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See detailMelodic perception
Larrouy, Pauline ULg

Scientific conference (2016, May 30)

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See detailInverse dynamics of a flexible 3D robotic arm for a trajectory tracking task
Lismonde, Arthur ULg; Sonneville, Valentin; Bruls, Olivier ULg

Scientific conference (2016, May 30)

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See detailEstetrol, a natural SERM exhibiting combined estrogenic and anti-estrogenic properties on mammary gland and breast cancer
Gallez, Anne ULg; Gérard, Céline ULg; Blacher, Silvia ULg et al

Poster (2016, May 30)

The increased risk of breast cancer and thromboembolism in women who take hormone replacement therapy (HRT) is a major public health problem. The discovery of new drugs with better safety profile would ... [more ▼]

The increased risk of breast cancer and thromboembolism in women who take hormone replacement therapy (HRT) is a major public health problem. The discovery of new drugs with better safety profile would provide useful advances for patient care. Estetrol (E4) is a liver friendly promising candidate for HRT. In preclinical and/or clinical studies, E4 has been effective against the main symptoms of menopause from a starting dose of 0.3 mg/kg/day. The aim of this study was to define the impact of E4 on mammary gland and breast cancer development. Our preclinical data show that E4 is less efficient than estradiol (E2) to induce mammary gland growth. Treatment with several concentrations of E4 has shown that E4 did not increase tumor development, when it is used at 0.3 mg/kg/day. However, at 3 mg/kg/day, E4 increased tumor growth similarly to E2 (0.08 mg/kg/day). E4 presents also some anti-estrogenic effects on mammary gland and antitumor activity on breast cancer by decreasing the strong proliferative effect of E2. While ERα is the predominant receptor mediating its effects, the dual weak-estrogenic/anti-estrogenic feature of E4 results from differential signaling pathways activation. Both nuclear and rapid extra-nuclear signaling pathways are necessary for a complete estrogenic effect of E4. However, the antitumor action of E4 is not due to a capacity to antagonize E2-induced nuclear activity. In conclusion, our results support that E4, if it is used in strictly controlled clinical applications, could have no or only limited impact on breast and breast cancer. [less ▲]

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See detailGC×GC-TOFMS for forensic blood VOC profiling
Dubois, Lena ULg; Perrault, Katelynn ULg; Stefanuto, Pierre-Hugues ULg et al

Poster (2016, May 30)

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See detailNormer le passé : politique, droit et histoire
Grandjean, Geoffrey ULg

Conference given outside the academic context (2016)

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See detail5-Azacytidine and Rapamycin: different and synergistic effect on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Conference (2016, May 27)

BACKGROUND: Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin ... [more ▼]

BACKGROUND: Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells OBJECTIVE: We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. METHODS: CD4+CD25+ and CD4+CD25- T cells were isolated from PBMC of normal controls using Miltenyi beads and FACS ARIA sorting. These cells subsets were cultured in the presence of anti-CD3/CD28 antibodies and 200 IU/ml of IL2 for 2 weeks. RAPA (100nM) and 5-azaC (1µM) were added to half of the cultures. We monitored cell expansion and after harvest, the cell phenotype, gene expression, T suppression activity and Annexin V binding were determined and compared to values obtained with control cell culture and with freshly-separated CD4+CD25+ and CD4+CD25- T cells. Also we tested the absolute number of Treg in the several culture conditions during the time of expansion. RESULTS: We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. CONCLUSION: 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

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See detailSubstrats neuronaux de l'encodage non réussi dans le vieillissement
François, Sarah ULg; Angel, Lucie; Salmon, Eric ULg et al

Conference (2016, May 27)

Objectifs En utilisant l'IRM fonctionnelle, nous nous sommes intéressés à l'effet de l'âge sur les substrats neuronaux de l'encodage non réussi – l'activation à l'encodage pour les items oubliés par la ... [more ▼]

