutes les patientes présentent un état de déconditionnement physique, non influencé par le délai de fin de traitement ou par le type de chirurgie, mais bien influencé par la présence d'une chimiothérapie puisque la VO2max apparaît significativement plus faible dans ce cas. Au terme des trois mois, la souplesse (p < 0,0001), la consommation maximale d'oxygène (p < 0,0001), la puissance maximale aérobie (p < 0,0001) et la distance de marche en six minutes (p < 0,0001) s’améliorent significativement au sein du groupe expérimental. Au sein du groupe contrôle, aucune amélioration n'est constatée, excepté pour la distance de marche (p = 0,0031). Par ailleurs, une augmentation significative de l'indice de masse corporelle (p = 0,034) et du pourcentage de graisse corporelle (p = 0,034) est observée au sein du groupe contrôle alors que ce paramètre diminue significativement au sein du groupe expérimental (p = 0,037). Enfin, toutes les patientes du groupe expérimental présentent un même profil de progression quelles que soient leurs caractéristiques individuelles initiales. Conclusion : Cette étude démontre ainsi les effets bénéfiques, tant sur le plan physique que de la composition corporelle, d’une prise en charge multidisciplinaire chez des femmes ayant été traitées pour le cancer du sein. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
See detailStructure and Dynamics of Ge-Se Liquids and Glasses under Pressure
Yildirim, Can ULg

Doctoral thesis (2016)

Among network forming glasses, chalcogenide glasses are of great importance not only for their optoelectronic applications, but also for the network structure that displays enhanced structural variability ... [more ▼]

Among network forming glasses, chalcogenide glasses are of great importance not only for their optoelectronic applications, but also for the network structure that displays enhanced structural variability due to the covalent bonding network. In this project, we study the Ge-Se binary alloy as the target system in order to investigate the structure and dynamics of the liquid and glassy phases under pressure by using a combination of ab initio molecular dynamics (AIMD) simulations and X-ray scattering experiments. The wide glass forming range of the GexSe100􀀀x system allows one to tune the stiffness of the network structure by increasing the mean coordination number with the Ge content which affects the macroscopic material properties such as resistance to aging, hardness, conductivity, and fragility. In this respect, we study 10 different AIMD generated and 5 experimentally produced (i.e melt quenching) compositions spanning the flexible-to-rigid elastic phase transitions according to Maxwell’s isostatic stability criterion. As for the liquid state, after having validated the structural models by comparing the experimental findings available, we examine the dynamics of Ge-Se melts at ambient pressure. The investigations on the diffusion coefficients and viscosity at 1050 K showed clear anomalies, departing from the expectation that atomic mobility should decrease as the system becomes more and more rigid. Furthermore, the relaxation behavior at 1050 K also shows similar anomalies when intermediate scattering factors are examined at q vector corresponding to the principal peak position of the total structure factor. To elucidate this anomaly, we discuss the effect of the topological constraints on the dynamics in liquid state. The results show that the isostatic systems have slower dynamics as compared to flexible and stressed rigid phases. Moreover, we speculate that the reason of this anomaly may originate from the distribution of the topological bond bending constraints of the higher coordinated species (i.e. Ge) results. In particular, the flexible, and stressed rigid compositions showed a high variance in the Ge bond bending constraints whereas the isostatic composition forms a network in which the bond bending constraints are homogeneously distributed. We link this behavior with a global fragility concept for network forming liquids in such a way that fragility minima are obtained both by experimental findings and the calculated fragility values of the AIMD generated compositions (i.e. VFT or MYEGA fits) when scaled to the isostatic composition for a number of different systems. As for the glassy phase, the AIMD generated structural models show good agreement in both real and reciprocal space. The equation of state and normalized stress-strain curves are compared to the available experiments in order to verify the pressure behavior of the simulations. The results show a good agreement. In addition to the simulations under pressure, we show results of X-ray absorption spectroscopy (XAS) and X-ray diffraction (XRD) experiments under pressure. Both simulations and the experiments show that there are no sign of crystallization during compression up to 42 GPa. One of the main important finding is the evolution of the Ge-Se bond length for the compositions studied. We observe a bond compression in the early stages of densification in the phase identified as low density amorphous (LDA), which is followed by an abrupt jump starting in pressures around 10-15 GPa, both in simulations and experiments. Furthermore, a semiconductor to metal transition is identified with the red shift in Ge K edge energy. The features of polyamorphism was also detected from the pressure evolution of the principal peak position of the structure factor which show two distinct slopes indicating different structural response to the applied pressure. In order to have a deeper understanding of the densification mechanisms, we apply neighbor analyses to our atomic trajectories and show that the tetrahedral to octahedral transformation (i.e LDA to HDA) starts to take place when the fifth and sixth neighbors effectively become the part of first shell neighbors, where the bond angles adapt themselves to 90 degrees. We furthermore speculate the effect of network rigidity of the glasses at ambient conditions onto the kinetics of the amorphous-amorphous transitions. It appears that the polyamorphic transitions are more sluggish as the network rigidity (i.e Ge content) increases. Finally we show that there is a universal threshold value in coordination change from LDA to HDA phases GexSe100􀀀x (where x 25) when scaled to reduced densities. [less ▲]

