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See detailAllocution de clôture
Van Cleynenbreugel, Pieter ULiege

Speech/Talk (2017)

Detailed reference viewed: 12 (0 ULiège)
See detailSartre en radio
Cormann, Grégory ULiege; Hamers, Jérémy ULiege

Scientific conference (2017, November 21)

Detailed reference viewed: 99 (3 ULiège)
See detailState Aid law in the European Union - the issue of tax rulings
Van Cleynenbreugel, Pieter ULiege

Speech/Talk (2017)

Detailed reference viewed: 8 (1 ULiège)
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See detailUnique alternating peptide-peptoid copolymers from dipeptides via Ugi reaction in water
Al Samad, Assala ULiege; De Winter, Julien; Gergaux, Pascal et al

in Chemical Communications (2017), 53(90), 12240-12243

Herein, we developed a strainghtforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid ... [more ▼]

Herein, we developed a strainghtforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid copolymers as well as block copolymers were produced in a single step in the presence of acrylic acid and carboxylic acid-terminated poly(ethylene glycol). The thermoresponsiveness of these polymers is highlighted [less ▲]

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See detailHorizontal integration under yardstick competition
Teusch, Jonas ULiege

Doctoral thesis (2017)

Horizontal integration through mergers and cross-ownership is ubiquitous; industries regulated by yardstick competition are no exception in this regard. However, even though yardstick competition is ... [more ▼]

Horizontal integration through mergers and cross-ownership is ubiquitous; industries regulated by yardstick competition are no exception in this regard. However, even though yardstick competition is applied to sectors of vital economic importance, such as energy and water networks, the welfare effects of horizontal integration in these settings have largely escaped scientific scrutiny. The dissertation therefore studies the welfare implications of horizontal integration under yardstick competition and identifies potential trade-offs. Specifically, whereas mergers and cross-ownership may bring about efficiency gains, there is a possibility that horizontal integration simultaneously decreases the effectiveness of regulation, benefiting certain firms at the expense of consumers and competitors. Key conditions for such strategic effects to occur and to dominate efficiency effects are derived in a principal-agent model. The thesis also demonstrates that the issue is not merely of academic interest, but has affected the practical application of yardstick competition in the electricity distribution industries of both Belgium and Norway. Chapter 1 analyses how horizontal mergers, joint ventures and regulatory decentralisation complicate the application of yardstick competition in Belgian electricity distribution. Chapter 2 develops a theoretical model of mergers under yardstick competition - formalising the welfare trade-offs at the heart of this dissertation. Chapter 3 leverages Data Envelopment Analysis to quantify both efficiency and strategic effects of horizontal restructuring in Norwegian electricity distribution and points to a recent merger that appears to have been driven by strategic motivations. Chapter 4 uses several econometric identification strategies - dynamic regression, matching on observables and instrumental variables - to establish that between 2007 and 2015, cross-ownership increased firm performance in Norwegian electricity distribution, which suggests that the net welfare effects were positive in this application. [less ▲]

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See detailA Methodology to Determine the Potential of Urban Densification through Roof Stacking
Amer, Mohamed ULiege; Mustafa, Ahmed; Teller, Jacques ULiege et al

in Sustainable Cities and Society (2017), 35

Facing the need to accommodate a growing number of inhabitants in major European cities, this research aimed to establish a methodology that facilitates decision making on urban densification through roof ... [more ▼]

Facing the need to accommodate a growing number of inhabitants in major European cities, this research aimed to establish a methodology that facilitates decision making on urban densification through roof stacking. The methodology adopts a systematic approach on three consecutive levels: urban, engineering, and social. Multiple criteria are identified to assess and map the roof stacking potential in terms of location and number of added floors. The Brussels Capital Region was chosen as a case study to experiment with the developed workflow chart and validate the proposed approach, using ArcGIS software, by creating a map of the urban densification potential through roof stacking of Brussels at the city scale. The results show a realistic potential of accommodating 30% of the expected population increase in Brussels by the year 2040 using only roof stacking, provided that the current urban regulations are respected. In addition, a theoretical potential to accommodate more than the expected population increase by the same year is proposed provided that urban planning regulations are relaxed in relation to the height of buildings. Further applications to other cities in Europe would help create additional opportunities to develop an automated tool for estimating such potentials on a wider scope. [less ▲]

