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See detailMethods to Increase the Robustness of Finite-Volume Flow Models in Thermodynamic Systems
Quoilin, Sylvain ULg; Bell, Ian ULg; Desideri, Adriano ULg et al

in Energies (2014), 7(3), 1621-1640

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when ... [more ▼]

This paper addresses the issues linked to simulation failures during integration in finite-volume flow models, especially those involving a two-phase state. This kind of model is particularly useful when modeling 1D heat exchangers or piping, e.g., in thermodynamic cycles involving a phase change. Issues, such as chattering or stiff systems, can lead to low simulation speed, instabilities and simulation failures. In the particular case of two-phase flow models, they are usually linked to a discontinuity in the density derivative between the liquid and two-phase zones. In this work, several methods to tackle numerical problems are developed, described, implemented and compared. In addition, methods available in the literature are also implemented and compared to the proposed approaches. Results suggest that the robustness of the models can be significantly increased with these different methods, at the price of a small increase of the error in the mass and energy balances. [less ▲]

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See detailFeruloylbenzotriazole and Weinreb Amide as Bioinspired Building Blocks: A Reactivity Study towards O-, N-, S-, and C-Nucleophiles
Roman, Bart; Monbaliu, Jean-Christophe ULg; De Coen, Laurens et al

in European Journal of Organic Chemistry (2014)

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See detailPersonalising metformin therapy: a clinician's perspective
SCHEEN, André ULg

in Lancet Diabetes & Endocrinology (2014)

If lifestyle changes are not effective for maintaining glycaemic control, metformin is recommended as the first glucose-lowering drug to use in a patient with type 2 diabetes, if the patient has no ... [more ▼]

If lifestyle changes are not effective for maintaining glycaemic control, metformin is recommended as the first glucose-lowering drug to use in a patient with type 2 diabetes, if the patient has no contraindications—eg, renal impairment or hypoxic disorders.1 However, the glucose-lowering response to metformin can vary greatly between patients, with some people responding poorly to this biguanide. Because of the well known therapeutic inertia with respect to pharmacological treatment of diabetes, insufficient glucose control might persist for a long time before any treatment adjustment is made in people who respond poorly to metformin monotherapy. [less ▲]

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See detailLa Revolución mexicana. Miradas desde Europa
Vanden Berghe, Kristine ULg; Vandermeulen, Marie ULg

Book published by P.I.E.Peter Lang (2014)

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See detailPrólogo
Vanden Berghe, Kristine ULg

in Vanden Berghe, Kristine (Ed.) La Revolución mexicana. Miradas desde Europa (2014)

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See detailRevisiting the Palaeolithic site of Kulbulak (Uzbekistan): First results from luminescence dating
Vandenberghe, D.A.G.; Flas, Damien ULg; De Dapper, Morgan et al

in Quaternary International (2014), 324

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See detailMigrations
Diepart, Jean-Christophe ULg; Pilgrim, John; Dulioust, Jérémie

in Save Cambodia's Wildlife (Ed.) Atlas of Cambodia: Maps on Socio-Economic Development and Environment (2014)

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See detailHow Does Pollen Chemistry Impact Development and Feeding Behaviour of Polylectic Bees?
Vanderplanck, Maryse; Moerman, Romain; Rasmont, Pierre et al

in PLoS ONE (2014), 9(1), 9

Larvae and imagos of bees rely exclusively on floral rewards as a food source but host-plant range can vary greatly among bee species. While oligolectic species forage on pollen from a single family of ... [more ▼]

Larvae and imagos of bees rely exclusively on floral rewards as a food source but host-plant range can vary greatly among bee species. While oligolectic species forage on pollen from a single family of host plants, polylectic bees, such as bumblebees, collect pollen from many families of plants. These polylectic species contend with interspecific variability in essential nutrients of their host-plants but we have only a limited understanding of the way in which chemicals and chemical combinations influence bee development and feeding behaviour. In this paper, we investigated five different pollen diets (Calluna vulgaris, Cistus sp., Cytisus scoparius, Salix caprea and Sorbus aucuparia) to determine how their chemical content affected bumblebee colony development and pollen/syrup collection. Three compounds were used to characterise pollen content: polypeptides, amino acids and sterols. Several parameters were used to determine the impact of diet on micro-colonies: (i) Number and weight of larvae (total and mean weight of larvae), (ii) weight of pollen collected, (iii) pollen efficacy (total weight of larvae divided by weight of the pollen collected) and (iv) syrup collection. Our results show that pollen collection is similar regardless of chemical variation in pollen diet while syrup collection is variable. Micro-colonies fed on S. aucuparia and C. scoparius pollen produced larger larvae (i.e. better mates and winter survivors) and fed less on nectar compared to the other diets. Pollen from both of these species contains 24-methylenecholesterol and high concentrations of polypeptides/total amino acids. This pollen nutritional “theme” seems therefore to promote worker reproduction in B. terrestris micro-colonies and could be linked to high fitness for queenright colonies. As workers are able to selectively forage on pollen of high chemical quality, plants may be evolutionarily selected for their pollen content, which might attract and increase the degree of fidelity of generalist pollinators, such as bumblebees. [less ▲]

