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See detailSequence Alignment Practical
Bessonov, Kyrylo ULg

Learning material (2013)

Detailed reference viewed: 11 (0 ULg)
See detailLes nouvelles familles: perspectives pour la thérapie familiale
D'Amore, Salvatore ULg

Scientific conference (2013, November 11)

L’émergence des nouvelles familles représente l’un des principaux changements démographiques des sociétés occidentales. Qu’elles soient monoparentales, adoptives, immigrées ou interculturelles, ces ... [more ▼]

L’émergence des nouvelles familles représente l’un des principaux changements démographiques des sociétés occidentales. Qu’elles soient monoparentales, adoptives, immigrées ou interculturelles, ces familles ont longtemps été perçues comme déviantes voire déficitaires par rapport au modèle standard de la famille « traditionnelle ». La souffrance psychique des membres de nouvelles familles semblerait dépendre, entre autres, du croisement de trois processus principaux : transitionnel (gestion du stress et de la souffrance liée à la séparation, divorces, émigrations, coming-out), relationnel (élaboration des pertes par rapport aux précédentes appartenances familiales et mobilisation de ressources pour la création de nouvelles), et sociétal (impact de la stigmatisation, racisme, homophobie, exclusion, manque de reconnaissance juridique et politique). [less ▲]

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See detailSAHBNET, An Accessible Surface-Based Elastic Network to Insert a Protein in a Complex Lipid Membrane
Dony, Nicolas ULg; Crowet, Jean-Marc ULg; Joris, Bernard ULg et al

Conference (2013, November 11)

Study of membrane proteins have become one of the most challenging fields in biology. Solving their structure is one important step toward the understanding of their physiological activity but despite the ... [more ▼]

Study of membrane proteins have become one of the most challenging fields in biology. Solving their structure is one important step toward the understanding of their physiological activity but despite the recent advances in membrane protein crystallization, it represents less than 1 % of the entries in the Protein Data Bank. Therefore, calculation methods to study membrane proteins are helpful to complement experimental studies and fill the gap between the information obtained from the sequence and/or structure, the experimental results and the biological activity. Molecular Dynamics is a method of choice for membrane simulations and the rising of coarse-grained forcefields has opened the way to longer simulations with reduced calculations times. However, these approaches have two main drawbacks, the preparation of complex systems and the preservation of the 3D protein structure, which is not trivial in coarse grained approach. To circumvent these problems, we propose to use a modified version of the Gromacs tool genbox to easily insert lipids and a network based on hydrogen bonds and accessible surface to maintain the protein 3D structure. This protocol is available through a website (gcgs.gembloux.ulg.ac.be). [less ▲]

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See detailDeregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways
Stellzig, J; Chariot, Alain ULg; Shostak, Kateryna ULg et al

in Oncogenesis (2013), e79

Signal transmission by the noncanonical IkappaB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IKKɛ, requires interaction with adapter proteins such as TRAF associated NF-κB activator (TANK). Although ... [more ▼]

Signal transmission by the noncanonical IkappaB kinases (IKKs), TANK-binding kinase 1 (TBK1) and IKKɛ, requires interaction with adapter proteins such as TRAF associated NF-κB activator (TANK). Although increased expression or dysregulation of both kinases has been described for a variety of human cancers, this study shows that deregulated expression of the TANK protein is frequently occurring in glioblastomas (GBMs). The functional relevance of TANK was analyzed in a panel of GBM-derived cell lines and revealed that knockdown of TANK arrests cells in the S-phase and prohibits tumor cell migration. Deregulated TANK expression affects several signaling pathways controlling cell proliferation and the inflammatory response. Interference with stoichiometrically assembled signaling complexes by overexpression or silencing of TANK prevented constitutive interferon-regulatory factor 3 (IRF3) phosphorylation. Knockdown of TANK frequently prevents constitutive activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). TANK-mediated ERK1/2 activation is independent from the canonical MAP kinase or ERK kinase (MEK) 1/2-mediated pathway and utilizes an alternative pathway that uses a TBK1/IKKɛ/Akt signaling axis, thus identifying a novel pathway suitable to block constitutive ERK1/2 activity. [less ▲]

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See detailLa presse régionale en déclin ?
Geuens, Geoffrey ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 11 (4 ULg)
Peer Reviewed
See detailInfinite Depth: du Movie Ride à la 3D relief, l'expérience de la profondeur.
Thonon, Jonathan ULg