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See detailIn silico modeling of bone formation under the influence of calcium phosphate-based biomaterials and osteochondrogenic growth factors
Manhas, Varun ULiege

Doctoral thesis (2017)

Bone regeneration is a complex process that involves regulation of different cell types by multiple biochemical, physical and mechanical factors. Unlike other biological tissues, bone can heal scarlessly ... [more ▼]

Bone regeneration is a complex process that involves regulation of different cell types by multiple biochemical, physical and mechanical factors. Unlike other biological tissues, bone can heal scarlessly and recover its original shape, size and strength. However, about 5% of bone defects result in non-unions. To tackle these non-unions, tissue engineering (TE) aims to develop bone substitutes or intelligent TE constructs to replace damaged, diseased or aging tissue. These bone substitutes/TE constructs are designed to support the chemotaxis, proliferation and differentiation of bone progenitor cells as well as being a biochemical agent delivery system. However, these delivery systems have a few limitations such as structural weakness of the carrier, high doses of biochemical agents being delivered due to burst release, unknown optimal concentrations of implanted cells and their high cost. Another drawback of these systems is the limited understanding on the relationship between biochemical agent dose, implanted cells, carrier volume, carrier material type and resultant bone formation. Given their significant medical potential, there is an increasing demand to design and develop improved bone substitutes/TE constructs. This PhD work fits in the long-term vision that mathematical models can be used as a part of design and manufacturing processes to develop improved treatment strategies and ultimately save experimental time and costs. In the first part of this work, a novel computational model was developed to predict the in vitro release of Ca2+ ions from calcium phosphate (CaP)-based scaffolds. The developed model was based on the Noyes-Whitney equation, the Fick’s second law of diffusion equation and the level-set method (LSM). The model was dependent on biophysicochemical phenomena such as dissolution, diffusion and degradation along with specific scaffold characteristics such as composition, size and shape. The predictions of the model were compared to dedicated experimental results. In the second part of this work, we investigated the use of a previously reported oxygen-dependent fracture healing model to elucidate the in vivo bone formation capacity of bone morphogenetic protein-2 (BMP-2) delivery systems in an ectopic environment. Specific attention was paid to the influence of BMP-2 dose and carrier volume on ectopic bone formation. The performance of this mathematical model was corroborated by comparison with experimental results published in the literature. Finally, the model was applied to investigate the influence of different BMP-2 release profiles on ectopic bone formation. In the third part of this work, we developed a novel computational model to predict the CaP and BMP-dependent ectopic bone formation in nude mice with and without incorporation of donor cells. The model specifically investigated the influence of BMP-2 dose, donor cell concentrations and calcium ion release on ectopic bone formation. The performance of this mathematical model was compared to the results of dedicated in-house experiments. The model was able to capture essential elements of the experimental results yet at the same time, a number of points for further improvement were identified. In the final part of this work, we investigated the application of the aforementioned CaP and BMP-dependent bone formation model to an orthotopic setting in sheep. The performance of the mathematical model was corroborated by comparing the model predictions with experimental results published in the literature. Subsequently, the model was applied to investigate the influence of different CaP-BMP-cell combinations on orthotopic bone formation, simulating in-house ongoing experiments. In conclusion, this PhD work illustrates a computational step taken towards enhancing the understanding on the role of CaP and BMPs in healing large bone defects. [less ▲]

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See detail“A Genome Mining Toolbox for CRISPR-associated Cas9 orthologues”
Golestan Hashemi, Farahnaz Sadat ULiege

Scientific conference (2017, November 19)

CRISPR-associated protein system can facilitate accurate and targeted editing of genomes. RNA-guided Cas9 can be employed as an efficient genome editing tool in human, plants, and animals. The Cas9 ... [more ▼]

