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See detailApproche électro-physiologique non invasive des malformations du développement cortical: EEG
RIKIR, Estelle ULg

Conference (2014, November 13)

L’électro-encéphalogramme (EEG) de surface, technique non invasive et peu couteuse, demeure la pierre angulaire de la mise au point des épilepsies. Le développement de dispositifs d’enregistrement au ... [more ▼]

L’électro-encéphalogramme (EEG) de surface, technique non invasive et peu couteuse, demeure la pierre angulaire de la mise au point des épilepsies. Le développement de dispositifs d’enregistrement au moyen de 64 à 256 électrodes a permis d’augmenter considérablement la résolution spatiale de l’EEG de surface (Lantz et al., Clin Neurophysiol 2003). D’autre part, le développement de l’imagerie de source électrique (ISE) a permis au moyen de modèles mathématiques de localiser le générateur cortical responsable du signal EEG enregistré en surface (Scherg et al., 1990; Pascual-Marqui, 2002). Les malformations corticales (MCs) représentent un large spectre d’anomalies structurelles congénitales (Barkovich et al., Brain 2012) et constituent une des principales causes d’épilepsie de l’adulte (Spencer & Huh, Lancet Neurol 2008). Cette épilepsie s’avère malheureusement pharmaco-résistante dans la plupart des cas (85%) (Papayannis et al., Seizure 2012). Si les MCs sont hétérogènes d’un point de vue structurel (radiologique et anatomopathologique), les études électro-physiologiques (EEG) ont démontré que cette hétérogénéité existait également au niveau fonctionnel, non seulement entre les différents types de MCs mais aussi parfois au sein d’une même malformation. Les dysplasies corticales focales (DCF), hautement épileptogènes (Chassoux et al., Brain 2000; Aubert et al., Brain 2009), restent « invisibles » à l’IRM dans 30 à 50 % des cas (Hauptman et al., Epilepsia 2012). Dans ce cas, l’EEG de surface et l’ISE aident à la localisation du foyer épileptique (Brodbeck et al., Epilepsia 2010; Rikir et al.,Epilepsia 2014). Morphologiquement, aucune anomalie en EEG de surface n’est spécifique d’une DCF (Sisodiya et al., Lancet Neurol 2009). Les MCs, notamment les schizencéphalies et polymicrogyries, sont parfois très vastes et impliquent structurellement plusieurs régions lobaires et sous-lobaires, compliquant l’approche chirurgicale. L’EEG haute résolution couplé à l’ISE peut montrer le caractère hétérogène de la malformation en terme d’épilpetogénicité et désigner ainsi la partie impliquée dans les crises d’épilepsie (Rikir et al., 2014 ; Maillard et al., 2009). En cas de malformation multifocale (sclérose tubéreuse de Bourneville, hétérotopies nodulaires), les anomalies EEG critiques et inter-critiques désignent parfois une origine unifocale des crises épileptiques rendant éventuellement possible un traitement chirurgical. Enfin, il a été montré prospectivement que l’EEG haute densité couplé à l’ISE contribuait à localiser la zone épileptogène dans les épilepsies en rapport les MCs , qu’il présentait une valeur ajoutée par rapport à une mise au point classique basée sur l’enregistrement VIDEOEEG et l’IRM cérébrale, et qu’il était particulièrement indiqué en cas d’IRM négative ainsi qu’en cas de discordance entre hypothèses électro-cliniques (VIDEOEEG) et données structurelles (IRM) (Rikir et al., Epilepisa 2014). [less ▲]

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See detailGreen roofs and facades : toward food and biodiversity functions
Mahy, Grégory ULg; Jijakli, Haissam ULg

Scientific conference (2014, November 12)

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See detaille syndrome de Pasqualini (Fertile eunuch syndrome)
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2014, November 12)

Pasqualini’s syndrome: hypoandrogenism with spermatogenesis Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in Revista de la Asociación Médica Argentina ... [more ▼]

Pasqualini’s syndrome: hypoandrogenism with spermatogenesis Pasqualini and Bur published the first case of eunuchoidism with preserved spermatogenesis in 1950 in Revista de la Asociación Médica Argentina. The hypoandrogenism with spermatogenesis syndrome included: (a) eunuchoidism, (b) testis with normal spermatogenesis and full volume, with mature spermatozoids in a high proportion of seminiferous tubes and undifferentiated and immature Leydig cells (c) full functional compensation through the administration of chorionic gonadotropin hormone, while hCG is administered (d) total urinary gonadotrophins within normal limits (e) this definition supposes the normal activity of the pituitary and the absence of congenital malformations in general. A first step in the understanding of the physiopathogeny of Pasqualini syndrome or the so called “fertile eunuch" syndrome was the absence of LH in plasma and urine of patients. The second breakthrough was the functional and genetic studies that validated the hypothesis of a functional deficit of LH in these men: it will then also be described in some women. Different groups including ours demonstrated in these cases a LH with varying degrees of immunological activity but biologically inactive in most of the patients, due to one or more inactivating mutations in the LHB gene. Finally, the full comprehension of Pasqualini syndrome allowed to reverse the hypoandrogenic phenotype and to restore fertility in these patients through the use of chorionic gonadotropin and the modern in-vitro fertility techniques. This conference is an historical review and a tribute to the memory of Rodolfo Q. Pasqualini. [less ▲]

