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See detailRééducation des plasties du LCA : quels pièges ?
Croisier, Jean-Louis ULg; BAUVIR, Philippe ULg; NAMUROIS, Marie-Hélène ULg et al

in Abstract Book du Symposium d'Axxon - Actualité en Kinésithérapie (2013, November)

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See detailA comparison of within-season yield prediction methodologies
Dumont, Benjamin ULg; Basso, Bruno; Bodson, Bernard ULg et al

Conference (2013, November)

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See detailLe mode excentrique appliqué aux rotateurs d'épaule
Forthomme, Bénédicte ULg; Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg et al

in Livret des interventions - XVèmes Rencontres Médimex - "Isocinétisme - Actualités et Controverses" (2013, November)

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See detailRefractory hypercalcemia and ectopic calcitonin secretion in a malignant pancreatic neuroendocrine tumor: hypocalcemic effects on cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; rubio almanza, Matilde; LOLY, Jean-Philippe ULg et al

in Acta Clinica Belgica (2013), 68(6), 42

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailPersistent low levels of serum hCG: please do not miss phantom hCG! (pseudohypergonadotropinemia syndrome)
VALDES SOCIN, Hernan Gonzalo ULg; SYRIOS, Petros ULg; GADISSEUR, Romy ULg et al

in Acta Clinica Belgica (2013), 68(6), 465

Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or ... [more ▼]

Introduction: Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophilic antibodies. This situation requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Observation: A 23 years old woman (GOPO status) consulted his gynaecologist because of persistent abdominal pain. She was diagnosed of having trophoblastic disease on the basis of persistently positive human chorionic gonadotropin (hCG) test (Roche Modular) results, in the absence of pregnancy. Persistent low levels of hCG (around 10 U/L) were detected in her plasma. The patient underwent a trial with methotrexate chemotherapy. Abdominal pain was unrelieved whereas plasma hCG was 8.9 U/L. A serology test for Chlamydia indicated persistent infection and a course of antibiotic treatment was underwent without any relief. A laparoscopic exploration ruled out any trophoblastic residue or pelvic adherences. The patient was referred to the Endocrine Unit for further pituitary and hormonal investigations. Plasma and urine samples were sent to Biology Service to exclude a false hCG positive value. While low levels of hCG were detected in serum by assay, no significant hCG was detected in the urine (0,1 U/L). When serum was treated with HBT tube for the detection of heterophilic antibodies, hCG levels were 0.98 U/L. After mouse serum treatment, hCG was not further detected in our patient, indicating the presence of phantom hCG due to the presence of human anti mouse heterophilic antibodies. Conclusions: Textbooks on obstetrics and gynecology emphasize the importance of plasma hCG testing in patients with trophoblastic diseases. The ability of laboratory measurements to guide the clinician appropriately in every circumstance is limited. Caution should be exercised when clinical findings and laboratory results are discordant. Current protocols for the diagnosis and treatment of trophoblastic disease should include a compulsory test for hCG in urine and a test for heterophilic antibodies when appropriate. In this case report, we demonstrated that phantom hCG, was caused by heterogenous human anti mouse antibodies. [less ▲]

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See detailRole of sea ice in global biogeochemical cycles: Emerging views and challenges
Vancoppenolle, M; Meiners, K.M.; Michel, C. et al

in Quaternary Science Reviews (2013), 79

Observations from the last decade suggest an important role of sea ice in the global biogeochemical cycles, promoted by (i) active biological and chemical processes within the sea ice; (ii) fluid and gas ... [more ▼]

Observations from the last decade suggest an important role of sea ice in the global biogeochemical cycles, promoted by (i) active biological and chemical processes within the sea ice; (ii) fluid and gas exchanges at the sea ice interface through an often permeable sea ice cover; and (iii) tight physical, biological and chemical interactions between the sea ice, the ocean and the atmosphere. Photosynthetic micro-organisms in sea ice thrive in liquid brine inclusions encased in a pure ice matrix, where they find suitable light and nutrient levels. They extend the production season, provide a winter and early spring food source, and contribute to organic carbon export to depth. Under-ice and ice edge phytoplankton blooms occur when ice retreats, favoured by increasing light, stratification, and by the release of material into the water column. In particular, the release of iron – highly concentrated in sea ice – could have large effects in the iron-limited Southern Ocean. The export of inorganic carbon transport by brine sinking below the mixed layer, calcium carbonate precipitation in sea ice, as well as active iceatmosphere carbon dioxide (CO2) fluxes, could play a central role in the marine carbon cycle. Sea ice processes could also significantly contribute to the sulphur cycle through the large production by ice algae of dimethylsulfoniopropionate (DMSP), the precursor of sulfate aerosols, which as cloud condensation nuclei have a potential cooling effect on the planet. Finally, the sea ice zone supports significant ocean-atmosphere methane (CH4) fluxes, while saline ice surfaces activate springtime atmospheric bromine chemistry, setting ground for tropospheric ozone depletion events observed near both poles. All these mechanisms are generally known, but neither precisely understood nor quantified at large scales. As polar regions are rapidly changing, understanding the large-scale polar marine biogeochemical processes and their future evolution is of high priority. Earth system models should in this context prove essential, but they currently represent sea ice as biologically and chemically inert. Paleoclimatic proxies are also relevant, in particular the sea ice proxies, inferring past sea ice conditions from glacial and marine sediment core records and providing analogs for future changes. Being highly constrained by marine biogeochemistry, sea ice proxies would not only contribute to but also benefit from a better understanding of polar marine biogeochemical cycles. [less ▲]