CRISPR-associated protein system can facilitate accurate and targeted editing of genomes. RNA-guided Cas9 can be employed as an efficient genome editing tool in human, plants, and animals. The Cas9 nuclease can be programmed by guide RNA (gRNA) in order to cut DNA at targeted regions. Therefore, concise mutations are introduced by homologous recombination or non-homologous end-joining repairing. Although the CRISPR/Cas9 is a powerful system, alternative strategies have been developed to decrease the risk of off-target activities such as using Cas9 orthologs. Additionally, only one activity can be mediated by the Cas9 protein from Streptococcus pyogenes (Sp) at different target regions. In other words, it is unable to simultaneously mediate a different activity at other targets. Besides SpCas9, some orthologous CRISPR–Cas9 systems from different species have been discovered and utilized for genome editing. Therefore, in order for wider application of CRISPR-Cas, new and applicable Cas proteins, with different requirements for PAM sequence, gRNA length, and tracrRNA and crRNA sequences, have emerged from several species as a new tool for effective genome editing. Consequently, discovery of various potential Cas9 proteins becomes a major concern for CRISPR/Cas-mediated genome editing technology to develop straightforward bioinformatics tools with high efficiency and versatility to facilitate the artificial design of possible gRNAs. Hence, we aimed to create an application tool to perform high-throughput detection of target sites based on the specific sequence and length of PAM followed by a constant length of target site for not only common Streptococcus pyogenes (SpCas9) but also for other CRISPR-Cas systems. To this end, different search modes for gRNA detection were applied including i) coding strand searching, ii) anti-coding strand searching, iii) both strand searching. Also, a complete list of all possible gRNAs along with their useful information can be provided for various potential Cas9 orthologs. Such progress expands the toolbox of genome editing and the possibilities for the site-specific genome engineering. [less ▲]

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See detailRiver, people and uncertainties : a socio-ecological resilience of Middle Senegal River Valley
Bruckmann, Laurent ULiege

Conference (2017, November 17)

In Senegal river basin, large dams were built during the 1980’s to secure water resources after a decade of water scarcity in the 1970’s: Manantali in the upper basin with a reservoir of 12km3 and Diama ... [more ▼]

In Senegal river basin, large dams were built during the 1980’s to secure water resources after a decade of water scarcity in the 1970’s: Manantali in the upper basin with a reservoir of 12km3 and Diama close to estuary to avoid saltwater intrusion during dry season. Senegal river water resources are known under the supervision of Senegal River Basin Development Organization (OMVS), which defines water allocation between different goals (electricity, irrigation, flood-recession agriculture). The Senegal river valley, located on northern part of the basin (with low precipitation < 300 mm), deals with different socio-ecological changes, following thirty years of dam management. Hydrological changes are characterized by a new hydrological regime, especially by a higher irregularity of annual flood. The main change is the development of an irrigated agriculture along the floodplain, and the valley is a strategic place for national rice production. In these context livelihoods are particularly affected by change and uncertainties around climate change, hydrology and economy. The agricultural landscape is currently remodeled around irrigation, where traditional activities are still included and combined. The aims of this communication is to determine the influence of both changes, socio-economic and hydro-climatic, in the reorganization of the agricultural landscape of the middle Senegal river valley, and especially the way they interact together. Water management at different scales (basin level versus local level), diversification of agriculture and socio-demographic dynamics are some important factors of the socio-ecological resilience of the middle Senegal river valley to uncertainties and mutations. [less ▲]

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See detailBig Data and Geomatics - Towards a new paradigm in spatial information management
Kasprzyk, Jean-Paul ULiege; Hallot, Pierre ULiege

Conference (2017, November 17)

Big Data and Geomatics : towards a new paradigm in spatial information management During the last decade, the technological advances allowed a massive acquisition of digital data whose volume grows ... [more ▼]

