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See detailIntegrin αvβ3 and RGD-based radiopharmaceuticals
WITHOFS, Nadia ULg; HUSTINX, Roland ULg

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2016), 40 (2016)

Positron emission tomography combined with computed tomography (PET/CT) using RGD-based radiopharmaceuticals allows quantification of tumour expression of integrin αvβ3 in vivo. Integrins and, in ... [more ▼]

Positron emission tomography combined with computed tomography (PET/CT) using RGD-based radiopharmaceuticals allows quantification of tumour expression of integrin αvβ3 in vivo. Integrins and, in particular, integrin αvβ3 are involved in numerous physiologic and pathologic processes, including angiogenesis. RGD-based radiopharmaceuticals targeting integrin αvβ3, expressed by activated endothelial cells, have been developed in order to quantify angiogenesis. However, integrin αvβ3 is also frequently expressed by tumour cells and/or tumour microenvironment cells, e.g., bone marrow derived cells and osteoclasts in bone. Upregulation of integrin αvβ3 by tumour cells promotes cell survival, proliferation, invasion, metastasis and resistance to treatment. Therefore, the PET signal related to RGD-based radiopharmaceuticals may not reflect angiogenesis only. Moreover, tumours may develop mechanisms other than angiogenesis to ensure blood supply such as vascular mimicry, vessel co-option and intussusceptive angiogenesis that might not be assessed with RGD PET/CT. In the setting of treatment assessment, a drop of the RGD PET signal certainly means tumour response (endothelial and/or tumour cell apoptosis and/or vessel normalisation). On the other hand, a stable or increased RGD PET signal may be related to absence of response or upregulation of integrin αvβ3 in adaptative response to therapy, promoting resistance. This review illustrates the complexity of the role of integrin αvβ3 in oncology and its role in non-oncologic diseases such as osteoarthtitis and cardiovascular diseases. [less ▲]

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See detail'Zetten' of 'leggen': hoe Franstalige leerders van het Nederlands spreken en gebaren over plaatsingsverschijnselen
Heyvaert, Pauline ULg

Conference (2016, February 19)

This research presents the results of a quantitative and qualitative analysis of the use of the Dutch placement verbs zetten (‘put’) and leggen (‘lay’) by French-speaking learners of Dutch. The experiment ... [more ▼]

This research presents the results of a quantitative and qualitative analysis of the use of the Dutch placement verbs zetten (‘put’) and leggen (‘lay’) by French-speaking learners of Dutch. The experiment consisted of two parts: a receptive as well as a productive part. The analysis focused on two aspects: speech, but also the gestures made by the participants were both quantitatively and qualitatively analyzed. The results confirm that the use of Dutch placement verbs is problematic for French-speaking learners of Dutch, but they also reveal some important tendencies. First, my analysis demonstrates that French-speaking learners tend to underuse these verbs, which can be explained by the fact that placement events in French are often described by means of a neutral verb such as mettre (‘put’) as opposed to the more specific verbs in Dutch. Secondly, the learners occasionally also tend to overuse the placement verbs in contexts where such verbs are not allowed, an observation which is seemingly paradoxical to the first one. Thirdly, some learners also tend to confuse zetten with leggen and vice versa. These findings are interesting given that the Dutch placement verbs, with a few exceptions, remain a relatively unexplored area within the field of linguistics. [less ▲]

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See detailBreaking or Remaking Colonial Stereotypes? Female Figures in Contemporary Germanophone Literature: Urs Widmer, Alex Capus and Lukas Bärfuss
Beck, Laura ULg

Scientific conference (2016, February 19)

In the last 20 years, germanophone literature has displayed an increasing postcolonial sensibility regarding the representation of European colonial past and the literary creation of the colonized Other ... [more ▼]

In the last 20 years, germanophone literature has displayed an increasing postcolonial sensibility regarding the representation of European colonial past and the literary creation of the colonized Other as well as the general representation of cultural foreigness. Contemporary germanophone literature is, it seems, more and more interested in breaking and productively dealing with colonial stereotypes such as the figure of the natural, barbaric, irrational, passive colonized Other as opposed to the one of the civilized and civilizing, rational, active and colonizing European. Binary categories between the Other and the Self are increasingly challenged and replaced by more balanced representations of cultural and intracultural diversities and hybridities. Irony, figures of inversion and polyphony take an important part in this postcolonial remapping of European colonial entanglement. At the same time postcolonial germanophone literature displays a growing preoccupation with the question of how to represent voices of the Other and how to insert other perspectives into the texts; with all the problems of legitimization that come along with it. Nevertheless it seems as if all this postcolonial sensibility fails utterly when it comes to the representation of European and non-European women in colonial and postcolonial contexts who are represented in rather conventional ways. Clichés such as the voluptuous, oversexualized and dangerous African woman as opposed to the pure and motherly white woman who guarantees European progeny and prevents male going native are still recurrent in otherwise subversive texts. But, at first sight, both European and non-European female figures remain conspicuously silent. The talk focuses on three contemporary germanophone novels, Urs Widmers "Im Kongo" (1996), Alex Capus’ "Eine Frage der Zeit" (2007) and Lukas Bärfuss’ "Hundert Tage" (2008), and examine the breaking and remaking of colonial stereotypes regarding the representation of their female figures. [less ▲]

