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See detailChapter 5. Metal homeostasis in plant mitochondria
Vigani, Gianpiero; Hanikenne, Marc ULg

in Logan, David C (Ed.) Plant Mitochondria, a volume in the Annual Plant Reviews series (in press)

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See detailCompte-rendu de l'ouvrage de Boyd Taylor COOLMAN et Dale M. COULTER : Trinity and creation
Close, Florence ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailDetermination of iohexol and iothalamate in serum and urine by capillary electrophoresis.
Van Houcke, Sofie K.; Seaux, Liesbeth; Cavalier, Etienne ULg et al

in Electrophoresis (in press)

Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or ... [more ▼]

Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or radioactive compounds. However, HPLC is a time-consuming and labour-intensive method. The aim of this study was to develop an assay for iohexol and iothalamate using capillary electrophoresis (CE). Iohexol and iothalamate were directly analysed by CE in serum and urine, using photometric detection (246 nm). Serum peak height was proportional to iohexol and iothalamate concentrations. Detection limits for iohexol and iothalamate were 10 mg/L and 5 mg/L. Limits of quantification were 13.0 mg/L and 15.0 mg/L. Within-run CVs were 4.9% and 6.5%; between-run CVs 3.1-9.9% and 3.8-13.7%. A good correlation was observed between CE and HPLC: y = 1.1703 x + 5.017 (iohexol) and y = 0.7807 x + 11.01 (iothalamate) [y = concentration obtained by CE (mg/L), x = concentration obtained by HPLC (mg/L)]. In addition, CE allowed to determine urinary iohexol concentration. Although the detection limit for CE was higher than for HPLC, CE can still be used for eGFR determination. Advantages of this high throughput method are the absence of sample pretreatment and a minimal sample volume requirement. This article is protected by copyright. All rights reserved. [less ▲]

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See detailFibroblast growth factor 23 in acute burn patients: Novel insights from an intact-form assay.
ROUSSEAU, Anne-Françoise ULg; Souberbielle; DELANAYE, Pierre ULg et al

in Burns : Journal of the International Society for Burn Injuries (in press)

INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress ... [more ▼]

INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress in understanding FGF23 physiology has emphasized the importance of assessing the intact form of FGF23. METHODS: The present cohort study is a complementary analysis of a previously published work. Patients >18 years, admitted within 24h after injury with burn surface area (BSA) >10% were included. C-terminal (c-term) and intact (i) FGF23 assay were performed at admission and every week during 4 weeks of follow-up. Inflammation and iron status were assessed at the same time points. RESULTS: Twenty patients were initially included and 12 were followed until day 28. The c-term FGF23 tended to gradually increase during the 4 weeks of follow-up while iFGF23 was quite stable into normal ranges. Iron status showed a typical inflammatory profile. C-term FGF23 was significantly positively correlated with c-reactive protein (CRP) and negatively correlated with iron levels. iFGF23 was not correlated with CRP or iron. CONCLUSION: FGF23 status following burn is characterized by a dissociation between c-term FGF23 and iFGF23. The hypothesis of an increased cleavage may be raised. Respective role of inflammation and iron levels in such deregulation need to be specified. Both c-term and intact assays should be performed in further studies aiming to increase knowledge on FGF23 regulation and effects in burn patients. [less ▲]

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See detailLa politique religieuse des Pippinides (714-768)
Close, Florence ULg

Book published by PULIM (in press)

L’image de Charles Martel pilleur d’Église figure encore dans bon nombre de nos manuels et grandes synthèses historiques. Il en va de même de celle de l’avènement de Pépin III à la royauté, élu par un ... [more ▼]

L’image de Charles Martel pilleur d’Église figure encore dans bon nombre de nos manuels et grandes synthèses historiques. Il en va de même de celle de l’avènement de Pépin III à la royauté, élu par un peuple franc unanime, sur un précepte du pape Zacharie, et oint par Boniface. Or, de multiples questions ont été soulevées, ces dernières années, de nouvelles orientations de recherche ont été suggérées, qui constituent un pressant appel à un nouvel examen de la crédibilité des sources principales de l'histoire du royaume franc. Selon toute vraisemblance, la conviction des Carolingiens de détenir leur pouvoir directement de Dieu ne remonte pas au-delà du changement de dynastie mais n’est pas née ex nihilo. Elle plonge ses racines dans les décennies qui précédèrent le coup d’État de 751. L’alliance franco-pontificale de 754 fut, de toute évidence, l’aboutissement d’une transformation progressive de l’attitude des Pippinides à l’égard de Rome, du sentiment religieux et de leur rapport au sacré. À la fois typologie de sources et florilège, ce volume entend donner un aperçu de l’ampleur et de la diversité du corpus de sources à ceux et celles qui souhaiteraient aborder ce pan de l’histoire politico-religieuse du haut Moyen Âge, en présentant vingt-six sources du VIIIe siècle – narratives, diplomatiques, épistolaires ou liturgiques – traduites et commentées, retenues pour leur caractère exemplatif. [less ▲]

