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See detailAs teorias semióticas face à fotografia
Dondero, Maria Giulia ULg

in Calavari, Suzi; Rodrigues, Angelica; Rocha, Nildicéia (Eds.) Proceedings VI SELIN – NOVAS PRÁTICAS EM PESQUISA SOBRE A LINGUAGEM: ROMPENDO FRONTEIRAS (2017, August)

Dans ce texte, je me propose de revenir sur les travaux en sémiotique qui ont marqué les études du champ interdisciplinaire de la photographie et de les poursuivre; l’objectif principal est de fournir ... [more ▼]

Dans ce texte, je me propose de revenir sur les travaux en sémiotique qui ont marqué les études du champ interdisciplinaire de la photographie et de les poursuivre; l’objectif principal est de fournir quelques pistes pour étudier, d’un point de vue sémiotique, l’image photographique en tant qu’objet pris dans des pratiques d’usage et d’interprétation diversifiées au sein des statuts sociaux de l’art, de la science, de la religion. [less ▲]

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See detailNETPerfTrace – Predicting Internet Path Dynamics and Performance with Machine Learning
Wassermann, Sarah ULg; Casas, Pedro; Cuvelier, Thibaut ULg et al

in Proceedings of Big-DAMA ’17 (2017, August)

We study the problem of predicting Internet path changes and path performance using traceroute measurements and machine learning models. Path changes are frequently linked to path inflation and ... [more ▼]

We study the problem of predicting Internet path changes and path performance using traceroute measurements and machine learning models. Path changes are frequently linked to path inflation and performance degradation, therefore the relevance of the problem. We introduce NETPerfTrace, an Internet Path Tracking system to forecast path changes and path latency variations. By relying on decision trees and using empirical distribution-based input features, we show that NETPerfTrace can predict (i) the remaining life time of a path before it actually changes and (ii) the number of path changes in a certain time period with relatively high accuracy. Through extensive evaluation, we demonstrate that NETPerfTrace highly outperforms DTRACK, a previous system with the same prediction targets. NETPerfTrace also offers path performance forecasting capabilities. In particular, our tool can predict path latency metrics, providing a system which can not only predict path changes, but also forecast their impact in terms of performance variations. We release NETPerfTrace as open software to the networking community, as well as all evaluation datasets. [less ▲]

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See detailGiving an account of fictional discourse. Meinongian logics versus modal logics
Leclercq, Bruno ULg

Conference (2017, August)

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See detailRegiospecific radiolabelling of Nanofitin on Ni Magnetic Beads with [18F]FBEM and in vivo PET studies
Dammicco, Sylvestre ULg; Goux, Marine; Lemaire, Christian ULg et al

in Nuclear Medicine & Biology (2017)

Introduction: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family ... [more ▼]

Introduction: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family and are highly stable over a wide range of pH (0-13) and temperature (Tm ~80°C). Their extreme stability, low cost of production and high tolerability for chemical coupling make Nanofitins a very interesting alternative to antibodies and their fragments. Here, a hexahistidine tagged model Nanofitin (H4) directed against hen egg white lysozyme was radiolabelled and injected in mice to provide a baseline biodistribution and pharmacokinetic profiles to support future Nanofitin development programs. Method: A single cysteine residue has been genetically inserted in a model Nanofitin and its regioselective radiolabelling has been performed with 4-[18F]fluorobenzamido-N-ethylamino-maleimide ([18F]FBEM). The synthesis of [18F]FBEM has been completely implemented on a radiosynthesis unit (FastLab) including HPLC purification and formulation. Coupling with the [18F]FBEM has been achieved on a solid support (Ni magnetic beads) allowing rapid purification at room temperature without organic solvent. PET-MRI studies on C57BL/6 mice were conducted after injection of [18F]FBEM-Cys-H4 in order to access the biodistribution of this Nanofitin model. Results: Radiochemical yield (decay corrected) of 54±7% (n=4) was obtained after optimization for coupling the [18F]FBEM to Nanofitin. Pharmacokinetics results of [18F]FBEM-Cys-H4 revealed a fast clearance through the liver and the kidneys. Conclusion: An efficient new method on Ni magnetic beads was developed to radiolabelled his-tagged biomolecules with [18F]FBEM. This procedure was applied on a Nanofitin model Cys-H4 and biodistribution kinetic studies were achieved to evaluate the potential use of Nanofitin for diagnostic imaging. Fast clearance indicates that Nanofitins represent very interesting tools for diagnostic imaging. [less ▲]

