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See detailRèglement Successions (650/2012) - aperçu général pour la planification successorale
Wautelet, Patrick ULg

Conference (2014, March)

Cette présentation donne un aperçu général des principes sur lesquel le Règlement 650/2012 est fondé, avec une attention particulière consacrée à l'impact du Règlement sur la pratique de la planification ... [more ▼]

Cette présentation donne un aperçu général des principes sur lesquel le Règlement 650/2012 est fondé, avec une attention particulière consacrée à l'impact du Règlement sur la pratique de la planification successorale [less ▲]

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See detailOlder adults, physical activity and the internet: Exploring their behaviours, beliefs and opinions
Mouton, Alexandre ULg; Cloes, Marc ULg

in International Journal of Physical Education (2014), 51(1), 18-29

Despite the numerous health benefits, population physical activity (PA) levels are low and decline with age. As the population grows older, with some major implications in terms of public health cost ... [more ▼]

Despite the numerous health benefits, population physical activity (PA) levels are low and decline with age. As the population grows older, with some major implications in terms of public health cost, innovative interventions to promote PA in older adults are of major interest. The Internet holds potential for delivering effective PA interventions and older adults are the largest-growing group of Internet users. Therefore, the main purpose of this study was to explore the older adults’ behaviours, beliefs and opinions about PA and Internet. At baseline, 75 older adults participated in the two stages of the study: (1) an assessment of their behaviours and beliefs about PA and web-based PA promotion; and (2) the experimentation of a single session of home-exercising followed by an interview regarding their opinion on this session. Results exposed that a minority of the participants were regularly active according to the stage of change for PA. Depending on their knowledge of PA, participants mainly perceived social and health aspects as barriers or motivators for their practice of PA. Senior adults considered home-exercising delivered via the Internet sufficiently relevant, acceptable, original, appreciated and reproducible only if it goes along with a reinforced social support and a community-centred PA promotion. [less ▲]

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See detailClinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg; Bellamy, Nicholas et al

in Rheumatology (2014)

Objectives. The aim of this study was to assess the efficacy of strontium ranelate in improving symptoms in knee OA. Methods. Symptoms were assessed over 3 years in patients with primary knee OA receiving ... [more ▼]

Objectives. The aim of this study was to assess the efficacy of strontium ranelate in improving symptoms in knee OA. Methods. Symptoms were assessed over 3 years in patients with primary knee OA receiving strontium ranelate 2 g/day (n = 454), 1 g/day (n = 445) or placebo (n = 472) in the Strontium Ranelate Efficacy in Knee Osteoarthritis Trial. Clinical response was evaluated using WOMAC subscores, minimal perceptible clinical improvement (MPCI), minimal clinically important improvement (MCII) and a modified OMERACT Osteoarthritis Research Society International (OARSI) responder definition. Patients who withdrew prematurely from the study were considered non-responders. Results. There was no significant effect on symptoms for strontium ranelate 1 g/day. At the dosage of 2 g/day, strontium ranelate was associated with greater response than placebo in terms of 520% improvement in WOMAC pain from baseline to the last visit (58% vs 47%, P = 0.002) and 550% improvement in WOMAC pain (42% vs 36%, P = 0.083). Significant differences were found in MPCI response for WOMAC pain (52% vs 40%, P<0.001), stiffness (47% vs 39%, P = 0.009) and physical function (46% vs 37%, P = 0.009) and in MCII response for WOMAC physical function (46% vs 37%, P = 0.013). There were also more OMERACT-OARSI-like responders with strontium ranelate (44% vs 35%, P = 0.004). The treatment placebo difference in MPCI response for WOMAC pain was significant after 6 months (P = 0.024), while that in MPCI and MCII response for WOMAC physical function reached significance after 12 months (P = 0.027 and P = 0.019, respectively). Conclusion. Treatment with strontium ranelate 2 g/day over 3 years is associated with a clinically meaningful improvement in pain from 6 months as well as physical function and stiffness as assessed by the number of responders above thresholds of clinical relevance. [less ▲]

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See detailLa nozione di "partecipazione" nella Glossematica di Louis Hjelmslev
Cigana, Lorenzo ULg

Doctoral thesis (2014)

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See detailGlobal Isochrons and Phase Sensitivity of Bursting Neurons
Mauroy, Alexandre ULg; Rhoads, Blane; Moehlis, Jeff et al

in SIAM Journal on Applied Dynamical Systems (2014), 13(1), 306-338

Phase sensitivity analysis is a powerful method for studying (asymptotically periodic) bursting neuron models. One popular way of capturing phase sensitivity is through the computation of isochrons ... [more ▼]