Big Data and Geomatics : towards a new paradigm in spatial information management During the last decade, the technological advances allowed a massive acquisition of digital data whose volume grows exponentially. Going from location-based social networks to smartphones, users produce huge amounts of data that are located in space and time. The various exploitations of these large and heterogeneous datasets have created a new field called “Big Data”. As most of these data are characterized by spatial and temporal components, it has become the next challenge to handle for geomatics researchers within the next incoming year. In this presentation, we provide an overview of the main domains in geomatics that are impacted by big data. Related fields are among other things: terrestrial spatial data acquisition where the rise of powerful laser scanners, that can acquire millions of points per second in order to precisely represent built heritage in 3D, revolutionized topography; Global Navigation Satellite Systems (GNSS), powered by the European constellation Galileo, imply original researches able to increase the position accuracy of a simple smartphone user; remote sensing is now enriched by a wide open access capability thanks to Copernicus satellites which provide timely information for the management of the environment. In order to effectively manage and analyse information related to each of these revolutions, Geographical Information System (GIS) research uses innovative data storage strategies based on CityGML for 3D data, semantic web linked-data and non-structured databases (NoSQL) for the integration of heterogeneous information, data warehouses and OnLine Analytical Processing (OLAP) for decision support. The presentation is based on concrete applications about smart cities, remote sensing, firefighting… [less ▲]

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See detailRembert Dodoens (1517-1585) Histoire des plantes Traduction française suivie d'un petit recueil par Charles de l'Escluse
Tits, Monique ULiege; Angenot, Luc ULiege

in Libert, Florence; Charles, Catherine; Poumay, Yves (Eds.) Balade patrimoniale en médecine, pharmacie et sciences biomédicales (2017)

Commentaires sur ce premier ouvrage écrit en Français et imprimé en Belgique à propos des plantes médicinales et toxiques utilisées au XVI e siècle. Ces plantes provenaient soit d'Europe ( y compris de ... [more ▼]

Commentaires sur ce premier ouvrage écrit en Français et imprimé en Belgique à propos des plantes médicinales et toxiques utilisées au XVI e siècle. Ces plantes provenaient soit d'Europe ( y compris de Belgique) mais aussi d'Afrique, Asie et quelques unes d'Amérique. L'ouvrage initial de Rembert Dodoens était écrit en Flamand brabançon et a été traduit en français par Charles de l'Escluse ( Carolus Clusius) qui y a ajouté des épices et quelques autres plantes par arpport à l'ouvrage flamand édité en 1554 [less ▲]

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See detailCarte interactomique entre l'oncoprotéine Tax du virus HTLV-1 et les protéines à domaines PDZ.
Blibek, Karim ULiege

Doctoral thesis (2017)

HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with the HTLV-1 ... [more ▼]

HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with the HTLV-1 virus, but only about 5 % develop the associated pathologies. At present, efforts are invested in the search for treatments that may improve the survival expectancy of patients infected by the HTLV-1 virus. The diagnosis of HTLV-1 infection is hampered by the viral genome latency (up to 40 years) and treatment options are limited. To propose novel therapeutic opportunities, it thus is necessary to better understand the host molecular mechanisms perturbed by the HTLV-1 infection. The HTLV-1 genome encodes for the Tax-1 protein, which confers the transforming ability of the virus. The Tax-1 protein is known as the transactivator factor of the HTLV-1 virus genome expression (TransActivator of pX region). It is also involved in the destabilization of several molecular mechanisms within the host, leading to cellular transformation. Tax-1 protein displays several functional domains and interacts with a wide range of cellular proteins. In particular, the Tax-1 protein sequence contains, at its carboxy-terminal end, a motif of four amino acids able to interact with PDZ domain (PSD95-DLG1-ZO1) containing proteins. It has been demonstrated that deletion of the PDZ binding motif (PBM) of the Tax-1 protein leads to a decrease of its oncogenic capacity in vitro. Cellular proteins containing PDZ domains are involved in the formation of cellular junctions, synapses and in cellular receptors assembly. Some of PDZ proteins are capable of relaying extracellular signals and participate in the control of proliferation. The human genome codes for at least 150 proteins with PDZ domains. However, the specificity of the oncoprotein Tax-1 to target these proteins remains unknown. In this study, we have mapped The Tax-1 - PDZ interactome using a combination of several methods. We reveal that Tax-1 selectively target a number of PDZ domains-containing proteins potentially involved in HTLV-1 pathogenesis. We validated our approach by focusing on the role of SDCBP and LNX2 proteins in HTLV-1 biology. Our work also demonstrated that the Tax-1-PDZ interactome might represent an attractive therapeutic target for HTLV-1-induced diseases. [less ▲]