Conference (2013, November 10)

Detailed reference viewed: 12 (1 ULg)
Peer Reviewed
See detailM.G. Vassanji’s A Place Within: Thinking through India, Transnationally
Munos, Delphine ULg

Conference (2013, November 10)

In their groundbreaking collection, Minor Transnationalism, Françoise Lionnet and Shu-mei Shih advocate a new approach to transnationalism, which, by shifting the ground of analysis to “transversal” ... [more ▼]

In their groundbreaking collection, Minor Transnationalism, Françoise Lionnet and Shu-mei Shih advocate a new approach to transnationalism, which, by shifting the ground of analysis to “transversal” movements of culture, departs from existing theoretical frameworks and allows for the emergence of “minor-to-minor networks” (8) that have the potential to circumvent the major altogether. Lionnet’s and Shih’s understanding of transnationalism not in terms of vertical relations between center and margin, but in terms of cultural transversalism, is particularly apt in the context of MG Vassanji’s writings, notably because his books often complicate those hackneyed notions of hybridity constructing Western locales as the privileged sites of plurality. In this paper, my contention is that Lionnet’s and Shih’s concept of ‘minor transnationalism’ also proves useful to deconstruct the discourse of ‘dominant’ Western-based diasporas that style themselves as “the legitimate archive with which to explore diasporic subjectivities” (Vijay Mishra, 3) — such as the hyper-visible ‘new’ Indian diaspora of global capital. Taking its cue from Lionnet’s and Shih’s concept of minor transnationalism, this paper looks at A Place Within (2008), the memoir of Vassanji’s travels across the land of his ancestors over two decades, with a view to showing how the author’s positionality as a ‘minor’ transnational (i.e. as a Canadian writer of Indian descent born on East-African soil) gives a new twist to the now-classic ‘return to the Indian homeland’ narrative — a staple, indeed, of the enormously popular Indian diasporic literature. At stake is the contention that Vassanji’s own brand of ‘minor transnationalism’ allows for a unique descent into the messiness of India, the ‘slippery’ nature of its past — well beyond diaspora’s dubious politics of retrieval and its investment in purist readings of the Indian homeland [less ▲]

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See detailTransient middle cerebral artery occlusion prevents habit formation in C57Bl/6J mice
Linden, Jérôme ULg; Plumier, Jean-Christophe ULg; Ferrara, André ULg et al

Poster (2013, November 10)

Pathologies affecting the striatum (e.g., Parkinson’s and Huntington’s disease) can result in impaired habit learning abilities. Likewise, such impairments have also been observed after stroke affecting ... [more ▼]

Pathologies affecting the striatum (e.g., Parkinson’s and Huntington’s disease) can result in impaired habit learning abilities. Likewise, such impairments have also been observed after stroke affecting the middle cerebral artery territory (encompassing the striatum). However, habit learning has never been investigated in animal stroke models, for which it could be a reliable measure of cognitive deficits. We thus assessed the ability to learn a habitual sequence of lever-presses using operant conditioning in mice after MCAO, one of the most common stroke models. C57Bl/6J mice underwent MCAO or sham surgery. Sensorimotor functioning was assessed using the vertical pole test, rotarod and amphetamine-induced rotation test. Habit learning was evaluated using the operant serial order learning (SOL) task: mice had to perform a series of two consecutive lever-presses (i.e., left then right) to obtain a food reward. Lesion extents were finally determined using anti-NeuN immunohistochemistry. MCAO mice were significantly impaired in both the rotarod and vertical pole test, and displayed a significantly greater number of ipsilateral rotations after amphetamine administration. In the operant SOL task, MCAO committed more errors than sham; moreover, they did not show any significant increase in performance along the sessions. Histological analysis showed consistent striatal and cortical infarctions. The lack of habit learning ability in MCAO mice is congruent with both the literature investigating the effect of striatal lesion in animals and the symptomatology observed in human stroke patients. Habit learning could thus be regarded as a reliable measure of functional outcome after MCAO, in combination with test assessing sensory and motor aspects. [less ▲]

Detailed reference viewed: 27 (3 ULg)
See detailEstrogens control female sexual motivation and receptivity in quail.
de Bournonville, Catherine ULg; Ball, Gregory, F.; Balthazart, Jacques ULg et al

Poster (2013, November 10)