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See detailExperiments and Evolving Frameworks of Scientific Exploration: Jean-André Personnel’s Work on Coral
Vandersmissen, Jan ULg

in Klemun, Marianne; Spring, Ulrike (Eds.) Expeditions as Experiments: Practising Observation and Documentation (in press)

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See detailRéexamen de la tablette scolaire T.Louvre inv. AF 1195 (Antinoé, VIe siècle = MP³ 2714.01)
Carlig, Nathan ULg

in Davoli, Paola; Pellé, Natascia (Eds.) Polymatheia. Studi offerti a Mario Capasso (in press)

Réexamen et nouvelle édition de la tablette scolaire T.Louvre inv. AF 1195 (MP³ 2714.1)

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See detailThe EU and crisis in Ukraine: policy continuity in times of disorder?
Natorski, Michal ULg

in Bouris, Dimitris; Schumacher, Tobias (Eds.) The Revised European Neighbourhood Policy. Continuity and Change in EU Foreign Policy (in press)

This chapter examines the dominant continuity of the EU’s transformative policy in Ukraine during the crisis in Ukraine. Natorski scrutinizes how the Euromaidan revolution, the annexation of Crimea and ... [more ▼]

This chapter examines the dominant continuity of the EU’s transformative policy in Ukraine during the crisis in Ukraine. Natorski scrutinizes how the Euromaidan revolution, the annexation of Crimea and the war in Donbass affected the dynamics of EU policy reproduction since 2013 and explains the EU-Ukraine-Russia discussions on the potential trade consequences of the Deep and Comprehensive Free Trade Area. The dynamics of the continuity of the EU policy towards Ukraine and the altered role of Russia are explained in terms of the discursive representations of the crisis in Ukraine by the EU. The chapter concludes that the policy reproduction and change depend on what actors make of the crisis and to what extent crisis representation can be mediated coherently through the background discursive schemes. [less ▲]

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See detailLes théories représentationnelles : panorama introductif
Gauvry, Charlotte ULg

in Dewalque, Arnaud; Gauvry, Charlotte (Eds.) Conscience et représentation. Introduction aux théories représentationnelles de l'esprit (in press)

Introduction au volume

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See detailHedge fund styles and macroeconomic uncertainty
Platania, Federico ULg; Lambert, Marie ULg

E-print/Working paper (in press)

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades ... [more ▼]

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades, examining which conditioning/macroeconomic variables strongly lead the time variation in fund trades. We report the significance of macroeconomic factors such as interest rates, dividend yield, GDP growth and US unemployment. We show that hedge fund managers do control the intensity of their exposures according to economic uncertainty and that differences between up- and down-market regimes can be observed. Commonly, Hedge funds tend to dislike high-dividend paying stocks. Besides, all hedge fund styles are shown to display pro-cyclical exposures towards directional equity factors as well as credit and liquidity risks. Small growth stocks, however, are revealed to be crisis investments whose allocation increases with unemployment, inflation or volatility. As volatility increases, the value of growth options embedded into growth stocks indeed increases. Growth stocks are shown to hedge market reversals and volatility. The outperformance of growth companies in recessions might also relate to their cost flexibility. Allocation to small stocks embed strong micro risks and might also constitute a hedge in economic slowdowns. This might explain why some funds with such a particular investment focus appear to be countercyclical. [less ▲]

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See detailMarket efficiency and hedge fund trading strategies
Platania, Federico ULg; Lambert, Marie ULg; Papageorgiou, Nicolas

E-print/Working paper (in press)

Stock and option markets can at times reflect differing information. We identify three reasons for the presence of these periods of "disagreement" between the cash and derivatives markets: 1) high ... [more ▼]