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See detailEnergy Dissipation Within the Wave Run-Up at Stepped Revetments
Kerpen, Nils B.; Bung, Daniel B.; Valero Huerta, Daniel ULg et al

in Journal of Ocean University of China (2017), 16(4), 649-654

To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment, hydraulic model tests with steady flow conditions are conducted and ... [more ▼]

To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment, hydraulic model tests with steady flow conditions are conducted and correlated with unsteady flow conditions of the wave run-up within a short time frame. Under irregular waves, the run-up reduction over a stepped revetment is dependent on the Iribarren number and decreases for decreasing Iribarren numbers. Velocity gradients are found to be similar in a steady and unsteady flow regime near the pseudo-bottom. [less ▲]

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See detailCharacterising Industrial Sites' Flexibility with Reservoir Models
Cuvelier, Thibaut ULg

Poster (2017, August)

Electro-intensive industrial sites are very dependent on electricity prices to remain competitive. Nevertheless, they can often tune their processes in order to decrease their electricity consumption ... [more ▼]

Electro-intensive industrial sites are very dependent on electricity prices to remain competitive. Nevertheless, they can often tune their processes in order to decrease their electricity consumption during the most critical periods, for example by using decision support systems based on mathematical modelling of their processes. Our goal is to estimate the flexibility potential of a complete site, not to tune each process very precisely. To this end, we propose a generic paradigm to help conceiving such models: reservoirs are the basic building block, which allows for great expressiveness while being close to the physics. More specifically, we do not need very precise models for our purposes, but ones that can be efficiently included in optimisation models. Our first results show that the obtained reservoir models can give sufficiently good approximations for metallurgical processes (more precisely, electric-arc and ladle furnaces). [less ▲]

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See detailEYK1 encoding erythrulose kinase as a catabolic selectable marker for genome editing in the non-conventional yeast Yarrowia lipolytica
Vandermies, Marie ULg; Denies, Olivia ULg; Nicaud, Jean-Marc et al

in Journal of Microbiological Methods (2017), 139

We report here on EYK1, encoding erythrulose kinase, as an efficient catabolic selectable marker for genome editing in Y. lipolytica. Compared to auxotrophic markers, EYK1 increases the growth rate of ... [more ▼]

We report here on EYK1, encoding erythrulose kinase, as an efficient catabolic selectable marker for genome editing in Y. lipolytica. Compared to auxotrophic markers, EYK1 increases the growth rate of transformants and allows improved efficiency of transformation. The utility of the marker EYK1 in a replicative vector was also demonstrated. [less ▲]

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See detailSearch for the signatures of mass-exchange episodes in massive binaries
Raucq, Françoise ULg

Doctoral thesis (2017)

Massive stars are known for their crucial role in our Universe, through their extreme stellar parameters, leading to a strong impact on their environment. However, there remain numbers of unanswered ... [more ▼]

Massive stars are known for their crucial role in our Universe, through their extreme stellar parameters, leading to a strong impact on their environment. However, there remain numbers of unanswered questions concerning the exact processes of their formation, their stability or the processes driving their strong stellar winds. In the context of this thesis work, we adress one of the most interesting of their peculiarities: their tendency to be part of binary of higher multiplicity systems. Whilst this multiplicity does help to solve some open issues by allowing us to study some of the fundamental properties of the stars, such as their minimum masses and radii as well as their stellar luminosities, it can also lead to interactions between the components of a system, which affect the subsequent evolution of the stars and give rise to additional open questions on the processes in place in such systems. Among the possible interactions taking place within close binary systems is the possibility of a transfer of mass and kinetic momentum through a Roche lobe overflow. This process has a huge impact on the subsequent evolution of both components and many aspects of this phenomenon are not well understood yet. The present work is devoted to the search for the signatures of such past mass-exchange episodes in a sample of four short-period massive multiple systems: HD 149404, LSS 3074, HD 17505 and HD 206267. We determined a new orbital solution for three of them. We then used phase-resolved spectroscopy to perform the spectral disentangling of the optical spectra of the components. The spectral disentangling is a mathematical tool which allows to separate the contributions of both components to the observed spectra of a system. We then analysed the reconstructed spectra with the CMFGEN atmosphere code to determine stellar parameters, such as the effective temperatures and surface gravities, and to constrain the surface chemical composition of each component. The first two parts of this dissertation are dedicated to the scientific background and the description of the numerical tools and methods used in this work. The third part presents our studies of the selected massive systems. We confirmed that the hypothesis of a past Roche lobe overflow episode is most plausible to explain the observed properties of the components of HD 149404. Photometric data permitted us to confirm that LSS 3074 is in an overcontact configuration, and a combined analysis with spectroscopy showed that the system has lost a significant fraction of its mass to its surroundings. We proposed several possible evolutionary pathways involving a Roche lobe overflow process to explain the current parameters of its components. We found no evidence of past mass-transfer episodes in the spectra of HD 17505 and showed that the current properties of its components can be explained by single star evolutionary models including rotational mixing. We found clues of binary interactions in the spectra of HD 206267, but suggested that the system did not experience a complete Roche lobe overflow episode at this stage of its evolution. [less ▲]