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See detailChocolate : Natural but also chemical product…
Echterbille, Julien ULg

Conference (2014, November 12)

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See detailSoil charcoal to assess the impacts of past human disturbances on tropical forests
Vleminckx, Jason; Morin-Rivat, Julie ULg; Biwolé, Achille et al

in PLoS ONE (2014)

The canopy of many central African forests is dominated by light-demanding tree species that do not regenerate well under themselves. The prevalence of these species might result from ancient slash-and ... [more ▼]

The canopy of many central African forests is dominated by light-demanding tree species that do not regenerate well under themselves. The prevalence of these species might result from ancient slash-and-burn agricultural activities that created large openings, while a decline of these activities since the colonial period could explain their deficit of regeneration. To verify this hypothesis, we compared soil charcoal abundance, used as a proxy for past slash-and-burn agriculture, and tree species composition assessed on 208 rainforest 0.2 ha plots located in three areas from Southern Cameroon. Species were classified in regeneration guilds (pioneer, non-pioneer light-demanding, shade-bearer) and characterized by their woodspecific gravity, assumed to reflect light requirement. We tested the correlation between soil charcoal abundance and: (i) the relative abundance of each guild, (ii) each species and family abundance and (iii) mean wood-specific gravity. Charcoal was found in 83% of the plots, indicating frequent past forest fires. Radiocarbon dating revealed two periods of fires: ‘‘recent’’ charcoal were on average 300 years old (up to 860 BP, n = 16) and occurred in the uppermost 20 cm soil layer, while ‘‘ancient’’ charcoal were on average 1900 years old (range: 1500 to 2800 BP, n = 43, excluding one sample dated 9400 BP), and found in all soil layers. While we expected a positive correlation between the relative abundance of light demanding species and charcoal abundance in the upper soil layer, overall there was no evidence that the current heterogeneity in tree species composition can be explained by charcoal abundance in any soil layer. The absence of signal supporting our hypothesis might result from (i) a relatively uniform impact of past slash-and-burn activities, (ii) pedoturbation processes bringing ancient charcoal to the upper soil layer, blurring the signal of centuries-old Human disturbances, or (iii) the prevalence of other environmental factors on species composition. [less ▲]

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See detailInfluence de la vitesse de croissance sur le classement de lames de bardage de Douglas wallon (Belgique)
Pollet, Caroline; Henin, Jean-Marc; Hebert, Jacques ULg et al

Poster (2014, November 12)

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See detailFalsification des médicaments en Afrique : état de la question
Marini Djang'Eing'A, Roland ULg; Hubert, Philippe ULg

Scientific conference (2014, November 12)

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See detailQui sont les exhibitionnistes? Pourquoi montrer son sexe en public?
Ernst, Martine; Garcet, Serge ULg

Diverse speeche and writing (2014)

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See detailLa francophonie dans tous ses états
Baiwir, Esther ULg

Conference (2014, November 12)

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See detailDISTRIBUTION OF CAPSULAR POLYSACCHARIDES OF STREPTOCOCCUS AGALACTIAE STRAINS FROM URUGUAY. MULTIPLEX PCR VERSUS CONVENTIONAL CAPSULAR SEROTYPING
Rodriguez Cuns, Grisel ULg; BOREUX, Raphaël ULg; ADAMS, Pauline et al

in XIX Lancefield International Symposium on Streptococci and Streptococcal Diseases, Program and Abstract book (2014, November 11)

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See detailLes potentialités de la création de jeux vidéo en ateliers dans le milieu culturel : retour sur l'expérience Chômeurs Blaster
Hurel, Pierre-Yves ULg

Conference given outside the academic context (2014)

Dans cette intervention je suis revenu sur les ateliers menés pour D'une Certaine Gaieté et ses résultats. Puis j'ai présenté les potentialités de ce dispositif si on l'adaptait au milieu muséal, en m ... [more ▼]

Dans cette intervention je suis revenu sur les ateliers menés pour D'une Certaine Gaieté et ses résultats. Puis j'ai présenté les potentialités de ce dispositif si on l'adaptait au milieu muséal, en m'appuyant notamment sur un prototype de jeu vidéo faisant référence à l'univers graphique de René Magritte. [less ▲]

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See detailSmart cross-linked polymer micelles for drug delivery
Riva, Raphaël ULg; Vanslambrouck, Stéphanie ULg; Ergül, Zeynep ULg et al

Conference (2014, November 11)

Nowadays, polymer crosslinking is widely used in industry to improve or to impart new properties to existing polymer material. In the pharmaceutical field, polymer crosslinking is of great interest for ... [more ▼]