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See detailIdentifying Late Egyptian Virtual Relative Clauses
Sojic, Nathalie ULg

Conference (2016, February 19)

Ancient Egyptian so-called "virtual" relative clauses (VRC) are adverbial clauses that function like relative clauses. Descriptions provided by Late Egyptian grammars inform students of their existence ... [more ▼]

Ancient Egyptian so-called "virtual" relative clauses (VRC) are adverbial clauses that function like relative clauses. Descriptions provided by Late Egyptian grammars inform students of their existence and of the possibility to translate them accordingly. But they are not of a great help if one wants to grasp and describe the Late Egyptian relativization system in a linguistic perspective. The talk, given on the occasion of the international Crossroads V conference, aimed at providing interpretive guidelines based on syntax, pragmatics and Discourse Analysis. In my communication, I showed that Discourse Analysis proved to be very fruitful in clarifying some contexts of use of LEg VRCs as well as some interpretive processes. [less ▲]

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See detailRetirement and cognitive functioning: A tricky association
Grotz, Catherine ULg; Adam, Stéphane ULg

in Pachana, N.A. (Ed.) Encyclopedia of Geropsychology (2016)

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See detailThe Egyptianness of the Coptic basic vocabulary: A typological view
Grossman, Eitan; Polis, Stéphane ULg

Conference (2016, February 18)

The notion of ‘basic vocabulary’ is associated with the linguist and anthropologist Morris Swadesh, who proposed a list of 200 (and later 100) items. These lists, while widely used in historical and ... [more ▼]

The notion of ‘basic vocabulary’ is associated with the linguist and anthropologist Morris Swadesh, who proposed a list of 200 (and later 100) items. These lists, while widely used in historical and comparative linguistics, are based on Swadesh’s intuitions rather than on empirical research. More recently, however, the Leipzig Loanword Typology Project conducted a cross-linguistic survey of loanwords (Haspelmath & Tadmor 2009). One of the results is a 100-item list of basic vocabulary entries — the ‘Leipzig-Jakarta list of basic vocabulary.’ This list is the product of four factors, computed for a database of 1440 meanings in 41 languages: borrowability, representation in the database, analyzability / simplicity, and age. As Tadmor (2009) points out, this is the first list of basic vocabulary items based on extensive cross-linguistic comparison, and it constitutes a ‘full-fledged basic vocabulary’ that ‘comprises the notions normally associated with this concept: stability (our age score), universality (our representation score) and simplicity (our analyzability score), as well as resistance to borrowing (our unborrowed score)’ (2009: 68). In this talk, we examine this list of 100 meanings in order to evaluate the influence of Greek on the Coptic basic vocabulary, or — to put it the other way around — the ‘Egyptian¬ness’ of the Coptic lexicon, which seems to reflect an intense language contact situation. As a first step, Coptic data were collected from Crum (1939), the most extensive Coptic dictionary, for four dialects: Sahidic, Bohairic, Fayyumic, and Akhmimic. All Coptic lexemes associated with a meaning on the list were collected, even if poorly attested. Additionally, a questionnaire was been submitted to Copticists in order to detect Greek loanwords that would also be used for expressing these 100 meanings. Furthermore, we used etymological tools (Černý 1976; Westendorf 1977; Vycichl 1983) in order to attribute an age score (from 0 = Greek loanword to 4 = Old Egyptian) to the lexemes at two levels: the formal level (when is the word first attested in Ancient Egyptian) and the semantic level (when is the Coptic meaning first associated with this word). The vast majority of meanings (ca. 85%) have at least one pre-Coptic Egyptian cognate, most of which are already attested in Old Kingdom texts. As a result of this study, we are able (1) to evaluate the influence of Greek on the basic vocabulary of the main Coptic dialects, (2) to describe the basic vocabulary of Coptic dialects independently and to observe how they differ from one another, (3) to produce a first estimate of the rate of change in basic vocabularies over the course of Egyptian as a whole. [less ▲]

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See detailRéception du jeu vidéo
Delbouille, Julie ULg

Scientific conference (2016, February 18)

Jeune, masculin, asocial : de nombreuses étiquettes sont associées par la presse et par le grand public aux amateurs de jeu vidéo. En se penchant non seulement sur les « publics du jeu vidéo », mais ... [more ▼]