Phase sensitivity analysis is a powerful method for studying (asymptotically periodic) bursting neuron models. One popular way of capturing phase sensitivity is through the computation of isochrons---subsets of the state space that each converge to the same trajectory on the limit cycle. However, the computation of isochrons is notoriously difficult, especially for bursting neuron models. In [W. E. Sherwood and J. Guckenheimer, SIAM J. Appl. Dyn. Syst., 9 (2010), pp. 659--703], the phase sensitivity of the bursting Hindmarsh--Rose model is studied through the use of singular perturbation theory: cross sections of the isochrons of the full system are approximated by those of fast subsystems. In this paper, we complement the previous study, providing a detailed phase sensitivity analysis of the full (three-dimensional) system, including computations of the full (two-dimensional) isochrons. To our knowledge, this is the first such computation for a bursting neuron model. This was made possible thanks to the numerical method recently proposed in [A. Mauroy and I. Mezić, Chaos, 22 (2012), 033112]---relying on the spectral properties of the so-called Koopman operator---which is complemented with the use of adaptive quadtree and octree grids. The main result of the paper is to highlight the existence of a region of high phase sensitivity called the almost phaseless set and to completely characterize its geometry. In particular, our study reveals the existence of a subset of the almost phaseless set that is not predicted by singular perturbation theory (i.e., by the isochrons of fast subsystems). We also discuss how the almost phaseless set is related to empirically observed phenomena such as addition/deletion of spikes and to extrema of the phase response of the system. Finally, through the same numerical method, we show that an elliptic bursting model is characterized by a very high phase sensitivity and other remarkable properties. [less ▲]

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See detailFacultative paedomorphosis and the pattern of intra- and interspecific variation in cranial skeleton: lessons from European newts (Ichthyosaura alpestris and Lissotriton vulgaris)
Ivanović, Ana; Cvijanović, Milena; Denoël, Mathieu ULg et al

in Zoomorphology (2014), 133(1), 99-109

Paedomorphosis, the presence of ancestral larval and juvenile traits that occur at the descendent adult stage, is an evolutionary phenomenon that shaped morphological evolution in many vertebrate lineages ... [more ▼]

Paedomorphosis, the presence of ancestral larval and juvenile traits that occur at the descendent adult stage, is an evolutionary phenomenon that shaped morphological evolution in many vertebrate lineages, including tailed amphibians. Among salamandrid species, paedomorphic and metamorphic phenotypes can be observed within single populations (facultative paedomorphosis). Despite wide interest in facultative paedomorphosis and polymorphism produced by heterochronic changes (heterochronic polymorphism), the studies that investigate intraspecific morphological variation in facultative paedomorphic species are largely missing. By quantifying the cranium size and development (bone development and remodeling), we investigated the variation at multiple levels (i.e., between sexes, populations and species) of two facultatively paedomorphic European newt species: the alpine and the smooth newt. The pattern of variation between paedomorphs (individuals keeping larval traits at the adult stage) and metamorphs (metamorphosed adult individuals) varied between species and among populations within a single species. The patterns of variation in size and skull formation appear to be more uniform in the alpine than in the smooth newt, indicating that developmental constraints differed between species (more pronounced in alpine than in smooth newt). Our study shows that the cranial skeleton provides detailed insight in the pattern of variation and divergence in heterochronic polymorphism within and between species and open new questions related to heterochronic polymorphism and evolution of cranial skeleton. [less ▲]

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See detailNew insights for an old topic: seagrasses as bioindicators of coastal trace element pollution
Richir, Jonathan ULg; Lejeune, Pierre; Gobert, Sylvie ULg

in ARGYRO ZENETOS, ZENETOS (Ed.) Mediterranean Marine Science (2014, March)

The marine magnoliophyte Posidonia oceanica (L.) Delile has been widely used since the mid-70th to biomonitor the coastal pollution of the Mediterranean in Cr, Ni, Cu, Zn, Cd, Pb and/or Fe. In contrast ... [more ▼]