Objectifs En utilisant l'IRM fonctionnelle, nous nous sommes intéressés à l'effet de l'âge sur les substrats neuronaux de l'encodage non réussi – l'activation à l'encodage pour les items oubliés par la suite. Méthodologie Dans un scanner IRM, nous avons soumis des volontaires (20 jeunes et 19 âgés) à une tâche de mémoire épisodique avec consignes d'encodage incident. Durant celle-ci, des dessins d'objets en noir et blanc leur étaient présentés. Il leur était demandé d'effectuer un jugement de taille sur ces objets. Ensuite, toujours dans le scanner, les objets de la phase d'encodage ainsi que de nouveaux objets leurs étaient présentés afin d'évaluer leur reconnaissance de ceux-ci. Pour ce faire, les volontaires effectuaient un jugement de Recollection/Familiarité/Nouveauté. Résultats Les résultats comportementaux montrent une recollection altérée mais une familiarité préservée chez nos volontaires âgés. L'analyse des résultats IRM a été effectuée selon un design évènementiel (SPM8), dans lequel nous avons comparé les aires cérébrales activées à l'encodage pour les items qui n'ont pas été reconnus ultérieurement et pour ceux qui ont donné lieu à un jugement de recollection (p<.001 non-corrigé). Dans les deux groupes, un pattern d'activation correspondant au réseau du mode par défaut (RMD). Chez les volontaires âgés, les résultats ont également mis en évidence une activation supplémentaire du réseau attentionnel fronto-pariétal. Ensuite, le contraste entre les activations pour les items qui n'ont pas été reconnus ultérieurement et ceux qui ont donné lieu à un jugement de familiarité a aussi mis en évidence des régions du RMD, mais dans une moindre mesure. En effet, les activités communes aux deux groupes d'âge n'ont montré qu'une activation du précuneus. Discussion Comparé à la recollection, l'oubli d'informations semble associé, à l'encodage, à un recrutement accru du RMD qui pourrait refléter une incapacité à mettre en place des processus d'encodage efficaces, à la fois chez les jeunes adultes et les adultes plus âgés. De plus, l'activation supplémentaire du réseau fronto-pariétal chez ces derniers pourrait indiquer un fonctionnement moins différencié des réseaux cérébraux associés à l'encodage en mémoire. Lorsque l'on compare l'oubli d'informations à la familiarité, l'activation moindre du RMD pourrait suggérer qu'un certain niveau d'activation du RMD (et donc la présence de pensées étrangères à la tâche) n'empêche pas forcément toute reconnaissance sur base d'un sentiment de familiarité. [less ▲]

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See detailDas MOBAK-Netzwerk: Kulturvergleichende Perspektive aus acht europäischen Ländern
Scheuer, Claude; Cloes, Marc ULg; Colella, Dario et al

in Kaboth, Holger; Heim, Christopher; Prohl, Robert (Eds.) Bildungsforschung im Sport (2016, May 27)

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See detailSingle molecule force spectroscopy on helical foldamers
Devaux, Floriane ULg; Li, Xuesong; Huc, Ivan et al

Poster (2016, May 27)

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See detailPsychopathologie légale : pour une complexité de la méthode
Englebert, Jérôme ULg

Scientific conference (2016, May 27)

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See detailThe association of timing of retirement with cognitive performance in old age: The role of leisure activities after retirement
Ihle, Andreas; Grotz, Catherine ULg; Adam, Stéphane ULg et al

in International Psychogeriatrics (2016)

Background: The role of timing of retirement on cognitive functioning in old age is inconclusive so far. Therefore, the present study set out to investigate the association of timing of retirement with ... [more ▼]

Background: The role of timing of retirement on cognitive functioning in old age is inconclusive so far. Therefore, the present study set out to investigate the association of timing of retirement with cognitive performance and its interplay with key correlates of cognitive reserve in a large sample of older adults. Methods: Two thousand two hundred and sixty three older adults served as sample for the present study. Different psychometric tests (TMT A, TMT B, Mill Hill) were administered. In addition, individuals were interviewed on their retirement, occupation, educational attainment, and regarding 18 leisure activities that have been carried out after retirement. Results: Earlier retirement (compared to retirement at legal age) was significantly associated with better performance in the TMT A, the TMT B, and the Mill Hill vocabulary test. Moderation analyses showed that in individuals with a moderate number of leisure activities in old age, earlier retirement was related to better cognitive performance, but not in those with a relatively large number of leisure activities. Hierarchical regression analyses revealed that entering leisure activities as additional predictor significantly increased explained variance in the cognitive measures over and above all other investigated markers of cognitive reserve (i.e., occupation and education). Conclusions: Present data further corroborate the view that leisure activities even in old age may lead to further enrichment effects and thereby may be related to better cognitive functioning. The role of engaging in activities in the context of major life events such as retirement is discussed. [less ▲]

