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See detailTextes sur les signes: les sources latines
Macedo, Gabriel ULg

in Macedo, Gabriel; Scappaticcio, Maria Chiara (Eds.) Signes dans les textes, textes sur les signes. Actes du colloque international. Liège, 6-7 septembre 2013. (in press)

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See detailFred Dretske, Seeing and Knowing (chapitres 2.1 et 2.2)
Zincq, Aurélien ULg

in Gauvry, Charlotte; Brisart, Robert (Eds.) Perception et concept. Le conceptualisme en question (in press)

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See detailLa fondation d’une théorie de l’agentivité chez Heidegger à l’époque de Sein und Zeit
Zincq, Aurélien ULg

in Boccaccini, Federico; Cormann, Grégory (Eds.) Le soi agent: Approches phénoménologiques (in press)

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See detailDynamic single-cell analysis of Saccharomyces cerevisiae under process perturbation: comparison of different methods for monitoring the intensity of population heterogeneity
Delvigne, Frank ULg; Baert, Jonathan ULg; Gofflot, Sébastien et al

in Journal of Chemical Technology & Biotechnology (in press)

BACKGROUND: Single cell biology has attracted a lot of attention these past few years and has led to numerous fundamental results pointing out the heterogeneity of clonal cell populations. In this context ... [more ▼]

BACKGROUND: Single cell biology has attracted a lot of attention these past few years and has led to numerous fundamental results pointing out the heterogeneity of clonal cell populations. In this context, microbial phenotypic heterogeneity under bioprocessing conditions needs to be further investigated. In this study, yeast based processes have been investigated by using on-line flow cytometry in combination with a fluorescent transcriptional reporter (GFP) and viability fluorescence tags (propidium iodide, PI). Methods aiming at expressing the dispersion of these fluorescence tags among the yeast populations have been investigated for different bioreactor operating conditions. RESULTS: Yeast viability was determined on the basis of PI uptake. Segregation between PI negative and positive subpopulations could be efficiently quantified on the basis of the mean-to-median ratio or the amplitude of the interquartile range. On the other hand, the same quantification could not be made for the segregation occurring at the level of GFP synthesis. Indeed, when cells were exposed to sub-lethal or mild stresses (such as in scale-down reactors) two GFP subpopulations could be visualized by real-time FC, but quantification by one of the above-mentioned methods was not possible. CONCLUSIONS: Yeast population heterogeneity was observed in representative bioreactor operating conditions. Difficulties for the determination of segregation at the level of GFP synthesis point out the fact that one needs to understand the segregation mechanisms for the applied fluorescent reporters, to judge whether simple mathematical tools may be applied or if more sophisticated computational tools are needed for the quantification of the microbial population segregation. [less ▲]

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See detailFocus sur les lymphocytes T dans la maladie du greffon contre l'hôte après allogreffe de cellules soucges hématopoïétiques: implications pour de nouvelles stratégies de prévention
Vrancken, L; Delens, Loïc ULg; BEGUIN, Yves ULg et al

in Oncol. Hematol. (in press)

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches ... [more ▼]

Malgré les stratégies de prévention actuelles, la maladie du greffon contre l’hôte (greffe-versus-hôte, GVH) aiguë (GVHa) reste une complication sévère et fréquente de l’allogreffe de cellules souches hématopoïétiques. Bien que la physiopathologie de celle-ci ne reste que partiellement élucidée à ce jour, il est classiquement admis que les lymphocytes T (LT) jouent un rôle important dans son processus biologique. Les progrès récents de l’immunologie des LT dans la GVHa ont permis de diversifier les pistes visant à prévenir la survenue de cette complication post-greffe. Plusieurs approches sont en cours d’exploration dans des essais cliniques avec des résultats encourageant tels que la manipulation ex vivo des LT avant leur transfert chez le patient afin de leur faire exprimer des gènes suicide, l’élimination in vivo des LT proliférant directement après la greffe, l’inhibition de l’activation des LT en interférant avec les voies de signalisation en aval du TCR ou celles induites par les cytokines, l’induction de l’anergie des LT en bloquant les signaux de costimulation, le blocage de l’adressage des LT vers les organes lymphoïdes secondaires et les tissus cibles, la promotion de l’immunotolérance par la perfusion de lymphocytes T régulateurs ou par l’utilisation d’agents favorisant leur différenciation et leurs fonctions in vivo et la modulation de l’expression génique des cellules immunitaires par des modulateurs épigénétiques. Outre la prévention de la GVHa, le défi des nouvelles stratégies consiste également à ne pas compromettre l’effet bénéfique de la greffe contre la tumeur ni la reconstitution des défenses anti-infectieuses. [less ▲]