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See detailL'évaluation de la mémoire implicite
Adam, Stéphane ULg

in Seron, Xavier; Van der Linden, Martial (Eds.) Traité de neuropsychologie clinique de l'adulte (Tome 1: Evaluation) (2014)

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See detailPhysiological and proteomic responses of different willow clones (Salix fragilis x alba) exposed to dredged sediment contaminated by heavy metals
Evlard, Aricia ULg; Sergeant, Kjell; Ferrandis, Salvador et al

in International Journal of Phytoremediation (2014), 16(11), 1148-1169

High biomass producing species are considered as tools for remediation of contaminated soils. Willows (Salix spp.) are prominent study subjects in this regard. In this study, different willow clones ... [more ▼]

High biomass producing species are considered as tools for remediation of contaminated soils. Willows (Salix spp.) are prominent study subjects in this regard. In this study, different willow clones (Salix fragilis x alba) were planted on heavy-metal polluted dredging sludge. A first objective was assessment of the biomass production for these clones. Using a Gupta statistic, four clones were identified as high biomass producers (HBP). For comparison, a group of four clones with lowest biomass production were selected (LBP). A second objective was to compare metal uptake as well as the physiological and proteomic responses of these two groups. All these complementary data's allow us to have a better picture of the health of the clones that would be used in phytoremediation programs. Cd, Zn, and Ni total uptake was higher in the HBPs but Pb total uptake was higher in LBPs. Our proteomic and physiological results showed that the LBPs were able to maintain cellular activity as much as the HBPs although the oxidative stress response was more pronounced in the LBPs. This could be due to the high Pb content found in this group although a combined effect of the other metals cannot be excluded. [less ▲]

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See detailA Fast Newton-Raphson Method in Stochastic Linearization
Canor, Thomas ULg; Blaise, Nicolas ULg; Denoël, Vincent ULg

in Proceedings of the Ninth International Conference on Structural Dynamics (2014)

Owing to its accessible implementation and rapidity, the equivalent linearization has become a common probabilistic approach for the analysis of large-dimension nonlinear structures, as encountered in ... [more ▼]

Owing to its accessible implementation and rapidity, the equivalent linearization has become a common probabilistic approach for the analysis of large-dimension nonlinear structures, as encountered in earthquake and wind engineering. It consists in replacing the nonlinear system by an equivalent linear one, by tuning the parameters of the equivalent system, in order to minimize some discrepancy error. Consequently classical analysis tools such as the spectral analysis may be reconditioned to approximate the solution of structures with slight to moderate nonlinearities. The tuning of the equivalent parameters requires the solution of a set of nonlinear algebraic equations involving integrals. It is typically performed with the fixed-point algorithm, which is known to behave poorly in terms of convergence. We therefore advocate for the use and implementation of a Newton-Raphson approach, which behaves much better, even in its dishonest formulation. Unfortunately, this latter option requires the costly construction of a Jacobian matrix. In the approach described in this paper, this issue is answered by introducing a series expansion method that provides a fast and accurate estimation of the residual function (whose solution provides the equivalent parameters) and a fast and approximate estimation of the Jacobian matrix. An illustration demonstrate the good accuracy obtained with the proposed method. [less ▲]

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See detailDemography
Diepart, Jean-Christophe ULg

in Save Cambodia's Wildlife (Ed.) Atlas of Cambodia: Maps on Socio-Economic Development and Environment (2014)

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See detailBouncing dynamics of a spring
Hubert, Maxime ULg; Ludewig, François ULg; Dorbolo, Stéphane ULg et al

in Physica D: Nonlinear Phenomena (2014), 272

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See detailMesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; Detry, Olivier; Weekers, Laurent et al

in Nephrology Dialysis Transplantation (2014)