Detailed reference viewed: 30 (2 ULg)
See detailCoupled Boltzmann Equation Solver: Effects of the Electron-Phonon Interaction on the Transport Coefficients
Pike, Nicholas ULg; Dewandre, Antoine ULg; Verstraete, Matthieu ULg

Scientific conference (2016, September 22)

Recent experimental and theoretical calculations point to a complex interplay between the electron and phonon baths in a wide variety of materials [1,2]. We propose a method of coupling the Boltzmann ... [more ▼]

Recent experimental and theoretical calculations point to a complex interplay between the electron and phonon baths in a wide variety of materials [1,2]. We propose a method of coupling the Boltzmann equations for the electron and phonon baths within the relaxation time approximation which we use to calculate the thermoelectric transport coefficients. Our model for the coupled Boltzmann Equation solver includes analytic models, including ${\bf k \cdot p}$ Hamiltonians and tight-binding Hamiltonians, for both the electron and phonon energies and analytic models for the electron and phonon relaxation mechanisms. From these calculations we hope to better understand the role and interplay of electron-phonon and phonon-phonon interactions on the thermoelectric transport coefficients. [1] - Phys. Rev. Lett. ${\bf 114}$, 115901 (2015). [2] - PNAS ${\bf 112}$, 14777-14782 (2015). [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
See detailREFINEMENT OF PERI-ANAESTHESIA PRACTICES FOR LABORATORY ANIMAL CARE
Thomas, Aurélie ULg

Doctoral thesis (2016)

Detailed reference viewed: 4 (2 ULg)
Full Text
See detailDie Familie von Medem. Zur Verbindung von Bildung, Literatur und Politik in Kurland
Leyh, Valérie ULg

Conference (2016, September 21)

Detailed reference viewed: 8 (0 ULg)
See detailSynthesis of poly(ionic liquid)-type nanogels, by cobalt-mediated radical cross-linking copolymerization for coating applications
Weiss-Maurin, Mathilde ULg

Doctoral thesis (2016)

To answer the increasing demand for long-lasting antibacterial polymeric coatings, this thesis explores a straightforward synthetic approach to cationically charged nanogels by cobalt-mediated radical ... [more ▼]

To answer the increasing demand for long-lasting antibacterial polymeric coatings, this thesis explores a straightforward synthetic approach to cationically charged nanogels by cobalt-mediated radical cross-linking copolymerization (CMRCcP), thus expanding previous works on the cobalt-mediated radical polymerization of poly(ionic liquid)s, or PILs. This method involves a vinyl monomer and a divinyl cross-linker, in presence of a complex of Cobalt(III) playing the role of both the initiator and the controlling agent. The syntheses of globular nanogels were first investigated under mild conditions, using a mono- and a divinyl co-monomer with similar reactivities. CMRCcP was implemented on either neutral (vinyl acetate (VAc) and divinyl adipate (DVA)) co-monomers, or hydrophilic (bromide-containing) ionic liquid co-monomers. Control over each polymerization was ascertained, and dormant cobalt-carbon chain-ends could be re-activated to form “second-generation” nanogels. CMRCcP of N-vinyl-3-ethyl imidazolium bromide (VEtImBr) and 1,13-divinyl-3-decyl diimidazolium bromide (DVImBr) was achieved in water at 30 °C, leading to hydrophilic poly(VEtImBr-co-DVImBr) nanogels. The antibacterial activity of these cross-linked structures was investigated, and an effect of architecture is detected. The hydrophobic pendants of these PIL-based nanogels were synthesized via direct CMRCcP in ethyl acetate, using bis(trifluromethanesulfonyl)imide (NTf2-) counter anions. An array of these poly(VEtImNTf2-co-DVImNTf2) nanogels was then investigated as possible coatings for porous patterned surfaces. Thin films of hydrophobic PIL-based nanogels were also evaluated in ionic conductivity tests. “Second-generation” nanogels exhibited better ionic conductivity, and were able to form better organized porous patterned surfaces than “first-generation” nanogels. Different cross-linked architecture were approached, using a mono- and a divinyl co-monomers of completely different reactivities: synthesizing poly(VEtImBr-co-DVA) nanogels met limited success, while copolymerizing VAc and DVImBr yielded too low conversion. A two-step arm-first process was implemented to form star-like poly(VEtImNTf2-co-DVImNTf2) nanogels with PVAc arms. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
See detailDealing with storm impacts on the forest sector through integrated and systemic approaches at the regional level
Riguelle, Simon ULg