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See detailExploring Metacognition as Support for Learning Transfer
Scharff, Lauren; Draeger, John; Verpoorten, Dominique ULg et al

in Teaching & Learning Inquiry: The ISSoTL Journal (in press)

The ability to transfer learning to new situations lies at the heart of lifelong learning and the employability of university graduates. Because students are often unaware of the importance of learning ... [more ▼]

The ability to transfer learning to new situations lies at the heart of lifelong learning and the employability of university graduates. Because students are often unaware of the importance of learning transfer and staff do not always explicitly articulate this expectation, this article explores the idea that metacognition (intentional awareness and the use of that awareness) might enhance the development of learning transfer. Our exploratory study includes results from a survey of 74 staff and 118 students from five institutions in Australia, Belgium, UK, and USA. Our data indicate that many staff and a majority of students do not have a clear understanding of what learning transfer entails, and that there are many mismatches between staff and student perceptions, attitudes, and behaviors regarding learning transfer. This helps explain why learning transfer does not occur as often as it could. We found significant positive correlations between thinking about transfer and thinking about learning processes and the likelihood to use awareness of metacognition to guide practice. Our findings suggest a positive relationship between metacognition and learning transfer. Implications for scholarship of teaching and learning are discussed. [less ▲]

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See detailOrigine et histoire de la folie : un nouveau Foucault, un nouveau fou
Englebert, Jérôme ULg

in Evolution Psychiatrique (in press)

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See detailOutcome after failure of allogeneic hematopoietic stem cell transplantation in children with acute leukemia: a study by the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Rorhlich; Roux, C; Tifratene, K et al

in Bone Marrow Transplantation (in press)

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation relapse. We aimed to compare treatment strategies in 334 consecutive children with acute leukemia relapse or progression after SCT in a recent ten-year period. Data could be analyzed in 288 patients (157 ALL, 123 AML and 8 biphenotypic AL) with a median age of 8.16 years at transplantation. The median delay from first SCT to relapse or progression was 182 days. The treatment consisted in chemotherapy alone (n=108), chemotherapy followed by second SCT (n=70), supportive/palliative care (n=67), combination of chemotherapy and DLI (n=30), or isolated reinfusion of donor lymphocytes (DLI) (n=13). The median OS duration after relapse was 164 days and differed according to therapy: DLI after chemotherapy = 385 d, second allograft = 391d, chemotherapy = 174d, DLI alone = 140d, palliative care = 43d. A second SCT or a combination of chemotherapy and donor lymphocytes infusion yielded similar outcome (HR=0.85, p=0.53) unlike chemotherapy alone (HR 1.43 p=0.04), palliative care (HR=4.24, p<0.0001) or isolated DLI (HR=1,94, p<0.04). Despite limitations in this retrospective setting, strategies including immunointervention appear superior to other approaches, mostly in AML. [less ▲]

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See detailThe clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study
Van Obbergh, F; Knoops, L; Devos, T et al

in Clinical Biochemistry (in press)

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice ... [more ▼]

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given at a fixed 400mg daily dose. A significant inverse relationship of imatinib concentration with the patients' weight was observed (Pearson's test: p=0.02,R2=0.1). More interestingly, patientswith poor response (switched to another tyrosine kinase inhibitor because of imatinib failure, or because of disease progression after an initial response) displayed a significantly lower mean imatinib concentration as compared to patients maintained on imatinib (822 ng/mL vs 1099 ng/mL; Student's t-test, p=0.04). Failure or disease progression occurred more often in patients in the lowest quartile of imatinib concentrations compared to patients in the highest quartile (p = 0.02, logrank test). No correlation could be established with other biological or clinical parameter, including complete cytogenic response and majormolecular response. In conclusion: in patients treatedwith imatinib at a fixed daily dose of 400 mg, imatinib plasma concentrations decreased with increasing body weight and were lower in patients switched to another tyrosine kinase inhibitor due to imatinib failure. Systematic determination of imatinib plasma trough levels should be encouraged in such patients. [less ▲]