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of ... [more ▼]

Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning. [less ▲]

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See detailOn the observability of the quark orbital angular momentum distribution
Courtoy, Aurore ULg; Goldstein, Gary R.; Hernandez, J. Osvaldo Gonzalez et al

in Physics Letters B (2014), 731(0), 141-147

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See detailTowards robust GWAS/GWAI protocol development for epistasis detection in context of real-life datasets
Bessonov, Kyrylo ULg

E-print/Working paper (2014)

The genome-wide association and interaction studies are a common practice these days but the correct application of statistical methods and workflows that consciously select best data processing ... [more ▼]

The genome-wide association and interaction studies are a common practice these days but the correct application of statistical methods and workflows that consciously select best data processing strategies is often missing in many GWA studies. Nevertheless given the multitude of such studies there is little consistency and consensus in data processing workflows and quality control steps. Data selection and filtering is often overlooked or poorly documented. Many times the default settings are blindly used disregarding any adjustments and/or optimizations under the context of specific dataset. In present study we want to bring awareness of paying a closer attention to parameter selection in genome-wide association interaction studies (GWAI). We had tested the impact of LD filtering, selection of epistasis algorithms (BOOST, MB-MDR) and marker selection and prioritization strategies on the final results variability under the context of the Ankylosin Spondolytis (AS) dataset obtained from WTCCC2 [1]. [less ▲]

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See detailHemolytic crisis induced by rasburicase administration revealing G-6-PD deficiency.
SID, Sélim ULg; Dugauquier, D.; DE PRIJCK, Bernard ULg et al

in Belgian Journal of Hematology (2014)

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See detailPeripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly.
SOMJA, Joan ULg; Bisig, B.; de Leval, L. et al

in Virchows Archiv : An International Journal of Pathology (2014)

Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14 ... [more ▼]

Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14)(p25;q11) and FISH-proved breakpoints in the IRF4 and TCRAD loci, leading to juxtaposition of both genes. A 64-year-old male patient presented with mild cytopenias and massive splenomegaly. Splenectomy showed diffuse red pulp involvement by a pleomorphic medium- to large-cell T-cell lymphoma with a CD2+ CD3+ CD5− CD7− CD4+ CD8+/− CD30− TCRbeta-F1+ immunophenotype, an activated cytotoxic profile, and strong MUM1 expression. The clinical course was marked by disease progression in the bone marrow under treatment and death at 4 months. In contrast with two t(6;14)(p25;q11.2)-positive lymphomas previously reported to be cytotoxic PTCL, NOS with bone marrow and skin involvement, this case was manifested by massive splenomegaly, expanding the clinical spectrum of PTCLs harboring t(6;14)(p25;q11.2) and supporting consideration of this translocation as a marker of biological aggressiveness. [less ▲]

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See detailLes dieux et la cité. Représentations des divinités tutélaires entre Grèce et Phénicie
Bonnet, Corinne; Pirenne-Delforge, Vinciane ULg

in Zenzen, Nicolas; Hölscher, Tonio; Trampedach, Kai (Eds.) Aneignung und Abgrenzung. Wechselnde Perspektiven auf die Antithese von ‘Ost’ und ‘West’ in der griechischen Antike (2014)

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See detailEstimation of the error distribution in nonparametric regression with cross-sectional data
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

E-print/Working paper (2014)

In this article, we study the nonparametric regression model Y=m(X)+varepsilon where m(x)=E[Y|X=x] and sigma²(x)=Var[varepsilon|X=x] are unknown smooth functions, and the error varepsilon has zero mean ... [more ▼]

In this article, we study the nonparametric regression model Y=m(X)+varepsilon where m(x)=E[Y|X=x] and sigma²(x)=Var[varepsilon|X=x] are unknown smooth functions, and the error varepsilon has zero mean and finite variance conditionally on X=x. The problem consists in estimating the cumulative distribution function of the error in a nonparametric way when the couple (X,Y) is obtained by cross-sectional sampling while the positive response Y can be right-censored. We propose a new estimator for the error distribution function based on the estimators of m(.) and sigma²(.) described in Heuchenne and Laurent 2014. A bootstrap procedure is developed to solve the critical problem of the smoothing parameter choice. We assess the performance of the proposed estimator through simulations. Finally, a data set based on the mortality of diabetics is analyzed. (Heuchenne Cédric and Laurent Géraldine, Nonparametric regression with cross-sectional data: an alternative to conditional product-limit estimators, 2014) [less ▲]

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