Nowadays, polymer crosslinking is widely used in industry to improve or to impart new properties to existing polymer material. In the pharmaceutical field, polymer crosslinking is of great interest for the elaboration of drug delivery devices, mostly hydrogels. Nevertheless, crosslinking is also very useful in nanovectorization of active principle. Indeed, each day, new drugs are synthesized and available on the market but in too many cases, the high hydrophobicity of some drugs makes them useless because of the absence of an appropriated administration method. The encapsulation of the drug into a nanocarrier, typically in the hydrophobic core of a polymer micelle, allows a significant increase of the drugs concentration in water in addition to the protection of the active principle against degradation. However, polymer micelles suffer of the main drawback to not be stable, leading to a premature release of the drug, when the concentration falls down the critical micellar concentration (CMC), which it is rapidly observed after intravenous injection. In order to get rid of the CMC, crosslinking of the micelle core is the most proposed strategy. Nevertheless, the crosslinking of the micelle core may have a non-negligible effect on the drug loading but mainly on the drug release due to the sequestration of the drug in the network. Over the last years, our lab investigated several strategies for the crosslinking of the micelle core made of amphiphilic and biocompatible block copolymers generally by UV radiation in order to fulfill the increasingly stringent requirements of biomedical applications. These strategies are very helpful to prepare injectable nanosized cross-linked particles loaded with an active particle. For some systems, the effect of the crosslinking rate on the drug loading and the drug release was evaluated using a model drug. As the crosslinking may interfere with the drug release after internalization of the carrier into the cell, a reversible crosslinking of the micelle core was proposed. Typically, the introduction of disulfide bond as inter-chain links allowed to delay the drug release by diffusion whereas into the cell, the reduction of the disulfide bridges into corresponding thiol led to the fast disassemble of the micelle and the specific release of the drug into cytoplasm. [less ▲]

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See detailCorporate board attributes and conditional accounting conservatism: Evidence from French firms
Boussaid, Nabila ULg; Sougné, Danielle ULg; Hamza, Taher

E-print/Working paper (2014)

In this paper we investigate the relationship between boards of directors’ attributes and conditional accounting conservatism in the French context. Using a pooled regression model to evaluate this ... [more ▼]

In this paper we investigate the relationship between boards of directors’ attributes and conditional accounting conservatism in the French context. Using a pooled regression model to evaluate this relationship for the period 2009-2012, our empirical results can be summarized as follows. Firstly, greater board activity encourages more conservative reporting in financial statements. Secondly, greater board size diminishes conditional accounting conservatism. Lastly, there is a positive relationship between gender diversity and conservatism. To ensure robustness we have calculated our results using alternative measures of accounting conservatism, namely time series and accrual-based measures in addition to asymmetric timeliness of earnings. These findings suggest that boards of directors’ attributes are an important factor in determining the financial reporting quality of French firms. [less ▲]

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See detailTracking dialects in a dead language: the case of Late Egyptian
Winand, Jean ULg

Scientific conference (2014, November 11)

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See detailCell cultivation in chitosan alginate hydrogel beads
Henrotin, Yves ULg; Kesteloot, Frédéric; Sanchez, Christelle ULg

Patent (2014)

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See detailUltrasonographic assessment of uterine involution and ovarian activity in West African Sahelian goats.
Zongo, Moussa; Traore, Boureima; Ababneh, Mohammed Mahmoud et al

in Journal of Veterinary Medicine and Animal Health (2014), 7(2), 71-76

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See detailPratiques et stratégies alimentaires dans l'Antiquité tardive : l'apport de la papyrologie
Marganne, Marie-Hélène ULg

Conference (2014, November 10)

Sans équivalent dans le monde antique et tardo-antique en raison des conditions climatiques favorables de l’Égypte, les sources papyrologiques, qu'elles soient littéraires, documentaires, magiques ou ... [more ▼]

Sans équivalent dans le monde antique et tardo-antique en raison des conditions climatiques favorables de l’Égypte, les sources papyrologiques, qu'elles soient littéraires, documentaires, magiques ou chrétiennes, écrites en grec, en latin ou même en copte, fournissent de nombreuses informations sur les denrées alimentaires, non seulement produites et importées dans le Pays du Nil durant la période byzantine (à partir de l'accession au principat de Dioclétien, en 284, jusqu'à la conquête arabe, en 641), mais également exportées et consommées dans le reste de l'Empire romain et dans d’autres contrées, ainsi que sur la manière de les utiliser. Après avoir inventorié les papyrus contenant des références à des produits alimentaires, leur genre, leur provenance, leur forme, leur langue et leur écriture, à l'aide de quelques exemples, on s’interrogera sur leur contenu et sur ce qu’il révèle des pratiques et stratégies alimentaires d’une société multiculturelle (Égyptiens, Grecs, Romains, Juifs, etc.) depuis l’époque hellénistique, de l’internationalisation et de l’intensification des relations commerciales sous l’Empire romain, sans oublier l’influence des préceptes religieux. [less ▲]

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