Jeune, masculin, asocial : de nombreuses étiquettes sont associées par la presse et par le grand public aux amateurs de jeu vidéo. En se penchant non seulement sur les « publics du jeu vidéo », mais également sur les discours véhiculés sur le médium, cette séance de cours vise à déconstruire les clichés habituellement associés au jeu vidéo et à restituer la place réelle que cette pratique culturelle occupe dans le monde francophone. [less ▲]

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See detailSecond argument realization in Earlier Egyptian
Motte, Aurore ULg; Winand, Jean ULg

Conference (2016, February 18)

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See detailDistribution of inorganic and organic contaminants in the intertidal surface sediments along the Hugli River Estuary, eastern part of India
Das, Krishna ULg; Sarkar, Santosh; Thomé, Jean-Pierre ULg et al

Conference (2016, February 17)

Hooghly estuary and coastal environment in north east coast of India has been strongly affected by the rapid human settlements, intensive boating and tourist activities, deforestation and ongoing ... [more ▼]

Hooghly estuary and coastal environment in north east coast of India has been strongly affected by the rapid human settlements, intensive boating and tourist activities, deforestation and ongoing agricultural and aquacultural practices. The present work investigated trace elements (TEs, T-Hg, Al, V, Cr, Fe, Mn, Cu, Zn, Co, Ni, Ca, Sr, Li, Be, P, Mo, Ag, Cd, Sn, Sb, Ba, Pb, Bi, U, As, Se) and organohalogen compounds in surface sediment (top 0-10cm) considering 8 sampling sites along the Hugli River Estuary (HRE), India. The studied organic compounds include polychlorobiphenyls (PCBs), hexachlorocyclohexane isomers (HCHs), dichlorodiphenyltrichloroethane and metabolites (DDTs) and polybromodiphenyl ethers (PBDEs). Textural analyses of the sediment reveal an overall dominance of mud. All trace elements could be detected at variable concentrations in the following descending order: Al>Fe>Ca> P>Mn> Cu> Zn> Ba >V >Cr>Sr>Ni> Li >Co >Pb>As >Se >U >Be >Sn>Bi >Ag >Mo >Cd >Sb. A synchronous enrichment of majority of the elements were observed at the site Gangasagar (~100 km south megacity Calcutta), situated at the confluence of Hugli River and Bay of Bengal, which might be attributed to cumulative impact of the physicochemical processes and multiple anthropogenic sources. It is revealed that PCBs and DDTs were the dominant compounds among the organic pollutants accounting concentrations up to 23.5 ng.g-1 and 4.4 ng.g-1 respectively at the site Babughat, adjacent to the megacity Calcutta. The results have implications for pollution in complex estuarine environment in a meso-macrotidal setup where there is significant influx of sediments carrying huge load of inorganic and organic pollutants mainly due to rapid urbanization and industrialization. [less ▲]

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See detailPsychopathologie de la ballade : Entrer en liberté
Englebert, Jérôme ULg

Scientific conference (2016, February 17)

Detailed reference viewed: 26 (1 ULg)
See detailL'Université de Liège et l'Allemagne durant l'entre-deux-guerres
Brüll, Christoph ULg

Scientific conference (2016, February 17)

The European scientific world was deeply affected by the Great War. Most links between academics were disrupted, and scholars gathered in two opposing groups. “Cultural demobilization” was a difficult ... [more ▼]

The European scientific world was deeply affected by the Great War. Most links between academics were disrupted, and scholars gathered in two opposing groups. “Cultural demobilization” was a difficult process. Until the middle of the 1920s, institutions would impose a “boycott” on the adversary camp, and few dared to transgress or ignore this. Taking the example of the historians, the conference will evoke the controversies caused by the renewal of scientific relations in Germany, in France and in Belgium. The efforts for the rebuilding of a common intellectual horizon were again frustrated by the rise of the Nazis in 1933. [less ▲]

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See detailLe Chèque Habitat en Région wallonne
Bourgeois, Marc ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 13 (0 ULg)
See detailLe patrimoine en 3D : de l’acquisition aux nuages de points intelligents
Billen, Roland ULg; Poux, Florent ULg; Hallot, Pierre ULg et al

Scientific conference (2016, February 17)

Detailed reference viewed: 54 (14 ULg)
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See detailGlycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials.
Sauvage, Eric ULg; Terrak, Mohammed ULg

in Antibiotics (2016), 5(1),

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding ... [more ▼]