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See detailProjet TADAM: RAPPORT FINAL 2007-2013
Demaret, Isabelle ULg; Litran, Géraldine; Magoga, Cécile et al

Report (2013)

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in ... [more ▼]

Background: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts resistant to other treatment. A new trial compared HAT and methadone treatment with HAT limited to 12 months in order to assess its feasibility and efficacy in Belgium. Methods: TADAM (Treatment Assisted by Diacetylmorphine) was an open label randomised controlled trial. The experimental treatment was based upon the Swiss model of HAT developed in 1994. The primary efficacy criterion was determined by an improvement in street heroin use or in (physical or mental) health or a decrease in criminal involvement. Participants were assessed every 3 months. Self-reported data were complemented with toxicological analyses and criminal proceedings. Findings: 74 participants were randomised in the trial: 36 in the experimental group and 38 in the control group. The experimental group counted 30% of responders more than the control group at 3 months (p<0.05), 6 months (p<0.05), and 9 months (p<0.01). At 12 months, the number of responders was still higher in the experimental group (11%) but the difference was no longer significant (p=0.35). Street heroin use increased in the experimental group at the 12-month assessment just before the end of HAT. Conclusion: HAT is feasible and effective. However, HAT should not have a predetermined duration for heroin users for which heroin addiction became a chronic relapsing disease. Other data: In addition to the outcomes of the randomised controlled trial, the report contains other exploratory data and analysis: satisfaction of in treatment, criminological data, opinion of heroin users not included in the trial, opinion of caregivers and field workers (in the HAT centre, in the partner centres, and in other centres in the addiction field), impact of the HAT centre on its neighbourhood and a socio-economic evaluation. Funding: The TADAM trial was funded at 80% by the Federal Minister of Social Affairs and Public Health. It was also funded the City and the University of Liège. [less ▲]

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See detail« L’instruction de la cause et les incidents »
Biemar, Bénédicte ULg

in Boularbah, Hakim; Georges, Frédéric (Eds.) Actualités en droit judiciaire (2013)

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See detailEvolution of the Io Footprint Brightness II: Modeling
Hess, Sébastien; Bonfond, Bertrand ULg; Chantry, Virginie ULg et al

in Planetary and Space Science (2013), 88

The interaction of Io with the Jovian magnetosphere creates the best known and brightest satellite-controlled aurorae in our solar system. These aurorae are generated by the precipitation of electrons ... [more ▼]

The interaction of Io with the Jovian magnetosphere creates the best known and brightest satellite-controlled aurorae in our solar system. These aurorae are generated by the precipitation of electrons, which are accelerated by the Alfvén waves carrying the current between the satellite and the planet. A recent study computed the energy deposited on top of Jupiter's ionosphere due to the electron precipitation and retrieved the correct mean brightness of Io-related aurorae. The model developed in this study takes into account the acceleration mechanism and the Alfvén wave propagation effects. We use the same method to investigate the brightness variation of the different components of the Io footprint as a function of longitude. These observations are discussed in a companion paper. We identify several effects that act together to modulate the footprint brightness such as Alfvén wave reflections, magnetic mirroring of the electrons, the local interaction at Io and kinetic effects close to Jupiter. We identify the effects contributing the most to the modulation of the brightnesses of the three brightest components of the Io footprints: the main and reflected Alfvén wing spots and the transhemispheric electron spot. We show in particular that the modulation of the efficiency of the electron acceleration can be of greater importance than the modulation of the power generated at Io. We reproduce the average modulation of the spot brightnesses and present an extensive discussion of possible explanations for the observed features not reproduced by our model. [less ▲]

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See detailFeedbacks correctifs écrits en anglais langue étrangère et attentes des élèves du secondaire
Noiroux, Kevin ULg

Conference (2013, November)

Grâce à des recherches qui montrent que l’élève ne s’améliore pas après avoir été corrigé, certains chercheurs pensent que la correction des erreurs écrites n’a pas sa place dans l’enseignement d’une ... [more ▼]

Grâce à des recherches qui montrent que l’élève ne s’améliore pas après avoir été corrigé, certains chercheurs pensent que la correction des erreurs écrites n’a pas sa place dans l’enseignement d’une langue étrangère. Cet article a pour but d’analyser les attentes des élèves pour voir s’ils sont demandeurs ou pas de corrections. Nos résultats montrent que les élèves du secondaire de Fédération Wallonie-Bruxelles veulent non seulement être corrigés, mais qu’ils s’intéressent de très près à la compréhension de leurs erreurs. Il faut cependant noter que les erreurs semblent être corrigées dans le cadre d’évaluations certificatives, ce qui est potentiellement inéquitable. [less ▲]