The marine magnoliophyte Posidonia oceanica (L.) Delile has been widely used since the mid-70th to biomonitor the coastal pollution of the Mediterranean in Cr, Ni, Cu, Zn, Cd, Pb and/or Fe. In contrast, other trace elements (TEs) like As, V, Ag, Be, Al, Mn, Co, Se, Mo, Sn, Sb and Bi, many of them categorized as TEs of environmental emerging concern, have been subject to nearly no ecotoxicological survey with that species. It has been shown that the French Mediterranean littoral was submitted to local, diffuse and/or chronic contaminations both by TEs broadly or little biomonitored with P. oceanica; high TE levels could further be linked to specific anthropic activities such as agriculture (Mo), mining (Cr, Sb, Zn), industries (As), storage and refinement of oil products (V, Pb) or presence of major ports and urban centres (Sn, Bi, Ag). It seems therefore necessary to expand the short list of the seven metals commonly monitored to other TEs, what is today easily achievable as current analytical methods allow the simultaneous determination of all a series of TEs within the same sample. Furthermore, only a multielement analysis in appropriate bioindicator species allow to correctly intercompare the pollution status of numerous sampling sites. To do this, we have calculated proper environmental indices, the trace element pollution index TEPI and the trace element spatial variation index TESVI. The TEPI is an index of the global contamination of a site, giving the same weight to each TE after mean normalization of their environmental concentrations. The TESVI estimates the global spatial variability of environmental concentrations of each TE levels, taking into account both punctual contaminations in impacted sites and the overall coastal spatial heterogeneity between all monitored sites.These two indices were successfully applied both at large (French Mediterranean littoral) and small (a Bay) spatial scales. Furthermore, they can be used in the framework of an intercomparative study compiling data from any previous monitoring surveys. We also highlighted that the ecophysiology and surrounding levels of TEs influenced in an equivalent manner the bioaccumulation process of TEs in P. oceanica. Consequently, this natural cyclic evolution of TE concentrations should be systematically quantified in regional reference sites. Finally, the rapid and proportionnal accumulation of TEs in P. oceanica traps huge amounts of contaminants and can stock them for longer periods of time in their bellow grounds tissues. P. oceanica meadows therefore play an efficient role of natural filter of TE coastal pollutions. [less ▲]

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See detailA differential Lyapunov framework for contraction analysis
Forni, Fulvio ULg; Sepulchre, Rodolphe ULg

in IEEE Transactions on Automatic Control (2014), 59(3), 614-628

Lyapunov's second theorem is an essential tool for stability analysis of differential equations. The paper provides an analog theorem for incremental stability analysis by lifting the Lyapunov function to ... [more ▼]

Lyapunov's second theorem is an essential tool for stability analysis of differential equations. The paper provides an analog theorem for incremental stability analysis by lifting the Lyapunov function to the tangent bundle. The Lyapunov function endows the state-space with a Finsler structure. Incremental stability is inferred from infinitesimal contraction of the Finsler metrics through integration along solutions curves. [less ▲]

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See detailThe feedback of massive stars on interstellar astrochemical processes
De Becker, Michaël ULg

in Astrophysics & Space Science (2014), 350(1), 237-243

Astrochemistry is a discipline that studies physico-chemical processes in astrophysical environments. Such environments are characterized by conditions that are substantially different from those existing ... [more ▼]

Astrochemistry is a discipline that studies physico-chemical processes in astrophysical environments. Such environments are characterized by conditions that are substantially different from those existing in usual chemical laboratories. Models which aim to explain the formation of molecular species in interstellar environments must take into account various factors, including many that are directly, or indirectly related to the populations of massive stars in galaxies. The aim of this paper is to review the influence of massive stars, whatever their evolution stage, on the physico-chemical processes at work in interstellar environments. These influences include the ultraviolet radiation field, the production of high energy particles, the synthesis of radionuclides and the formation of shocks that permeate the interstellar medium. [less ▲]

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See detailVieillissement: mieux comprendre pour mieux (inter)agir dans nos actes de soins
Schroyen, Sarah ULg; Marquet, Manon ULg

Conference given outside the academic context (2014)

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See detailPrognostic value of FDG PET/CT in liver transplantation for hepatocarcinoma
DETRY, Olivier ULg; Govaerts, L; BLETARD, Noëlla ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 08

AIM : FDG uptake has been shown to predict the outcome in large series of patients with hepatocarcinoma (HCC) in Asia, but few data are available regarding European populations. Our aim was to evaluate ... [more ▼]