Doctoral thesis (2016)

Wind is one the most damaging natural hazard that forests are facing worldwide and in Europe. Destructive storms lead to severe forest damage and consequently cause disruptions in daily forest management ... [more ▼]

Wind is one the most damaging natural hazard that forests are facing worldwide and in Europe. Destructive storms lead to severe forest damage and consequently cause disruptions in daily forest management and timber supply chains. Major dysfunctions can happen at each step of forest-wood chains and at each level of management, leading to huge economic losses and long-lasting crises within public organisations and private companies. In this context, the first part of this work aims at handling those complex and multi-facetted storm-related issues with new approaches in order to mitigate economic, environmental and societal impacts of storms on the forest-based sector. In a first step, an overview of risk management practices in forestry is presented, as well as major determinants of storm damage risk management. SWOT analyses are also used for highlighting main issues and opportunities in current windthrow management process. In a second step, an integrated framework is proposed for tackling those strategic issues and seizing opportunities arising from the uncertain decision-making context. A systemic perspective is also presented for managing storm damage risk at regional, national or supranational level with a holistic perspective. In regards to those original approaches, the thesis also highlights some of the crucial challenges public authorities might address for enhancing their affectivity in this process. In the second part of the manuscript, three particular aspects of storm damage management are considered: contingency planning, the development of decision-supporting tools for the forest community, and timber storage planning at the regional level. Those topics are illustrated by case studies taking place in Wallonia, Belgium. In particular, the development of a model-based decision support system (DSS) illustrate how systemic analysis can help on the one hand designing balanced strategies for the regional forest-based sector in case of severe wind damage and on the other hand identifying bottlenecks that should be solved before the next huge storm to enhance systemic resilience and resistance. Regarding timber conservation, a GIS-based methodology for locating optimal areas for sprinkling storage at the regional scale is presented, together with an applied study on the influence of anaerobic storage process on the quality of spruce logs. From a wider perspective, this thesis reveals that taking decision under uncertainty will remain a key challenge to address in forestry, especially in the context of climatic change. However, original methodologies focusing on systemic and integrated risk management approaches can help in this effort. Finally, the work emphasises the urgent need of effective risk management policies at regional, national, and international levels to guide researchers, forest managers and industrials. [less ▲]

Detailed reference viewed: 25 (4 ULg)
See detailLa lutte contre le jihadisme et l' 'Etat islamique' : le cadre de droit constitutionnel
Behrendt, Christian ULg

Scientific conference (2016, September 20)

Conférence donnée lors de la Journée d'étude du "Centre d'Etude de Droit militaire et de Droit de la Guerre" de l'Ecole Royale Militaire, Bruxelles, campus de l'Ecole Royale Militaire, 20 septembre 2016.