Detailed reference viewed: 12 (1 ULg)
See detailLa spectacularisation du pouvoir. Festivités politiques et religieuses dans les anciens Pays-Bas des XVIe et XVIIe siècles
Delfosse, Annick ULg; Dekoninck, Ralph

Scientific conference (2013, November 09)

Detailed reference viewed: 19 (0 ULg)
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See detailCoupes sombres (Martin Arnold et Walt Disney)
Belloi, Livio ULg

Conference (2013, November 09)

À partir de 2010, l'œuvre du cinéaste expérimental autrichien Martin Arnold a connu une mutation profonde. Alors que ses œuvres précédentes s'employaient à détourner des films de fiction hollywoodiens, le ... [more ▼]

À partir de 2010, l'œuvre du cinéaste expérimental autrichien Martin Arnold a connu une mutation profonde. Alors que ses œuvres précédentes s'employaient à détourner des films de fiction hollywoodiens, le travail contemporain d'Arnold vise, quant à lui, à retravailler des fragments de dessins animés issus de la production Disney. La présente communication se propose d'examiner ce corpus contemporain et d'en dégager les enjeux. Une attention toute particulière est réservée à "Shadow Cuts" (2010), film à l'occasion duquel Arnold renoue avec ses premières amours (le scratching visuel et sonore). [less ▲]

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See detailIncreased affinity of N-Methyl-AG525 stereoisomers for SK2 and SK3 channels
Liégeois, Jean-François ULg; Seutin, Vincent ULg; Dilly, Sébastien ULg

Poster (2013, November 09)

Small conductance calcium-activated potassium (SK, KCa2) channels represent interesting and challenging targets in medicinal chemistry. So far, the reference ligand is apamin, a peptide used in most ... [more ▼]

Small conductance calcium-activated potassium (SK, KCa2) channels represent interesting and challenging targets in medicinal chemistry. So far, the reference ligand is apamin, a peptide used in most published studies including the [125I] analog for binding studies. Nonpeptidic ligands with high affinity have been developed for several years. Currently, different questions remain to be solved. No selective and brain-penetrating agent is available. In addition, replacing [125I]apamin in binding experiments would be also interesting. We have developed different series of compounds initially derived from laudanosine (1). The quaternized derivative, N-methyl-laudanosine (NML), was found to be a weak SK blocker but highly reversible in electrophysiological experiments (2). Then, bis-charged derivatives were synthesized. Potentially brain-penetrating AG525 stereoisomers were obtained and tested for their affinity for SK channels (3). The affinity of one enantiomer, AG525E1, was found to be close to that of dequalinium (Ki ~ 200 nM) while the two other stereoisomers had a lower affinity. Following this study, quaternization of AG525 stereoisomers was carried out and the affinity of these compounds for SK channel subtypes was determined in comparison with that of parent compounds. We observed a significant increase of affinity for SK2 and SK3 channels for the bis-charged N-methyl derivatives as compared to the basic AG525 stereoisomers to. The ratio of selectivity was increased a little in the case of bis-charged N-methyl derivatives. In addition, the influence of stereochemistry was quite different between both groups. For basic AG525 stereoisomers, the S,S-enantiomer (AG525E1) was the most potent while, within bis-charged N-methyl analogues, both enantiomers had higher affinity. Further in silico approaches should permit to explain these results. References: (1) Graulich et al., Bioorg. Med. Chem. 2005, 13, 1201 (2) Scuvée-Moreau et al., J. Pharmacol. Exp. Ther. 2002, 302, 1176 (3) Graulich et al., Bioorg. Med. Chem. Lett., 2008, 18, 3440 [less ▲]

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See detailLibraries and their Role in Open Access: Challenges and Opportunities
Morse, Laura; Renaville, François ULg; Stohn, Christine

Conference (2013, November 08)

The open access movement gains momentum with an increasing number of institutions and funders adopting open access mandates for their funded research. Consequently, an increasing amount of material ... [more ▼]