AIM : FDG uptake has been shown to predict the outcome in large series of patients with hepatocarcinoma (HCC) in Asia, but few data are available regarding European populations. Our aim was to evaluate the prognostic value of pretreatment FDG PET-CT in patients treated by liver transplantation. Methods: We retrospectively analyzed the data of 27 patients (24 M and 3 W, mean age 58 ± 9 years). The mean follow-up was 26 ± 18 months (min 1 month, max 66 months). All patients had an FDG PET-CT before the transplantation. The FDG PET/CT was performed according to a standard clinical protocol: 4 MBqFDG/kg body weight, uptake 60 min., low-dose non-enhanced CT. We measured the SUVmax and SUVmean of the tumor and the normal liver. The tumor/liver activity ratios (RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors: MILAN, CLIP, OKUDA, TNM stage, alphafoetoprotein level, portal thrombosis, size of the largest nodule, tumor differentiation, microvascular invasion, underlying cirrhosis and liver function. Results : The DFS was 87.2% at 1y and 72.1% at 3y. The OS was 85.2% at 1y and 80.7% at 3y. According to an univariate Cox model, RSUVmax, RSUVmean and healthy liver were predictors of DFS and RSUVmax, RSUVmean, size of the largest nodule, CLIP, liver involvement>50%, and healthy liver predicted the OS. According to a multivariate Cox model, only RSUVmax predicted DFS and RSUVmax and liver involvement>50% predicted OS. An ROC analysis of the ratios showed that the 1.15 cut-off for RSUVmax was best for predicting both the DFS (Cox regression:HR 14.4, p=0.02) and OS (HR 5.6, p=0.049). The Kaplan-Meier curves and Logrank tests confirmed those results. Even though the MILAN criteria alone were not predictive, it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 relapsed. Conclusions: The RSUVmax is a strong prognostic factor for recurrence and death in patients with HCC treated by liver transplantation with a cut-off value of 1,15. further prospective studies should test whether the metabolic index should be systematically included in the preoperative assessment. [less ▲]

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See detailControlled DCD donation is part of the solution to liver graft shortage, regardless of donor age
DETRY, Olivier ULg; MEURISSE, Nicolas ULg; DELWAIDE, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2014, March), 77(1), 16

Aim: Results of donation after circulatory death (DCD) liver transplantation (LT) are impaired by ischemic bile duct lesions caused by procurement warm ischemia. Donor age is a risk factor in deceased ... [more ▼]

Aim: Results of donation after circulatory death (DCD) liver transplantation (LT) are impaired by ischemic bile duct lesions caused by procurement warm ischemia. Donor age is a risk factor in deceased donor LT, and particularly in DCD-LT. At the authors institute, age is not an absolute exclusion criterion to discard DCD liver grafts, controlled DCD donors receive comfort therapy before withdrawal, and cold ischemia is minimized. The aim of the present study was to report on the results of the first 10 years of this experience, and particularly on graft survival and the rate of post-transplant biliary complications, according to DCD donor age. 
 Methods: The authors retrospectively studied a consecutive series of 70 DCD-LT performed from 2003 to 2012, with at least one year of follow-up. This series was divided according to donor’s age, including 32 liver grafts from donors <55years, 20 between 56 and 69 years, and 18 from older donors >69 years. The three groups were compared in terms of donor and recipient demographics, procurement and transplantation conditions, peak laboratory values during the first post-transplant 72 hours, and results at one and four years. Median follow-up was 43 months. 
 Results: Overall graft survival was 98.5%, 91.4% and 69.5% at 1 month, 1 year and 4 years, respectively, without graft loss secondary to ischemic bile duct lesions. Cancer was the primary cause of graft loss and patient death. No difference other than age was noted between the three groups in donor and recipient characteristics, and in procurement conditions. There was no primary non-function but one patient needed re-transplantation for artery thrombosis. Biliary complications occurred similarly in the three groups. Graft and patient survival rates were not different at one and four years between the three groups. During the study period, there was an increasing liver procurement and transplantation activity, and in 2012, 30% of performed LT were DCD-LT, allowing a mean LT waiting time of 66 days. 
 Conclusions: This study shows comparable results between controlled DCD-LT from younger and older donors. Donor age >50 years should not be a contraindication to DCD-LT if other donor risk factors (such as warm and cold ischemia time) are minimized. DCD-LT with short cold ischemia may provide a significant source of liver grafts, decreasing waiting time. [less ▲]

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See detailShergottites: Partial Melts of a Depleted Martian Mantle
Médard, Etienne; Collinet, Max ULg

Poster (2014, March)

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See detailPourquoi tant de richesse? Dossier Reliques & reliquaires
George, Philippe ULg

in Arts Sacrés (2014), 28

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See detailReliability and validity of the Quality of Life Systemic Inventory for Children (QLSI-C): Preliminary result of a modular assessment tool of quality of life using e-Health technologies
Toucheque, Malorie ULg; Etienne, Anne-Marie ULg