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See detailL’initiative citoyenne européenne : porte ouverte des institutions européennes pour le citoyen?
Debras, François ULg; Nossent, Jérôme ULg

Conference (2016, May 27)

L’objectif de notre recherche n’est pas de nous concentrer sur la création ni sur le parcours d’une initiative citoyenne européenne mais bien d’étudier les conséquences politiques qui ont suivi ces ... [more ▼]

L’objectif de notre recherche n’est pas de nous concentrer sur la création ni sur le parcours d’une initiative citoyenne européenne mais bien d’étudier les conséquences politiques qui ont suivi ces initiatives. Pour ce faire, et compte tenu de la proximité temporelle du lancement du procédé, nous proposons de concentrer notre analyse sur les différentes suites qui furent données à la première des trois propositions ayant abouti, « Right2water ». Hormis la réponse obligatoire de la Commission, nous analysons l’impact et la mobilisation des enjeux de l’initiative par les institutions, les partis politiques, les députés européens et nationaux. L’initiative citoyenne européenne s’est-elle traduite en règlements ? En propositions ? A-t-elle été récupérée dans des programmes et discours politiques ou, à l’inverse, a-t-elle été écartée de l’agenda politique européen ? En d’autres mots, les propositions citoyennes ont-elles un poids sur la scène politique européenne ? L’initiative ouvre-t-elle la porte des institutions aux revendications des citoyens ? [less ▲]

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See detailPathologies of the puerperium in the cow. How to define, diagnose, understand and treat.
Hanzen, Christian ULg

Learning material (2016)

The aim of this conference is to answer to the 8 following questions In which economical context are we working ? Is puerperium important for the reproductive performance of the cow ? How to define the ... [more ▼]

The aim of this conference is to answer to the 8 following questions In which economical context are we working ? Is puerperium important for the reproductive performance of the cow ? How to define the pathologies of the puerperium ? What’s the prevalence of these pathologies ? How to diagnose the pathologies of the puerperium ? When to detect these pathologies ? What kind of relations exist between these pathologies ? How to treat these pathologies ? [less ▲]

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See detail• BibliothEP: a study evaluating the effectiveness of bibliotherapy for premature ejaculation
Kempeneers, Philippe ULg; Andrianne, Robert ULg; Bauwens, Sabrina et al

Conference (2016, May 27)

Objective. The BibliothEP study aimed to assess the efficacy of a bibliotherapy for premature ejaculation (PE) Design and method. The study was conducted in two phases. First, a sample of 120 participants ... [more ▼]

Objective. The BibliothEP study aimed to assess the efficacy of a bibliotherapy for premature ejaculation (PE) Design and method. The study was conducted in two phases. First, a sample of 120 participants suffering from PE read a concise cognitive behavioural self-help manual for PE (51 A5 pages including illustrations) and were compared after treatment to 66 waiting list controls. Second, 36 subjects received and read the self-help manual and were compared after treatment to 32 subjects having received the same manual plus a complementary brief guidance (45-90 minutes) from a coach not specialised in sex therapy, but who had been specifically trained to support the bibliotherapy intervention (by attending a 5-hour training module). The main outcome measures were self-determined latency time to ejaculation, feelings of control, sexual satisfaction, PE-related distress and subjective impression of improvement. Results. At 6-month posttreatment, all participants showed significant improvements as compared to waiting list condition. The improvements were maintained at 12 month. They were slightly greater in the case of complementary therapist support. Improvements were demonstrated for all forms of PE, but the intervention appeared to be slightly more effective when the problem was of moderate severity. In all cases, improvements in sexual functioning were accompanied by improvements in sexual cognitions. Conclusions. The cost-effectiveness of the self-help manual makes it a valuable first-line treatment for any form of PE. Moreover, the outcome of the bibliotherapy process might be increased by coaching from a health worker specifically trained to this aim. [less ▲]

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