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See detailForeseeing New Control Challenges in Electricity Prosumer Communities
Olivier, Frédéric ULg; Marulli, Daniele; Ernst, Damien ULg et al

in Proc. of the 10th Bulk Power Systems Dynamics and Control Symposium – IREP’2017 (2017, August)

This paper is dedicated to electricity prosumer communities, which are groups of people producing, sharing and consuming electricity locally. This paper focuses on building a rigorous mathematical ... [more ▼]

This paper is dedicated to electricity prosumer communities, which are groups of people producing, sharing and consuming electricity locally. This paper focuses on building a rigorous mathematical framework in order to formalise sequen- tial decision making problems that may soon be encountered within electricity prosumer communities. After introducing our formalism, we propose a set of optimisation problems reflecting several types of theoretically optimal behaviours for energy exchanges between prosumers. We then discuss the advantages and disadvantages of centralised and decentralised schemes and provide illustrations of decision making strategies, allowing a prosumer community to generate more distributed electricity (compared to commonly applied strategies) by mitigating over- voltages over a low-voltage feeder. We finally investigate how to design distributed control schemes that may contribute reaching (at least partially) the objectives of the community, by resort in to machine learning techniques to extract, from centralised solution(s), decision making patterns to be applied locally. First empirical results show that, even after a post-processing phase so that it satisfies physical constraints, the learning approach still performs better than predetermined strategies targeting safety first, then cost minimisation. [less ▲]

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See detailPrevalence of voice disorders among teachers at the beginning of their career
Schiller, Isabel ULg

Poster (2017, August)

Due to the high vocal demands associated with their profession, teachers face an increased risk of developing voice disorders. Research suggests that up to 50 % of experienced teachers are affected. Even ... [more ▼]

Due to the high vocal demands associated with their profession, teachers face an increased risk of developing voice disorders. Research suggests that up to 50 % of experienced teachers are affected. Even student teachers, whose vocal load is still relatively low, report voice problems with a frequency of 20 % (Simberg, Laine, Sala, & Rönnemaa, 2000). Little is known about the prevalence of voice disorders among teachers at the very beginning of their career. In Germany, teachers must complete a two-year teaching practice as part of their professional training after they graduate from university, consisting of attending specialized courses and giving lessons. The aim of this symptom-based study was to determine the prevalence of voice problems among this population. A self-administered questionnaire was answered by 73 German teachers in teaching practice. The prevalence of a voice problem was defined based on the presence of two symptoms that persisted for a minimum of two weeks. Results revealed that 37 % of teachers had voice problems during their teaching practice. Among the most frequent symptoms were hoarseness, an urge to clear one’s throat and problems speaking at a loud voice. Considering that the participants had not even begun teaching full-time, the prevalence of reported voice problems is worrisome. It could be associated with their lacking experience in how to use their voice effectively. The findings highlight the necessity of early intervention programs focusing on vocal hygiene and effective voice use in classroom situations. [less ▲]

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See detailSynthesis and complexation of superbulky imidazolium-2-dithiocarboxylate ligands
Beltran Alvarez, Tomás Francisco ULg; Zaragoza, Guillermo; Delaude, Lionel ULg

in Dalton Transactions (Cambridge, England : 2003) (2017), 46(28), 9036-9048

The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the ... [more ▼]

The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the corresponding imidazolium-2-dithiocarboxylate zwitterions in high yields. These new dithiolate ligands were fully characterized and their coordination chemistry toward common Re(i) and Ru(ii) metal sources was thoroughly investigated. Neutral [ReBr(CO)3(S2C[middle dot]NHC)] chelates featured three facially-arranged carbonyl groups on a distorted octahedron, whereas cationic [RuCl(p-cymene)(S2C[middle dot]NHC)]PF6 complexes displayed a piano-stool geometry. The molecular structures of the six new compounds revealed that the NHC[middle dot]CS2 inner salts were highly flexible. Indeed, the torsion angle between their anionic and cationic moieties varied between ca. 63[degree] in the free ligands and 3[degree] in the ruthenium complexes. Concomitantly, the S-C-S bite angle underwent a contraction from 131[degree] to 110-113[degree] upon chelation. Computation of the %VBur parameter showed that the dithiocarboxylate unit of the NHC[middle dot]CS2 betaines chiefly determined the steric requirements of the imidazolium moieties, irrespective of the metal center involved in the complexation. The replacement of the p-methyl substituents of IDip*Me with p-methoxy groups in IDip*OMe did not significantly affect the ligand bulkiness. The more electron-donating methoxy group led, however, to small changes in various IR wavenumbers used to probe the electron donor properties of the carbene moiety. [less ▲]