Poster (2014, March)

Objective: Use of generic versus specific tools in psychological assessment is a controversial issue. Generic instruments can be used to measure QOL for numerous chronic illnesses; however, they may not ... [more ▼]

Objective: Use of generic versus specific tools in psychological assessment is a controversial issue. Generic instruments can be used to measure QOL for numerous chronic illnesses; however, they may not be sensitive to particular aspects of the disease. Unfortunately, disease-specific measures cannot be used to compare results across diseases or conditions. The QLSI-C is an assessment tool that uses a modular approach developed to overcome these shortcomings. QLSI-C was devised as a generic scale to be integrated with disease specific modules. The purpose of this study is to report on reliability and validity of the QLSI-C generic scale and the cystic fibrosis (CF)-specific module. Methods: QLSI-C was administered to 20 children with CF and 20 healthy children (ages 8-12 years) in Belgium. Internal consistency was assessed using Cronbach’s coefficient. Validity of the QLSI-C was measured using the known-groups method, i.e., analysis of variance (ANOVA) to distinguish between healthy children and children with CF. To examine the validity of the QLSI-C, correlations were calculated between the generic scale and CF-specific module. Results: Internal consistency for the QLSI-C generic scale with the CF-specific module was good ( =.82). ANOVA results revealed a significant difference between CF and healthy children for the QOL score (p=.005), with higher average scores (i.e., lower QoL) for CF children (M=4.35) than healthy children (M=1.25). Correlations between QoL scores on the generic scale and CF-specific module demonstrated medium effect size (r=0.47; p=.04). Conclusions: To date, three specific modules are available for the QLSI-C: (1) cancer; (2) asthma; (3) cystic fibrosis. Originality of this tool is strengthened by use of e-Health technologies (i.e., iPad app for administering the QLSI-C). Satisfactory psychometric properties and state-of-the-art use of technology suggests that the QLSI-C has potential utility for use in clinical trials, research, and clinical practice. [less ▲]

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See detailAssessment using e-Health technologies in pediatric psychology: Developing an App on iPad for the Quality of Life Systemic Inventory for Children (QLSI-C)
Toucheque, Malorie ULg; Tilkin, Caroline; Dupuis, Gilles et al

Poster (2014, March)

Objective:Integration of e-Health technologies for purposes of both assessment and intervention has recently become an interest area in pediatric psychology. The purpose of this study is to present ... [more ▼]

Objective:Integration of e-Health technologies for purposes of both assessment and intervention has recently become an interest area in pediatric psychology. The purpose of this study is to present psychometric characteristics of a technology-based (i.e., iPad administration) approach for measuring quality of life (QoL) in children. Methods: Sample consisted of 80 children (8-12 years) recruited from elementary schools in Belgium. They completed the Quality of Life Systemic Inventory for Children (QLSI-C) twice over a two-week delay, in a crossover design that used paper and iPad-based modes of administration. QLSI-C takes a unique approach to assessing QoL relative to existing measures. Specifically, it considers QoL to be the difference (gap score) between the present situation (state score) and the child’s expectations (goal), weighted by the importance (rank) assigned for each life domain. Cronbach’s coefficient was computed to assess internal consistency for each of the four global scores (State, Goal, Gap, Rank). ANOVA was used to assess the equivalence of the new iPad and paper formats. Test-retest reliability was assessed using correlational analysis. Results: Alpha coefficients for the global scores were as follows: State (.87), Goal (.94), Gap (.72), and Rank (.79). ANOVA results indicate that main effects for group (p = 0.75) and time (p= 0.31) were not statistically significant, nor was the interaction effect (p = 0.86) for the QoL score (Gap). Correlations for the test-retest reliability of the 4 global scores ranged from .66 to .90. Conclusions: The iPad format of QLSI-C appears valid in comparison to the original paper format and test-retest stability for the iPad format is good. This technology approach to assessment is more attractive for children, decreases time for administration, and enhances the ease of scoring. Thus, these advantages might encourage both clinicians and researchers to consider using e-Health developments in assessment in pediatric psychology. [less ▲]

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See detailQui est Georges Simenon?
Demoulin, Laurent ULg

in Baradel, Anne (Ed.) Simenon. Reporter-photographe. 1931-1935. De la Belgique à la Turquie (2014)

Présentation générale de la vie et de la carrière littéraire de Georges Simenon.

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