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex machineries. Both activities are essential for the synthesis of a functional stress-bearing PG shell. Although good progress has been made in terms of the functional and structural understanding of GT, finding a clinically useful antibiotic against them has been challenging until now. In contrast, the TP/PBP module has been successfully targeted by beta-lactam derivatives, but the extensive use of these antibiotics has selected resistant bacterial strains that employ a wide variety of mechanisms to escape the lethal action of these antibiotics. In addition to traditional beta-lactams, other classes of molecules (non-beta-lactams) that inhibit PBPs are now emerging, opening new perspectives for tackling the resistance problem while taking advantage of these valuable targets, for which a wealth of structural and functional knowledge has been accumulated. The overall evidence shows that PBPs are part of multiprotein machineries whose activities are modulated by cofactors. Perturbation of these systems could lead to lethal effects. Developing screening strategies to take advantage of these mechanisms could lead to new inhibitors of PG assembly. In this paper, we present a general background on the GTs and TPs/PBPs, a survey of recent issues of bacterial resistance and a review of recent works describing new inhibitors of these enzymes. [less ▲]

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See detailDesiccation cracks formation in clay-barrier for nuclear waste disposal
Hubert, Julien ULg; Prime, Noémie; Plougonven, Erwan ULg et al

Conference (2016, February 16)

In geotechnical engineering, the desiccation cracking of soil is commonly observed. This phenomenon is detrimental to the behavior of earth material and earth structure. Desiccation cracks can lead to the ... [more ▼]

In geotechnical engineering, the desiccation cracking of soil is commonly observed. This phenomenon is detrimental to the behavior of earth material and earth structure. Desiccation cracks can lead to the overall failure of many geotechnical structures: • They can affect the slope stability of earth dams or embankments; • They can initiate internal erosion of embankments due to water flow through the cracks; • They can compromise the efficiency of soil barriers such as landfill liners and top covers. Nowadays, the storage of nuclear waste in deep impermeable geological layers is considered. These storages are based on the multi-barrier principle, the last of which being the host rock, typically a clayey material. In this context, maintaining the very low hydraulic conductivity of the host rock is crucial. Unfortunately, the ventilation of excavated galleries causes convective drying of the host material and can lead to crack formation. This work aims to understand in which conditions exactly, during convective drying, does cracking occur in clayey materials. An experimental campaign has been carried out to characterize the drying behavior of Boom clay which is the host rock at the underground research facility in Mol (Belgium). X-Ray micro-tomography has been used to analyze crack development as well as shrinkage. The experiments are used to calibrate the transfer parameters of a convective drying law based on the limit layer model. This calibration is based on agreement of the drying kinetics. A numerical study is then performed and aims at reproducing the behavior observed during the experiments. A thermo-hydro-mechanical coupled model is used to determine the stress distribution during the drying and a tensile failure criterion is suggested to predict crack genesis. Simulations are performed using the in-house built FEM code LAGAMINE. [less ▲]

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See detailAdoption homoparentale: défis psychosociaux, coparentalité et développement de l’enfant
Messina, Roberta ULg

Scientific conference (2016, February 16)

Detailed reference viewed: 23 (0 ULg)
See detailRecyclable shape-memory materials based on photo- or thermo-reversible reactions
Defize, Thomas ULg; Riva, Raphaël ULg; Thomassin, Jean-Michel ULg et al

Poster (2016, February 16)

Shape-memory polymers (SMPs) are remarkable materials able to switch from a stressed deformed state (temporary shape) to their initial relaxed state (permanent shape) by the application of a stimulus ... [more ▼]

Shape-memory polymers (SMPs) are remarkable materials able to switch from a stressed deformed state (temporary shape) to their initial relaxed state (permanent shape) by the application of a stimulus, such as heat or light. Typically, the shape-memory property is generally observed for chemically or physically cross-linked polymers that exhibit an elastomeric behavior above a phase transition, e.g. glass or melting transition. As an example, cross-linked semi-crystalline poly(ε-caprolactone) (PCL) is widely studied for the development of SMPs. As most of SMPs are irreversibly cross-linked material, their reprocessing is impossible preventing any recycling. Thereby, reversible reactions, allowing the formation/cleavage of the network, raise tremendous interest for the development of new SMPs. Recently, we reported the preparation reversibly cross-linked PCL-based SMP using the Diels-Alder (DA) reaction between furan and maleimide end-groups of 4-arm star-shaped PCL, well-known to create reversible bonds. After implementation, this shape-memory material was demonstrated to be recyclable, and was characterized by excellent fixity and recovery before and after recycling experiments. However, the relatively low retro DA temperature of the furan-maleimide adducts led to an inelastic deformation during shape-memory tensile cycles. In order to get rid of this drawback, an alternative approach was investigated. The substitution of the DA reaction by a photo-reversible reaction, typically the photo-induced (2+2) cycloaddition of coumarins, was proposed to prepare cross-linked PCL matrix presenting one-way and two-way memory properties, since photolabile adducts are supposed to be stable during shape-memory tensile cycles. [less ▲]

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