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See detailShape and spin determination of Barbarian asteroids
Devogele, Maxime ULg; Devogele, Maxime ULg; Tanga, P. et al

in Astronomy and Astrophysics (2017)

The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such ... [more ▼]

The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such properties were identified. As has been suggested, large scale topographic features could play a role in the polarimetric response, if the shapes of Barbarians are particularly irregular and present a variety of scattering/incidence angles. This idea is supported by the shape of (234) Barbara, that appears to be deeply excavated by wide concave areas revealed by photometry and stellar occultations. Aims. With these motivations, we started an observation campaign to characterise the shape and rotation properties of Small Main- Belt Asteroid Spectroscopic Survey (SMASS) type L and Ld asteroids. As many of them show long rotation periods, we activated a worldwide network of observers to obtain a dense temporal coverage. Methods. We used light-curve inversion technique in order to determine the sidereal rotation periods of 15 asteroids and the con- vergence to a stable shape and pole coordinates for 8 of them. By using available data from occultations, we are able to scale some shapes to an absolute size. We also study the rotation periods of our sample looking for confirmation of the suspected abundance of asteroids with long rotation periods. Results. Our results show that the shape models of our sample do not seem to have peculiar properties with respect to asteroids with similar size, while an excess of slow rotators is most probably confirmed. [less ▲]

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See detailTypical versus delayed speech onset influences verbal reporting of autistic interests
Chiodo, Liliane ULg; Majerus, Steve ULg; Mottron, Laurent

in Molecular Autism (2017)

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is ... [more ▼]

The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is associated with clinical, cognitive, and neural differences. It is unknown whether these different speech development pathways and associated cognitive differences are involved in the heterogeneity of the restricted interests that characterize autistic adults. [less ▲]

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See detailAcromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database.
PETROSSIANS, Patrick ULg; Daly, Adrian ULg; Natchev, Emil et al

in Endocrine-Related Cancer (2017)

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly ... [more ▼]

Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liege Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs. 46.4 years; p<0.001). The median delay from first symptoms to diagnosis was two years longer in females (p=0.015). Ages at diagnosis and first symptoms increased significantly over time (p<0.001). Tumors were larger in males than females (p<0.001); tumor size and invasion were inversely related to patient age (p<0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (p<0.001). GH was inversely related to age in both sexes (p<0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6-4.4% had experienced a fracture. This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis. [less ▲]

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See detailQuality evaluation of peach chips and anticancer activity of pectin extracted from chips dehydrated by explosion puffing drying
Lyu, Jian ULg

Doctoral thesis (2017)

The objectives of this research are to discriminate the overall quality level of peach and nectarine chips prepared by explosion puffing drying (EPD), determine the changes of texture and water soluble ... [more ▼]

The objectives of this research are to discriminate the overall quality level of peach and nectarine chips prepared by explosion puffing drying (EPD), determine the changes of texture and water soluble pectin (WSP) during EPD processing and study the anticancer activity of WSP on malignant mesothelioma (MM). Principle component analysis (PCA), Analytic hierarchy process (AHP), K-mean cluster and Discriminant analysis (DA) are used to distinguish the overall quality level of peach and nectarine chips and get the characteristic evaluation indicators, which of them (e. g. rehydration ratio and expansion ratio) are corresponding to texture properties of dehydrated products. Additionally, biochemical changes of the cell wall (e. g. pectin) are also related to texture changes. The investigate on the changes of texture and WSP at different stages of EPD processing in which osmotic dehydration (OD) was used as the pretreatment, show that OD with the appropriated concentration can improve the texture quality of dried products. The drying processing causes the degradation and structure modification of WSP, which can induce apoptosis in MM cells. EPD technology can be carried out as a potential pathway on modification of pectin, which may contribute to the development of a potential therapy against MM. [less ▲]

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See detailItem purification versus adjustments for multiple comparisons in DIF detection
Drabinova, Adela; Martinkova, Patricia; Magis, David ULg

Poster (2017, July 18)

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