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Peer Reviewed
See detailUsage des boîtiers de vote électronique et développement professionnel de l’enseignant-universitaire
Detroz, Pascal ULiege; Younes, Nathalie

Conference (2017, November 16)

Les boitiers de vote font l’objet de très nombreux articles. Les auteurs cherchent par exemple à voir si l’utilisation de cet outil a un effet sur la motivation des étudiants et leur participation au ... [more ▼]

Les boitiers de vote font l’objet de très nombreux articles. Les auteurs cherchent par exemple à voir si l’utilisation de cet outil a un effet sur la motivation des étudiants et leur participation au cours (Caldwell, 2007), sur leur engagement (Mc Gowan et Gunderson,2010), sur le climat de classe (Bain et Przybyla, 2009) ou encore sur les apprentissages qu’ils réalisent (Preszler et al., 2007). Au final, comme souvent lorsqu’il s’agit de technologie, il semble que ce soit la pédagogie supportée par l’outil qui fasse la différence : l’usage sera pertinent s’il entre en résonance et en concordance avec une pédagogie efficace. Certes, l’outil en lui-même peut avoir un effet sur la pédagogie. Influencer, de par son fonctionnement - les possibilités qu’il offre, parfois les contraintes qu’il fait peser - la manière de concevoir des dispositifs pédagogiques. Il peut ainsi modifier le rapport des enseignants à leur pédagogie, c’est-à-dire, finalement, stimuler ou catalyser le développement professionnel des enseignants dans le domaine de la pédagogie universitaire. L’effet de l’outil et de son usage sur ce développement professionnel est au cœur de notre article. En effet, nous avons greffé - sur deux dispositifs d’accompagnement technopédagogique d’enseignants novices dans le domaine des BVE - un dispositif de recherche observant l’effet de cet usage accompagné. L’un de ces dispositifs d’accompagnement était court : l’enseignant est interviewé à deux reprises et observé lors d’une séance de cours durant laquelle les BVE sont utilisés. L’autre est plus long et comprend des autoconfrontations, des interviews, le recueil de l’avis des étudiants… La méthodologie utilisée dans cette étude, de type qualitatif, confirme notre intuition de départ : l’usage accompagné de BVE chez des enseignants novices peut, sous certaines conditions dont nous ferons état lors de la communication, accélérer le développement professionnel de ces derniers. [less ▲]

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See detailPratiques d’évaluation des acquis, ancienneté et attitudes face à l’évaluation
Romainville, Marc; Detroz, Pascal ULiege; Auquière, Amélie ULiege et al

Conference (2017, November 16)

La présente communication est issue d’une recherche plus globale visant à identifier et à mieux comprendre les pratiques d’évaluation des acquis des étudiants auxquelles recourent les enseignants de ... [more ▼]

La présente communication est issue d’une recherche plus globale visant à identifier et à mieux comprendre les pratiques d’évaluation des acquis des étudiants auxquelles recourent les enseignants de l’enseignement supérieur et en particulier les facteurs personnels (ancienneté, attitudes vis-à-vis de l’évaluation…) et contextuels (année d’étude, taille du groupe, disciplines…) qui influencent ces pratiques. Les données ont été recueillies en 2016, d’une part, via une enquête en ligne (élaborée à l’aide du logiciel d’enquêtes Qualtrics) auprès d’enseignants de l’enseignement supérieur belge francophone que ce soit à l’Université ou en Hautes écoles (2292 réponses) et, d’autre part, via 37 entretiens semi-structurés individuels réalisés auprès d’un échantillon de ces mêmes enseignants dans des filières d’études contrastées. Les résultats présentés dans le cadre de cette communication ont trait à l’impact de deux variables personnelles : l’ancienneté des enseignants et leurs attitudes vis-à-vis de l’évaluation. Autrement dit, on cherchera à savoir si l’ancienneté et le développement professionnel qui l’accompagne traditionnellement ont des incidences sur le type de pratiques d’évaluation des acquis des enseignants. En particulier, recourent-ils à des outils de plus en plus diversifiés ou ont-ils tendance à se spécialiser dans l’un ou l’autre ? Et si oui, pourquoi ? Accentuent-ils par ailleurs le recours à l’évaluation continue par rapport au poids du contrôle terminal ? On cherchera ensuite à comprendre comment les pratiques se reconfigurent en fonction des attitudes des enseignants vis-à-vis de l’évaluation et en particulier vis-à-vis de sa fonction et de son rapport à l’apprentissage : dans quel sens une conception davantage intégrative de l’évaluation colore-t-elle les pratiques déclarées d’évaluation ? [less ▲]