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See detailBattista Guarino, 'Sermone del cane e del cavallo'. Un texte inconnu à la cour des Este
Valenti, Gianluca ULg; Van den Abeele, Baudouin

in Actes du Colloque international Chevaux, chiens, faucons. L’art vétérinaire antique et médiéval à travers les sources écrites, archéologiques et iconographiques (in press)

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See detailSostanza e forma nella tradizione del romanzo arturiano in prosa
Leonardi, Lino; Morato, Nicola ULg

E-print/Working paper (in press)

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See detailA fresh look on the limit on ultralight axion-like particles from SN1987A
Payez, Alexandre ULg

in 10th Patras Workshop on Axions, WIMPs and WISPs (in press)

We revisit the limit on very light axion-like particles (ALPs) from the absence of gamma rays coincidental with the neutrino burst from SN1987A. We use updated supernova simulations, modern models for the ... [more ▼]

We revisit the limit on very light axion-like particles (ALPs) from the absence of gamma rays coincidental with the neutrino burst from SN1987A. We use updated supernova simulations, modern models for the magnetic field inside the Galaxy, and a Primakoff cross section which takes into account proton-degeneracy and mass-reduction effects. We finally give an updated exclusion plot for the electromagnetic coupling of sub-eV ALPs, comparing our new bound with other limits as well as with future ALP searches. [less ▲]

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See detailDisorders of consciousness: new advances in neuroimaging techniques
Soddu, Andrea ULg; Bruno, Marie-Aurélie ULg; VANHAUDENHUYSE, Audrey ULg et al

in Zanotti, Bruno (Ed.) Vegetative State (in press)

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See detailAux sources des liturgies indo-iraniennes
Swennen, Philippe ULg; Redard, Céline ULg; Ferrer-Losilla, Joan Josep ULg et al

Book published by Collection Religion (Presses universitaires de l’Université de Liège) (in press)

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See detailFin de siècle/Jahrhundertwende: Eine Tendenzgeschichte
Küpper, Achim ULg

in Roland, Hubert (Ed.) Eine kleine deutsch-französische Literaturgeschichte vom 18. Jahrhundert bis zum Ersten Weltkrieg (in press)

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See detailAnode (electro)catalysts for direct borohydride and ammonia borane fuel cells
Olu, Pierre-Yves ULg; Zadick, Anicet; Job, Nathalie ULg et al

in Electrocatalysts for low temperature fuel cells. Fundamental and recent trends. (in press)

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See detailGellert, Schlegel und die "Lettres de Ninon de Lenclos". Eine Übersetzungsgeschichte
Viehöver, Vera ULg

in Fink, Wolfgang (Ed.) Vernunft und Gefühl. Christian Fürchtegott Gellert und die Umbruchperiode der Aufklärung (1740-1770) (in press)

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See detailConfesseur du Prince : un profil singulier ? L’exemple de la cour espagnole de Bruxelles au XVIIe siècle.
Pirlet, Pierre-François ULg

in Les clergés de cour en Europe (fin XVe siècle - XVIIIe siècle). Service religieux et service politique dans les systèmes curiaux - Actes du colloque[Titre à préciser] (in press)

Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son ... [more ▼]

Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son représentant pour les aspects temporels, ce religieux a la faculté unique d'examiner, de conseiller et de juger la spiritualité du premier personnage de l'État. Attaché à la personne du Prince, les relations de cet ecclésiastique avec les autres courtisans ne peuvent être appréhendées au moyen d'une grille de lecture hiérarchisant les rapports sociaux : échappant à l'organisation laïque – mais pas protocolaire – de la cour et ne dépendant pas directement de la Chapelle royale, le confesseur bénéficie d'une autonomie relative. En outre, son pouvoir politique, en partie officiel grâce aux dignités et charges dont ce religieux est pourvu, est avant tout perçu comme une magistrature d'influence à la portée difficilement mesurable. Enfin, les obligations matérielles liées à l'appartenance de ce prélat à un ordre religieux achèvent de distinguer cet ecclésiastique des autres serviteurs princiers. Cette communication visera à distinguer les particularités de la charge de confesseur princier au sein de la société de cour. L'étude portera particulièrement sur la cour de Bruxelles durant la première moitié du xviie siècle. [less ▲]

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