The open access movement gains momentum with an increasing number of institutions and funders adopting open access mandates for their funded research. Consequently, an increasing amount of material becomes freely available, either from institutional repositories or from traditional or newly established journals. Libraries can play a dual role in supporting this movement: Firstly, they can provide services supporting the deposit of research output in their institutional repositories, including support for making it widely discoverable via indexes such as Google Scholar and library discovery systems. Secondly, libraries can make open access materials discoverable by their patrons through such indexes, thus expanding their collection to include materials that they would not necessarily license. This session will describe the experience of the University Libraries of Liège in Belgium and Harvard. University of Liège chose a top-down approach and made it compulsory for researchers to deposit their output in the institutional repository—ORBi. To support this mandate, the library offers services that help researchers deposit and disseminate their publications. Both libraries—Liège and Harvard—enable their students and faculty to discover open access content beyond their library’s acquired collection via their library discovery system. The session will also address challenges that arise from indexing open access publications and how index providers and libraries can deal with such publications, especially with articles that are deposited in different institutional repositories or published in so-called hybrid journals that contain a mix of open access and subscription articles. Finally, we will discuss with the audience how they see libraries’ role evolving in this area, what challenges they are currently facing, and the solutions and opportunities they have found. [less ▲]

Detailed reference viewed: 199 (19 ULg)
See detailGeorges Ier d'Amboise (1460-1510). Une figure plurielle de la Renaissance
Dumont, Jonathan ULg; Fagnart, Laure ULg

Book published by Presses universitaires de Rennes (2013)

Archevêque de Rouen, cardinal, légat a latere, Georges Ier d’Amboise (1460–1510) est l’une des personnalités les plus fascinantes de la première Modernité européenne. Le prélat ne s’est toutefois pas ... [more ▼]

Archevêque de Rouen, cardinal, légat a latere, Georges Ier d’Amboise (1460–1510) est l’une des personnalités les plus fascinantes de la première Modernité européenne. Le prélat ne s’est toutefois pas contenté de cumuler les fonctions ecclésiastiques les plus prestigieuses. Pendant une dizaine d’années, en qualité de principal conseiller de Louis XII, il fut l’artisan de la politique royale, tant en France qu’à l’étranger. Son action concerne également les arts. Que ce soit en tant que bâtisseur et amateur averti d’architecture – comme en témoigne le château de Gaillon – ou que bibliophile et collectionneur, Georges Ier d’Amboise participe résolument à la diffusion des idées et des formes venues d’Italie. Les 2 et 3 décembre 2010 – à l’occasion du 500e anniversaire de la mort du cardinal –, un colloque international a été organisé à l’Université de Liège avec le soutien de "Transitions. Département de recherches sur le Moyen Âge tardif & la première Modernité". Les actes du colloque "Georges Ier d’Amboise (1460–1510). Une figure plurielle de la Renaissance", dirigés par Jonathan Dumont et Laure Fagnart, rassemblent la plupart des contributions présentées à ce colloque et se proposent, de la sorte, de traiter les aspects politiques, religieux et culturels de la vie du prélat, ambitionnant ainsi de faire le point sur l’état de nos connaissances, tout en dégageant de nouvelles pistes de recherches. [less ▲]

Detailed reference viewed: 35 (8 ULg)
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See detailNew Insights into Thymus Physiology
Geenen, Vincent ULg

Scientific conference (2013, November 08)

Detailed reference viewed: 17 (0 ULg)
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See detailEvaluation of shielding effectiveness of composite wall with a time domain discontinuous Galerkin method
Kameni, Abelin; Modave, Axel ULg; Boubekeur, Mohamed et al

in European Physical Journal : Applied physics (2013), 64(2), 24508

This article presents a Time Domain Discontinuous Galerkin method applied for solving the conservative form of Maxwell equations and computing the radiated fields in electromagnetic compatibility problems ... [more ▼]

This article presents a Time Domain Discontinuous Galerkin method applied for solving the conservative form of Maxwell equations and computing the radiated fields in electromagnetic compatibility problems. The results obtained in homogenous media for the transverse magnetic waves are validated in two cases. We compare our solution to an analytical solution of Maxwell’s equations based on characteristic method. Our results on shielding effectiveness of a conducting wall are same as those obtained from analytical expression in frequency domain. The propagation in heterogeneous medium is explored. The shielding effectiveness of a composite wall partially filled by circular conductives inclusions is computed. The proposed results are in conformity with the classical predictive homogenizations rules. [less ▲]

Detailed reference viewed: 47 (9 ULg)
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See detailPINP in renal impaired patients: the assay matters
CAVALIER, Etienne ULg; DELANAYE, Pierre ULg

Poster (2013, November 08)

Detailed reference viewed: 34 (4 ULg)