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See detailDwelling on Dwelling: Home and Nature in (Native) American Literature
Lombard, David ULiege

Conference (2017, November 16)

As Greg Garrard stresses, “[i]nterpretation and critique of the various inflections of dwelling is a major task for ecocritics interested in a predominantly political, rather than moral or spiritual ... [more ▼]

As Greg Garrard stresses, “[i]nterpretation and critique of the various inflections of dwelling is a major task for ecocritics interested in a predominantly political, rather than moral or spiritual, project of cultural critique that can take us beyond pastoral and nature writing, from the landscapes of leisure to the uneven terrain of real work” (2012). In this paper, I will examine American literary texts dealing with representations of dwelling or “home” as a refuge from the “tensions” or problems caused by modern civilisation and technology. Starting with Thoreau’s Walden (1854), I will focus on the relationships between such refuges, the natural environment, and socio-political critique. Indeed, Thoreau’s work displays a philosophy on nature and dwelling that has influenced other writers to ponder on the negative effects that modern technologies, capitalism and consumerism have had on the human self and, more largely, on our physical environment. Adopting an ecocritical perspective, I will therefore consider Thoreau’s stay in Walden Pond as well as Edward Abbey’s house trailer (Desert Solitaire, 1968), Christopher McCandless’s “magic bus” as depicted in Jon Krakauer’s Into the Wild (1992) or Ken Ilgunas’s “vandwelling” (Walden on Wheels, 2013) to study the socio-political and environmental concerns raised by dwelling experiences in such peculiar or isolated “homes”. Finally, I will also briefly discuss the Native American perspective through an analysis of Leslie Marmon Silko’s novel Ceremony (1977) as an example of the Laguna Pueblo’s perception of nature or the “land” as “home”. [less ▲]

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See detailUn autre regard sur la participation des écoles et des élèves à l’enquête du PISA
Raiche, Gilles; Béland, Sébastien; Magis, David ULiege

Conference (2017, November 16)

Le Programme international pour le suivi des acquis des élèves (PISA) a pour objectif de produire des indicateurs sur les habiletés et les connaissances qui contribuent au succès des élèves, des écoles ... [more ▼]

Le Programme international pour le suivi des acquis des élèves (PISA) a pour objectif de produire des indicateurs sur les habiletés et les connaissances qui contribuent au succès des élèves, des écoles, des systèmes éducatifs et des environnements d’apprentissage (CMEC, 2015, p. 7). Depuis 2000, l’enquête du PISA est planifiée à tous les trois ans pour les élèves de 15 ans en ciblant spécifiquement les matières suivantes : la compréhension de l’écrit, la culture mathématique et la culture scientifique. Dans le cadre de la dernière passation, les résultats des Canadiens à cette enquête ont été salués dans l’ensemble du pays : les élèves se classent dans le groupe des pays les plus performants pour toutes les disciplines couvertes. Par contre, le taux de participation des écoles ainsi que les taux d’exclusions des élèves au regard de divers handicaps, qui pourraient éventuellement avoir un impact sur les résultats et le classement international, ont été critiqués à travers le pays. Cette présentation a comme objectif d’étudier le rendement des élèves canadiens au programme international des acquis scolaires (PISA) entre 2000 à 2015 en fonction de différentes caractéristiques relatives à la participation des écoles et au taux d’exclusion des élèves présentant certains handicaps. Des modèles de régression linéaire à niveaux multiples sont utilisés à cette fin. [less ▲]