Detailed reference viewed: 21 (0 ULg)
See detailRelationships between mind-wandering, personal goals processing, and future thinking.
Stawarczyk, David ULg; D'Argembeau, Arnaud ULg

Conference (2016, September 20)

Mind-wandering refers to the occurrence of thoughts whose content is both decoupled from stimuli present in the immediate environment and unrelated to the task currently being carried out. Although this ... [more ▼]

Mind-wandering refers to the occurrence of thoughts whose content is both decoupled from stimuli present in the immediate environment and unrelated to the task currently being carried out. Although this phenomenon has been the object of increasing interest from the scientific community during le last decade, proportionally few studies have attempted to clearly determine the form, content, and possible functions of this particular kind of cognitions. In this presentation, we will review recent evidence from studies mainly performed in our lab suggesting that most instances of mind-wandering refer to the anticipation and planning of future events and are also closely related to the processing of personal goals. More specifically, we will first discuss the findings from behavioral research that examined the phenomenological features of mind-wandering with the use of experience sampling procedures during laboratory tasks. Results of these studies mainly revealed that most of reported mind-wandering episodes are temporally oriented towards the future and that this ‘prospective bias’ can be increased when participants’ attention had been oriented toward their personal goals prior to performing the tasks. We will next review the results of neuroimaging studies that investigated the neural correlates of mind-wandering and we will more specifically focus on meta-analytic evidences suggesting that the neural correlates of mind-wandering strongly overlap with those associated with episodic future thinking and personal goal processing. Together, these results suggest that mind-wandering may have an important adaptive value and could in particular play a key role in planning and preparing for upcoming events related to the individuals’ personal goals. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
See detailStudy on contribution of lipids towards the mechanical properties of milk fat globule membrane monolayer
Malik, Priyanka ULg; Danthine, Sabine ULg; Blecker, Christophe ULg

Conference (2016, September 20)

Milk fat globule membrane (MFGM) stabilizes fat globule in milk in form of emulsion. The primary monolayer of MFGM is rich in proteins and secondary bilayer is rich in polar lipids. MFGM finds application ... [more ▼]

Milk fat globule membrane (MFGM) stabilizes fat globule in milk in form of emulsion. The primary monolayer of MFGM is rich in proteins and secondary bilayer is rich in polar lipids. MFGM finds application as an additive in dairy and food industry (e.g. emulsions, infant formulas & reduced-fat products) for its emulsifying and stabilizing properties. MFGM received much attention in recent years due to both its health- beneficial & technological functionalities. This work has been carried out with the objective to understand contribution of various components towards the surface properties of complete MFGM. MFGM was isolated from fresh raw cream. During isolation of MFGM apart from polar lipids and MFGM proteins, neutral lipids are also isolated which have their origin in fat globules but are often considered as a constituent of MFGM. The MFGM was further fractioned into lipid fraction, defatted fraction and polar lipids. The mechanical properties of monolayer were studied for the above fractions using Langmuir film balance. Study of surface properties can also be linked to their techno-functional properties by calculating film elasticity of the compression isotherm which can be linked to emulsifying and stabilizing properties. The analysis of compression isotherms revealed that film elasticity is highly influenced by polar lipids. The behaviour of the MFGM appeared to be influenced by neutral lipid and defatted fraction during beginning of compression and by polar lipids at the end of compression. [less ▲]

Detailed reference viewed: 16 (6 ULg)
Full Text
See detailDevelopment and validation of analytical methods for quantifying isoflavones and equol in biological matrices
Daems, Frédéric ULg

Doctoral thesis (2016)

Isoflavones are natural plant substances that attract widespread interest because of their association with a large variety of beneficial effects on human health. When they are ingested by animals or ... [more ▼]

Isoflavones are natural plant substances that attract widespread interest because of their association with a large variety of beneficial effects on human health. When they are ingested by animals or humans, most of these compounds are metabolized by bacteria present in the digestive system. Among the isoflavone microbial metabolites, equol is probably the most widely studied because it seems to have numerous health benefits. In the human population, however, not everyone is able to produce equol. Equol enrichment of some food, such as cow's milk, could be an alternative strategy for making equol’s health benefits available to everyone. The main objective of the present thesis was to develop analytical tools for quantifying these compounds in several biological matrices, thus contributing to the feasibility study being conducted on producing milk naturally enriched with equol. For this purpose, four analytical procedures, using ultra performance liquid chromatography coupled with tandem mass spectrometry (UPLC®-MS/MS), were developed and fully validated. The analytical tools were then applied successfully in two original exploratory studies that sought to quantify equol concentrations in commercial cow's milk in Belgium and study the evolution of isoflavone concentration in red clover (Trifolium pratense L.) silage in laboratory-scale silos. This thesis describes new and reliable analytical tools that will help to improve current knowledge about the feasibility of producing cow's milk naturally enriched with equol and to study isoflavone metabolization in dairy cow. [less ▲]

Detailed reference viewed: 16 (1 ULg)