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See detailL'heure du bilan
Billen, Roland ULg

Article for general public (2013)

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See detailAC vs. DC electrophoretic deposition of hydroxyapatite on titanium
Ozhukil Kollath, Vinayaraj ULg; Chen, Qiang; Closset, Raphaël ULg et al

in Journal of the European Ceramic Society (2013), 33(13-14), 27152721

In this study, electrophoretic deposition (EPD) of hydroxyapatite (HA) powder on titanium plate was performed using butanol as solvent under direct current (DC) and alternating current (AC) fields. The ... [more ▼]

In this study, electrophoretic deposition (EPD) of hydroxyapatite (HA) powder on titanium plate was performed using butanol as solvent under direct current (DC) and alternating current (AC) fields. The zeta potential of the suspensions was measured to define their stability and the charge on the particles. Coating thickness was varied by adjusting the voltage and time of deposition. Surface morphology and cross section thickness were studied using scanning electron microscopy and image analysis software. Surface crack density was calculated from the micrographs. The results showed that the samples of similar thickness have higher grain density when coated using AC as compared to DC EPD. This facile but novel test proves the capability of AC-EPD to attain denser and uniform HA coatings from non-aqueous medium. [less ▲]

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See detailDictionnaire universel des créatrices
Nazé, Yaël ULg

in Dictionnaire universel des créatrices (2013)

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See detail(G)astronomie - Big bang cookies
Nazé, Yaël ULg

Article for general public (2013)

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See detailCorps commun et rupture anthropologique dans la schizophrénie
Englebert, Jérôme ULg

Conference (2013, November)

S’agissant d’une référence qui demeure incontournable en psychologie clinique et en psychopathologie, nous proposons de partir du cadre psychanalytique. Nous ferons le constat de difficultés tant ... [more ▼]

S’agissant d’une référence qui demeure incontournable en psychologie clinique et en psychopathologie, nous proposons de partir du cadre psychanalytique. Nous ferons le constat de difficultés tant théoriques que techniques concernant les notions d’espace, de temps et, plus fondamentalement, concernant le corps qui est cantonné à sa disposition hystérique. Par ailleurs, nous verrons que la phénoménologie permet de penser ce corps en tant que fondement de notre identité et de notre relation à l’autre. Il s’agit d’une donnée implicite qui n’est pas interrogée, une « sentinelle silencieuse » pour reprendre les propos de Merleau-Ponty. À partir de là, nous pourrons exposer en quoi la problématique schizophrénique se situe au niveau d’une rupture anthropologique quant à la manière de vivre son corps. Nous développerons également la différence qu’il y a entre le corps-pour-soi et le corps-pour-autrui et celle entre le corps paranoïde et le corps paranoïaque. Enfin, en guise de mise en perspective, nous développerons les concepts deleuzien de territorialisation et de ritournelle et montrerons en quoi le clinicien, s’il a à prendre en compte le corps de son patient dans sa réflexion, doit avant tout accepter de mobiliser son propre corps, de toucher son patient, de l’observer et de se laisser toucher par lui. [less ▲]

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See detailASSOCIATION BETWEEN CHONDROCYTE HYPERTROPHY AND ANGIOGENESIS OF CARTILAGE IN OSTEOARTHRITIS
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Delcour, Jean-Pierre et al

Conference (2013, November)

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See detailDevelopment of a Standard Reference Material for Metabolomics Research
Phinney, K; Ballihaut, G; Bedner, M et al

in Analytical Chemistry (2013), 85(24), 11732-11738

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology ... [more ▼]

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not towards specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research. [less ▲]

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See detailBONE SIALOPROTEIN AS A KEY FACTOR IN THE PATHOPHYSIOLOGY OF OSTEOARTHRITIS
Pesesse, Laurence ULg; Sanchez, Christelle ULg; Walsh, David et al

Conference (2013, November)

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See detailEsterification of vertebrate like steroids in molluscs: A target of endocrine disruptors?
Giusti, Arnaud ULg; Joaquim-Justo, Célia ULg

in Comparative Biochemistry and Physiology. C : Comparative Pharmacology and Toxicology (2013), 158(4), 187-198

Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to ... [more ▼]

Alterations of the reproductive organs of gastropod molluscs exposed to pollutants have been reported in natural populations for more than 40 years. In some cases these impacts have been linked to exposure to endocrine disrupting chemicals (EDCs), which are known to induce adverse impacts on vertebrates, mainly by direct binding to steroid receptors or by altering hormone synthesis. Investigations on the mechanisms of action of endocrine disruptors in molluscs show that EDCs induce modifications of endogenous titres of androgens (e.g., testosterone, androstenedione) and oestrogens (e.g., 17ß-oestradiol). Alterations of the activity of enzymes related to steroid metabolism (i.e., cytochrome P450 aromatase, acyltransferases) are also often observed. In bivalves and gastropods, fatty acid esterification of steroids might constitute the major regulation of androgen and oestrogen homeostasis. The present review indicates that metabolism of steroid hormones to fatty acid esters might be a target of synthetic EDCs. Alterations of this process would impact the concentrations of free, potentially bioactive, form of steroids. [less ▲]

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