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See detailCarte interactomique entre l'oncoprotéine Tax du virus HTLV-1 et les protéines à domaines PDZ.
Blibek, Karim ULiege

Scientific conference (2017, November 16)

ABSTRACT HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with ... [more ▼]

ABSTRACT HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with the HTLV-1 virus, but only about 5 % develop the associated pathologies. At present, efforts are invested in the search for treatments that may improve the survival expectancy of patients infected by the HTLV-1 virus. The diagnosis of HTLV-1 infection is hampered by the viral genome latency (up to 40 years) and treatment options are limited. To propose novel therapeutic opportunities, it thus is necessary to better understand the host molecular mechanisms perturbed by the HTLV-1 infection. The HTLV-1 genome encodes for the Tax-1 protein, which confers the transforming ability of the virus. The Tax-1 protein is known as the transactivator factor of the HTLV-1 virus genome expression (TransActivator of pX region). It is also involved in the destabilization of several molecular mechanisms within the host, leading to cellular transformation. Tax-1 protein displays several functional domains and interacts with a wide range of cellular proteins. In particular, the Tax-1 protein sequence contains, at its carboxy-terminal end, a motif of four amino acids able to interact with PDZ domain (PSD95-DLG1-ZO1) containing proteins. It has been demonstrated that deletion of the PDZ binding motif (PBM) of the Tax-1 protein leads to a decrease of its oncogenic capacity in vitro. Cellular proteins containing PDZ domains are involved in the formation of cellular junctions, synapses and in cellular receptors assembly. Some of PDZ proteins are capable of relaying extracellular signals and participate in the control of proliferation. The human genome codes for at least 150 proteins with PDZ domains. However, the specificity of the oncoprotein Tax-1 to target these proteins remains unknown. In this study, we have mapped The Tax-1 - PDZ interactome using a combination of several methods. We reveal that Tax-1 selectively target a number of PDZ domains-containing proteins potentially involved in HTLV-1 pathogenesis. We validated our approach by focusing on the role of SDCBP and LNX2 proteins in HTLV-1 biology. Our work also demonstrated that the Tax-1-PDZ interactome might represent an attractive therapeutic target for HTLV-1-induced diseases. KEYWORDS: HTLV-1, Leukemia, Tax-1, interactions, PDZ. [less ▲]

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See detailOverview and future challenges of nearly Zero Energy Buildings (nZEB) design in Southern Europe
Attia, Shady ULiege; Polyvios, Eleftheriou; Xeni, Flouris et al

in Energy and Buildings (2017), 155

In times of great transition of the European construction sector to energy efficient and nearly zero energy buildings (nZEB), a market observation containing qualitative and quantitative indications ... [more ▼]

In times of great transition of the European construction sector to energy efficient and nearly zero energy buildings (nZEB), a market observation containing qualitative and quantitative indications should help to fill out some of the current gaps concerning the EU 2020 carbon targets. Next to the economic challenges, there are equally important factors that hinder renovating the existing residential building stock and adding newly constructed high performance buildings. Under these circumstances this paper summarises the findings of a cross-comparative study of the societal and technical barriers of nZEB implementation in 7 Southern European countries. The study analyses the present situation and provides an overview on future prospects for nZEB in Southern Europe. The result presents an overview of challenges and provides recommendations based on available empirical evidence to further lower those barriers in the European construction sector. The paper finds that the most Southern European countries are poorly prepared for nZEB implementation and especially to the challenge/opportunity of retrofitting existing buildings. Creating a common approach to further develop nZEB targets, concepts and definitions in synergy with the climatic, societal and technical state of progress in Southern Europe is essential. The paper provides recommendations for actions to shift the identified gaps into opportunities for future development of climate adaptive high performance buildings. [less ▲]

Detailed reference viewed: 301 (10 ULiège)