Stock and option markets can at times reflect differing information. We identify three reasons for the presence of these periods of "disagreement" between the cash and derivatives markets: 1) high volatility and noise trading; 2) high level of risk aversion; 3) speculation versus hedging trades. This paper investigates the role that hedge funds, a proxy for sophisticated investors, play in the price discovery process between stock and option markets and the disagreement/agreement periods. We observe that a disparity in information between the two markets is often associated with deleveraging in directional exposures and reversal strategies. Posterior to the event, active tactical asset allocation in small and value factor investing takes place. We investigate four specific macro events which resulted in significant rebalancing by hedge fund manegers: the Thai Baht depreciation, the Dot-com bubble, the credit crunch and the Nasdaq correction. [less ▲]

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See detailStructural characterization and functional properties of antihypertensive Cymodocea nodosa sulfated polysaccharide
Ben Abdallah Kolsi, Rihab; Fakhfakh, Jawhar; Krichen, Fatma et al

in Carbohydrate Polymers (in press)

A sulfated polysaccharide was successfully isolated from Cymodocea nodosa (CNSP). This is the first report that indicates the chemical composition, structural characterization, functional and ... [more ▼]

A sulfated polysaccharide was successfully isolated from Cymodocea nodosa (CNSP). This is the first report that indicates the chemical composition, structural characterization, functional and antihypertensive properties of this polysaccharide. The CNSP consisted mainly of sulfate (23.17%), total sugars (54.90%), galactose (44.89%), mannose (17.30%), arabinose (12.05%), xylose (9.18%), maltose (1.07%) and uronic acid (11.03%) with low water activity (0.49). CNSP had an XRD pattern that was typical for a semi-crystalline polymer with homogeneous structure. It also displayed an important anti-hypertensive activity (IC50 = 0.43 mg ml) with a dose-dependent manner using a synthetic substrate, N-hippuryl-His-Leu hydrate salt (HHL). Overall, the results indicate that CNSP have attractive chemical, functional and biological properties, with a preliminary structural may have a backbone of branched 6-O-sulfated (1 → 4) galactosidic linkages, which can be considered in the future as alternative additive in various foods, cosmetic and pharmaceutical preparations. [less ▲]

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See detailOptimized approach to retrieve information on atmospheric carbonyl sulfide (OCS) above the Jungfraujoch station and change in its abundance since 1995
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Vollmer, M. K. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (in press)

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss ... [more ▼]

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss Alps. More than 200 lines of the nu3 fundamental band of OCS have been systematically evaluated and we selected 4 microwindows on the basis of objective criteria minimizing the effect of interferences, mainly by solar features, carbon dioxide and water vapor absorption lines, while maximizing the information content. Implementation of this new retrieval strategy provided an extended time series of the OCS abundance spanning the 1995-2015 time period, for the study of the long-term trend and seasonal variation of OCS in the free troposphere and stratosphere. Three distinct periods characterize the evolution of the tropospheric partial columns: a first decreasing period (1995-2002), an intermediate increasing period (2002-2008), and the more recent period (2008-2015) which shows no significant trend. Our FTIR tropospheric and stratospheric time series are compared with new in situ gas chromatography mass spectrometry (GCMS) measurements performed by Empa (Laboratory for Air Pollution/Environmental Technology) at the Jungfraujoch since 2008, and with space-borne solar occultation observations by the ACE-FTS instrument on-board the SCISAT satellite, respectively, and they show good agreement. The OCS signal recorded above Jungfraujoch appears to be closely related to anthropogenic sulfur emissions. [less ▲]

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULg

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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See detailEfficient ANOVA for directional data
Ley, Christophe; Swan, Yvik ULg; Verdebout, Thomas

in Annals of the Institute of Statistical Mathematics (in press)

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See detailQuadratic reformulations of nonlinear binary optimization problems
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

in Mathematical Programming (in press)

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these ... [more ▼]

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these problems when the objective function is a quadratic polynomial. However, no similarly efficient methods are available for the higher degree case. Since high degree objectives are becoming increasingly important in certain application areas, such as computer vision, various techniques have been recently developed to reduce the general case to the quadratic one, at the cost of increasing the number of variables. In this paper we initiate a systematic study of these quadratization approaches. We provide tight lower and upper bounds on the number of auxiliary variables needed in the worst-case for general objective functions, for bounded-degree functions, and for a restricted class of quadratizations. Our upper bounds are constructive, thus yielding new quadratization procedures. Finally, we completely characterize all ``minimal'' quadratizations of negative monomials. [less ▲]

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